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The map label for this gene is cmk

Identifier: 158335769

GI number: 158335769

Start: 2659730

End: 2661307

Strand: Direct

Name: cmk

Synonym: AM1_2620

Alternate gene names: 158335769

Gene position: 2659730-2661307 (Clockwise)

Preceding gene: 158335768

Following gene: 158335770

Centisome position: 40.9

GC content: 52.41

Gene sequence:

>1578_bases
ATGGACAATGTGCCTATTATTCGAACGGTGTCAGGACTGCGTCATTTCTTGCGCTGTTTTCCTGGCAACCTTAATACAGG
CGCCAGCCCTTCCAGTACAGTCATTGGTCAGATTGGGTTGGTGCCGACCATGGGAGCATTGCATGCAGGGCATCTCAGCT
TGATTCAGCGGGCTCGCCAAGAAAATCAATGTGTGATTGTCAGCATTTTCGTCAACCCGCTTCAGTTTGCCGCCCATGAA
GACCTGACCGAATACCCGCAAACTTTAAATCAAGACCAAGCCTTATGCCAAGAACAGGGAGTCAATACTATTTTCGCCCC
ATCTACAGACACCCTTCTCGCCGACGCTCCCCTCACCCAGGTGATTCCGCCTGCGTCTCTTACAGAATATCTCTGTGGGC
CCCATCGCCCCGATCATTTCACCGGGGTAGCAACCATTGTCTTGAAGTTGCTGAATATTGTCCAGCCTACTCGGGCTTAC
TTTGGCCAAAAAGATGCGCAACAGCTGGCAATTATTCAGCGTCTGGTTCAGGACTTCAATCTAGATGTCACAATTGTCCC
CTGCAAGCTGATTAGGGACGCGACAGGCTTAGCTTTAAGTTCTCGCAATCAGTACTTAAATGCCCAAGAAGCACAACAAG
CCACCATTTTGCACCACAGTTTGCAAGCTGCTAGACACACCTTTCAGGGGGGAAGTTGCGATCGCAACTCTGTTCTCGCC
ACCGTGGCCCAAACATTAGCTAAAGGACCCCAGGTAGAGGTGGAGTATATTGATCTGGTCGATCCTGTGACGTTACAGCC
GTTAGAACAGATCACCACCCAAGGTCTAGTCGCCATTGCCGCCCGGGTCGGCTCGGCCCGATTGATCGACAATATGCTTT
TGGATGCCCGCTTACCCATCCTGGCCATTGATGGGCCAGCTGGGGCGGGCAAATCAACGGTCACCCGTCGCTGTGCCCAA
GCTATAGGATTGCAATATCTAGACACGGGGGCCATGTATCGCGCCGTCGCTTGGCTGGCCCTAGACCAACAGGTTGAGGT
ATCAGACCCATTTGCGATCGCAGATCTCGTCGAAGATTGCCAGATCGAGCTCAAGCCCCATGCAGATCCTCAGCAGCAGC
CCCAGGTCTGGGTCAACCACCAGGAGGTCACCCAAGCCATTCGTACTCCAGACGTAACAGCACTGGTGTCAGCCGTTGCT
GCCCAACCCCCAGTACGAGAAGCTCTCGTTAAACAACAGCAACGATTAGGTCGTCAGGGTGGCCTGATTGCCGAAGGTCG
AGATATTGGCACCAATGTCTTTCCTGACGCAGGCCTCAAAATCTTCTTAACGGCTTCCATTGAAGAACGGGCCCGTCGTC
GTCAACAAGATCTGAAGAATCAGAACTTACCCCCCCAGACACAATCAGAATTAGAAGACCTGATTGCCAGTCGCGATCAG
CAGGACAGCCAACGGGAATTTGCTCCCCTGCGCAAAGCATACGATGCTGTGGAAATTAATACGGATGGCATGACGATTGA
GCAGGTGATCACTCGCATCACCACCCTTTACCAAGAGCGATTTCCAGACAGAGCATAA

Upstream 100 bases:

>100_bases
CCAGACGATACACTAGCTTAGAGACCAGTCATCCCAATCGCTTTGCCAAAGCACCTCGTCAAGGAACTGGCCCTGTCGTC
TGCCTTTTTTTCTAACTGTC

Downstream 100 bases:

>100_bases
TCTTTGTTTTGCCTAGATAGCATCGGTCTTGCCCTGGCGTTCAACCCCCTCTCAGAAGAAGATTCAATTCTTAAGAGGGA
ATTCTGATTTGCTCCTTCAG

Product: bifunctional pantoate ligase/cytidylate kinase

Products: NA

Alternate protein names: Pantothenate synthetase; PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme; Cytidylate kinase; CK; Cytidine monophosphate kinase; CMP kinase

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MDNVPIIRTVSGLRHFLRCFPGNLNTGASPSSTVIGQIGLVPTMGALHAGHLSLIQRARQENQCVIVSIFVNPLQFAAHE
DLTEYPQTLNQDQALCQEQGVNTIFAPSTDTLLADAPLTQVIPPASLTEYLCGPHRPDHFTGVATIVLKLLNIVQPTRAY
FGQKDAQQLAIIQRLVQDFNLDVTIVPCKLIRDATGLALSSRNQYLNAQEAQQATILHHSLQAARHTFQGGSCDRNSVLA
TVAQTLAKGPQVEVEYIDLVDPVTLQPLEQITTQGLVAIAARVGSARLIDNMLLDARLPILAIDGPAGAGKSTVTRRCAQ
AIGLQYLDTGAMYRAVAWLALDQQVEVSDPFAIADLVEDCQIELKPHADPQQQPQVWVNHQEVTQAIRTPDVTALVSAVA
AQPPVREALVKQQQRLGRQGGLIAEGRDIGTNVFPDAGLKIFLTASIEERARRRQQDLKNQNLPPQTQSELEDLIASRDQ
QDSQREFAPLRKAYDAVEINTDGMTIEQVITRITTLYQERFPDRA

Sequences:

>Translated_525_residues
MDNVPIIRTVSGLRHFLRCFPGNLNTGASPSSTVIGQIGLVPTMGALHAGHLSLIQRARQENQCVIVSIFVNPLQFAAHE
DLTEYPQTLNQDQALCQEQGVNTIFAPSTDTLLADAPLTQVIPPASLTEYLCGPHRPDHFTGVATIVLKLLNIVQPTRAY
FGQKDAQQLAIIQRLVQDFNLDVTIVPCKLIRDATGLALSSRNQYLNAQEAQQATILHHSLQAARHTFQGGSCDRNSVLA
TVAQTLAKGPQVEVEYIDLVDPVTLQPLEQITTQGLVAIAARVGSARLIDNMLLDARLPILAIDGPAGAGKSTVTRRCAQ
AIGLQYLDTGAMYRAVAWLALDQQVEVSDPFAIADLVEDCQIELKPHADPQQQPQVWVNHQEVTQAIRTPDVTALVSAVA
AQPPVREALVKQQQRLGRQGGLIAEGRDIGTNVFPDAGLKIFLTASIEERARRRQQDLKNQNLPPQTQSELEDLIASRDQ
QDSQREFAPLRKAYDAVEINTDGMTIEQVITRITTLYQERFPDRA
>Mature_525_residues
MDNVPIIRTVSGLRHFLRCFPGNLNTGASPSSTVIGQIGLVPTMGALHAGHLSLIQRARQENQCVIVSIFVNPLQFAAHE
DLTEYPQTLNQDQALCQEQGVNTIFAPSTDTLLADAPLTQVIPPASLTEYLCGPHRPDHFTGVATIVLKLLNIVQPTRAY
FGQKDAQQLAIIQRLVQDFNLDVTIVPCKLIRDATGLALSSRNQYLNAQEAQQATILHHSLQAARHTFQGGSCDRNSVLA
TVAQTLAKGPQVEVEYIDLVDPVTLQPLEQITTQGLVAIAARVGSARLIDNMLLDARLPILAIDGPAGAGKSTVTRRCAQ
AIGLQYLDTGAMYRAVAWLALDQQVEVSDPFAIADLVEDCQIELKPHADPQQQPQVWVNHQEVTQAIRTPDVTALVSAVA
AQPPVREALVKQQQRLGRQGGLIAEGRDIGTNVFPDAGLKIFLTASIEERARRRQQDLKNQNLPPQTQSELEDLIASRDQ
QDSQREFAPLRKAYDAVEINTDGMTIEQVITRITTLYQERFPDRA

Specific function: Displays a CMP kinase activity

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1786325, Length=261, Percent_Identity=39.8467432950192, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1787139, Length=219, Percent_Identity=40.6392694063927, Blast_Score=146, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322046, Length=286, Percent_Identity=37.0629370629371, Blast_Score=168, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANCY_ACAM1 (B0C6S1)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001516941.1
- ProteinModelPortal:   B0C6S1
- GeneID:   5681432
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_2620
- HOGENOM:   HBG428839
- OMA:   LGEKDWQ
- ProtClustDB:   PRK13477
- BioCyc:   AMAR329726:AM1_2620-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01349
- InterPro:   IPR003136
- InterPro:   IPR011994
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00017
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02224 Cytidylate_kin; PF02569 Pantoate_ligase

EC number: =6.3.2.1; =2.7.4.14

Molecular weight: Translated: 57534; Mature: 57534

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: ACT_SITE 51-51 BINDING 75-75 BINDING 75-75 BINDING 168-168 BINDING 191-191

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNVPIIRTVSGLRHFLRCFPGNLNTGASPSSTVIGQIGLVPTMGALHAGHLSLIQRARQ
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ENQCVIVSIFVNPLQFAAHEDLTEYPQTLNQDQALCQEQGVNTIFAPSTDTLLADAPLTQ
CCCEEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCCEEECCCHHH
VIPPASLTEYLCGPHRPDHFTGVATIVLKLLNIVQPTRAYFGQKDAQQLAIIQRLVQDFN
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
LDVTIVPCKLIRDATGLALSSRNQYLNAQEAQQATILHHSLQAARHTFQGGSCDRNSVLA
CCEEEECHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
TVAQTLAKGPQVEVEYIDLVDPVTLQPLEQITTQGLVAIAARVGSARLIDNMLLDARLPI
HHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCE
LAIDGPAGAGKSTVTRRCAQAIGLQYLDTGAMYRAVAWLALDQQVEVSDPFAIADLVEDC
EEECCCCCCCHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
QIELKPHADPQQQPQVWVNHQEVTQAIRTPDVTALVSAVAAQPPVREALVKQQQRLGRQG
EEEECCCCCCCCCCCEEECHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
GLIAEGRDIGTNVFPDAGLKIFLTASIEERARRRQQDLKNQNLPPQTQSELEDLIASRDQ
CEEECCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
QDSQREFAPLRKAYDAVEINTDGMTIEQVITRITTLYQERFPDRA
CHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDNVPIIRTVSGLRHFLRCFPGNLNTGASPSSTVIGQIGLVPTMGALHAGHLSLIQRARQ
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ENQCVIVSIFVNPLQFAAHEDLTEYPQTLNQDQALCQEQGVNTIFAPSTDTLLADAPLTQ
CCCEEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCCEEECCCHHH
VIPPASLTEYLCGPHRPDHFTGVATIVLKLLNIVQPTRAYFGQKDAQQLAIIQRLVQDFN
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
LDVTIVPCKLIRDATGLALSSRNQYLNAQEAQQATILHHSLQAARHTFQGGSCDRNSVLA
CCEEEECHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
TVAQTLAKGPQVEVEYIDLVDPVTLQPLEQITTQGLVAIAARVGSARLIDNMLLDARLPI
HHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCE
LAIDGPAGAGKSTVTRRCAQAIGLQYLDTGAMYRAVAWLALDQQVEVSDPFAIADLVEDC
EEECCCCCCCHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
QIELKPHADPQQQPQVWVNHQEVTQAIRTPDVTALVSAVAAQPPVREALVKQQQRLGRQG
EEEECCCCCCCCCCCEEECHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
GLIAEGRDIGTNVFPDAGLKIFLTASIEERARRRQQDLKNQNLPPQTQSELEDLIASRDQ
CEEECCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
QDSQREFAPLRKAYDAVEINTDGMTIEQVITRITTLYQERFPDRA
CHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA