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The map label for this gene is hemH [H]

Identifier: 158335118

GI number: 158335118

Start: 1953609

End: 1954772

Strand: Direct

Name: hemH [H]

Synonym: AM1_1959

Alternate gene names: 158335118

Gene position: 1953609-1954772 (Clockwise)

Preceding gene: 158335117

Following gene: 158335121

Centisome position: 30.04

GC content: 48.71

Gene sequence:

>1164_bases
ATGGGCCGTGTCGGTGTTCTATTACTGAATCTAGGGGGACCAGAACAGCTAAAGGATGTACGTCCTTTTTTGTATAACCT
GTTTGCTGACCCAGAAATTTTACGACTGCCATTTGCCTGGATGCAAAAGCCTTTTGCCGGGTTAATTTCAACCATGCGAG
CCCGAACGTCTCGGGACAACTATCGGCAAATCGGAGGCGGATCCCCTCTACGACGGATCACCGAAGCCCAAGCCCACGCG
CTCCAAGACGACTTACAGGCTAAGGGATGTGACGCCCAGGTCTATATCGGTATGCGTTACTGGCACCCTTTTACAGAAGA
GGCCGTCAACCGCATTAAACAGGATGGCATTGAAGAGCTGGTTATCCTGCCCTTGTATCCTCAGTTTTCTATTAGTACGA
GTGGTTCAAGTATCCGGTTATTGGAAAAGATTTGGTCTGAAGATCCAGCATTACAAAAAATCAAGTACACCGTTATCTCC
TCTTGGCACGATCGCCCTGGCTATGTTCAAGTTATGGCCGACTTTTTGCGTCAAGAGCTGGATCAATTTGAGAATCCAGA
CCAAACGACCGTATTTTTTAGCGCCCATGGCGTCCCTCTCAGCTATGTGACTGAATCAGGAGACCCCTATCAGCAGGAGA
TTGAAGCCAGTACCCAGCTGATCATGGAAGCGTTAAAACGCCCTAATCCCCATATCTTGGCCTATCAAAGCCGAGTGGGA
CCGATGGAGTGGTTACGCCCCTACACCACGAATGTGATTGCCCATTTAGGTCAGCAAGGGGTTAAAGATTTAGTGGTGGT
TCCCATTAGCTTTATCTCGGAACATATCGAGACGCTCCAAGAAATCGATATGGAATACCGGCATTTAGCGCTAGAGTCAG
GCATTGAAAATTTTCGCCGGATGCCAGCTGTCAATACCCATCCAGACTTTATTGATACCCTCAGTGAGATGGTGCTGGAA
TATCTGGACAAGCCTTCCCTTAGGTTCTCTCAAGTTTTTCGCCCCCAGAAAAAGATCAAGCTGTATCCTCAAGAGCGTTG
GGAATGGGGGATGACCACCACAGCAGAGCGCTGGAATGGTCGCTTTGCGATGGTCGGCTTTATTGCATTACTGGTTGAAC
TGATCAGCGGTTATGGTCCCCTGCATTTAGCGGGGCTACTTTAA

Upstream 100 bases:

>100_bases
CTGCATAGCTCTATCAGAAATATTGGTCATTTGTCAATGCTTTACCCAGACAATGTTGTTAAAATAAGTAACAGAGTTTA
ACAAAGGCAATCATCAGGTT

Downstream 100 bases:

>100_bases
GCTATAGCTTTTTAGAAAGTTCAGCCTTCCAGAGTTTGTGCCAGTGGCTGCGGACAGCCCGGTTGGCATCGTACATCGTC
GAATACCGTGCTTGGATATT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MGRVGVLLLNLGGPEQLKDVRPFLYNLFADPEILRLPFAWMQKPFAGLISTMRARTSRDNYRQIGGGSPLRRITEAQAHA
LQDDLQAKGCDAQVYIGMRYWHPFTEEAVNRIKQDGIEELVILPLYPQFSISTSGSSIRLLEKIWSEDPALQKIKYTVIS
SWHDRPGYVQVMADFLRQELDQFENPDQTTVFFSAHGVPLSYVTESGDPYQQEIEASTQLIMEALKRPNPHILAYQSRVG
PMEWLRPYTTNVIAHLGQQGVKDLVVVPISFISEHIETLQEIDMEYRHLALESGIENFRRMPAVNTHPDFIDTLSEMVLE
YLDKPSLRFSQVFRPQKKIKLYPQERWEWGMTTTAERWNGRFAMVGFIALLVELISGYGPLHLAGLL

Sequences:

>Translated_387_residues
MGRVGVLLLNLGGPEQLKDVRPFLYNLFADPEILRLPFAWMQKPFAGLISTMRARTSRDNYRQIGGGSPLRRITEAQAHA
LQDDLQAKGCDAQVYIGMRYWHPFTEEAVNRIKQDGIEELVILPLYPQFSISTSGSSIRLLEKIWSEDPALQKIKYTVIS
SWHDRPGYVQVMADFLRQELDQFENPDQTTVFFSAHGVPLSYVTESGDPYQQEIEASTQLIMEALKRPNPHILAYQSRVG
PMEWLRPYTTNVIAHLGQQGVKDLVVVPISFISEHIETLQEIDMEYRHLALESGIENFRRMPAVNTHPDFIDTLSEMVLE
YLDKPSLRFSQVFRPQKKIKLYPQERWEWGMTTTAERWNGRFAMVGFIALLVELISGYGPLHLAGLL
>Mature_386_residues
GRVGVLLLNLGGPEQLKDVRPFLYNLFADPEILRLPFAWMQKPFAGLISTMRARTSRDNYRQIGGGSPLRRITEAQAHAL
QDDLQAKGCDAQVYIGMRYWHPFTEEAVNRIKQDGIEELVILPLYPQFSISTSGSSIRLLEKIWSEDPALQKIKYTVISS
WHDRPGYVQVMADFLRQELDQFENPDQTTVFFSAHGVPLSYVTESGDPYQQEIEASTQLIMEALKRPNPHILAYQSRVGP
MEWLRPYTTNVIAHLGQQGVKDLVVVPISFISEHIETLQEIDMEYRHLALESGIENFRRMPAVNTHPDFIDTLSEMVLEY
LDKPSLRFSQVFRPQKKIKLYPQERWEWGMTTTAERWNGRFAMVGFIALLVELISGYGPLHLAGLL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=336, Percent_Identity=39.5833333333333, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI60499025, Length=336, Percent_Identity=39.5833333333333, Blast_Score=234, Evalue=7e-62,
Organism=Escherichia coli, GI1786681, Length=324, Percent_Identity=29.9382716049383, Blast_Score=134, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6324750, Length=344, Percent_Identity=34.3023255813954, Blast_Score=196, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17864156, Length=326, Percent_Identity=35.8895705521472, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=32.8125, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45552018, Length=172, Percent_Identity=41.8604651162791, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 44381; Mature: 44249

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRVGVLLLNLGGPEQLKDVRPFLYNLFADPEILRLPFAWMQKPFAGLISTMRARTSRDN
CCCEEEEEEECCCHHHHHHHHHHHHHHHCCCHHEECCHHHHHCHHHHHHHHHHHHHCCCH
YRQIGGGSPLRRITEAQAHALQDDLQAKGCDAQVYIGMRYWHPFTEEAVNRIKQDGIEEL
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCHHHHHHHHHHHCCHHHE
VILPLYPQFSISTSGSSIRLLEKIWSEDPALQKIKYTVISSWHDRPGYVQVMADFLRQEL
EEEECCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DQFENPDQTTVFFSAHGVPLSYVTESGDPYQQEIEASTQLIMEALKRPNPHILAYQSRVG
HHCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
PMEWLRPYTTNVIAHLGQQGVKDLVVVPISFISEHIETLQEIDMEYRHLALESGIENFRR
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MPAVNTHPDFIDTLSEMVLEYLDKPSLRFSQVFRPQKKIKLYPQERWEWGMTTTAERWNG
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHEECCCHHHCCCCCCCCHHHHCC
RFAMVGFIALLVELISGYGPLHLAGLL
CHHHHHHHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure 
GRVGVLLLNLGGPEQLKDVRPFLYNLFADPEILRLPFAWMQKPFAGLISTMRARTSRDN
CCEEEEEEECCCHHHHHHHHHHHHHHHCCCHHEECCHHHHHCHHHHHHHHHHHHHCCCH
YRQIGGGSPLRRITEAQAHALQDDLQAKGCDAQVYIGMRYWHPFTEEAVNRIKQDGIEEL
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCHHHHHHHHHHHCCHHHE
VILPLYPQFSISTSGSSIRLLEKIWSEDPALQKIKYTVISSWHDRPGYVQVMADFLRQEL
EEEECCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DQFENPDQTTVFFSAHGVPLSYVTESGDPYQQEIEASTQLIMEALKRPNPHILAYQSRVG
HHCCCCCCEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
PMEWLRPYTTNVIAHLGQQGVKDLVVVPISFISEHIETLQEIDMEYRHLALESGIENFRR
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MPAVNTHPDFIDTLSEMVLEYLDKPSLRFSQVFRPQKKIKLYPQERWEWGMTTTAERWNG
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHEECCCHHHCCCCCCCCHHHHCC
RFAMVGFIALLVELISGYGPLHLAGLL
CHHHHHHHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA