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The map label for this gene is fba [H]

Identifier: 158334673

GI number: 158334673

Start: 1494032

End: 1495111

Strand: Direct

Name: fba [H]

Synonym: AM1_1506

Alternate gene names: 158334673

Gene position: 1494032-1495111 (Clockwise)

Preceding gene: 158334671

Following gene: 158334678

Centisome position: 22.97

GC content: 49.07

Gene sequence:

>1080_bases
ATGGCGCTTGTACCAATGCGGCTTTTGCTCGATCATGCCGCCGAAAACGGCTACGGCATTCCGGCATACAACGTGAACAA
TATGGAGCAAATCATCTCCATTATGCAAGCTGCAGATGAGGCAGATAGCCCCGTCATTTTGCAAGCTTCTCGTGGTGCCC
GTAGCTATGCGGGTGAGCATTTTCTCCGCCACCTAATTACAGCTGCGGTTGAGTCCTACCCTCATATCCCCATCGCGATG
CACCAAGACCATGGCAATAGCCCTTCCACATGCTATTCCGCCATGAAGAATGGGTTTACCAGCGTCATGATGGATGGTTC
CTTGGAAGCAGATGCTAAGACCCCTGCAAGCTTTGAGTACAACGTTGATGTGACTCGTAAAGTTGTACAAGTCGCTCATG
CCATTGGCGTCAGCGTTGAAGGTGAGCTAGGTTGCTTAGGTTCCTTGGAAACGGGTCAAGGTGACAAGGAAGATGGTCAT
GGTTTTGAAGGGACCCTCAGCCGCGACCAGCTCCTGACTGACCCTGACGAAGCTGTTGAGTTTGTTGAGCAGACTCAAGT
GGATGCCCTAGCCGTTGCCATTGGCACTAGCCACGGTGCTTATAAGTTTTCTCGTAAGCCCACTGGTGAGATTCTAGCCA
TTAGCCGCATTGAAGAGATTCATAGCCGCTTACCCAACACTCACTTGGTCATGCACGGGTCCTCTTCTGTACCCCAAGAG
TGGATCGACATGATCAACGCTCATGGCGGCAAAATTCCTGAAACCTATGGTGTTCCTGTAGAGGAAATCCAAAAGGGAAT
CAAGAGCGGTGTTCGCAAGGTCAATATTGATACTGACAATCGTTTAGCGATTACAGCCGCTATTCGGGAAGCAGCATCTA
AAGATCCTAGCAACTTTGACCCCCGTCATTTCTTGAAGCCTTCTATCAAGTACATGAAGCAAGTTTGCCTAGCTCGTTAT
GAGTCTTTTGGCACTTCTGGAAATGCCAGCAAGATTAAGCAACAGCCCCTAGACATTTTTGCCATTAAATATGCCAAGGG
TGAGTTGGATGCAACGACTAAGAAAACCGTAACTGCCTAA

Upstream 100 bases:

>100_bases
CGGAGAACCCGCTAGACAGGGTAGGATATCTAAAGATTAGCGTAAGAATTCGGCGCAGTTTTCGCTTTTTATCGACGACA
AACATTTAGGAGGATCAACT

Downstream 100 bases:

>100_bases
ATCAGTAGTGCAAATTTAGGTGGTGCGATCACACCACCTAAATTTGTCGTTAACGGCATTCCCACTCTCAGCATTGCTAG
TCTGCTTAAGGGGAAATGTT

Product: fructose-bisphosphate aldolase, class II

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MALVPMRLLLDHAAENGYGIPAYNVNNMEQIISIMQAADEADSPVILQASRGARSYAGEHFLRHLITAAVESYPHIPIAM
HQDHGNSPSTCYSAMKNGFTSVMMDGSLEADAKTPASFEYNVDVTRKVVQVAHAIGVSVEGELGCLGSLETGQGDKEDGH
GFEGTLSRDQLLTDPDEAVEFVEQTQVDALAVAIGTSHGAYKFSRKPTGEILAISRIEEIHSRLPNTHLVMHGSSSVPQE
WIDMINAHGGKIPETYGVPVEEIQKGIKSGVRKVNIDTDNRLAITAAIREAASKDPSNFDPRHFLKPSIKYMKQVCLARY
ESFGTSGNASKIKQQPLDIFAIKYAKGELDATTKKTVTA

Sequences:

>Translated_359_residues
MALVPMRLLLDHAAENGYGIPAYNVNNMEQIISIMQAADEADSPVILQASRGARSYAGEHFLRHLITAAVESYPHIPIAM
HQDHGNSPSTCYSAMKNGFTSVMMDGSLEADAKTPASFEYNVDVTRKVVQVAHAIGVSVEGELGCLGSLETGQGDKEDGH
GFEGTLSRDQLLTDPDEAVEFVEQTQVDALAVAIGTSHGAYKFSRKPTGEILAISRIEEIHSRLPNTHLVMHGSSSVPQE
WIDMINAHGGKIPETYGVPVEEIQKGIKSGVRKVNIDTDNRLAITAAIREAASKDPSNFDPRHFLKPSIKYMKQVCLARY
ESFGTSGNASKIKQQPLDIFAIKYAKGELDATTKKTVTA
>Mature_358_residues
ALVPMRLLLDHAAENGYGIPAYNVNNMEQIISIMQAADEADSPVILQASRGARSYAGEHFLRHLITAAVESYPHIPIAMH
QDHGNSPSTCYSAMKNGFTSVMMDGSLEADAKTPASFEYNVDVTRKVVQVAHAIGVSVEGELGCLGSLETGQGDKEDGHG
FEGTLSRDQLLTDPDEAVEFVEQTQVDALAVAIGTSHGAYKFSRKPTGEILAISRIEEIHSRLPNTHLVMHGSSSVPQEW
IDMINAHGGKIPETYGVPVEEIQKGIKSGVRKVNIDTDNRLAITAAIREAASKDPSNFDPRHFLKPSIKYMKQVCLARYE
SFGTSGNASKIKQQPLDIFAIKYAKGELDATTKKTVTA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=333, Percent_Identity=32.1321321321321, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=31.6109422492401, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788072, Length=327, Percent_Identity=29.3577981651376, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789293, Length=303, Percent_Identity=25.0825082508251, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322790, Length=376, Percent_Identity=25, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38963; Mature: 38832

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVPMRLLLDHAAENGYGIPAYNVNNMEQIISIMQAADEADSPVILQASRGARSYAGEH
CCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
FLRHLITAAVESYPHIPIAMHQDHGNSPSTCYSAMKNGFTSVMMDGSLEADAKTPASFEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEE
NVDVTRKVVQVAHAIGVSVEGELGCLGSLETGQGDKEDGHGFEGTLSRDQLLTDPDEAVE
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
FVEQTQVDALAVAIGTSHGAYKFSRKPTGEILAISRIEEIHSRLPNTHLVMHGSSSVPQE
HHHHHHHHHEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCCHH
WIDMINAHGGKIPETYGVPVEEIQKGIKSGVRKVNIDTDNRLAITAAIREAASKDPSNFD
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCEEHHHHHHHHHCCCCCCCC
PRHFLKPSIKYMKQVCLARYESFGTSGNASKIKQQPLDIFAIKYAKGELDATTKKTVTA
CHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCHHCCCC
>Mature Secondary Structure 
ALVPMRLLLDHAAENGYGIPAYNVNNMEQIISIMQAADEADSPVILQASRGARSYAGEH
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
FLRHLITAAVESYPHIPIAMHQDHGNSPSTCYSAMKNGFTSVMMDGSLEADAKTPASFEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEE
NVDVTRKVVQVAHAIGVSVEGELGCLGSLETGQGDKEDGHGFEGTLSRDQLLTDPDEAVE
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
FVEQTQVDALAVAIGTSHGAYKFSRKPTGEILAISRIEEIHSRLPNTHLVMHGSSSVPQE
HHHHHHHHHEEEEEECCCCCEEECCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCCCHH
WIDMINAHGGKIPETYGVPVEEIQKGIKSGVRKVNIDTDNRLAITAAIREAASKDPSNFD
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCEEHHHHHHHHHCCCCCCCC
PRHFLKPSIKYMKQVCLARYESFGTSGNASKIKQQPLDIFAIKYAKGELDATTKKTVTA
CHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9298645 [H]