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The map label for this gene is nrd [H]

Identifier: 158335535

GI number: 158335535

Start: 2385859

End: 2387808

Strand: Direct

Name: nrd [H]

Synonym: AM1_2383

Alternate gene names: 158335535

Gene position: 2385859-2387808 (Clockwise)

Preceding gene: 158335534

Following gene: 158335536

Centisome position: 36.68

GC content: 48.92

Gene sequence:

>1950_bases
ATGGTTGCCACTCAATCTTTTATAACTGAACTCAGCGAATCCCAAAAAGCGGTTCTCCAAAAGTATCTGATCGAAGATGA
AGTCTCCTGGGAAGACGTCGTTCACCGAGTAGCGACCTATGTTGCCAGTGCGGAATCAACACCAGAGCAGCAAAGCTATT
GGCAAGAAAAATTTCTGTCGATTTTGCAGCCCATGAAGTTTGTGCCTGGTGGTTCCATCTTGGCCAACTGTGATCATGGC
ACCCGTGGCTTGCTGAATTGTTTTGTCCTTTCGGCTGAAGATCACATCCATGACATCACTAAATTAGTGTCTGACTCGGT
ACTCACCACCAAATTCAGAGGTGGGGTGGGGATCAATATTGGGGCAGAAGGCTCCAAGGGATATATCCGCCAAAAAGGCG
CACCGTTTCAAGATGGGAAAGCGCTTGGTCCCTGTGCAGTCTTAGATATGGTGTCTGAGAACTCCAAGAAAATCACCACT
GGCAACAAGGCCCGCCGAGGTGCATTTCTATTTTCCATGAACTGGAAGCACCCTGATATTTGGGAATTTATTCAGGCGAA
AACCCAGTCCACCATTGATGCCAATTTTGCCAAGTCAGTGATGGAGGAGTTAGCCCAACTGGCTCAACAGGATGAACCGT
CTCAGGGAAAGCAAGAGAAGCTCAAAGCTTTACATACAGAGGTCGGCACAGCTTGGGTGGAAACCCATCTCAATCCAGAA
GGTAAACGCGATCGCAGATGGCATAACGCCAACATCTCAGTGCAGCTAGATGACGAGTTCTTTGCCAAACTCGATCAAGG
CGATGAAGAAGCCAACAAACTCTGGCAGGCTATGGCTGAAAATGCCCATGCTACCGCAGACCCTGGCTTACTGCTGATCG
ACAATGCCAAGCGTCGGAGTCCGATTCGAGATTTTGTTACTTGTACCAATCCCTGTGGGGAAATCTTCCTCCCCCCCAAC
TCAGCGTGTAACCTCGGCTCTCTGGTGCTCACCAAGTTTGTCCGTCGGACTGCAGAGGGCAACATTGAAATTGATTGGGA
TGACTTAGCTGAGACCGTCAGAATTGCGATTCGCTTTCTGGATAACGTTCTCGATGTCTCTGAATTTGCGACTCCCGACC
AAAAACATAATGTCCGCGATGTCTTTCGTCAGTTGGGCTTAGGCATTATGGGCTGGGCTGATTACCTGAAACTCGCTCGG
ATTCCCTATGATTCAGCCCGACACTTAGAAGAAATCGATCGCTGGGGCAGCTGGATTGCAGCTCATGCCTACCGAACCTC
GGAAGCAATTGCCGCTGAAAAAGGAGCCTGTGGTGTTTGGGATCAGATTAAAGATATCCAGACTGGCAATCCTTTTGAAC
GCTGGATGGATAGTGAAGGGAACTACTATAACGGCACAGAAGCTCACCATAACGATCGTCAAGATTTGACCCAAGTGCCT
CGCCGTAACTCCACAGTTTTATCCATTGCCCCCACAGGAAGCATTGCCCAGCTGGCAGCCTGCTCTTGGGCTTTTGAGCC
AGACTTTGGTTTAACCCTATGGAAGCAAGTGTTTGTGGACGCTTCTCGTAGTCAGCAAAACTGGGTGCAAATTCTCAATC
CTTATTTGGATGAGTTGAACCTACCAGAAGCTGATGCTGAGATCGTCAAGCAAACGGGATCGCTTGCCGATACTAACTAT
GGCAAGCAACATCCAGAAATTGCCCGTAGTTTCAAGATTGCCCGGGAGATTCCACCCGGTTGGCATATCCTTGTGCAGTC
CAAATGGCAGAGCTGGATTGATTCTTCTATTTCTAAGACCATCAATCTCCCGGCTCATGCCACAGTAGACGAAATCAAGC
AGATTTATCGATTGGCCGAAAAAGCAGGACTCAAAGGCGTCACAATCTACCGATCCGGCACCTTAGACTCTGAACCGATC
AAGGTCGGCAATAGCGAGAAAGACTCCTAG

Upstream 100 bases:

>100_bases
CACTAGCATGGGATAGCTAGTGAGCCATGCAATACTTGGAAAATTAATTCTACATAGCGCGATTTCATCCCGTTCTTCTG
ACCTCAACGCTAGATGTGCC

Downstream 100 bases:

>100_bases
TCCCCATCACCCAGACGCAGAAGAAGGTATAGGCATGGCCCAAACGGATGACTTATTAGGCTTAATCGATAGCTTTCCAG
ATGCCTTTAATCAGGTTGAA

Product: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 649; Mature: 649

Protein sequence:

>649_residues
MVATQSFITELSESQKAVLQKYLIEDEVSWEDVVHRVATYVASAESTPEQQSYWQEKFLSILQPMKFVPGGSILANCDHG
TRGLLNCFVLSAEDHIHDITKLVSDSVLTTKFRGGVGINIGAEGSKGYIRQKGAPFQDGKALGPCAVLDMVSENSKKITT
GNKARRGAFLFSMNWKHPDIWEFIQAKTQSTIDANFAKSVMEELAQLAQQDEPSQGKQEKLKALHTEVGTAWVETHLNPE
GKRDRRWHNANISVQLDDEFFAKLDQGDEEANKLWQAMAENAHATADPGLLLIDNAKRRSPIRDFVTCTNPCGEIFLPPN
SACNLGSLVLTKFVRRTAEGNIEIDWDDLAETVRIAIRFLDNVLDVSEFATPDQKHNVRDVFRQLGLGIMGWADYLKLAR
IPYDSARHLEEIDRWGSWIAAHAYRTSEAIAAEKGACGVWDQIKDIQTGNPFERWMDSEGNYYNGTEAHHNDRQDLTQVP
RRNSTVLSIAPTGSIAQLAACSWAFEPDFGLTLWKQVFVDASRSQQNWVQILNPYLDELNLPEADAEIVKQTGSLADTNY
GKQHPEIARSFKIAREIPPGWHILVQSKWQSWIDSSISKTINLPAHATVDEIKQIYRLAEKAGLKGVTIYRSGTLDSEPI
KVGNSEKDS

Sequences:

>Translated_649_residues
MVATQSFITELSESQKAVLQKYLIEDEVSWEDVVHRVATYVASAESTPEQQSYWQEKFLSILQPMKFVPGGSILANCDHG
TRGLLNCFVLSAEDHIHDITKLVSDSVLTTKFRGGVGINIGAEGSKGYIRQKGAPFQDGKALGPCAVLDMVSENSKKITT
GNKARRGAFLFSMNWKHPDIWEFIQAKTQSTIDANFAKSVMEELAQLAQQDEPSQGKQEKLKALHTEVGTAWVETHLNPE
GKRDRRWHNANISVQLDDEFFAKLDQGDEEANKLWQAMAENAHATADPGLLLIDNAKRRSPIRDFVTCTNPCGEIFLPPN
SACNLGSLVLTKFVRRTAEGNIEIDWDDLAETVRIAIRFLDNVLDVSEFATPDQKHNVRDVFRQLGLGIMGWADYLKLAR
IPYDSARHLEEIDRWGSWIAAHAYRTSEAIAAEKGACGVWDQIKDIQTGNPFERWMDSEGNYYNGTEAHHNDRQDLTQVP
RRNSTVLSIAPTGSIAQLAACSWAFEPDFGLTLWKQVFVDASRSQQNWVQILNPYLDELNLPEADAEIVKQTGSLADTNY
GKQHPEIARSFKIAREIPPGWHILVQSKWQSWIDSSISKTINLPAHATVDEIKQIYRLAEKAGLKGVTIYRSGTLDSEPI
KVGNSEKDS
>Mature_649_residues
MVATQSFITELSESQKAVLQKYLIEDEVSWEDVVHRVATYVASAESTPEQQSYWQEKFLSILQPMKFVPGGSILANCDHG
TRGLLNCFVLSAEDHIHDITKLVSDSVLTTKFRGGVGINIGAEGSKGYIRQKGAPFQDGKALGPCAVLDMVSENSKKITT
GNKARRGAFLFSMNWKHPDIWEFIQAKTQSTIDANFAKSVMEELAQLAQQDEPSQGKQEKLKALHTEVGTAWVETHLNPE
GKRDRRWHNANISVQLDDEFFAKLDQGDEEANKLWQAMAENAHATADPGLLLIDNAKRRSPIRDFVTCTNPCGEIFLPPN
SACNLGSLVLTKFVRRTAEGNIEIDWDDLAETVRIAIRFLDNVLDVSEFATPDQKHNVRDVFRQLGLGIMGWADYLKLAR
IPYDSARHLEEIDRWGSWIAAHAYRTSEAIAAEKGACGVWDQIKDIQTGNPFERWMDSEGNYYNGTEAHHNDRQDLTQVP
RRNSTVLSIAPTGSIAQLAACSWAFEPDFGLTLWKQVFVDASRSQQNWVQILNPYLDELNLPEADAEIVKQTGSLADTNY
GKQHPEIARSFKIAREIPPGWHILVQSKWQSWIDSSISKTINLPAHATVDEIKQIYRLAEKAGLKGVTIYRSGTLDSEPI
KVGNSEKDS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=615, Percent_Identity=23.9024390243902, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17555242, Length=479, Percent_Identity=23.5908141962422, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320914, Length=602, Percent_Identity=24.7508305647841, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322123, Length=618, Percent_Identity=22.3300970873786, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17352481, Length=591, Percent_Identity=25.2115059221658, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 72652; Mature: 72652

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVATQSFITELSESQKAVLQKYLIEDEVSWEDVVHRVATYVASAESTPEQQSYWQEKFLS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ILQPMKFVPGGSILANCDHGTRGLLNCFVLSAEDHIHDITKLVSDSVLTTKFRGGVGINI
HHHHHHCCCCCCEEECCCCCCHHHHHHHEECCHHHHHHHHHHHHCHHHHEEECCCEEEEE
GAEGSKGYIRQKGAPFQDGKALGPCAVLDMVSENSKKITTGNKARRGAFLFSMNWKHPDI
CCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCEEEEEECCCCCHH
WEFIQAKTQSTIDANFAKSVMEELAQLAQQDEPSQGKQEKLKALHTEVGTAWVETHLNPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GKRDRRWHNANISVQLDDEFFAKLDQGDEEANKLWQAMAENAHATADPGLLLIDNAKRRS
CCCCCCEECCCEEEEECHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCC
PIRDFVTCTNPCGEIFLPPNSACNLGSLVLTKFVRRTAEGNIEIDWDDLAETVRIAIRFL
CHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHH
DNVLDVSEFATPDQKHNVRDVFRQLGLGIMGWADYLKLARIPYDSARHLEEIDRWGSWIA
HHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AHAYRTSEAIAAEKGACGVWDQIKDIQTGNPFERWMDSEGNYYNGTEAHHNDRQDLTQVP
HHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHCC
RRNSTVLSIAPTGSIAQLAACSWAFEPDFGLTLWKQVFVDASRSQQNWVQILNPYLDELN
CCCCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
LPEADAEIVKQTGSLADTNYGKQHPEIARSFKIAREIPPGWHILVQSKWQSWIDSSISKT
CCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHH
INLPAHATVDEIKQIYRLAEKAGLKGVTIYRSGTLDSEPIKVGNSEKDS
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVATQSFITELSESQKAVLQKYLIEDEVSWEDVVHRVATYVASAESTPEQQSYWQEKFLS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
ILQPMKFVPGGSILANCDHGTRGLLNCFVLSAEDHIHDITKLVSDSVLTTKFRGGVGINI
HHHHHHCCCCCCEEECCCCCCHHHHHHHEECCHHHHHHHHHHHHCHHHHEEECCCEEEEE
GAEGSKGYIRQKGAPFQDGKALGPCAVLDMVSENSKKITTGNKARRGAFLFSMNWKHPDI
CCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCEEEEEECCCCCHH
WEFIQAKTQSTIDANFAKSVMEELAQLAQQDEPSQGKQEKLKALHTEVGTAWVETHLNPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GKRDRRWHNANISVQLDDEFFAKLDQGDEEANKLWQAMAENAHATADPGLLLIDNAKRRS
CCCCCCEECCCEEEEECHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCC
PIRDFVTCTNPCGEIFLPPNSACNLGSLVLTKFVRRTAEGNIEIDWDDLAETVRIAIRFL
CHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHH
DNVLDVSEFATPDQKHNVRDVFRQLGLGIMGWADYLKLARIPYDSARHLEEIDRWGSWIA
HHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AHAYRTSEAIAAEKGACGVWDQIKDIQTGNPFERWMDSEGNYYNGTEAHHNDRQDLTQVP
HHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHCC
RRNSTVLSIAPTGSIAQLAACSWAFEPDFGLTLWKQVFVDASRSQQNWVQILNPYLDELN
CCCCEEEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
LPEADAEIVKQTGSLADTNYGKQHPEIARSFKIAREIPPGWHILVQSKWQSWIDSSISKT
CCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHH
INLPAHATVDEIKQIYRLAEKAGLKGVTIYRSGTLDSEPIKVGNSEKDS
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]