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The map label for this gene is menA [H]

Identifier: 158334291

GI number: 158334291

Start: 1088286

End: 1089176

Strand: Direct

Name: menA [H]

Synonym: AM1_1110

Alternate gene names: 158334291

Gene position: 1088286-1089176 (Clockwise)

Preceding gene: 158334282

Following gene: 158334292

Centisome position: 16.73

GC content: 50.06

Gene sequence:

>891_bases
ATGACCACCCAAACCCTGCCAACTCGTAAACTATGGTTCGCTGCCCTAAAGCCCCCTATGTATAGTGTGGCTGTGATACC
AATTTGGGTGGGATCTGCGATCGCATGGTCAGAACAACAGCACTTAAACGCCCCCATCTTCTGGACTTTCCTCAGCGCCG
CCATCCTGATTATTGCCTGGCTTAATCTCACCAATGATGTTTTTGATGCCGACACCGGGATTGACGTGAACAAGGCTCAT
TCCTTGGTTAACTTAACGGGCAATCAGTCCCTGATCTTTTGGCTAGCCAACGGTTTTCTGGGATTAGGCTGTCTAGGATT
AGTAGCGATCGCTTGGTGGCAGCAGGACGTCACGGTATTAGCCCTCATCCTCTTGAGTTGTTTTCTGGGCTACACCTACC
AAGGCCCACCGTTCCGCTTGGGATATCAAGGTCTAGGAGAACTGATTTGTTTTGTTACCTTTGGTCCCCTTGCCGTTTCC
GCAGCCTACTATAGTCAAACCCAAGCCTGGTCGATTCGCCCCTTACCTGCCGCTATCATTATCGGCCTCACCACCAGCTT
GATTCTATTCTGCTCCCATTTTCACCAAGTCGCGGATGATTTATCAGCAGGGAAACGGTCCCCCATTGCTCGTCTCGGCA
CCGCCCGGGGCGCTCGATTATTGCCTTGGATTTGCGGGGGGATTTTTGGGTTGATTTTGATCTTTATGGGGTTCAACCTA
TTTAGCAATGGAGTTGTGTTGAGCTGGGTCAGTCTCCCCCTCGCCATCCATCTCTGTCGACATGTGTGGCGATATCACGA
TCAGCCAGACCAAGTTAAAGACTGCAAATTTATCGCGGTAGGCCTACATTTTGTGAGTGGTTTGTTATTAGGAATTGGTT
TGCTGGCTTAA

Upstream 100 bases:

>100_bases
AAAGGGGCAACCCGTGTGGTTCACCGCCCCCTTGTTCACAAATGCTTAGAAAGAGCCAATCCTGTACCCTAAACTTAATG
AAGGCCATTGCAATTTTTCT

Downstream 100 bases:

>100_bases
TATAGTATCGTTCTACCCTTGAGGGGCTCTAACTCTCACTTGATGAGTCACCCTTAGTCATTCAGGCTGAGGAGAAGGGT
ACGGTTATGTCTCACCCTGC

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTTQTLPTRKLWFAALKPPMYSVAVIPIWVGSAIAWSEQQHLNAPIFWTFLSAAILIIAWLNLTNDVFDADTGIDVNKAH
SLVNLTGNQSLIFWLANGFLGLGCLGLVAIAWWQQDVTVLALILLSCFLGYTYQGPPFRLGYQGLGELICFVTFGPLAVS
AAYYSQTQAWSIRPLPAAIIIGLTTSLILFCSHFHQVADDLSAGKRSPIARLGTARGARLLPWICGGIFGLILIFMGFNL
FSNGVVLSWVSLPLAIHLCRHVWRYHDQPDQVKDCKFIAVGLHFVSGLLLGIGLLA

Sequences:

>Translated_296_residues
MTTQTLPTRKLWFAALKPPMYSVAVIPIWVGSAIAWSEQQHLNAPIFWTFLSAAILIIAWLNLTNDVFDADTGIDVNKAH
SLVNLTGNQSLIFWLANGFLGLGCLGLVAIAWWQQDVTVLALILLSCFLGYTYQGPPFRLGYQGLGELICFVTFGPLAVS
AAYYSQTQAWSIRPLPAAIIIGLTTSLILFCSHFHQVADDLSAGKRSPIARLGTARGARLLPWICGGIFGLILIFMGFNL
FSNGVVLSWVSLPLAIHLCRHVWRYHDQPDQVKDCKFIAVGLHFVSGLLLGIGLLA
>Mature_295_residues
TTQTLPTRKLWFAALKPPMYSVAVIPIWVGSAIAWSEQQHLNAPIFWTFLSAAILIIAWLNLTNDVFDADTGIDVNKAHS
LVNLTGNQSLIFWLANGFLGLGCLGLVAIAWWQQDVTVLALILLSCFLGYTYQGPPFRLGYQGLGELICFVTFGPLAVSA
AYYSQTQAWSIRPLPAAIIIGLTTSLILFCSHFHQVADDLSAGKRSPIARLGTARGARLLPWICGGIFGLILIFMGFNLF
SNGVVLSWVSLPLAIHLCRHVWRYHDQPDQVKDCKFIAVGLHFVSGLLLGIGLLA

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:
GO:0004659: 1,4-dihydroxy-2-naphthoate phytyltransferase
GO:0016021: 1,4-dihydroxy-2-naphthoate phytyltransferase
GO:0016740: 1,4-dihydroxy-2-naphthoate phytyltransferase

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=197, Percent_Identity=29.4416243654822, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790365, Length=281, Percent_Identity=28.8256227758007, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011937
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32440; Mature: 32308

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQTLPTRKLWFAALKPPMYSVAVIPIWVGSAIAWSEQQHLNAPIFWTFLSAAILIIAW
CCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCHHCCCCHHHCCCCHHHHHHHHHHHHHHH
LNLTNDVFDADTGIDVNKAHSLVNLTGNQSLIFWLANGFLGLGCLGLVAIAWWQQDVTVL
HHHCCHHHCCCCCCCHHHHHHEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
ALILLSCFLGYTYQGPPFRLGYQGLGELICFVTFGPLAVSAAYYSQTQAWSIRPLPAAII
HHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IGLTTSLILFCSHFHQVADDLSAGKRSPIARLGTARGARLLPWICGGIFGLILIFMGFNL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
FSNGVVLSWVSLPLAIHLCRHVWRYHDQPDQVKDCKFIAVGLHFVSGLLLGIGLLA
HCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTQTLPTRKLWFAALKPPMYSVAVIPIWVGSAIAWSEQQHLNAPIFWTFLSAAILIIAW
CCCCCCHHHHHHHHCCCCCCEEEEEEEECCCHHCCCCHHHCCCCHHHHHHHHHHHHHHH
LNLTNDVFDADTGIDVNKAHSLVNLTGNQSLIFWLANGFLGLGCLGLVAIAWWQQDVTVL
HHHCCHHHCCCCCCCHHHHHHEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
ALILLSCFLGYTYQGPPFRLGYQGLGELICFVTFGPLAVSAAYYSQTQAWSIRPLPAAII
HHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IGLTTSLILFCSHFHQVADDLSAGKRSPIARLGTARGARLLPWICGGIFGLILIFMGFNL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
FSNGVVLSWVSLPLAIHLCRHVWRYHDQPDQVKDCKFIAVGLHFVSGLLLGIGLLA
HCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]