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The map label for this gene is galE [H]

Identifier: 158335216

GI number: 158335216

Start: 2053646

End: 2054608

Strand: Direct

Name: galE [H]

Synonym: AM1_2059

Alternate gene names: 158335216

Gene position: 2053646-2054608 (Clockwise)

Preceding gene: 158335215

Following gene: 158335217

Centisome position: 31.58

GC content: 50.57

Gene sequence:

>963_bases
ATGAAGACGATTTTAATCACAGGGGCAACTGGATTTGTAGGCGGGCATCTATTGTCCTGCTTAGAAGGGCATCCCTACAA
ACTCAGACTAGCCCTTAGAAAGCCCCCTCAATCCCCACTCCCACCAGGAGCAGACCTGATCCAAGTTGGGGATATCAACG
CCCTAACCAACTGGCAAGAAGCGCTCATCGACGTTGATATTGTCATTCATCTGGCCTCCCGCGCCCATATCCTCAAGGAA
ACCGTGGCCGATCCAATGGCTGCGTTTAAGGAGGTCAATGTTGAGGGAACCCAGGCTCTCGCTCAGCAATCAATAAAAGC
GGGCGTTCAGCACTTTGTCTTTATTAGTTCCATTGGAGCCATGGCGACTTTGAGTGATGTCGGTTTAACAGAAGCGTCGC
CGTGCCGTCCTGACTCGCCCTATGGTCGCAGTAAGTGGCAAGCAGAGCAGGATTTAATGGCCCTTGCTCAACCCACCAAG
ATGCGGTGGACAATTTTTCGACCAACCTTGGTGTATGGTCCCCGCAATCCAGGCAATATGGCGCGATTAATCAAGCTGGT
CGATCAGGGATTCCCCTTGCCCTTTGGCTTAATTAACAATCGCCGAAGCCTTGTTTACGTGGGCAATTTAGTTGAGGCCA
TTGTGGCCAGCCTGAACCATCCCCAAGCCTTCAATAAAACCTTTTTGATCAGTGATGGGCGGACGGTATCCACGGCTGAA
CTTATTCGGGCCATTGCCCAAGCTTTACAACGTCCAGTTCGATTGCTGCCCATACCGCCCATCTTGATCAAGCTCTTGGG
CATACTAACCGGTAAAACGGATGCGGTTGATCGACTTTTAGGATCATTGGCGGTTGATAGTGATAAGATTTTCCAGACTT
TAGATTGGACGCCCCCCTACTCTATGGAACAAGGCCTACACAAAACTGCAGAATGGTATGCTCAGGGCGCTTCCAAAGCG
TAA

Upstream 100 bases:

>100_bases
GTCCGAGGAACTTTGATGCAATCTCAGAGCTGATCAGTCCAAGCCGTTGAAGTGCCCTTACCGTACTATGATGGCCTAGG
CCTTCCCATGCAGGCTAGCC

Downstream 100 bases:

>100_bases
GGCAAACCCATCCGTCTCGATACTCCGTGCTCAAGTGATTCACTAAGGATTCATGGTCTTTATCGTTGTTTGTTGTCTAG
TAAGCTGCATATTCAGCATG

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MKTILITGATGFVGGHLLSCLEGHPYKLRLALRKPPQSPLPPGADLIQVGDINALTNWQEALIDVDIVIHLASRAHILKE
TVADPMAAFKEVNVEGTQALAQQSIKAGVQHFVFISSIGAMATLSDVGLTEASPCRPDSPYGRSKWQAEQDLMALAQPTK
MRWTIFRPTLVYGPRNPGNMARLIKLVDQGFPLPFGLINNRRSLVYVGNLVEAIVASLNHPQAFNKTFLISDGRTVSTAE
LIRAIAQALQRPVRLLPIPPILIKLLGILTGKTDAVDRLLGSLAVDSDKIFQTLDWTPPYSMEQGLHKTAEWYAQGASKA

Sequences:

>Translated_320_residues
MKTILITGATGFVGGHLLSCLEGHPYKLRLALRKPPQSPLPPGADLIQVGDINALTNWQEALIDVDIVIHLASRAHILKE
TVADPMAAFKEVNVEGTQALAQQSIKAGVQHFVFISSIGAMATLSDVGLTEASPCRPDSPYGRSKWQAEQDLMALAQPTK
MRWTIFRPTLVYGPRNPGNMARLIKLVDQGFPLPFGLINNRRSLVYVGNLVEAIVASLNHPQAFNKTFLISDGRTVSTAE
LIRAIAQALQRPVRLLPIPPILIKLLGILTGKTDAVDRLLGSLAVDSDKIFQTLDWTPPYSMEQGLHKTAEWYAQGASKA
>Mature_320_residues
MKTILITGATGFVGGHLLSCLEGHPYKLRLALRKPPQSPLPPGADLIQVGDINALTNWQEALIDVDIVIHLASRAHILKE
TVADPMAAFKEVNVEGTQALAQQSIKAGVQHFVFISSIGAMATLSDVGLTEASPCRPDSPYGRSKWQAEQDLMALAQPTK
MRWTIFRPTLVYGPRNPGNMARLIKLVDQGFPLPFGLINNRRSLVYVGNLVEAIVASLNHPQAFNKTFLISDGRTVSTAE
LIRAIAQALQRPVRLLPIPPILIKLLGILTGKTDAVDRLLGSLAVDSDKIFQTLDWTPPYSMEQGLHKTAEWYAQGASKA

Specific function: INVOLVED IN THE SYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN (ECA) AND REQUIRED FOR SYNTHESIS OF LIPOPOLYSACCHARIDE O-SIDE CHAINS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:
GO:0003824: UDP-glucose 4-epimerase
GO:0003978: UDP-glucose 4-epimerase
GO:0005488: UDP-glucose 4-epimerase
GO:0006012: UDP-glucose 4-epimerase
GO:0016853: UDP-glucose 4-epimerase
GO:0044237: UDP-glucose 4-epimerase
GO:0050662: UDP-glucose 4-epimerase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI116268111, Length=304, Percent_Identity=28.2894736842105, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI7657641, Length=340, Percent_Identity=25.2941176470588, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321437, Length=354, Percent_Identity=24.5762711864407, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34864; Mature: 34864

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTILITGATGFVGGHLLSCLEGHPYKLRLALRKPPQSPLPPGADLIQVGDINALTNWQE
CCEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHH
ALIDVDIVIHLASRAHILKETVADPMAAFKEVNVEGTQALAQQSIKAGVQHFVFISSIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MATLSDVGLTEASPCRPDSPYGRSKWQAEQDLMALAQPTKMRWTIFRPTLVYGPRNPGNM
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCCHH
ARLIKLVDQGFPLPFGLINNRRSLVYVGNLVEAIVASLNHPQAFNKTFLISDGRTVSTAE
HHHHHHHHCCCCCCCHHHCCCCCEEEHHHHHHHHHHHCCCCCHHCCEEEEECCCEECHHH
LIRAIAQALQRPVRLLPIPPILIKLLGILTGKTDAVDRLLGSLAVDSDKIFQTLDWTPPY
HHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCH
SMEQGLHKTAEWYAQGASKA
HHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKTILITGATGFVGGHLLSCLEGHPYKLRLALRKPPQSPLPPGADLIQVGDINALTNWQE
CCEEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHH
ALIDVDIVIHLASRAHILKETVADPMAAFKEVNVEGTQALAQQSIKAGVQHFVFISSIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MATLSDVGLTEASPCRPDSPYGRSKWQAEQDLMALAQPTKMRWTIFRPTLVYGPRNPGNM
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCEEEECCCCCCHH
ARLIKLVDQGFPLPFGLINNRRSLVYVGNLVEAIVASLNHPQAFNKTFLISDGRTVSTAE
HHHHHHHHCCCCCCCHHHCCCCCEEEHHHHHHHHHHHCCCCCHHCCEEEEECCCEECHHH
LIRAIAQALQRPVRLLPIPPILIKLLGILTGKTDAVDRLLGSLAVDSDKIFQTLDWTPPY
HHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCH
SMEQGLHKTAEWYAQGASKA
HHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8820651; 10521656 [H]