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The map label for this gene is hbpA [H]

Identifier: 158335238

GI number: 158335238

Start: 2071656

End: 2073470

Strand: Reverse

Name: hbpA [H]

Synonym: AM1_2081

Alternate gene names: 158335238

Gene position: 2073470-2071656 (Counterclockwise)

Preceding gene: 158335239

Following gene: 158335237

Centisome position: 31.88

GC content: 45.95

Gene sequence:

>1815_bases
ATGGCTGTAAAGAAAATTTCAATCTGGCAAAAAGCTCCCCAAGTTGTTTTATCGGCCCTACTGATTACCACAGCGGCAGT
GCCATTGGGATGTCAGCCACGACAAGGTGCAGGGGATACGGGTGTCAAAGTTTTAGATACGTTTCGGGCGTCAGTTTATC
GAAGCCTCGATCCCCCTAAGCAATTTGATGTGGCTTCCGCCCGGATTATCAGCAACATCTATGACCCTCTCTTGGAATAT
CACTATCTCAAACGTCCCTATGAGTTGGTACCCAACCTTTTAGAGACCATGCCAGAATTGGGCGAGGATAAGCTCACCTA
CACCTTTAAATTGCGGAAAGGCATCAAATTTCATGATGATCCCTGTTTCCCAGACGGCAAAGGTCGGGAACTGAATGCCG
ATGATGTGATTTACACCCTGAAGCGGTTTGCGGATGTCAATGTTAACCCCCAAAGTTACCCTACCCTGCTAGAAAATCGG
ATTAAAGGGCTAGATGAGTTTAGGGAAAAAACTCGGCAGCAAAAAGATCTCGACTATGACCAGGAAAACGTCCCAGGTAT
CGAAAAGGTAGATTCCCATACCTTCAAGATTGTCATGACTGAGCAGGATCCCCTGCTATTGATGTCTTTTGCGGCTAGTC
CTCTCTCCATCGTTCCCAGAGAAGCCGTTGAAGAGTATGGCCGCAAATTGGAACACCACGGCGTCGGGACAGGGCCATAT
ATCCTGGATAAAAATCCGCGCAAAGGGGTAATGGTGCTCAAGAAAAACCCCAATTATCATGGCACATACCCTACCGAAGG
AGAGCCAGAGGATCAAAGCCAGGGGCTGCTAGAAGATGCAGGCGAAAAACTGCCCTTAATTGATGAAATTCGGATTCCTT
TAATTGAAGAAGCGCAACCCCGAATGCTCAAATTTCTGAAGGGTGAGCTGGATTCCATTGGCATTGATCGAGATAATTTT
TCCAAAATGGCTGAAAAGGTAGGAGAGAAATTTCAGCTAAAGGGTGAGTTCGCAGGTAAGTTCAACATTGCTTCGGCCAA
TGATCTGGCATCGTTTTACATCACCATTAACTTTAGAGATAAAACCTTTGGGCAAAATAAAGTGCTGCGTCAAGCCTTAG
CCTATGCGCTAGATACCCCTACCTATATTGAGAAAATGGAAAATGGTCGGGGTCTTGCCCTCAACACCATTGTCCCCTTA
CCCATTGCGGGAAGTGAAGAAACGATTCCGGTGAAATGGTATTCCCATGATCCAACCCAAGCGAAAGCAAAGTTAAAAGA
AGCAGGATATCCAGACGGTAAAGGATTACCGCCCATCACGATCTTGTATCCATCGCAAGATAAGATTACCAAGCAGAATT
ATGAGTTCTTACGCAATCAACTGGCCCAATCTGGCTTTCAGCTTAAAGGAGAGTTTTTAACCTTCTCTGAATTTCTGAAA
CGGAAGGAAGGCGGAAGTTTTCAGCTATCCAGTAGCGGCTGGGGGGCAGATTATCCGGATGCAGAAAACTTCTATCAACT
GTTCTATGGCCCGAATAAGGCACCGGGACCGAATGCGGGGTCTTACCAAAATCCTGAATATGATCGGCTTTACGAACAGA
TGCGACGCATGTCTCCCGGTGCAGAGCGCAACAAAATTATTGAGAAGATGGCTTTGATTTTGAAAGAAGATGTACCGATT
GTCTTTCTTAAAGCCCGGATTAATGTGGGAATGCGCCAGAAATGGCTCCTCAACTCCAAACCCAACCTGATGCTAGGCTC
GACTTCTAAATTTTTGGATATCGATACTGAGGCCAAAGCCAAAGGATTGAAGTAA

Upstream 100 bases:

>100_bases
CTCAGATTTGATCAAACCATAACTTCCCATTAATCTTGTCTCAACGGTTTGATGATGTCCCACTGATGGATTTGTCGTTA
ATGTAGCGTTGTCTGAATTT

Downstream 100 bases:

>100_bases
TGGTTGGGTATATTATTCGCCGCTTGCTATACATCATTCCCACCATCCTGGGAGTTGCGGTCATTATTTTCGTGTTGTTC
AACGTGGCCGGAGAAGATCC

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MAVKKISIWQKAPQVVLSALLITTAAVPLGCQPRQGAGDTGVKVLDTFRASVYRSLDPPKQFDVASARIISNIYDPLLEY
HYLKRPYELVPNLLETMPELGEDKLTYTFKLRKGIKFHDDPCFPDGKGRELNADDVIYTLKRFADVNVNPQSYPTLLENR
IKGLDEFREKTRQQKDLDYDQENVPGIEKVDSHTFKIVMTEQDPLLLMSFAASPLSIVPREAVEEYGRKLEHHGVGTGPY
ILDKNPRKGVMVLKKNPNYHGTYPTEGEPEDQSQGLLEDAGEKLPLIDEIRIPLIEEAQPRMLKFLKGELDSIGIDRDNF
SKMAEKVGEKFQLKGEFAGKFNIASANDLASFYITINFRDKTFGQNKVLRQALAYALDTPTYIEKMENGRGLALNTIVPL
PIAGSEETIPVKWYSHDPTQAKAKLKEAGYPDGKGLPPITILYPSQDKITKQNYEFLRNQLAQSGFQLKGEFLTFSEFLK
RKEGGSFQLSSSGWGADYPDAENFYQLFYGPNKAPGPNAGSYQNPEYDRLYEQMRRMSPGAERNKIIEKMALILKEDVPI
VFLKARINVGMRQKWLLNSKPNLMLGSTSKFLDIDTEAKAKGLK

Sequences:

>Translated_604_residues
MAVKKISIWQKAPQVVLSALLITTAAVPLGCQPRQGAGDTGVKVLDTFRASVYRSLDPPKQFDVASARIISNIYDPLLEY
HYLKRPYELVPNLLETMPELGEDKLTYTFKLRKGIKFHDDPCFPDGKGRELNADDVIYTLKRFADVNVNPQSYPTLLENR
IKGLDEFREKTRQQKDLDYDQENVPGIEKVDSHTFKIVMTEQDPLLLMSFAASPLSIVPREAVEEYGRKLEHHGVGTGPY
ILDKNPRKGVMVLKKNPNYHGTYPTEGEPEDQSQGLLEDAGEKLPLIDEIRIPLIEEAQPRMLKFLKGELDSIGIDRDNF
SKMAEKVGEKFQLKGEFAGKFNIASANDLASFYITINFRDKTFGQNKVLRQALAYALDTPTYIEKMENGRGLALNTIVPL
PIAGSEETIPVKWYSHDPTQAKAKLKEAGYPDGKGLPPITILYPSQDKITKQNYEFLRNQLAQSGFQLKGEFLTFSEFLK
RKEGGSFQLSSSGWGADYPDAENFYQLFYGPNKAPGPNAGSYQNPEYDRLYEQMRRMSPGAERNKIIEKMALILKEDVPI
VFLKARINVGMRQKWLLNSKPNLMLGSTSKFLDIDTEAKAKGLK
>Mature_603_residues
AVKKISIWQKAPQVVLSALLITTAAVPLGCQPRQGAGDTGVKVLDTFRASVYRSLDPPKQFDVASARIISNIYDPLLEYH
YLKRPYELVPNLLETMPELGEDKLTYTFKLRKGIKFHDDPCFPDGKGRELNADDVIYTLKRFADVNVNPQSYPTLLENRI
KGLDEFREKTRQQKDLDYDQENVPGIEKVDSHTFKIVMTEQDPLLLMSFAASPLSIVPREAVEEYGRKLEHHGVGTGPYI
LDKNPRKGVMVLKKNPNYHGTYPTEGEPEDQSQGLLEDAGEKLPLIDEIRIPLIEEAQPRMLKFLKGELDSIGIDRDNFS
KMAEKVGEKFQLKGEFAGKFNIASANDLASFYITINFRDKTFGQNKVLRQALAYALDTPTYIEKMENGRGLALNTIVPLP
IAGSEETIPVKWYSHDPTQAKAKLKEAGYPDGKGLPPITILYPSQDKITKQNYEFLRNQLAQSGFQLKGEFLTFSEFLKR
KEGGSFQLSSSGWGADYPDAENFYQLFYGPNKAPGPNAGSYQNPEYDRLYEQMRRMSPGAERNKIIEKMALILKEDVPIV
FLKARINVGMRQKWLLNSKPNLMLGSTSKFLDIDTEAKAKGLK

Specific function: Important role in heme acquisition or metabolism [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=501, Percent_Identity=25.748502994012, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1787495, Length=567, Percent_Identity=23.2804232804233, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787052, Length=554, Percent_Identity=25.0902527075812, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787762, Length=527, Percent_Identity=21.0626185958254, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1789397, Length=523, Percent_Identity=20.8413001912046, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081878, Length=534, Percent_Identity=21.7228464419476, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 68209; Mature: 68078

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKKISIWQKAPQVVLSALLITTAAVPLGCQPRQGAGDTGVKVLDTFRASVYRSLDPPK
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
QFDVASARIISNIYDPLLEYHYLKRPYELVPNLLETMPELGEDKLTYTFKLRKGIKFHDD
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
PCFPDGKGRELNADDVIYTLKRFADVNVNPQSYPTLLENRIKGLDEFREKTRQQKDLDYD
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QENVPGIEKVDSHTFKIVMTEQDPLLLMSFAASPLSIVPREAVEEYGRKLEHHGVGTGPY
CCCCCCCHHCCCCEEEEEEECCCCEEEEECCCCCHHHCCHHHHHHHHHHHHHCCCCCCCE
ILDKNPRKGVMVLKKNPNYHGTYPTEGEPEDQSQGLLEDAGEKLPLIDEIRIPLIEEAQP
EECCCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCHHHHCCCCCCCHHHHCCCCCCCCCH
RMLKFLKGELDSIGIDRDNFSKMAEKVGEKFQLKGEFAGKFNIASANDLASFYITINFRD
HHHHHHHCCHHHCCCCHHHHHHHHHHHCHHEEECCCCCCEEECCCCCCCEEEEEEEEECC
KTFGQNKVLRQALAYALDTPTYIEKMENGRGLALNTIVPLPIAGSEETIPVKWYSHDPTQ
CCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHH
AKAKLKEAGYPDGKGLPPITILYPSQDKITKQNYEFLRNQLAQSGFQLKGEFLTFSEFLK
HHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEECCCEEHHHHHHH
RKEGGSFQLSSSGWGADYPDAENFYQLFYGPNKAPGPNAGSYQNPEYDRLYEQMRRMSPG
HCCCCCEEECCCCCCCCCCCHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
AERNKIIEKMALILKEDVPIVFLKARINVGMRQKWLLNSKPNLMLGSTSKFLDIDTEAKA
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHEECCCCCCEEEECCCCEEECCCHHHC
KGLK
CCCC
>Mature Secondary Structure 
AVKKISIWQKAPQVVLSALLITTAAVPLGCQPRQGAGDTGVKVLDTFRASVYRSLDPPK
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
QFDVASARIISNIYDPLLEYHYLKRPYELVPNLLETMPELGEDKLTYTFKLRKGIKFHDD
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
PCFPDGKGRELNADDVIYTLKRFADVNVNPQSYPTLLENRIKGLDEFREKTRQQKDLDYD
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QENVPGIEKVDSHTFKIVMTEQDPLLLMSFAASPLSIVPREAVEEYGRKLEHHGVGTGPY
CCCCCCCHHCCCCEEEEEEECCCCEEEEECCCCCHHHCCHHHHHHHHHHHHHCCCCCCCE
ILDKNPRKGVMVLKKNPNYHGTYPTEGEPEDQSQGLLEDAGEKLPLIDEIRIPLIEEAQP
EECCCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCHHHHCCCCCCCHHHHCCCCCCCCCH
RMLKFLKGELDSIGIDRDNFSKMAEKVGEKFQLKGEFAGKFNIASANDLASFYITINFRD
HHHHHHHCCHHHCCCCHHHHHHHHHHHCHHEEECCCCCCEEECCCCCCCEEEEEEEEECC
KTFGQNKVLRQALAYALDTPTYIEKMENGRGLALNTIVPLPIAGSEETIPVKWYSHDPTQ
CCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEEEECCCCHH
AKAKLKEAGYPDGKGLPPITILYPSQDKITKQNYEFLRNQLAQSGFQLKGEFLTFSEFLK
HHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEECCCEEHHHHHHH
RKEGGSFQLSSSGWGADYPDAENFYQLFYGPNKAPGPNAGSYQNPEYDRLYEQMRRMSPG
HCCCCCEEECCCCCCCCCCCHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCC
AERNKIIEKMALILKEDVPIVFLKARINVGMRQKWLLNSKPNLMLGSTSKFLDIDTEAKA
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHEECCCCCCEEEECCCCEEECCCHHHC
KGLK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]