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The map label for this gene is accC [H]

Identifier: 158335279

GI number: 158335279

Start: 2110005

End: 2111354

Strand: Reverse

Name: accC [H]

Synonym: AM1_2122

Alternate gene names: 158335279

Gene position: 2111354-2110005 (Counterclockwise)

Preceding gene: 158335280

Following gene: 158335277

Centisome position: 32.46

GC content: 50.52

Gene sequence:

>1350_bases
ATGCGTTTTTCTAAGATTTTAATTGCGAATCGGGGCGAGATTGCCTTGAGGATACTCCGCACCTGTGGAGAGATGGGAAT
TTCCACTGTTGCCGTTCATTCCACTGTGGATCAGCAATCTCTCAATGTGCAGTTGGCAGATGAAGCGGTCTGCATTGGGG
AACCCGCCAGCAGTAAGAGCTACCTCAATATTCCCAATATTATTTCGGCTGCCTTAACGCGGAATGCGACGGCCATTCAT
CCGGGATATGGTTTCCTGGCCGAAAATGCCCGCTTTGCCGAGATCTGTGCTGATCATAAGATTCACTTTATTGGTCCCAC
ACCCGAAGCCATGAGGGCGATGGGAGACAAGTCTACGGCCAAAGAAACGATGCAAAAGGCTGGGGTTCCTACTGTCCCAG
GAAGCGATGGCCTGGTACCGGATGAAGCGACGGCTAAAAAAATTGCGGATGATATGGGCTATCCCGTTATGGTTAAAGCC
ACGGCCGGGGGCGGTGGTCGAGGGATGCGCTTAGTGCGGGAACCTGAAAACTTAGGCAAGCTCTATTTAGCGGCCCAGGG
CGAAGCAGAGGCTGCGTTTGGTAATCCTGGGGTCTATATTGAAAAATTTATCGAAAACCCTCGTCATATTGAATTTCAGA
TTTTTGCAGATAGCTATGGCAATGTGGTTCATTTGGGCGAGCGGGATTGCTCGATTCAGCGACGGCACCAAAAGTTACTG
GAAGAATCGCCCAGTCCAGCCCTAAGCCCAGAGCTAAGAGAAAAAATGGGTTCCGCCGCTGTCCGGGCAGCTCAATCGAT
TGGCTATGTCGGTGCCGGCACCGTTGAGTTTCTCCTGTCTTCGACAGGGGAGTTCTATTTTATGGAGATGAATACCCGCA
TCCAGGTGGAACATCCGGTGACGGAAGTAACAACGGGCTTAGATTTGATTGCGGAGCAGATCCGCATTGCCCAGGGTGAA
AAACTCAGTGTGACCCAAGATCAAGTCAAGCTAACGGGGCATGCCATCGAGTGCCGCATCAATGCCGAAGATCCCGACCA
TAATTTCCGCCCCCACCCAGGACGTATCAATGGCTATCTACCCCCTGGTGGGCCTGGGGTGCGGGTTGATTCTCATGTTT
ATACGGATTATGAGATTCCCCCTTATTATGATTCGCTGATTGGTAAACTCATTGTTTGGGGACGAGATCGACCGACTGCG
ATCGCACGCATGAAACGCGCCCTGCAAGAATGTGCAATTACCGGGTTGCCCACCACCATTGGCTTCCACCAAAAAATTCT
AGACACTCCAGAATTTGTTCAAGGTAAGGTTTATACCAATTTCATTCAAGAAGTGATGGGATTGCAATGA

Upstream 100 bases:

>100_bases
CGCTTCACGCAGCTCCTTGGGGGTTCAGACTTGGGGCGTGTAGCAGGTTCGTCCTGGGTCATTGCGAGAAGGTTATTGAG
CGTTACGCTCCTGTTAAAAC

Downstream 100 bases:

>100_bases
TGGTCTTGATGGGGCTGCTAGGCGGATTGCTTACATCGACTCTGACTTTCCACCTCAATAAGGTGAGATGGACAAAAGCA
GCCTAGAACAACATTCTCAG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MRFSKILIANRGEIALRILRTCGEMGISTVAVHSTVDQQSLNVQLADEAVCIGEPASSKSYLNIPNIISAALTRNATAIH
PGYGFLAENARFAEICADHKIHFIGPTPEAMRAMGDKSTAKETMQKAGVPTVPGSDGLVPDEATAKKIADDMGYPVMVKA
TAGGGGRGMRLVREPENLGKLYLAAQGEAEAAFGNPGVYIEKFIENPRHIEFQIFADSYGNVVHLGERDCSIQRRHQKLL
EESPSPALSPELREKMGSAAVRAAQSIGYVGAGTVEFLLSSTGEFYFMEMNTRIQVEHPVTEVTTGLDLIAEQIRIAQGE
KLSVTQDQVKLTGHAIECRINAEDPDHNFRPHPGRINGYLPPGGPGVRVDSHVYTDYEIPPYYDSLIGKLIVWGRDRPTA
IARMKRALQECAITGLPTTIGFHQKILDTPEFVQGKVYTNFIQEVMGLQ

Sequences:

>Translated_449_residues
MRFSKILIANRGEIALRILRTCGEMGISTVAVHSTVDQQSLNVQLADEAVCIGEPASSKSYLNIPNIISAALTRNATAIH
PGYGFLAENARFAEICADHKIHFIGPTPEAMRAMGDKSTAKETMQKAGVPTVPGSDGLVPDEATAKKIADDMGYPVMVKA
TAGGGGRGMRLVREPENLGKLYLAAQGEAEAAFGNPGVYIEKFIENPRHIEFQIFADSYGNVVHLGERDCSIQRRHQKLL
EESPSPALSPELREKMGSAAVRAAQSIGYVGAGTVEFLLSSTGEFYFMEMNTRIQVEHPVTEVTTGLDLIAEQIRIAQGE
KLSVTQDQVKLTGHAIECRINAEDPDHNFRPHPGRINGYLPPGGPGVRVDSHVYTDYEIPPYYDSLIGKLIVWGRDRPTA
IARMKRALQECAITGLPTTIGFHQKILDTPEFVQGKVYTNFIQEVMGLQ
>Mature_449_residues
MRFSKILIANRGEIALRILRTCGEMGISTVAVHSTVDQQSLNVQLADEAVCIGEPASSKSYLNIPNIISAALTRNATAIH
PGYGFLAENARFAEICADHKIHFIGPTPEAMRAMGDKSTAKETMQKAGVPTVPGSDGLVPDEATAKKIADDMGYPVMVKA
TAGGGGRGMRLVREPENLGKLYLAAQGEAEAAFGNPGVYIEKFIENPRHIEFQIFADSYGNVVHLGERDCSIQRRHQKLL
EESPSPALSPELREKMGSAAVRAAQSIGYVGAGTVEFLLSSTGEFYFMEMNTRIQVEHPVTEVTTGLDLIAEQIRIAQGE
KLSVTQDQVKLTGHAIECRINAEDPDHNFRPHPGRINGYLPPGGPGVRVDSHVYTDYEIPPYYDSLIGKLIVWGRDRPTA
IARMKRALQECAITGLPTTIGFHQKILDTPEFVQGKVYTNFIQEVMGLQ

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:
GO:0003824: Acetyl-CoA carboxylase, biotin carboxylase
GO:0004075: Acetyl-CoA carboxylase, biotin carboxylase
GO:0005524: Acetyl-CoA carboxylase, biotin carboxylase
GO:0008152: Acetyl-CoA carboxylase, biotin carboxylase
GO:0016874: Acetyl-CoA carboxylase, biotin carboxylase
GO:0046872: Acetyl-CoA carboxylase, biotin carboxylase

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=49.4331065759637, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=49.8876404494382, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=49.8876404494382, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=49.8876404494382, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=47.6404494382022, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=47.6404494382022, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=47.6404494382022, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=31.6306483300589, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=31.6306483300589, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=31.6306483300589, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=31.6306483300589, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=31.6306483300589, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI134142062, Length=511, Percent_Identity=31.1154598825832, Blast_Score=243, Evalue=4e-64,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=56.4732142857143, Blast_Score=488, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71987519, Length=439, Percent_Identity=51.0250569476082, Blast_Score=440, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17567343, Length=446, Percent_Identity=47.7578475336323, Blast_Score=411, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=45.2115812917595, Blast_Score=380, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=28.8801571709234, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=28.6836935166994, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI133931226, Length=485, Percent_Identity=30.1030927835052, Blast_Score=217, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319685, Length=442, Percent_Identity=43.6651583710407, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=43.3035714285714, Blast_Score=351, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.3125, Blast_Score=347, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6323863, Length=489, Percent_Identity=32.9243353783231, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6324343, Length=511, Percent_Identity=32.4853228962818, Blast_Score=242, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=48.5393258426966, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=47.7477477477478, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=47.7477477477478, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=47.7477477477478, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=47.7477477477478, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=47.7477477477478, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=47.7477477477478, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=47.7477477477478, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=47.7477477477478, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=47.7477477477478, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=47.7477477477478, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24651759, Length=407, Percent_Identity=47.6658476658477, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24586458, Length=506, Percent_Identity=31.0276679841897, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI161076407, Length=506, Percent_Identity=31.0276679841897, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24586460, Length=506, Percent_Identity=31.0276679841897, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI161076409, Length=506, Percent_Identity=31.0276679841897, Blast_Score=248, Evalue=8e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48986; Mature: 48986

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSKILIANRGEIALRILRTCGEMGISTVAVHSTVDQQSLNVQLADEAVCIGEPASSKS
CCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHCEEEECCCEEEECCCCCCCC
YLNIPNIISAALTRNATAIHPGYGFLAENARFAEICADHKIHFIGPTPEAMRAMGDKSTA
EECCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHCCHHHH
KETMQKAGVPTVPGSDGLVPDEATAKKIADDMGYPVMVKATAGGGGRGMRLVREPENLGK
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCCCCE
LYLAAQGEAEAAFGNPGVYIEKFIENPRHIEFQIFADSYGNVVHLGERDCSIQRRHQKLL
EEEEECCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EESPSPALSPELREKMGSAAVRAAQSIGYVGAGTVEFLLSSTGEFYFMEMNTRIQVEHPV
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCEEEEECCH
TEVTTGLDLIAEQIRIAQGEKLSVTQDQVKLTGHAIECRINAEDPDHNFRPHPGRINGYL
HHHHHHHHHHHHHHHHCCCCEEECCHHHEEEECEEEEEEECCCCCCCCCCCCCCCCCCCC
PPGGPGVRVDSHVYTDYEIPPYYDSLIGKLIVWGRDRPTAIARMKRALQECAITGLPTTI
CCCCCCCEECCEEEECCCCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCHH
GFHQKILDTPEFVQGKVYTNFIQEVMGLQ
HHHHHHCCCHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRFSKILIANRGEIALRILRTCGEMGISTVAVHSTVDQQSLNVQLADEAVCIGEPASSKS
CCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHCEEEECCCEEEECCCCCCCC
YLNIPNIISAALTRNATAIHPGYGFLAENARFAEICADHKIHFIGPTPEAMRAMGDKSTA
EECCHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHCCHHHH
KETMQKAGVPTVPGSDGLVPDEATAKKIADDMGYPVMVKATAGGGGRGMRLVREPENLGK
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCCCCE
LYLAAQGEAEAAFGNPGVYIEKFIENPRHIEFQIFADSYGNVVHLGERDCSIQRRHQKLL
EEEEECCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EESPSPALSPELREKMGSAAVRAAQSIGYVGAGTVEFLLSSTGEFYFMEMNTRIQVEHPV
HCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCEEEEECCH
TEVTTGLDLIAEQIRIAQGEKLSVTQDQVKLTGHAIECRINAEDPDHNFRPHPGRINGYL
HHHHHHHHHHHHHHHHCCCCEEECCHHHEEEECEEEEEEECCCCCCCCCCCCCCCCCCCC
PPGGPGVRVDSHVYTDYEIPPYYDSLIGKLIVWGRDRPTAIARMKRALQECAITGLPTTI
CCCCCCCEECCEEEECCCCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCHH
GFHQKILDTPEFVQGKVYTNFIQEVMGLQ
HHHHHHCCCHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]