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The map label for this gene is hemN [C]

Identifier: 158334462

GI number: 158334462

Start: 1276315

End: 1277529

Strand: Reverse

Name: hemN [C]

Synonym: AM1_1283

Alternate gene names: 158334462

Gene position: 1277529-1276315 (Counterclockwise)

Preceding gene: 158334465

Following gene: 158334458

Centisome position: 19.64

GC content: 50.45

Gene sequence:

>1215_bases
GTGAAAATAGCTCAACCTGCGCGGATTGCCAGCGCTTGGCCTACTTCTGCTTATATTCATATTCCGTTTTGTCGACGGCG
TTGTTTTTATTGTGATTTTCCCATCTCGGTGATTGGAGATCACAAGCGAGGAGAGACCTCTTTGGCGATTGCCGATTATG
TCAATCTTTTATGCCAGGAAATTGAGATCACTGCCTCGGGACCGCGCCCTCTAAAAACCCTCTTTTTCGGTGGTGGAACC
CCTTCTCTGTTATCTGCTCAGCAATTAGAGCAGATTTTGCGGTGCTTAGAACAACAATTTGGCTTGGAGCCGGACATAGA
AGTTTCCATTGAAATGGATCCAGGAACGTTTTCCTGGCCGCTCATGCGGCAGTTTAAGGCCTTGGGTATAACCAGAGTCA
GTTTGGGGGTTCAAGCTTTTTCGGAGGAGTTGTTGCAAGCATGCGGGCGCTCCCATACAGTGGCGGATATCGGTGATGCG
ATCGCAATTCTCCACCAAGCCGGTATCACTAATTTTGGACTGGATTTGATTTCGGGCTTACCTAACCAAACTCTAGACCA
ATGGCAGGCCAGTTTAGAAGCAGCTTTAGCTTTGGAGCCCACTCATCTTTCCACCTATGACTTAGTGATTGAGCCCACGA
CCGTTTTTGGGAAAAAGTATCAGCCAGGAATCCAGCCCCTCCCCTCAGATGAAATCGCGGCACAGATGTATCGCCTCGCT
GTCGCTACCCTAACCGCTGCTGGCTATGACCATTACGAAATCTCTAACTATGCCCGTCCAGGGTATACCTGTCGGCATAA
TCAAGTTTATTGGCGCAACAACCCCTATTATGGCTTCGGCATGGGGGCGACCAGCTATGTGCATGGACAAAGGGTTAGCC
GTCCTCGGACCCGCAAAGCTTATGCCGATTGGGTAAAACGGCTGATTGCAGCCCAAGGGCAGATGAACGATGCAGTGAGT
TCTGACCTGGACATTTTGCTGGAAACCCTAATGATGGGCCTCAGATTGTCAACGGGGGTCTCCCTCTCCACATTGCAAGA
TCTGGCCAGCCCTCAGATAGTGAATACTTTGCTACAGTGTCTCGCTCCCTACCAGAAGCAGGGCTGGGTGCAGTTACCTC
ACCATCCAGAGGAGGCCATCCGTTTAACGGACCCGGACGGCTTCTTGTTCTCTAACACGATTCTGACGGCGATTTGGCAG
GCTTTAGATCCATAA

Upstream 100 bases:

>100_bases
GGCGTTTTTTTTCTTGACCAAAAAGATTCCTTTAAAATACGTAAATCTAGATCAACTTTGGTCGTAAATGGTCTGATTTT
ATCTTGAGGCAATCCAGTTT

Downstream 100 bases:

>100_bases
GCTGTTTCCCAGTCCTTGAGAGTAGAGGTATTGTTCAAGGGCTGGGGAAACATTGTCGTCTAGGTGGTTAGATCCAAACT
CGATTGGATGGTTAATTCCA

Product: coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKIAQPARIASAWPTSAYIHIPFCRRRCFYCDFPISVIGDHKRGETSLAIADYVNLLCQEIEITASGPRPLKTLFFGGGT
PSLLSAQQLEQILRCLEQQFGLEPDIEVSIEMDPGTFSWPLMRQFKALGITRVSLGVQAFSEELLQACGRSHTVADIGDA
IAILHQAGITNFGLDLISGLPNQTLDQWQASLEAALALEPTHLSTYDLVIEPTTVFGKKYQPGIQPLPSDEIAAQMYRLA
VATLTAAGYDHYEISNYARPGYTCRHNQVYWRNNPYYGFGMGATSYVHGQRVSRPRTRKAYADWVKRLIAAQGQMNDAVS
SDLDILLETLMMGLRLSTGVSLSTLQDLASPQIVNTLLQCLAPYQKQGWVQLPHHPEEAIRLTDPDGFLFSNTILTAIWQ
ALDP

Sequences:

>Translated_404_residues
MKIAQPARIASAWPTSAYIHIPFCRRRCFYCDFPISVIGDHKRGETSLAIADYVNLLCQEIEITASGPRPLKTLFFGGGT
PSLLSAQQLEQILRCLEQQFGLEPDIEVSIEMDPGTFSWPLMRQFKALGITRVSLGVQAFSEELLQACGRSHTVADIGDA
IAILHQAGITNFGLDLISGLPNQTLDQWQASLEAALALEPTHLSTYDLVIEPTTVFGKKYQPGIQPLPSDEIAAQMYRLA
VATLTAAGYDHYEISNYARPGYTCRHNQVYWRNNPYYGFGMGATSYVHGQRVSRPRTRKAYADWVKRLIAAQGQMNDAVS
SDLDILLETLMMGLRLSTGVSLSTLQDLASPQIVNTLLQCLAPYQKQGWVQLPHHPEEAIRLTDPDGFLFSNTILTAIWQ
ALDP
>Mature_404_residues
MKIAQPARIASAWPTSAYIHIPFCRRRCFYCDFPISVIGDHKRGETSLAIADYVNLLCQEIEITASGPRPLKTLFFGGGT
PSLLSAQQLEQILRCLEQQFGLEPDIEVSIEMDPGTFSWPLMRQFKALGITRVSLGVQAFSEELLQACGRSHTVADIGDA
IAILHQAGITNFGLDLISGLPNQTLDQWQASLEAALALEPTHLSTYDLVIEPTTVFGKKYQPGIQPLPSDEIAAQMYRLA
VATLTAAGYDHYEISNYARPGYTCRHNQVYWRNNPYYGFGMGATSYVHGQRVSRPRTRKAYADWVKRLIAAQGQMNDAVS
SDLDILLETLMMGLRLSTGVSLSTLQDLASPQIVNTLLQCLAPYQKQGWVQLPHHPEEAIRLTDPDGFLFSNTILTAIWQ
ALDP

Specific function: Unknown

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=268, Percent_Identity=34.3283582089552, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1789325, Length=304, Percent_Identity=37.5, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI87082341, Length=403, Percent_Identity=26.7990074441687, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 44819; Mature: 44819

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAQPARIASAWPTSAYIHIPFCRRRCFYCDFPISVIGDHKRGETSLAIADYVNLLCQE
CCCCCCCHHHCCCCCCEEEECCHHHCCEEEECCCHHHCCCCCCCCCHHHHHHHHHHHHHH
IEITASGPRPLKTLFFGGGTPSLLSAQQLEQILRCLEQQFGLEPDIEVSIEMDPGTFSWP
HEEECCCCCCCEEEEECCCCCHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCH
LMRQFKALGITRVSLGVQAFSEELLQACGRSHTVADIGDAIAILHQAGITNFGLDLISGL
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCC
PNQTLDQWQASLEAALALEPTHLSTYDLVIEPTTVFGKKYQPGIQPLPSDEIAAQMYRLA
CCHHHHHHHHHHHHHHEECCCCCCEEEEEEECHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VATLTAAGYDHYEISNYARPGYTCRHNQVYWRNNPYYGFGMGATSYVHGQRVSRPRTRKA
HHHHHHCCCCCEECCCCCCCCCEEECCEEEECCCCEEEECCCCCHHHCCHHCCCCHHHHH
YADWVKRLIAAQGQMNDAVSSDLDILLETLMMGLRLSTGVSLSTLQDLASPQIVNTLLQC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHH
LAPYQKQGWVQLPHHPEEAIRLTDPDGFLFSNTILTAIWQALDP
HCCHHHCCCEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIAQPARIASAWPTSAYIHIPFCRRRCFYCDFPISVIGDHKRGETSLAIADYVNLLCQE
CCCCCCCHHHCCCCCCEEEECCHHHCCEEEECCCHHHCCCCCCCCCHHHHHHHHHHHHHH
IEITASGPRPLKTLFFGGGTPSLLSAQQLEQILRCLEQQFGLEPDIEVSIEMDPGTFSWP
HEEECCCCCCCEEEEECCCCCHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCH
LMRQFKALGITRVSLGVQAFSEELLQACGRSHTVADIGDAIAILHQAGITNFGLDLISGL
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCC
PNQTLDQWQASLEAALALEPTHLSTYDLVIEPTTVFGKKYQPGIQPLPSDEIAAQMYRLA
CCHHHHHHHHHHHHHHEECCCCCCEEEEEEECHHHHCCCCCCCCCCCCCHHHHHHHHHHH
VATLTAAGYDHYEISNYARPGYTCRHNQVYWRNNPYYGFGMGATSYVHGQRVSRPRTRKA
HHHHHHCCCCCEECCCCCCCCCEEECCEEEECCCCEEEECCCCCHHHCCHHCCCCHHHHH
YADWVKRLIAAQGQMNDAVSSDLDILLETLMMGLRLSTGVSLSTLQDLASPQIVNTLLQC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHH
LAPYQKQGWVQLPHHPEEAIRLTDPDGFLFSNTILTAIWQALDP
HCCHHHCCCEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]