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The map label for this gene is qor [C]

Identifier: 158334783

GI number: 158334783

Start: 1588732

End: 1589742

Strand: Direct

Name: qor [C]

Synonym: AM1_1618

Alternate gene names: 158334783

Gene position: 1588732-1589742 (Clockwise)

Preceding gene: 158334781

Following gene: 158334784

Centisome position: 24.43

GC content: 52.42

Gene sequence:

>1011_bases
ATGAAAGCCATTGGGTACAAGGATGCGGGGTCAGCAGCAGATGCCCTGATCGAATTTGAAACAGCAACGCCCCAACCAGG
TCCAAAAGACTTACTCGTGGAGGTCCGGGGTGTTTCAGTAAATCCAGTGGATGTCAAACTGAGGGCCAGTGCTCAACCCG
ATGGTGAACCTCGCATTTTGGGGTTTGATGCTGCTGGGGTCGTACAGGAAGTAGGTTCAGCCGTGACTCGGTTTCGTCCT
GGTGACGAAGTGTTCTATGCCGGCGACATTACTCGCCCCGGAACCAATGCTCCGTTTCAGGTCGTCGATGAACGAATTGT
GGGTCGCAAACCCTCCTCCCTGGGGTTTACAGAAGCTGCTGGCATCCCCCTGACCAGTATTACAGCCTGGGAAATGCTAT
TTGATAGCTTTGGGCTTAAAGAAGGGGAAGGCAGCGGGGAAGCGCTCCTCGTAATCGGCGGTGCAGGGGGAGTGGGTTCG
ATTCTGATTCAGCTTGCCAAGAAACTCACAGGGCTGACTGTAGTTGCCACGGCATCTCGCGAGGATACCCATGCTTGGGT
CAAGAAAATGGGAGCCGATTATGTGGTTAATCACCGTAACCCCCTAGACGAAGAACTGAAGTTCTTGGGCATTACCCCCC
GATATGTAGCAGCCCTAACCCACACGGACAAGCATTTTGCTGCCATCCGAGAGTTGATTAAGCCCCGGGGACATATGGCG
CTGATTGATGATCCAGGCGCTCTGGATGTGGCTTCCCTGAAAACCAAGGCGATTTCTTTGAGCTGGGAATTTATGTTTAC
CCGATCGATGTTTCAAACCGAGGATATTGACGTCCAGCATCAGTTGCTGAATCGAGTTTCAGAGCTACTCGACAATGGCA
CGCTGATCTCGACGGTCAATCATCATGGTGGCAGTCTCAATATTGAAAATCTGCGTGCTGCTCATGAATTCCAAGAAAGC
GGCAAGGCCATTGGCAAGACCGTGTTGGATGGGCTTGCGGCAGCTGGTTAA

Upstream 100 bases:

>100_bases
AAATATCCGAATTATTATTTCGCTAAAAGCCTGTTTATCTTTCTAATTTAAATAATTATCATGCGGATAACGGTCTAATG
ATTCGATAGGAGGCGAAATA

Downstream 100 bases:

>100_bases
ACCTTATTCCGTTTGCTAAGGAGGGATATCTAGTCCACTGGGGTTGATCGTGACCTCCTGTCAGCCTTGATTTCGTATAG
GGATTGTATTGTTTCACACG

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKAIGYKDAGSAADALIEFETATPQPGPKDLLVEVRGVSVNPVDVKLRASAQPDGEPRILGFDAAGVVQEVGSAVTRFRP
GDEVFYAGDITRPGTNAPFQVVDERIVGRKPSSLGFTEAAGIPLTSITAWEMLFDSFGLKEGEGSGEALLVIGGAGGVGS
ILIQLAKKLTGLTVVATASREDTHAWVKKMGADYVVNHRNPLDEELKFLGITPRYVAALTHTDKHFAAIRELIKPRGHMA
LIDDPGALDVASLKTKAISLSWEFMFTRSMFQTEDIDVQHQLLNRVSELLDNGTLISTVNHHGGSLNIENLRAAHEFQES
GKAIGKTVLDGLAAAG

Sequences:

>Translated_336_residues
MKAIGYKDAGSAADALIEFETATPQPGPKDLLVEVRGVSVNPVDVKLRASAQPDGEPRILGFDAAGVVQEVGSAVTRFRP
GDEVFYAGDITRPGTNAPFQVVDERIVGRKPSSLGFTEAAGIPLTSITAWEMLFDSFGLKEGEGSGEALLVIGGAGGVGS
ILIQLAKKLTGLTVVATASREDTHAWVKKMGADYVVNHRNPLDEELKFLGITPRYVAALTHTDKHFAAIRELIKPRGHMA
LIDDPGALDVASLKTKAISLSWEFMFTRSMFQTEDIDVQHQLLNRVSELLDNGTLISTVNHHGGSLNIENLRAAHEFQES
GKAIGKTVLDGLAAAG
>Mature_336_residues
MKAIGYKDAGSAADALIEFETATPQPGPKDLLVEVRGVSVNPVDVKLRASAQPDGEPRILGFDAAGVVQEVGSAVTRFRP
GDEVFYAGDITRPGTNAPFQVVDERIVGRKPSSLGFTEAAGIPLTSITAWEMLFDSFGLKEGEGSGEALLVIGGAGGVGS
ILIQLAKKLTGLTVVATASREDTHAWVKKMGADYVVNHRNPLDEELKFLGITPRYVAALTHTDKHFAAIRELIKPRGHMA
LIDDPGALDVASLKTKAISLSWEFMFTRSMFQTEDIDVQHQLLNRVSELLDNGTLISTVNHHGGSLNIENLRAAHEFQES
GKAIGKTVLDGLAAAG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=199, Percent_Identity=35.1758793969849, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI194239674, Length=214, Percent_Identity=31.3084112149533, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI13236495, Length=214, Percent_Identity=31.3084112149533, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI194239676, Length=224, Percent_Identity=31.25, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI24308257, Length=269, Percent_Identity=26.7657992565056, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI28557745, Length=195, Percent_Identity=32.8205128205128, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1790485, Length=204, Percent_Identity=29.9019607843137, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71987554, Length=169, Percent_Identity=34.3195266272189, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17507255, Length=193, Percent_Identity=32.6424870466321, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319520, Length=200, Percent_Identity=29.5, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35849; Mature: 35849

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIGYKDAGSAADALIEFETATPQPGPKDLLVEVRGVSVNPVDVKLRASAQPDGEPRIL
CCCCCCCCCCCHHHHEEEEECCCCCCCCCEEEEEEECCEECCEEEEEEECCCCCCCCCEE
GFDAAGVVQEVGSAVTRFRPGDEVFYAGDITRPGTNAPFQVVDERIVGRKPSSLGFTEAA
EECHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCC
GIPLTSITAWEMLFDSFGLKEGEGSGEALLVIGGAGGVGSILIQLAKKLTGLTVVATASR
CCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCC
EDTHAWVKKMGADYVVNHRNPLDEELKFLGITPRYVAALTHTDKHFAAIRELIKPRGHMA
CHHHHHHHHCCCCEEECCCCCHHHHHHEECCCHHHHHHHHCCHHHHHHHHHHHCCCCCEE
LIDDPGALDVASLKTKAISLSWEFMFTRSMFQTEDIDVQHQLLNRVSELLDNGTLISTVN
EECCCCCCCHHHHHEEEEEEEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEC
HHGGSLNIENLRAAHEFQESGKAIGKTVLDGLAAAG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAIGYKDAGSAADALIEFETATPQPGPKDLLVEVRGVSVNPVDVKLRASAQPDGEPRIL
CCCCCCCCCCCHHHHEEEEECCCCCCCCCEEEEEEECCEECCEEEEEEECCCCCCCCCEE
GFDAAGVVQEVGSAVTRFRPGDEVFYAGDITRPGTNAPFQVVDERIVGRKPSSLGFTEAA
EECHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCC
GIPLTSITAWEMLFDSFGLKEGEGSGEALLVIGGAGGVGSILIQLAKKLTGLTVVATASR
CCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCC
EDTHAWVKKMGADYVVNHRNPLDEELKFLGITPRYVAALTHTDKHFAAIRELIKPRGHMA
CHHHHHHHHCCCCEEECCCCCHHHHHHEECCCHHHHHHHHCCHHHHHHHHHHHCCCCCEE
LIDDPGALDVASLKTKAISLSWEFMFTRSMFQTEDIDVQHQLLNRVSELLDNGTLISTVN
EECCCCCCCHHHHHEEEEEEEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEC
HHGGSLNIENLRAAHEFQESGKAIGKTVLDGLAAAG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA