Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 158334259

GI number: 158334259

Start: 1046869

End: 1048032

Strand: Reverse

Name: fabF [H]

Synonym: AM1_1078

Alternate gene names: 158334259

Gene position: 1048032-1046869 (Counterclockwise)

Preceding gene: 158334260

Following gene: 158334258

Centisome position: 16.11

GC content: 48.45

Gene sequence:

>1164_bases
ATGATAGCCAAAGTTGTTGTTACTGGAATGGGGATAGTCTCAGCCCTAGCACCTAGTCTGGATAAGACTTGGCAGCGACT
ACTGTGTGGTGAGTCAGGGATTCAACATTACCATCCTTTTCCAGAGATCCCTGCCCAACCTTTAGCCTTGGTTGGTTCTC
AGCCTAGTCATCTTGAAGACTTATTAAAACCTGCTTTGTCTGAAGCGTTGGACGATGCAGGCCTAGCACCACCGATTACT
GATTGTGGTGTTGCTATCGGGTCTAGTCGCGGTTTTCAATTTCAATGGGAGAAGGGAGCATCTGCTTATCACACCTCCAT
TCCCTCTTATGGTGAAGAGAGGTTGCTTTTAGCTGACCCAGAGCAACTTGTCCACATTTATGGCGTGTCTCCTGCCTCAA
TCGTTGCCCAGTCTATTGCAGCTCAAGGCCCTATTCTTGCGCCCCGTGCTGCTTGTGCTACAGGGATTTGGGCAATTGCT
CAAGGAGCTGATCTGATAAGGGCAGGCTATTGTTCGCGAGTGATTGTCGGTGCTGTTGAAGCCCCCATCACACCATTGAC
CCTCGCTGGGTTTAATAAAATGGGTGCGATGGCTCAATCAGGTGCCTACCCTTTTGATCAAAACCGGGAAGGGTTTGTTT
TAGGGGAAGGGGCCGCTATTTTAGTTCTAGAAGAAGAGTCGGTCGCTCAGAAACGACAGGCCAAAATATATGGTCAAGTC
TTGGGGGTAGGATTAACGGTGGATGCCTATCATATGACTGCACCTGAAACCAGTAGGCGGGTTGCCATAACCGCTATTCA
AGATTGCCTGCAGCGCAGTGGTTTAAAGGCATCGGATGTTGGTTACATTCATGCCCATGGCACGGCCACTCATCTAAATG
ATCAAGCAGAAGCTGTGGTAATTAAAGCACTATTTCCACCTGCAGTCGCCGTTAGCTCTACAAAAGGAGCTACAGGACAT
ACATTAGGAGCATCAGCAGCCTTTGGATGCATCTTCAGTTTGATGGCTCTTTCTCATAAAGTACTTCCGCCTTGTGTCGG
CTTGCAAGAGCCAGCGTTTGACCTGAATTTTGTTCGTGAACCCCATAGGCATAATGTGCAGTCTGCCTTATGCCTAAGCT
CTGGTTTCGGTGGACAAAACACGGTCTTAGCCTTATCTTCATGA

Upstream 100 bases:

>100_bases
AGCTGCCAAAAATCTCTACGCTCAAAACGGATTTAGCTGCCAACCCTTATGATGGCAAGGTGGACAACAACTGTGGTTTG
AGAAAATTTTGTAATCCTGC

Downstream 100 bases:

>100_bases
GCATAAGTGTGGAAGGATACATTGCGTTTTGTGCGGCAACTCTTTCCGTAATGAGTGGGGATTGAGAATGATGGATCTCT
TTGGCAATGAATTGGGCACA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MIAKVVVTGMGIVSALAPSLDKTWQRLLCGESGIQHYHPFPEIPAQPLALVGSQPSHLEDLLKPALSEALDDAGLAPPIT
DCGVAIGSSRGFQFQWEKGASAYHTSIPSYGEERLLLADPEQLVHIYGVSPASIVAQSIAAQGPILAPRAACATGIWAIA
QGADLIRAGYCSRVIVGAVEAPITPLTLAGFNKMGAMAQSGAYPFDQNREGFVLGEGAAILVLEEESVAQKRQAKIYGQV
LGVGLTVDAYHMTAPETSRRVAITAIQDCLQRSGLKASDVGYIHAHGTATHLNDQAEAVVIKALFPPAVAVSSTKGATGH
TLGASAAFGCIFSLMALSHKVLPPCVGLQEPAFDLNFVREPHRHNVQSALCLSSGFGGQNTVLALSS

Sequences:

>Translated_387_residues
MIAKVVVTGMGIVSALAPSLDKTWQRLLCGESGIQHYHPFPEIPAQPLALVGSQPSHLEDLLKPALSEALDDAGLAPPIT
DCGVAIGSSRGFQFQWEKGASAYHTSIPSYGEERLLLADPEQLVHIYGVSPASIVAQSIAAQGPILAPRAACATGIWAIA
QGADLIRAGYCSRVIVGAVEAPITPLTLAGFNKMGAMAQSGAYPFDQNREGFVLGEGAAILVLEEESVAQKRQAKIYGQV
LGVGLTVDAYHMTAPETSRRVAITAIQDCLQRSGLKASDVGYIHAHGTATHLNDQAEAVVIKALFPPAVAVSSTKGATGH
TLGASAAFGCIFSLMALSHKVLPPCVGLQEPAFDLNFVREPHRHNVQSALCLSSGFGGQNTVLALSS
>Mature_387_residues
MIAKVVVTGMGIVSALAPSLDKTWQRLLCGESGIQHYHPFPEIPAQPLALVGSQPSHLEDLLKPALSEALDDAGLAPPIT
DCGVAIGSSRGFQFQWEKGASAYHTSIPSYGEERLLLADPEQLVHIYGVSPASIVAQSIAAQGPILAPRAACATGIWAIA
QGADLIRAGYCSRVIVGAVEAPITPLTLAGFNKMGAMAQSGAYPFDQNREGFVLGEGAAILVLEEESVAQKRQAKIYGQV
LGVGLTVDAYHMTAPETSRRVAITAIQDCLQRSGLKASDVGYIHAHGTATHLNDQAEAVVIKALFPPAVAVSSTKGATGH
TLGASAAFGCIFSLMALSHKVLPPCVGLQEPAFDLNFVREPHRHNVQSALCLSSGFGGQNTVLALSS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=34.3675417661098, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=41.2162162162162, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI41872631, Length=328, Percent_Identity=25.9146341463415, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1787337, Length=408, Percent_Identity=33.3333333333333, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=27.1634615384615, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=29.8543689320388, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71983535, Length=257, Percent_Identity=35.0194552529183, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI212642053, Length=355, Percent_Identity=25.9154929577465, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17550940, Length=187, Percent_Identity=29.9465240641711, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=31.981981981982, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24644341, Length=425, Percent_Identity=31.7647058823529, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI19920632, Length=393, Percent_Identity=23.6641221374046, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221330659, Length=393, Percent_Identity=23.6641221374046, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24581345, Length=273, Percent_Identity=22.3443223443223, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 40416; Mature: 40416

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAKVVVTGMGIVSALAPSLDKTWQRLLCGESGIQHYHPFPEIPAQPLALVGSQPSHLED
CCCEEEEHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHH
LLKPALSEALDDAGLAPPITDCGVAIGSSRGFQFQWEKGASAYHTSIPSYGEERLLLADP
HHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCEEEECCCCCHHCCCCCCCCCCEEEEECH
EQLVHIYGVSPASIVAQSIAAQGPILAPRAACATGIWAIAQGADLIRAGYCSRVIVGAVE
HHEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
APITPLTLAGFNKMGAMAQSGAYPFDQNREGFVLGEGAAILVLEEESVAQKRQAKIYGQV
CCCCCEEECCCHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEECCHHHHHHHHHHHHHHH
LGVGLTVDAYHMTAPETSRRVAITAIQDCLQRSGLKASDVGYIHAHGTATHLNDQAEAVV
HCCCEEEEEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCEEEEECCCEECCCCCCCEEE
IKALFPPAVAVSSTKGATGHTLGASAAFGCIFSLMALSHKVLPPCVGLQEPAFDLNFVRE
EEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCC
PHRHNVQSALCLSSGFGGQNTVLALSS
CCCCCHHHHHHHHCCCCCCCCEEEECC
>Mature Secondary Structure
MIAKVVVTGMGIVSALAPSLDKTWQRLLCGESGIQHYHPFPEIPAQPLALVGSQPSHLED
CCCEEEEHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHH
LLKPALSEALDDAGLAPPITDCGVAIGSSRGFQFQWEKGASAYHTSIPSYGEERLLLADP
HHHHHHHHHHHHCCCCCCCHHHHHEECCCCCCEEEECCCCCHHCCCCCCCCCCEEEEECH
EQLVHIYGVSPASIVAQSIAAQGPILAPRAACATGIWAIAQGADLIRAGYCSRVIVGAVE
HHEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
APITPLTLAGFNKMGAMAQSGAYPFDQNREGFVLGEGAAILVLEEESVAQKRQAKIYGQV
CCCCCEEECCCHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEECCHHHHHHHHHHHHHHH
LGVGLTVDAYHMTAPETSRRVAITAIQDCLQRSGLKASDVGYIHAHGTATHLNDQAEAVV
HCCCEEEEEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCEEEEECCCEECCCCCCCEEE
IKALFPPAVAVSSTKGATGHTLGASAAFGCIFSLMALSHKVLPPCVGLQEPAFDLNFVRE
EEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCC
PHRHNVQSALCLSSGFGGQNTVLALSS
CCCCCHHHHHHHHCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]