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The map label for this gene is chaA [H]

Identifier: 158335477

GI number: 158335477

Start: 2328410

End: 2329495

Strand: Direct

Name: chaA [H]

Synonym: AM1_2325

Alternate gene names: 158335477

Gene position: 2328410-2329495 (Clockwise)

Preceding gene: 158335475

Following gene: 158335479

Centisome position: 35.8

GC content: 50.09

Gene sequence:

>1086_bases
GTGACTCTCAAAAATCGTATTTTTATTGTCTTACTGCTGTTTATCCCTGTCTCGATTGCAGCAGATCTCCTGGAGTGGGG
ACCGCTCCCTCTATTTGCGACATCAGCGCTCGCTATTGTGCCTTTAGCTGCATGGATGGGCACAGCAACGGAAGAGATTG
CTGTGGTCATTGGTCCCTCCGCCGGTGGACTGCTCAATGCCACCTTTGGTAATGCTACGGAACTAATTATTGCTTTTATC
GCCCTCCAAGCCGGTTTGGTAGAGGTGGTCAAAGCCAGTATTACCGGTTCCATTTTGGGTAACCTCCTTCTCGTGATGGG
GCTGTCCATGCTGCTGGGCGGACTGCGATTTAAAGAGCAAACCTTTCAGCCCGTTGTGGCTCGCGTGAATGCCTCATCCA
TGAACTTAGCGGTCATTGCAATTTTGTTGCCCACCGCCATCAAGTTCTCCGCCGAAGGCATCGAGAGTCAGGTTCTCCAG
AACCTTTCCATTGCCGTTGCCATCGTGTTGATTGGAGTTTATGGTTTAACGCTTCTGTTCTCCATGAAAACCCACACCTA
TCTGTTTGACGTGGGAGTGGCTGGCATGGAATCAGAAGAAGAGCCCCATGAAGAAGGCTCAGGTAATTTGCGATTATGGA
TTGGTGTTTTACTCGCAGCAACCCTAGCGGTTGCCGTTGAATCTGAATTTTTAGTGGGCAGTTTAGAAGCAGCCACTGAG
CAACTTGGGTTGACGCCCTTGTTTACAGGGGTGATTTTACTCCCCATTATTGGTAATGCCGCAGAGCATGCCACCGCCGT
CACCGTGGCCATGAAAGACAAGATGGACTTATCTGTTTCTGTTGCCGTCGGCTCCAGTATGCAGATTGCCCTGTTTGTTG
CCCCAGCCTTAGTCCTGGCAGGCTGGGTAATTGGTCAGCCCATGGACTTAGACTTTAACCCCTTTGAATTGGTCGCTGTT
GCCGTATCAGTCCTGATTGCCAATTCGATTAGCTCAGATGGTCAGTCCAACTGGTTAGAAGGGACGCTGCTCCTCGCCAC
CTATGCAGTGTTAGGATTAGCCTTTTATTTTCATCCTCTGACGTGA

Upstream 100 bases:

>100_bases
CACACCGAAATGCCCCTGATAACCGCCCATTAATCTGAGGCAAATCTAGATTTTCCCAAATTGATTTTGATGTACTTGTA
AACCCAACTCATCTGCAATT

Downstream 100 bases:

>100_bases
TCAGCCCTTAAGAATCTGGCGTCACTACATATTCAGACTCAATAGGCTCTAGCCGCCCTGATTGAACCAGCGCCTGGTAA
ATCATGGCGGCGACTTCTGC

Product: calcium/proton exchanger

Products: Na (I) [Periplasm]; Ca (II) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTLKNRIFIVLLLFIPVSIAADLLEWGPLPLFATSALAIVPLAAWMGTATEEIAVVIGPSAGGLLNATFGNATELIIAFI
ALQAGLVEVVKASITGSILGNLLLVMGLSMLLGGLRFKEQTFQPVVARVNASSMNLAVIAILLPTAIKFSAEGIESQVLQ
NLSIAVAIVLIGVYGLTLLFSMKTHTYLFDVGVAGMESEEEPHEEGSGNLRLWIGVLLAATLAVAVESEFLVGSLEAATE
QLGLTPLFTGVILLPIIGNAAEHATAVTVAMKDKMDLSVSVAVGSSMQIALFVAPALVLAGWVIGQPMDLDFNPFELVAV
AVSVLIANSISSDGQSNWLEGTLLLATYAVLGLAFYFHPLT

Sequences:

>Translated_361_residues
MTLKNRIFIVLLLFIPVSIAADLLEWGPLPLFATSALAIVPLAAWMGTATEEIAVVIGPSAGGLLNATFGNATELIIAFI
ALQAGLVEVVKASITGSILGNLLLVMGLSMLLGGLRFKEQTFQPVVARVNASSMNLAVIAILLPTAIKFSAEGIESQVLQ
NLSIAVAIVLIGVYGLTLLFSMKTHTYLFDVGVAGMESEEEPHEEGSGNLRLWIGVLLAATLAVAVESEFLVGSLEAATE
QLGLTPLFTGVILLPIIGNAAEHATAVTVAMKDKMDLSVSVAVGSSMQIALFVAPALVLAGWVIGQPMDLDFNPFELVAV
AVSVLIANSISSDGQSNWLEGTLLLATYAVLGLAFYFHPLT
>Mature_360_residues
TLKNRIFIVLLLFIPVSIAADLLEWGPLPLFATSALAIVPLAAWMGTATEEIAVVIGPSAGGLLNATFGNATELIIAFIA
LQAGLVEVVKASITGSILGNLLLVMGLSMLLGGLRFKEQTFQPVVARVNASSMNLAVIAILLPTAIKFSAEGIESQVLQN
LSIAVAIVLIGVYGLTLLFSMKTHTYLFDVGVAGMESEEEPHEEGSGNLRLWIGVLLAATLAVAVESEFLVGSLEAATEQ
LGLTPLFTGVILLPIIGNAAEHATAVTVAMKDKMDLSVSVAVGSSMQIALFVAPALVLAGWVIGQPMDLDFNPFELVAVA
VSVLIANSISSDGQSNWLEGTLLLATYAVLGLAFYFHPLT

Specific function: According To Ref.1 The Natural Activity Of This Protein Is As A Calcium/Proton Antiporter, But It Can Act As A Weak Sodium/Proton Antiporter. The Presence Of A Preferred Substrate And Normal Ph Cytoplasmic Values Might Prevent Significant Sodium/Proton An

COG id: COG0387

COG function: function code P; Ca2+/H+ antiporter

Gene ontology:
GO:0006812: Calcium/proton exchanger
GO:0008324: Calcium/proton exchanger
GO:0016021: Calcium/proton exchanger
GO:0055085: Calcium/proton exchanger

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320075, Length=368, Percent_Identity=41.8478260869565, Blast_Score=243, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6324008, Length=403, Percent_Identity=25.5583126550869, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004713
- InterPro:   IPR004798
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 37769; Mature: 37638

Theoretical pI: Translated: 4.13; Mature: 4.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKNRIFIVLLLFIPVSIAADLLEWGPLPLFATSALAIVPLAAWMGTATEEIAVVIGPS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
AGGLLNATFGNATELIIAFIALQAGLVEVVKASITGSILGNLLLVMGLSMLLGGLRFKEQ
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TFQPVVARVNASSMNLAVIAILLPTAIKFSAEGIESQVLQNLSIAVAIVLIGVYGLTLLF
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMKTHTYLFDVGVAGMESEEEPHEEGSGNLRLWIGVLLAATLAVAVESEFLVGSLEAATE
HHHHCEEEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGLTPLFTGVILLPIIGNAAEHATAVTVAMKDKMDLSVSVAVGSSMQIALFVAPALVLA
HHCCCHHHHHHHHHHHHCCCHHHHHEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHH
GWVIGQPMDLDFNPFELVAVAVSVLIANSISSDGQSNWLEGTLLLATYAVLGLAFYFHPL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
T
C
>Mature Secondary Structure 
TLKNRIFIVLLLFIPVSIAADLLEWGPLPLFATSALAIVPLAAWMGTATEEIAVVIGPS
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
AGGLLNATFGNATELIIAFIALQAGLVEVVKASITGSILGNLLLVMGLSMLLGGLRFKEQ
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TFQPVVARVNASSMNLAVIAILLPTAIKFSAEGIESQVLQNLSIAVAIVLIGVYGLTLLF
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMKTHTYLFDVGVAGMESEEEPHEEGSGNLRLWIGVLLAATLAVAVESEFLVGSLEAATE
HHHHCEEEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGLTPLFTGVILLPIIGNAAEHATAVTVAMKDKMDLSVSVAVGSSMQIALFVAPALVLA
HHCCCHHHHHHHHHHHHCCCHHHHHEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHH
GWVIGQPMDLDFNPFELVAVAVSVLIANSISSDGQSNWLEGTLLLATYAVLGLAFYFHPL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm]; Ca (II) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + Proton [Periplasm] = Proton [Cytoplasm] + Na (I) [Periplasm] Ca (II) [Cytoplasm] + Proton [Periplasm] = Ca (II) [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377 [H]