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The map label for this gene is fabG [C]

Identifier: 158335822

GI number: 158335822

Start: 2712918

End: 2713853

Strand: Direct

Name: fabG [C]

Synonym: AM1_2675

Alternate gene names: 158335822

Gene position: 2712918-2713853 (Clockwise)

Preceding gene: 158335821

Following gene: 158335824

Centisome position: 41.71

GC content: 53.1

Gene sequence:

>936_bases
ATGAAATTTGATAATAACTCTACGACGACCGACGTACTCAACGGCATTGATCTATCGGGTAAGACCGTCCTTATAACTGG
AGCATCAACAGGTCTTGGGGCCGAGACTGCGCGGGCGACCGCCGCTTGTGGTGCTGATGTCACCCTCGTTGCGAGATCAG
TAGATAAGCTGTCTAAAGTCGCCGAATCAATCCTATCGGAAACGGGTCGCTCGCCCAATACCGCAGTCTTGGAATTGGAC
AAACCTGCCACGATTCGCAGCTTTGCCCAAGAGTGGCTTAGCCGTCACGAAAAGCTCGATATTCTGATCAACAACGCAGG
CATTATGGCACCTCCGTTGACCCGTAACGCGGAGGGTTGGGAAAGCCAGTTTGCGACGAACCATCTGGGTCACTTTCTGC
TGACCAATTTGCTGGTCGATGCCATCAAGGCCTCAGGAGAAGCCCGCGTTGTCAACCTGTCATCTGCTGGGCACTGGTAT
TCAACGGTAGATTTAGACGACCCGAATTTCCAAAACCGCGACTATGAAGCGCTTCAAGCCTATGGTCAATCAAAAACGGC
AAACATCTGGTTCACGGTAGAACTCGCTCGTCGTTGGGCAGATCACGGTGTGAACAGCTTTGCAGTACACCCAGGCGGCA
TCCAGACCGAGCTTGGCCGAAATCTGGAACCGGAAATGGCCAAGAGGTTTGAGCAGATGATCAAGGATTATCCGGATATC
TGGAAGACGGTCCCTCAAGGAGCGGCAACATCCTGCTGGGCTGCGACATCGCCTGATCTGAGCGGCAAGACAGGCCTGTA
TCTGGAAGATTGTCACATTTCTGAGCCGGGTGCCGGAGATGTGCTCGATGGCGGATACGCTCCACACGCCTACGATGCCG
ATGGCGCAAAACAACTGTGGATACTTTCGAACGATCTGTTAGGCACAGAGTTCTGA

Upstream 100 bases:

>100_bases
CAATCGCCTAAAGGATAGGCGTTCAAACTATCAATGGAGAGGCCACACAGATTGTTTATACAGCCTGGTAATAACACCTC
AAAAGAAAATGAGACGAACC

Downstream 100 bases:

>100_bases
GATTAAACGCAGCAGCTAAACCCGCACTGGGACCGAAACCAGCCTGAACCACTCCCATCTGTCACCCTCATCCATGCTGG
AAGCCCCACTACTGTGTGGC

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKFDNNSTTTDVLNGIDLSGKTVLITGASTGLGAETARATAACGADVTLVARSVDKLSKVAESILSETGRSPNTAVLELD
KPATIRSFAQEWLSRHEKLDILINNAGIMAPPLTRNAEGWESQFATNHLGHFLLTNLLVDAIKASGEARVVNLSSAGHWY
STVDLDDPNFQNRDYEALQAYGQSKTANIWFTVELARRWADHGVNSFAVHPGGIQTELGRNLEPEMAKRFEQMIKDYPDI
WKTVPQGAATSCWAATSPDLSGKTGLYLEDCHISEPGAGDVLDGGYAPHAYDADGAKQLWILSNDLLGTEF

Sequences:

>Translated_311_residues
MKFDNNSTTTDVLNGIDLSGKTVLITGASTGLGAETARATAACGADVTLVARSVDKLSKVAESILSETGRSPNTAVLELD
KPATIRSFAQEWLSRHEKLDILINNAGIMAPPLTRNAEGWESQFATNHLGHFLLTNLLVDAIKASGEARVVNLSSAGHWY
STVDLDDPNFQNRDYEALQAYGQSKTANIWFTVELARRWADHGVNSFAVHPGGIQTELGRNLEPEMAKRFEQMIKDYPDI
WKTVPQGAATSCWAATSPDLSGKTGLYLEDCHISEPGAGDVLDGGYAPHAYDADGAKQLWILSNDLLGTEF
>Mature_311_residues
MKFDNNSTTTDVLNGIDLSGKTVLITGASTGLGAETARATAACGADVTLVARSVDKLSKVAESILSETGRSPNTAVLELD
KPATIRSFAQEWLSRHEKLDILINNAGIMAPPLTRNAEGWESQFATNHLGHFLLTNLLVDAIKASGEARVVNLSSAGHWY
STVDLDDPNFQNRDYEALQAYGQSKTANIWFTVELARRWADHGVNSFAVHPGGIQTELGRNLEPEMAKRFEQMIKDYPDI
WKTVPQGAATSCWAATSPDLSGKTGLYLEDCHISEPGAGDVLDGGYAPHAYDADGAKQLWILSNDLLGTEF

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI166795268, Length=295, Percent_Identity=39.3220338983051, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI225579078, Length=297, Percent_Identity=39.7306397306397, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI186928839, Length=296, Percent_Identity=38.1756756756757, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI7706523, Length=320, Percent_Identity=33.125, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI10190746, Length=306, Percent_Identity=37.2549019607843, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI19923931, Length=261, Percent_Identity=39.0804597701149, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI146231950, Length=300, Percent_Identity=33.6666666666667, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI193804850, Length=259, Percent_Identity=34.7490347490347, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI13375997, Length=180, Percent_Identity=30, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI209862901, Length=277, Percent_Identity=26.7148014440433, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI19923983, Length=277, Percent_Identity=26.7148014440433, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI72534732, Length=193, Percent_Identity=27.979274611399, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787335, Length=209, Percent_Identity=29.6650717703349, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787526, Length=144, Percent_Identity=32.6388888888889, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786812, Length=240, Percent_Identity=28.3333333333333, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87082100, Length=208, Percent_Identity=27.8846153846154, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193207620, Length=319, Percent_Identity=30.4075235109718, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17532805, Length=285, Percent_Identity=32.6315789473684, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71992402, Length=282, Percent_Identity=31.2056737588652, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17558006, Length=307, Percent_Identity=30.9446254071661, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17532791, Length=285, Percent_Identity=26.6666666666667, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17535059, Length=283, Percent_Identity=30.3886925795053, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI32565532, Length=226, Percent_Identity=33.1858407079646, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17505416, Length=272, Percent_Identity=30.1470588235294, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI72001364, Length=278, Percent_Identity=28.4172661870504, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=242, Percent_Identity=29.7520661157025, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324820, Length=222, Percent_Identity=30.1801801801802, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324148, Length=201, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI22024069, Length=279, Percent_Identity=40.5017921146953, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24586328, Length=289, Percent_Identity=37.3702422145329, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI20129347, Length=316, Percent_Identity=32.2784810126582, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI19921754, Length=267, Percent_Identity=38.5767790262172, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28573296, Length=286, Percent_Identity=38.1118881118881, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI161076371, Length=260, Percent_Identity=39.2307692307692, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI45554248, Length=263, Percent_Identity=39.5437262357414, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24640117, Length=263, Percent_Identity=39.5437262357414, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45553409, Length=256, Percent_Identity=35.15625, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24647948, Length=256, Percent_Identity=35.15625, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24647946, Length=256, Percent_Identity=35.15625, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24656154, Length=298, Percent_Identity=31.2080536912752, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19922628, Length=298, Percent_Identity=31.2080536912752, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24647931, Length=286, Percent_Identity=29.020979020979, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357041, Length=220, Percent_Identity=30.9090909090909, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI23397609, Length=229, Percent_Identity=30.5676855895196, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571526, Length=220, Percent_Identity=28.6363636363636, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644339, Length=220, Percent_Identity=32.2727272727273, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358495, Length=210, Percent_Identity=29.0476190476191, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 33623; Mature: 33623

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFDNNSTTTDVLNGIDLSGKTVLITGASTGLGAETARATAACGADVTLVARSVDKLSKV
CCCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
AESILSETGRSPNTAVLELDKPATIRSFAQEWLSRHEKLDILINNAGIMAPPLTRNAEGW
HHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCH
ESQFATNHLGHFLLTNLLVDAIKASGEARVVNLSSAGHWYSTVDLDDPNFQNRDYEALQA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHH
YGQSKTANIWFTVELARRWADHGVNSFAVHPGGIQTELGRNLEPEMAKRFEQMIKDYPDI
HCCCCCCEEEEEHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHH
WKTVPQGAATSCWAATSPDLSGKTGLYLEDCHISEPGAGDVLDGGYAPHAYDADGAKQLW
HHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
ILSNDLLGTEF
EEECCCCCCCC
>Mature Secondary Structure
MKFDNNSTTTDVLNGIDLSGKTVLITGASTGLGAETARATAACGADVTLVARSVDKLSKV
CCCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
AESILSETGRSPNTAVLELDKPATIRSFAQEWLSRHEKLDILINNAGIMAPPLTRNAEGW
HHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCH
ESQFATNHLGHFLLTNLLVDAIKASGEARVVNLSSAGHWYSTVDLDDPNFQNRDYEALQA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHH
YGQSKTANIWFTVELARRWADHGVNSFAVHPGGIQTELGRNLEPEMAKRFEQMIKDYPDI
HCCCCCCEEEEEHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHH
WKTVPQGAATSCWAATSPDLSGKTGLYLEDCHISEPGAGDVLDGGYAPHAYDADGAKQLW
HHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
ILSNDLLGTEF
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]