Click here to switch to the map view.

The map label for this gene is pdhA [H]

Identifier: 158334526

GI number: 158334526

Start: 1329804

End: 1330832

Strand: Direct

Name: pdhA [H]

Synonym: AM1_1352

Alternate gene names: 158334526

Gene position: 1329804-1330832 (Clockwise)

Preceding gene: 158334519

Following gene: 158334527

Centisome position: 20.45

GC content: 47.23

Gene sequence:

>1029_bases
ATGGTTCAAGAAAGAGTTCTACCCAAATTTCCCACCCCTACAATCAAGATTACTCATGATGAAGGGCTTATCCTATACGA
GGATATGGTTTTGGGACGGGCTTTTGAAGATAAATGTGCCGAGATGTATTACCGCGGCAAGATGTTCGGCTTTGTCCATC
TGTATAACGGTCAAGAGGCTGTTTCTACAGGCATTGCCAAGGCCATGCGTCCAGACGATTTTATTTGCAGCACCTATCGA
GATCACGTTCATGCCCTGAGTGCAGGCGTCCCAGCCCGGCAAGTTATGGCCGAACTATTCGGCAAAGAGACCGGTTGCAG
CAAAGGCCGAGGAGGATCAATGCATCTATTCTCCTCAGAACATAACTTGATTGGTGGCTTTGCCTTTGTCGCAGAAGGGA
TCCCTGTTGCCACTGGTGTTGCCTTTCAAAGCCGCTATCGTCGAGAAGCGATGGGCGATGCAGCTTCCGATCACGTCACA
GCCTGCTTCTTCGGTGATGGAGCTAGTAATAATGGCCAGTTCTTTGAGTGCCTAAACATGGCCTCTCTCTGGAAATTACC
CATCTTGTTTGTGGTGGAAAATAATAAATGGGCGATTGGCATGGCCCATGAACGCGCTAGCTCAGAGACCGAGATTTACA
AGAAAGCTAAAGTCTTTGGCATGGAAGGGGTTGAAGTCGATGGCATGGATGTATTGGCAGTTCGTGAAGTCGCCCAAACT
GCAATTGCTAGGGCTAGAGCCGGTGAGGGACCAACCTTAATCGAAGCATTGACCTACCGCTTTAGAGGTCACTCCCTAGC
TGATCCAGATGAACTCAGATCTGCAGCAGAGAAAGAAGAATGGTTAGCCCGAGACCCGATCACGAAATTTAAGTCTTACT
TAGTCGACCAAAAACTTGTTAAAGAGCAAGAGTTACTTGACATTGACAGAAAAATTCAAACCCTAATTGAAGAAGCTGTT
CAATTTGCGGAAGAGAGTCCTGATCCCAAACCAGAAGATCTCTACCGATATATCTTTGTGGATGACTGA

Upstream 100 bases:

>100_bases
GATTATTGAAATCTAAACATTCCCTAATACCAGACCCTGACAGGTGGCTCAATTAATTAAGCCTTGGCAACATCATCCCA
ACTGAGGACACTATACATCA

Downstream 100 bases:

>100_bases
TATTACGTCTTTACCTAGTGTGAAACAACCTAGTTATTCAAGCTTTTGAAGCATAAAGTATGATTGAAACTAGGTGTCTC
ATATCAAAAGCTATTGCAGT

Product: pyruvate dehydrogenase E1 component subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MVQERVLPKFPTPTIKITHDEGLILYEDMVLGRAFEDKCAEMYYRGKMFGFVHLYNGQEAVSTGIAKAMRPDDFICSTYR
DHVHALSAGVPARQVMAELFGKETGCSKGRGGSMHLFSSEHNLIGGFAFVAEGIPVATGVAFQSRYRREAMGDAASDHVT
ACFFGDGASNNGQFFECLNMASLWKLPILFVVENNKWAIGMAHERASSETEIYKKAKVFGMEGVEVDGMDVLAVREVAQT
AIARARAGEGPTLIEALTYRFRGHSLADPDELRSAAEKEEWLARDPITKFKSYLVDQKLVKEQELLDIDRKIQTLIEEAV
QFAEESPDPKPEDLYRYIFVDD

Sequences:

>Translated_342_residues
MVQERVLPKFPTPTIKITHDEGLILYEDMVLGRAFEDKCAEMYYRGKMFGFVHLYNGQEAVSTGIAKAMRPDDFICSTYR
DHVHALSAGVPARQVMAELFGKETGCSKGRGGSMHLFSSEHNLIGGFAFVAEGIPVATGVAFQSRYRREAMGDAASDHVT
ACFFGDGASNNGQFFECLNMASLWKLPILFVVENNKWAIGMAHERASSETEIYKKAKVFGMEGVEVDGMDVLAVREVAQT
AIARARAGEGPTLIEALTYRFRGHSLADPDELRSAAEKEEWLARDPITKFKSYLVDQKLVKEQELLDIDRKIQTLIEEAV
QFAEESPDPKPEDLYRYIFVDD
>Mature_342_residues
MVQERVLPKFPTPTIKITHDEGLILYEDMVLGRAFEDKCAEMYYRGKMFGFVHLYNGQEAVSTGIAKAMRPDDFICSTYR
DHVHALSAGVPARQVMAELFGKETGCSKGRGGSMHLFSSEHNLIGGFAFVAEGIPVATGVAFQSRYRREAMGDAASDHVT
ACFFGDGASNNGQFFECLNMASLWKLPILFVVENNKWAIGMAHERASSETEIYKKAKVFGMEGVEVDGMDVLAVREVAQT
AIARARAGEGPTLIEALTYRFRGHSLADPDELRSAAEKEEWLARDPITKFKSYLVDQKLVKEQELLDIDRKIQTLIEEAV
QFAEESPDPKPEDLYRYIFVDD

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:
GO:0004739: Pyruvate dehydrogenase E1 component, alpha subunit
GO:0006096: Pyruvate dehydrogenase E1 component, alpha subunit
GO:0008152: Pyruvate dehydrogenase E1 component, alpha subunit
GO:0016624: Pyruvate dehydrogenase E1 component, alpha subunit
GO:0043231: Pyruvate dehydrogenase E1 component, alpha subunit
GO:0055114: Pyruvate dehydrogenase E1 component, alpha subunit

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=339, Percent_Identity=37.4631268436578, Blast_Score=244, Evalue=6e-65,
Organism=Homo sapiens, GI4505685, Length=338, Percent_Identity=38.4615384615385, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI291084742, Length=334, Percent_Identity=38.622754491018, Blast_Score=228, Evalue=4e-60,
Organism=Homo sapiens, GI291084744, Length=341, Percent_Identity=37.8299120234604, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI291084757, Length=338, Percent_Identity=35.7988165680473, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI11386135, Length=331, Percent_Identity=28.0966767371601, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI258645172, Length=336, Percent_Identity=27.9761904761905, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17536047, Length=335, Percent_Identity=37.910447761194, Blast_Score=235, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI32564172, Length=335, Percent_Identity=37.910447761194, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI86563357, Length=285, Percent_Identity=28.0701754385965, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI86563355, Length=285, Percent_Identity=28.0701754385965, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6321026, Length=321, Percent_Identity=37.3831775700935, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24639744, Length=338, Percent_Identity=37.2781065088757, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI28571106, Length=338, Percent_Identity=37.2781065088757, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24639740, Length=338, Percent_Identity=37.2781065088757, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24639748, Length=343, Percent_Identity=36.734693877551, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24639746, Length=312, Percent_Identity=37.8205128205128, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21355903, Length=350, Percent_Identity=23.7142857142857, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38217; Mature: 38217

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQERVLPKFPTPTIKITHDEGLILYEDMVLGRAFEDKCAEMYYRGKMFGFVHLYNGQEA
CCCCCCCCCCCCCEEEEECCCCEEEEHHHHHCCHHHHHHHHHHHCCCEEEEEEEECCHHH
VSTGIAKAMRPDDFICSTYRDHVHALSAGVPARQVMAELFGKETGCSKGRGGSMHLFSSE
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCC
HNLIGGFAFVAEGIPVATGVAFQSRYRREAMGDAASDHVTACFFGDGASNNGQFFECLNM
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHH
ASLWKLPILFVVENNKWAIGMAHERASSETEIYKKAKVFGMEGVEVDGMDVLAVREVAQT
HHHHCCCEEEEEECCEEEEEEHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
AIARARAGEGPTLIEALTYRFRGHSLADPDELRSAAEKEEWLARDPITKFKSYLVDQKLV
HHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KEQELLDIDRKIQTLIEEAVQFAEESPDPKPEDLYRYIFVDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEECC
>Mature Secondary Structure
MVQERVLPKFPTPTIKITHDEGLILYEDMVLGRAFEDKCAEMYYRGKMFGFVHLYNGQEA
CCCCCCCCCCCCCEEEEECCCCEEEEHHHHHCCHHHHHHHHHHHCCCEEEEEEEECCHHH
VSTGIAKAMRPDDFICSTYRDHVHALSAGVPARQVMAELFGKETGCSKGRGGSMHLFSSE
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCC
HNLIGGFAFVAEGIPVATGVAFQSRYRREAMGDAASDHVTACFFGDGASNNGQFFECLNM
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHH
ASLWKLPILFVVENNKWAIGMAHERASSETEIYKKAKVFGMEGVEVDGMDVLAVREVAQT
HHHHCCCEEEEEECCEEEEEEHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
AIARARAGEGPTLIEALTYRFRGHSLADPDELRSAAEKEEWLARDPITKFKSYLVDQKLV
HHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KEQELLDIDRKIQTLIEEAVQFAEESPDPKPEDLYRYIFVDD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA