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The map label for this gene is clpC [H]

Identifier: 158335106

GI number: 158335106

Start: 1941548

End: 1944016

Strand: Direct

Name: clpC [H]

Synonym: AM1_1947

Alternate gene names: 158335106

Gene position: 1941548-1944016 (Clockwise)

Preceding gene: 158335105

Following gene: 158335107

Centisome position: 29.85

GC content: 51.48

Gene sequence:

>2469_bases
ATGTTTGAACGCTTTACAGAAAAAGCCATTAAAGTCATCATGCTGGCTCAAGAGGAAGCCCGCCGCTTGGGGCACAATTT
TGTCGGCACAGAGCAAATTCTTTTGGGGCTCATTGGAGAAGGAACTGGCGTTGCCGCCAAAGTTTTGAAATCCATGGGGG
TTAACCTTAAAGATGCTCGCGTTGAAGTAGAAAAAATTATCGGTCGCGGTTCTGGATTTGTTGCGGTAGAGATTCCCTTT
ACCCCCAGAGCCAAGCGCGTTCTCGAGTTGTCGTTAGAAGAGGCCCGTCAGCTGGGTCACAACTACATTGGCACGGAGCA
CTTGCTGTTAGGACTCATCCGTGAGGGTGAAGGGGTCGCCGCCCGTGTTCTAGAAAATCTTGGAGTTGACCTGGCTAAGG
TACGCACCCAAGTCATCCGCATGTTGGGTGAAACAGCAGAAGTCTCTGCTGGCGGTGGTCAAGGACGTACTAAGACCCCA
ACCTTAGATGAGTTTGGCGCCAACCTGACCAACCTTGCCTCTGAAGGCAAGCTAGACCCCGTTGTGGGACGCCAAAAAGA
AATTGAGCGGGTGATTCAGATTCTCGGTCGTCGGACGAAGAACAATCCAGTCTTGATTGGTGAACCGGGCGTGGGTAAAA
CTGCGATCGCAGAAGGTCTCGCCCAGCGGATCGCCAATGGAGATATCCCCGACATCCTAGAAGAGAAGCGCGTGGTCACC
TTGGATATTGGTCTGCTGGTTGCCGGTACCAAATATCGAGGGGAATTCGAAGAGCGTCTCAAGAAAATCATGGATGAGAT
TCGCCAAGCCTCCAACGTGATTTTGGTGATTGACGAAGTTCATACCCTGATTGGTGCAGGGGCTGCTGAAGGGGCTATTG
ATGCTGCGAATATCCTCAAGCCTGCGTTGGCTCGGGGTGAACTCCAGTGCATCGGTGCCACCACTTTAGATGAGTATCGC
AAGCATATCGAGCGAGATGCCGCCCTGGAACGTCGTTTCCAGCCGGTGATGGTGGGTGAGCCTTCTGTGGAAGAAACCAT
CGAAATTCTTTACGGCTTGCGCGAGCGCTATGAGCAGCACCATAAACTCAGCATTTTGGATGAGTCTTTAGAAGCGGCAG
CCAAGCTTTCGGATCGCTATATCTCCGACCGCTATCTGCCTGACAAGGCCATTGACCTGATTGATGAAGCTGGTTCTAGA
GTTCGGTTAATTAACTCTCAACTTCCCCCAGCAGCCAAAGAATTGGACAAGGAACTACGCAAAGTTCTTAAAGATAAGGA
TGATGCCGTTCGCTCCCAAGACTTTGACAAAGCCGGTGAACTGCGCGACCGCGAGATGGAAATCAAATCCGAGATCAAAG
CGATCGCTCAGAACAAAAAGTCGAGCGAGGAGAACAAGGACGATTCCCCCAAGGTGACGGAAGAGGATATTGCCCATATT
GTGGCTTCCTGGACCGGGGTTCCCGTCAGCAAGCTGACGGAATCTGAGTCTGAGAAGCTGCTGCATATGGAAGATACCCT
ACACCAGCGATTGATCGGTCAGGATGAAGCGGTTCGTGCCATCTCTCGAGCGATTCGCCGGGCCCGTGTGGGTCTCAAGA
ATCCTAACCGTCCGATTGCTAGCTTTATTTTCTCTGGTCCAACTGGAGTCGGTAAGACTGAGCTGACCAAGGCTCTGGCC
ACTTACTTCTTTGGCTCCGAAGAAGCCATGATTCGCTTGGATATGTCCGAGTATATGGAGCGACACACGGTCTCCAAGTT
GATTGGCTCGCCGCCTGGCTACGTGGGCTATAACGAAGGCGGTCAGCTAACCGAGGCAGTTCGTCGACGTCCTTACACTG
TGGTCCTCTTCGACGAAATCGAAAAGGCTCACCCCGACGTCTTCAATATGCTGCTGCAAATTCTGGAAGATGGTCGCTTA
ACCGACGCCAAAGGACGAACCGTCGACTTCAAGAACACCCTGTTGATCATGACCTCAAATATTGGGTCGAAGGTGATTGA
AAAGGGTGGCGGCGGCCTCGGCTTTGAATTTGCTGAGGACGAAGCGGATTCTCAATACAATCGCATCCGCTCCTTGGTCA
ACGAAGAGCTGAAGGGCTATTTCCGACCGGAATTCTTAAACCGACTCGACGAAATCATCGTCTTCCGTCAGCTCACTAAG
GATGAAGTGAAGGAAATTTCCGAACTATTACTGAAGGAAGTCTTCAGTCGTTTGGAAGAGAAAAGCATCACCTTGAATAT
CACTGATCGCTTTAAGGAGCGATTGGTGGAAGAGGGCTACAATCCCAGTTATGGGGCTCGTCCCTTACGTCGAGCCATTA
TGCGTCTGCTCGAGGACACCTTGGCCGAAGAGATTCTCTCTGGTCGGGTGAAGGAAGGCGACACGGCCATTGTTGATGTA
GACGAAGATCAGCAAGTTAAGATTGCCTCGGCTGAAAAACGGGAACTGCTGCCGCAAGCTGCAGAGTAA

Upstream 100 bases:

>100_bases
CTCATCGATCCAGTGAGAATCCTTATGTAATCGCCAATTCAGCCGATCTATCGTGCTAAAATTGGGTTTACCAGCAAGCA
GCAGGTTGTGGGAAAACGCC

Downstream 100 bases:

>100_bases
TCGATTTCGCCTGCTAATGCTGGAAAAGGGAAATCCGAAAGGGTTTCCCTTTCTTGTAGTCGATAATGGTTAAAGAAATC
TATGACTGCAGAAACAACGG

Product: ATP-dependent protease, ATP-binding subunit ClpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 822; Mature: 822

Protein sequence:

>822_residues
MFERFTEKAIKVIMLAQEEARRLGHNFVGTEQILLGLIGEGTGVAAKVLKSMGVNLKDARVEVEKIIGRGSGFVAVEIPF
TPRAKRVLELSLEEARQLGHNYIGTEHLLLGLIREGEGVAARVLENLGVDLAKVRTQVIRMLGETAEVSAGGGQGRTKTP
TLDEFGANLTNLASEGKLDPVVGRQKEIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLAQRIANGDIPDILEEKRVVT
LDIGLLVAGTKYRGEFEERLKKIMDEIRQASNVILVIDEVHTLIGAGAAEGAIDAANILKPALARGELQCIGATTLDEYR
KHIERDAALERRFQPVMVGEPSVEETIEILYGLRERYEQHHKLSILDESLEAAAKLSDRYISDRYLPDKAIDLIDEAGSR
VRLINSQLPPAAKELDKELRKVLKDKDDAVRSQDFDKAGELRDREMEIKSEIKAIAQNKKSSEENKDDSPKVTEEDIAHI
VASWTGVPVSKLTESESEKLLHMEDTLHQRLIGQDEAVRAISRAIRRARVGLKNPNRPIASFIFSGPTGVGKTELTKALA
TYFFGSEEAMIRLDMSEYMERHTVSKLIGSPPGYVGYNEGGQLTEAVRRRPYTVVLFDEIEKAHPDVFNMLLQILEDGRL
TDAKGRTVDFKNTLLIMTSNIGSKVIEKGGGGLGFEFAEDEADSQYNRIRSLVNEELKGYFRPEFLNRLDEIIVFRQLTK
DEVKEISELLLKEVFSRLEEKSITLNITDRFKERLVEEGYNPSYGARPLRRAIMRLLEDTLAEEILSGRVKEGDTAIVDV
DEDQQVKIASAEKRELLPQAAE

Sequences:

>Translated_822_residues
MFERFTEKAIKVIMLAQEEARRLGHNFVGTEQILLGLIGEGTGVAAKVLKSMGVNLKDARVEVEKIIGRGSGFVAVEIPF
TPRAKRVLELSLEEARQLGHNYIGTEHLLLGLIREGEGVAARVLENLGVDLAKVRTQVIRMLGETAEVSAGGGQGRTKTP
TLDEFGANLTNLASEGKLDPVVGRQKEIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLAQRIANGDIPDILEEKRVVT
LDIGLLVAGTKYRGEFEERLKKIMDEIRQASNVILVIDEVHTLIGAGAAEGAIDAANILKPALARGELQCIGATTLDEYR
KHIERDAALERRFQPVMVGEPSVEETIEILYGLRERYEQHHKLSILDESLEAAAKLSDRYISDRYLPDKAIDLIDEAGSR
VRLINSQLPPAAKELDKELRKVLKDKDDAVRSQDFDKAGELRDREMEIKSEIKAIAQNKKSSEENKDDSPKVTEEDIAHI
VASWTGVPVSKLTESESEKLLHMEDTLHQRLIGQDEAVRAISRAIRRARVGLKNPNRPIASFIFSGPTGVGKTELTKALA
TYFFGSEEAMIRLDMSEYMERHTVSKLIGSPPGYVGYNEGGQLTEAVRRRPYTVVLFDEIEKAHPDVFNMLLQILEDGRL
TDAKGRTVDFKNTLLIMTSNIGSKVIEKGGGGLGFEFAEDEADSQYNRIRSLVNEELKGYFRPEFLNRLDEIIVFRQLTK
DEVKEISELLLKEVFSRLEEKSITLNITDRFKERLVEEGYNPSYGARPLRRAIMRLLEDTLAEEILSGRVKEGDTAIVDV
DEDQQVKIASAEKRELLPQAAE
>Mature_822_residues
MFERFTEKAIKVIMLAQEEARRLGHNFVGTEQILLGLIGEGTGVAAKVLKSMGVNLKDARVEVEKIIGRGSGFVAVEIPF
TPRAKRVLELSLEEARQLGHNYIGTEHLLLGLIREGEGVAARVLENLGVDLAKVRTQVIRMLGETAEVSAGGGQGRTKTP
TLDEFGANLTNLASEGKLDPVVGRQKEIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLAQRIANGDIPDILEEKRVVT
LDIGLLVAGTKYRGEFEERLKKIMDEIRQASNVILVIDEVHTLIGAGAAEGAIDAANILKPALARGELQCIGATTLDEYR
KHIERDAALERRFQPVMVGEPSVEETIEILYGLRERYEQHHKLSILDESLEAAAKLSDRYISDRYLPDKAIDLIDEAGSR
VRLINSQLPPAAKELDKELRKVLKDKDDAVRSQDFDKAGELRDREMEIKSEIKAIAQNKKSSEENKDDSPKVTEEDIAHI
VASWTGVPVSKLTESESEKLLHMEDTLHQRLIGQDEAVRAISRAIRRARVGLKNPNRPIASFIFSGPTGVGKTELTKALA
TYFFGSEEAMIRLDMSEYMERHTVSKLIGSPPGYVGYNEGGQLTEAVRRRPYTVVLFDEIEKAHPDVFNMLLQILEDGRL
TDAKGRTVDFKNTLLIMTSNIGSKVIEKGGGGLGFEFAEDEADSQYNRIRSLVNEELKGYFRPEFLNRLDEIIVFRQLTK
DEVKEISELLLKEVFSRLEEKSITLNITDRFKERLVEEGYNPSYGARPLRRAIMRLLEDTLAEEILSGRVKEGDTAIVDV
DEDQQVKIASAEKRELLPQAAE

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:
GO:0000166: ATP-dependent protease, ATP-binding subunit ClpC
GO:0003677: ATP-dependent protease, ATP-binding subunit ClpC
GO:0004518: ATP-dependent protease, ATP-binding subunit ClpC
GO:0005524: ATP-dependent protease, ATP-binding subunit ClpC
GO:0006289: ATP-dependent protease, ATP-binding subunit ClpC
GO:0008233: ATP-dependent protease, ATP-binding subunit ClpC
GO:0017111: ATP-dependent protease, ATP-binding subunit ClpC
GO:0019538: ATP-dependent protease, ATP-binding subunit ClpC

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=341, Percent_Identity=37.5366568914956, Blast_Score=205, Evalue=1e-52,
Organism=Escherichia coli, GI1788943, Length=874, Percent_Identity=47.254004576659, Blast_Score=747, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=807, Percent_Identity=37.9182156133829, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6320464, Length=710, Percent_Identity=47.7464788732394, Blast_Score=624, Evalue=1e-179,
Organism=Saccharomyces cerevisiae, GI6323002, Length=901, Percent_Identity=36.2930077691454, Blast_Score=536, Evalue=1e-153,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 91535; Mature: 91535

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFERFTEKAIKVIMLAQEEARRLGHNFVGTEQILLGLIGEGTGVAAKVLKSMGVNLKDAR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHH
VEVEKIIGRGSGFVAVEIPFTPRAKRVLELSLEEARQLGHNYIGTEHLLLGLIREGEGVA
HHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHH
ARVLENLGVDLAKVRTQVIRMLGETAEVSAGGGQGRTKTPTLDEFGANLTNLASEGKLDP
HHHHHHHCCHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCC
VVGRQKEIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLAQRIANGDIPDILEEKRVVT
CCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHCCCEEE
LDIGLLVAGTKYRGEFEERLKKIMDEIRQASNVILVIDEVHTLIGAGAAEGAIDAANILK
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHCCCCCCCCHHHHHHH
PALARGELQCIGATTLDEYRKHIERDAALERRFQPVMVGEPSVEETIEILYGLRERYEQH
HHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HKLSILDESLEAAAKLSDRYISDRYLPDKAIDLIDEAGSRVRLINSQLPPAAKELDKELR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
KVLKDKDDAVRSQDFDKAGELRDREMEIKSEIKAIAQNKKSSEENKDDSPKVTEEDIAHI
HHHHCCHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
VASWTGVPVSKLTESESEKLLHMEDTLHQRLIGQDEAVRAISRAIRRARVGLKNPNRPIA
HHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
SFIFSGPTGVGKTELTKALATYFFGSEEAMIRLDMSEYMERHTVSKLIGSPPGYVGYNEG
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCC
GQLTEAVRRRPYTVVLFDEIEKAHPDVFNMLLQILEDGRLTDAKGRTVDFKNTLLIMTSN
CHHHHHHHHCCCEEEEEHHHHHHCHHHHHHHHHHHHCCCEECCCCCEEECCCEEEEEECC
IGSKVIEKGGGGLGFEFAEDEADSQYNRIRSLVNEELKGYFRPEFLNRLDEIIVFRQLTK
CCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DEVKEISELLLKEVFSRLEEKSITLNITDRFKERLVEEGYNPSYGARPLRRAIMRLLEDT
HHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LAEEILSGRVKEGDTAIVDVDEDQQVKIASAEKRELLPQAAE
HHHHHHCCCCCCCCEEEEECCCCCCEEECCHHHHHCCCCCCC
>Mature Secondary Structure
MFERFTEKAIKVIMLAQEEARRLGHNFVGTEQILLGLIGEGTGVAAKVLKSMGVNLKDAR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHH
VEVEKIIGRGSGFVAVEIPFTPRAKRVLELSLEEARQLGHNYIGTEHLLLGLIREGEGVA
HHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHH
ARVLENLGVDLAKVRTQVIRMLGETAEVSAGGGQGRTKTPTLDEFGANLTNLASEGKLDP
HHHHHHHCCHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCC
VVGRQKEIERVIQILGRRTKNNPVLIGEPGVGKTAIAEGLAQRIANGDIPDILEEKRVVT
CCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHCCCEEE
LDIGLLVAGTKYRGEFEERLKKIMDEIRQASNVILVIDEVHTLIGAGAAEGAIDAANILK
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHCCCCCCCCHHHHHHH
PALARGELQCIGATTLDEYRKHIERDAALERRFQPVMVGEPSVEETIEILYGLRERYEQH
HHHHCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HKLSILDESLEAAAKLSDRYISDRYLPDKAIDLIDEAGSRVRLINSQLPPAAKELDKELR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
KVLKDKDDAVRSQDFDKAGELRDREMEIKSEIKAIAQNKKSSEENKDDSPKVTEEDIAHI
HHHHCCHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
VASWTGVPVSKLTESESEKLLHMEDTLHQRLIGQDEAVRAISRAIRRARVGLKNPNRPIA
HHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
SFIFSGPTGVGKTELTKALATYFFGSEEAMIRLDMSEYMERHTVSKLIGSPPGYVGYNEG
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCC
GQLTEAVRRRPYTVVLFDEIEKAHPDVFNMLLQILEDGRLTDAKGRTVDFKNTLLIMTSN
CHHHHHHHHCCCEEEEEHHHHHHCHHHHHHHHHHHHCCCEECCCCCEEECCCEEEEEECC
IGSKVIEKGGGGLGFEFAEDEADSQYNRIRSLVNEELKGYFRPEFLNRLDEIIVFRQLTK
CCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DEVKEISELLLKEVFSRLEEKSITLNITDRFKERLVEEGYNPSYGARPLRRAIMRLLEDT
HHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LAEEILSGRVKEGDTAIVDVDEDQQVKIASAEKRELLPQAAE
HHHHHHCCCCCCCCEEEEECCCCCCEEECCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]