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The map label for this gene is tuaD [H]

Identifier: 158335518

GI number: 158335518

Start: 2368111

End: 2369490

Strand: Direct

Name: tuaD [H]

Synonym: AM1_2366

Alternate gene names: 158335518

Gene position: 2368111-2369490 (Clockwise)

Preceding gene: 158335517

Following gene: 158335521

Centisome position: 36.41

GC content: 49.57

Gene sequence:

>1380_bases
ATGAAAGTCTGTGTGATTGGAACAGGTTATGTCGGTCTAGTGACTGGCGCTTGTTTAGCTCGCATTGGTCATCACGTCAT
TTGTGTTGATAACAACGAAGAAAAAGTCAAAGTCATGCAGGCTGGTCAGTCCCCTATTTTTGAGCCTGGCCTATCAGAAA
TTCTGCGTGAGTCCATTGATGCTGGCAATATTGAGTTCACAACGGACTTAAAGGCGGGTGTCGAACATGGTGATATTTTG
TTTATTGCTGTGGGAACTCCGGCACTGCCGACAGGGGAGAGTGATACCCGCTATGTTGAAGCGGTGGCTAGAGGGATTGG
TTCCCACTTAACGGGTGACTATAAGGTCATTGTCAATAAGTCGACGGTGCCGATTGGCTCAGGGGACTGGGTGAAGATGA
TTGTCTTGGATGGCCTAGCAGATGCTAAAAAGCAGGCTGGAGAAGCAATCGACACCTCTAATTTAGACAGCAAAGGCTTG
TTCGACGTCGTTAGTAATCCTGAATTCCTCCGGGAAGGCTCTGCTGTCTTTGACACCTTTAACCCCGATCGCATCGTCTT
AGGAGGGGCCGATCCCAATGCGATCGCAAAAATGCAGGAACTCTATGAGCCCATCGTCAAACGTCAGTTCGCAGAAGATC
AATCTCTCCCACCTGTCCCCGTGGTGGTCACGGATCTGAGCTCTGCAGAAATGGTGAAGTACGCTGCGAATGCCTTTTTG
GCTACCAAAATTAGCTTTATCAACGAAGTGGCTAATATTTGCGATCGCGTAGGTGCTGACGTGGTGCAGGTCGCCAAAGG
CATTGGTTTAGACTCCCGGATCGGCAGCAAGTTTCTTCAAGCGGGCCTCGGCTGGGGGGGATCTTGTTTCCCTAAAGATG
TATCTGCCCTAGTGCATACAGCTACGGACTATGGCTATGAAGCGATCTTGCTAGAGTCCACCATCAAAGTGAACCGGCAT
CAGCGTGTGATCGTGATTGAGAAGCTCCAGCAGACCCTGAAAATTTTAAAGGGGAAAACTGTGGGTCTACTGGGTTTAAC
CTTTAAGCCCGATACAGACGATATGCGAGACGCACCAGCCCTCACCCTGATTGACGAGCTTAATCGCCTAGGGGCCAAGG
TTAAAGCCTATGATCCCTTATTGTCCCAAAGTGGTTCCAGTCATGGTCTGTCCAATGTCAGCGTAGAAACGGATGTTGAA
CGTTTAGCCGATCATTGCGACGCCCTGGTTCTAGTCACGGACTGGGATGTCTTTGAGACGTTGAACTACAAGCGGATGGC
CGAGCTGATGACGCATCCTGTAATCATTGATGGTCGTAATTACCTGGATCGCAAGATGCTGGAAGAGGCTGGCTTCCAAT
ATGTTGGCATTGGCCACTAA

Upstream 100 bases:

>100_bases
CTGCAAAATTAGAGGACCCACTGCCCTAGGCAGCTCAGTACTCTATTTCCCCTTTGACGATGCGCCCTTGAATACATTGC
TGGTTATATAGGAGTTTTAT

Downstream 100 bases:

>100_bases
TTCCCGGCCGCATCGAGCTTAAGATCCGACCGGCTCGATGCGGCCATAGCGGGCCTTAAAAATCAGATGAGGCTGTTCAA
GCTGATTGAGCCAGGCCCAC

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKVCVIGTGYVGLVTGACLARIGHHVICVDNNEEKVKVMQAGQSPIFEPGLSEILRESIDAGNIEFTTDLKAGVEHGDIL
FIAVGTPALPTGESDTRYVEAVARGIGSHLTGDYKVIVNKSTVPIGSGDWVKMIVLDGLADAKKQAGEAIDTSNLDSKGL
FDVVSNPEFLREGSAVFDTFNPDRIVLGGADPNAIAKMQELYEPIVKRQFAEDQSLPPVPVVVTDLSSAEMVKYAANAFL
ATKISFINEVANICDRVGADVVQVAKGIGLDSRIGSKFLQAGLGWGGSCFPKDVSALVHTATDYGYEAILLESTIKVNRH
QRVIVIEKLQQTLKILKGKTVGLLGLTFKPDTDDMRDAPALTLIDELNRLGAKVKAYDPLLSQSGSSHGLSNVSVETDVE
RLADHCDALVLVTDWDVFETLNYKRMAELMTHPVIIDGRNYLDRKMLEEAGFQYVGIGH

Sequences:

>Translated_459_residues
MKVCVIGTGYVGLVTGACLARIGHHVICVDNNEEKVKVMQAGQSPIFEPGLSEILRESIDAGNIEFTTDLKAGVEHGDIL
FIAVGTPALPTGESDTRYVEAVARGIGSHLTGDYKVIVNKSTVPIGSGDWVKMIVLDGLADAKKQAGEAIDTSNLDSKGL
FDVVSNPEFLREGSAVFDTFNPDRIVLGGADPNAIAKMQELYEPIVKRQFAEDQSLPPVPVVVTDLSSAEMVKYAANAFL
ATKISFINEVANICDRVGADVVQVAKGIGLDSRIGSKFLQAGLGWGGSCFPKDVSALVHTATDYGYEAILLESTIKVNRH
QRVIVIEKLQQTLKILKGKTVGLLGLTFKPDTDDMRDAPALTLIDELNRLGAKVKAYDPLLSQSGSSHGLSNVSVETDVE
RLADHCDALVLVTDWDVFETLNYKRMAELMTHPVIIDGRNYLDRKMLEEAGFQYVGIGH
>Mature_459_residues
MKVCVIGTGYVGLVTGACLARIGHHVICVDNNEEKVKVMQAGQSPIFEPGLSEILRESIDAGNIEFTTDLKAGVEHGDIL
FIAVGTPALPTGESDTRYVEAVARGIGSHLTGDYKVIVNKSTVPIGSGDWVKMIVLDGLADAKKQAGEAIDTSNLDSKGL
FDVVSNPEFLREGSAVFDTFNPDRIVLGGADPNAIAKMQELYEPIVKRQFAEDQSLPPVPVVVTDLSSAEMVKYAANAFL
ATKISFINEVANICDRVGADVVQVAKGIGLDSRIGSKFLQAGLGWGGSCFPKDVSALVHTATDYGYEAILLESTIKVNRH
QRVIVIEKLQQTLKILKGKTVGLLGLTFKPDTDDMRDAPALTLIDELNRLGAKVKAYDPLLSQSGSSHGLSNVSVETDVE
RLADHCDALVLVTDWDVFETLNYKRMAELMTHPVIIDGRNYLDRKMLEEAGFQYVGIGH

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=486, Percent_Identity=35.3909465020576, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI296040438, Length=387, Percent_Identity=35.6589147286822, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI296040443, Length=321, Percent_Identity=37.0716510903427, Blast_Score=182, Evalue=5e-46,
Organism=Escherichia coli, GI1788340, Length=416, Percent_Identity=25.9615384615385, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI48994968, Length=435, Percent_Identity=28.5057471264368, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17560350, Length=482, Percent_Identity=36.3070539419087, Blast_Score=273, Evalue=9e-74,
Organism=Drosophila melanogaster, GI17136908, Length=486, Percent_Identity=34.156378600823, Blast_Score=270, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 49558; Mature: 49558

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVCVIGTGYVGLVTGACLARIGHHVICVDNNEEKVKVMQAGQSPIFEPGLSEILRESID
CEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHCC
AGNIEFTTDLKAGVEHGDILFIAVGTPALPTGESDTRYVEAVARGIGSHLTGDYKVIVNK
CCCEEEEECHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
STVPIGSGDWVKMIVLDGLADAKKQAGEAIDTSNLDSKGLFDVVSNPEFLREGSAVFDTF
CCCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHHCCCCEEECC
NPDRIVLGGADPNAIAKMQELYEPIVKRQFAEDQSLPPVPVVVTDLSSAEMVKYAANAFL
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
ATKISFINEVANICDRVGADVVQVAKGIGLDSRIGSKFLQAGLGWGGSCFPKDVSALVHT
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ATDYGYEAILLESTIKVNRHQRVIVIEKLQQTLKILKGKTVGLLGLTFKPDTDDMRDAPA
HHCCCEEEEEEEHHHEECCCCEEEEHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCH
LTLIDELNRLGAKVKAYDPLLSQSGSSHGLSNVSVETDVERLADHCDALVLVTDWDVFET
HHHHHHHHHHCCCHHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHH
LNYKRMAELMTHPVIIDGRNYLDRKMLEEAGFQYVGIGH
CCHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCEEECCC
>Mature Secondary Structure
MKVCVIGTGYVGLVTGACLARIGHHVICVDNNEEKVKVMQAGQSPIFEPGLSEILRESID
CEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHCC
AGNIEFTTDLKAGVEHGDILFIAVGTPALPTGESDTRYVEAVARGIGSHLTGDYKVIVNK
CCCEEEEECHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
STVPIGSGDWVKMIVLDGLADAKKQAGEAIDTSNLDSKGLFDVVSNPEFLREGSAVFDTF
CCCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHHCCCCEEECC
NPDRIVLGGADPNAIAKMQELYEPIVKRQFAEDQSLPPVPVVVTDLSSAEMVKYAANAFL
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
ATKISFINEVANICDRVGADVVQVAKGIGLDSRIGSKFLQAGLGWGGSCFPKDVSALVHT
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ATDYGYEAILLESTIKVNRHQRVIVIEKLQQTLKILKGKTVGLLGLTFKPDTDDMRDAPA
HHCCCEEEEEEEHHHEECCCCEEEEHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCH
LTLIDELNRLGAKVKAYDPLLSQSGSSHGLSNVSVETDVERLADHCDALVLVTDWDVFET
HHHHHHHHHHCCCHHHHCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHH
LNYKRMAELMTHPVIIDGRNYLDRKMLEEAGFQYVGIGH
CCHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]