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The map label for this gene is ion [H]

Identifier: 158334955

GI number: 158334955

Start: 1782607

End: 1783257

Strand: Reverse

Name: ion [H]

Synonym: AM1_1792

Alternate gene names: 158334955

Gene position: 1783257-1782607 (Counterclockwise)

Preceding gene: 158334956

Following gene: 158334952

Centisome position: 27.42

GC content: 45.78

Gene sequence:

>651_bases
ATGGCTATTCCCTCTTCAATTGCTGTACGTGAGCTACCGCTATTCCCGCTACCTGATGTAGTCTTGTTTCCAGGGCGACC
ACTTCCGTTGCATATTTTTGAATATCGCTATCGGATAATGATGAACACTATCTTGGAAGAAGATCGGCAATTTGGTGTTT
TGATGTGGGATCCGAACAAGGGTGAGGCGGCTGTTGTAGGTTGTTGTGCTGAAATCACAAAACATGAAAGGCTGCCTGAT
GATCGAATCATGATTTTAACACTGGGGCGGCAGCGGTTTAAGGTACTCCACTACGTTCGTGAAAAACCTTACCGTGTTGG
GCTAGTAGAGTGGATTGAAGACCAACCTTTGCCTGTGGATCATGACCTACAAGCGTTGACTACAGACGTTACTCAGTTGT
TGCAAGATGTTGTTCGACTCTCTGCAAAGCTAACGGAGCAAGACATTAACCTTCCAGATGATATTCCTAGCCTACCTGTG
GATCTTTCCTACTGGGTTGCGAGTAATTTCTATGGTGCAGCTTTAGAGCAACAATCTTTATTGGAAATGCAGGATACACA
AGCTCGGCTAGAACGCGAAGCTGAGATTTTGACGTCTACCCGCAACCATCTGGCCGCGCGTACAGTTTTAAAAGATACAC
TAGAGCCCTAA

Upstream 100 bases:

>100_bases
CTACAGTTGATAGGCGCTTGTCTGAGTTGTTTGTGAATTCTTCGGGAGACATGGGCTAGAGTGAATAAGAGTACTCCCTA
TCCCACCTCTTCCGTTGCCA

Downstream 100 bases:

>100_bases
AAACATCTGGCTTGACACCATTTAATTGCCCAAAAGCACAAATGCGCCCGAACTATAGATAAATCGGGCGCATTTGTGCT
TTTTATAAGGTTTTAGCTAC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MAIPSSIAVRELPLFPLPDVVLFPGRPLPLHIFEYRYRIMMNTILEEDRQFGVLMWDPNKGEAAVVGCCAEITKHERLPD
DRIMILTLGRQRFKVLHYVREKPYRVGLVEWIEDQPLPVDHDLQALTTDVTQLLQDVVRLSAKLTEQDINLPDDIPSLPV
DLSYWVASNFYGAALEQQSLLEMQDTQARLEREAEILTSTRNHLAARTVLKDTLEP

Sequences:

>Translated_216_residues
MAIPSSIAVRELPLFPLPDVVLFPGRPLPLHIFEYRYRIMMNTILEEDRQFGVLMWDPNKGEAAVVGCCAEITKHERLPD
DRIMILTLGRQRFKVLHYVREKPYRVGLVEWIEDQPLPVDHDLQALTTDVTQLLQDVVRLSAKLTEQDINLPDDIPSLPV
DLSYWVASNFYGAALEQQSLLEMQDTQARLEREAEILTSTRNHLAARTVLKDTLEP
>Mature_215_residues
AIPSSIAVRELPLFPLPDVVLFPGRPLPLHIFEYRYRIMMNTILEEDRQFGVLMWDPNKGEAAVVGCCAEITKHERLPDD
RIMILTLGRQRFKVLHYVREKPYRVGLVEWIEDQPLPVDHDLQALTTDVTQLLQDVVRLSAKLTEQDINLPDDIPSLPVD
LSYWVASNFYGAALEQQSLLEMQDTQARLEREAEILTSTRNHLAARTVLKDTLEP

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG2802

COG function: function code R; Uncharacterized protein, similar to the N-terminal domain of Lon protease

Gene ontology:
GO:0004176: ATP-dependent protease La (LON) domain protein
GO:0006508: ATP-dependent protease La (LON) domain protein
GO:0008233: ATP-dependent protease La (LON) domain protein

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI73747840, Length=107, Percent_Identity=38.3177570093458, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI37622896, Length=107, Percent_Identity=38.3177570093458, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI148528975, Length=223, Percent_Identity=27.8026905829596, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 24812; Mature: 24681

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPSSIAVRELPLFPLPDVVLFPGRPLPLHIFEYRYRIMMNTILEEDRQFGVLMWDPNK
CCCCCCCHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
GEAAVVGCCAEITKHERLPDDRIMILTLGRQRFKVLHYVREKPYRVGLVEWIEDQPLPVD
CCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCEECHHHHHCCCCCCCC
HDLQALTTDVTQLLQDVVRLSAKLTEQDINLPDDIPSLPVDLSYWVASNFYGAALEQQSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHH
LEMQDTQARLEREAEILTSTRNHLAARTVLKDTLEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIPSSIAVRELPLFPLPDVVLFPGRPLPLHIFEYRYRIMMNTILEEDRQFGVLMWDPNK
CCCCCCHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
GEAAVVGCCAEITKHERLPDDRIMILTLGRQRFKVLHYVREKPYRVGLVEWIEDQPLPVD
CCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCEECHHHHHCCCCCCCC
HDLQALTTDVTQLLQDVVRLSAKLTEQDINLPDDIPSLPVDLSYWVASNFYGAALEQQSL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHH
LEMQDTQARLEREAEILTSTRNHLAARTVLKDTLEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA