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The map label for this gene is thrA [H]

Identifier: 158335218

GI number: 158335218

Start: 2055652

End: 2056974

Strand: Reverse

Name: thrA [H]

Synonym: AM1_2061

Alternate gene names: 158335218

Gene position: 2056974-2055652 (Counterclockwise)

Preceding gene: 158335219

Following gene: 158335214

Centisome position: 31.63

GC content: 52.15

Gene sequence:

>1323_bases
GTGGGTTTCAAAATTGGCTTACTTGGATTAGGAACCGTAGGTACAGGAGTGGGCGAGATCTTTGCTAACCCCAAAGGCCG
ACATCCCCTCTTGCAAGAGCTTGAAATTGCCAAAGTTGGGGTGCGGTCCTTAGAGAAAGCGCGCAGCCTAAATCTCCCGA
CTGAGGTGCTCACCACGGATCTCAACGCCATCGTCAATGATCCCACCATCGATATGGTGGTTGAAGTCATTGGTGGTCTT
GAACCCGCTCGGTCCCTGATTCTAGAAGCCATCGCTCAAGGGAAGCATGTGGTCACTGCCAACAAAGCCGTGATTGCCCG
CTTTGGCGAGGAAATTTTTCAAGCCGCAACTCAAGCAGGCGTCTACGTCATGATTGAGGCAGCAGTGGCGGGTGGGATTC
CGGTGATTCAGCCCCTCAAGGAATCTCTAGGCGCCAACCGGATCCATACCCTCATCGGTATTCTGAATGGCACCACCAAC
TATATCCTCACCAAGATGCAGCAGTCGGGAGCAGCCTTTGACGATGTGCTGGCGGAAGCCCAAGAACTTGGATATGCCGA
AGCAGACCCCACTGCGGATGTGGATGGCTTAGATGCTGGCGATAAAATTGCGATTCTGGCCTCCCTGGCCTTTGGAGGGC
GGATTGACTTAGAGCAGGTTCATCGGGAAGGCATTCGCCAGGTAAGTGCAGCGGATATTAACTATGCCAAGAACCTGGGA
TTTGTAATCAAACTACTTGCGATCGCAAAAGTGCCTCCCACAACTGCCGAGCTGCCGCCGCCTCAATTAGAGGCCCGTGT
TCATCCCACATTAGTTCCCGTCGATCATCCCCTAGCAAACGTCAATGATGTCTATAACGCCCTGCTAATCGAAGCCAATC
CGTTGGGACAAGTGATGTTCTTTGGTCCCGGAGCAGGGGCTGGGCCGACGGCGAGTGCCGTGGTTGCCGATTTGATTAAT
ATTGCGGCTTTGCTCAAAACAGGTATCGTCGCCAATGATCCAGAGTCCTCTCGCATCCACCCGTTGCTGGCTTGTTCCCA
CCAGCATTACTGCAATATTGCACCGATGAATGATCTGGTGACCCGCTTCTATGCTCGGTTTTTAACCAAAGATCATCCAG
GGGTGATTGGCAAGTTAGGGACTGTCTTTGGTAATCACGGCGTCAGCTTAGAATCTGTTGTCCAAACGGGCATCAAGGCC
GAGCTAGCTGAAATTGTGGTGGTCACCCATGATGTCCAAGAAGGTAATTTCCATCAAGCCTTAGACGAAATTCGCCAGAT
GGAAGCCATTAGCTCTATTCCCAGTCTGCTGCGTGTTTTGTAG

Upstream 100 bases:

>100_bases
CGGCCCACCGATTGCAAGTCCCGCAAATTTTCCCTATATCTTGTTGAAGACTTGAATCTGAATGTCACAATAAAGTTTGT
GATCGAGATGGGGCATAACC

Downstream 100 bases:

>100_bases
AGACTTAATTACTGAGAGATTTGTGAGTACTTAGATATCGTTCCGCGATTAGAATTGCGATCGTAACTCCGATCAAGCTG
ATCCAAGCGCCCAAACTGCC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MGFKIGLLGLGTVGTGVGEIFANPKGRHPLLQELEIAKVGVRSLEKARSLNLPTEVLTTDLNAIVNDPTIDMVVEVIGGL
EPARSLILEAIAQGKHVVTANKAVIARFGEEIFQAATQAGVYVMIEAAVAGGIPVIQPLKESLGANRIHTLIGILNGTTN
YILTKMQQSGAAFDDVLAEAQELGYAEADPTADVDGLDAGDKIAILASLAFGGRIDLEQVHREGIRQVSAADINYAKNLG
FVIKLLAIAKVPPTTAELPPPQLEARVHPTLVPVDHPLANVNDVYNALLIEANPLGQVMFFGPGAGAGPTASAVVADLIN
IAALLKTGIVANDPESSRIHPLLACSHQHYCNIAPMNDLVTRFYARFLTKDHPGVIGKLGTVFGNHGVSLESVVQTGIKA
ELAEIVVVTHDVQEGNFHQALDEIRQMEAISSIPSLLRVL

Sequences:

>Translated_440_residues
MGFKIGLLGLGTVGTGVGEIFANPKGRHPLLQELEIAKVGVRSLEKARSLNLPTEVLTTDLNAIVNDPTIDMVVEVIGGL
EPARSLILEAIAQGKHVVTANKAVIARFGEEIFQAATQAGVYVMIEAAVAGGIPVIQPLKESLGANRIHTLIGILNGTTN
YILTKMQQSGAAFDDVLAEAQELGYAEADPTADVDGLDAGDKIAILASLAFGGRIDLEQVHREGIRQVSAADINYAKNLG
FVIKLLAIAKVPPTTAELPPPQLEARVHPTLVPVDHPLANVNDVYNALLIEANPLGQVMFFGPGAGAGPTASAVVADLIN
IAALLKTGIVANDPESSRIHPLLACSHQHYCNIAPMNDLVTRFYARFLTKDHPGVIGKLGTVFGNHGVSLESVVQTGIKA
ELAEIVVVTHDVQEGNFHQALDEIRQMEAISSIPSLLRVL
>Mature_439_residues
GFKIGLLGLGTVGTGVGEIFANPKGRHPLLQELEIAKVGVRSLEKARSLNLPTEVLTTDLNAIVNDPTIDMVVEVIGGLE
PARSLILEAIAQGKHVVTANKAVIARFGEEIFQAATQAGVYVMIEAAVAGGIPVIQPLKESLGANRIHTLIGILNGTTNY
ILTKMQQSGAAFDDVLAEAQELGYAEADPTADVDGLDAGDKIAILASLAFGGRIDLEQVHREGIRQVSAADINYAKNLGF
VIKLLAIAKVPPTTAELPPPQLEARVHPTLVPVDHPLANVNDVYNALLIEANPLGQVMFFGPGAGAGPTASAVVADLINI
AALLKTGIVANDPESSRIHPLLACSHQHYCNIAPMNDLVTRFYARFLTKDHPGVIGKLGTVFGNHGVSLESVVQTGIKAE
LAEIVVVTHDVQEGNFHQALDEIRQMEAISSIPSLLRVL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=368, Percent_Identity=25.8152173913043, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786183, Length=251, Percent_Identity=29.8804780876494, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46504; Mature: 46373

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFKIGLLGLGTVGTGVGEIFANPKGRHPLLQELEIAKVGVRSLEKARSLNLPTEVLTTD
CCEEEEEEECCCHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LNAIVNDPTIDMVVEVIGGLEPARSLILEAIAQGKHVVTANKAVIARFGEEIFQAATQAG
HHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCC
VYVMIEAAVAGGIPVIQPLKESLGANRIHTLIGILNGTTNYILTKMQQSGAAFDDVLAEA
EEEEEEEHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHH
QELGYAEADPTADVDGLDAGDKIAILASLAFGGRIDLEQVHREGIRQVSAADINYAKNLG
HHCCCCCCCCCCCCCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FVIKLLAIAKVPPTTAELPPPQLEARVHPTLVPVDHPLANVNDVYNALLIEANPLGQVMF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHEEEEECCCCCEEEE
FGPGAGAGPTASAVVADLINIAALLKTGIVANDPESSRIHPLLACSHQHYCNIAPMNDLV
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEECCCCCCCCCCHHHHH
TRFYARFLTKDHPGVIGKLGTVFGNHGVSLESVVQTGIKAELAEIVVVTHDVQEGNFHQA
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCHHHH
LDEIRQMEAISSIPSLLRVL
HHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
GFKIGLLGLGTVGTGVGEIFANPKGRHPLLQELEIAKVGVRSLEKARSLNLPTEVLTTD
CEEEEEEECCCHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LNAIVNDPTIDMVVEVIGGLEPARSLILEAIAQGKHVVTANKAVIARFGEEIFQAATQAG
HHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCC
VYVMIEAAVAGGIPVIQPLKESLGANRIHTLIGILNGTTNYILTKMQQSGAAFDDVLAEA
EEEEEEEHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHH
QELGYAEADPTADVDGLDAGDKIAILASLAFGGRIDLEQVHREGIRQVSAADINYAKNLG
HHCCCCCCCCCCCCCCCCCCCCEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FVIKLLAIAKVPPTTAELPPPQLEARVHPTLVPVDHPLANVNDVYNALLIEANPLGQVMF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHEEEEECCCCCEEEE
FGPGAGAGPTASAVVADLINIAALLKTGIVANDPESSRIHPLLACSHQHYCNIAPMNDLV
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEECCCCCCCCCCHHHHH
TRFYARFLTKDHPGVIGKLGTVFGNHGVSLESVVQTGIKAELAEIVVVTHDVQEGNFHQA
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCHHHH
LDEIRQMEAISSIPSLLRVL
HHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]