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The map label for this gene is map [C]

Identifier: 158334244

GI number: 158334244

Start: 1029927

End: 1030754

Strand: Reverse

Name: map [C]

Synonym: AM1_1062

Alternate gene names: 158334244

Gene position: 1030754-1029927 (Counterclockwise)

Preceding gene: 158334245

Following gene: 158334243

Centisome position: 15.85

GC content: 47.95

Gene sequence:

>828_bases
ATGAACATTCTCTCTAATCTATTGGCACAGCCTGCCCAGCCCTCTGTACCGAAGCAACGAGGTCGAGGGATTGAAATCAA
GTCCAAGCGTGAGATTGAAATCATGCGACAGGCGTCCCGAATTGTCGCCACGGTTCTGAAAGAAATTTCTGAATTGGTGG
AACCGGGCATGACCACGGCTGATTTGGATGCCCATGCCGAAAAGCGAATTCGCGAGATGGGAGCCACCCCTAGTTTCAAG
GGATATCACGGTTTTCCCGCTTCTATTTGCGCCAGCATTAACCATGAAGTGGTCCATGGTATTCCCAATCCCAAAAAAGT
GATTCAGTCAGGTGATGTCTTAAAGGTTGATACGGGCGCGTATTTTGAAGGCTTTCATGGCGATTCCTGTATTACCATTG
CGGTTGAAGAAGTTACTCCTGATGCGGCCAAACTCATCAAAATAGCTGAAGAATCCCTCTTTAAGGGTATTGAGCAGGTT
AAAGAAGGCAATTACCTCATGGATATTGCCGGAGCTATCCAAGACCATGTGGAAGGAAATGGTTTTGTAGTGGTAGAAGA
CTTTACTGGACATGGGGTCGGTCGTAATCTCCACGAAGAACCCTCGGTGTTTAACTATCGCACCCGCCAGATGCGCAATG
TCAAACTTCGCTCTGGGATGACGTTAGCCATTGAGCCGATTCTCAATGCGGGTTCCAAGGTGACCAAGATTCTCAAAGAT
CGCTGGACGGCAGTGACGGTTGATAATGCGCTGTCAGCTCAGTTTGAGCACACCATTCTGGTCACTAAAACTGGATATGA
AATCCTGACAGATCGCAATCTGGTGTAG

Upstream 100 bases:

>100_bases
GGCGCTATCCTTATGGATAGGGTGATCAATTCATGTAGCTTGCTGCTGCATTGTTCAGTCGATTGGTCTATATCCACAGC
AAACCTGTCTTCAAAAACGC

Downstream 100 bases:

>100_bases
AACAACGGCCTCAAAGGCCTGGCTCAAAGAATCTCCTAGCCTAGGAATTGATTGTGCGGTCCCACTCGCATTTCTGAACT
GCTTTAAGTTCCTTATGAAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MNILSNLLAQPAQPSVPKQRGRGIEIKSKREIEIMRQASRIVATVLKEISELVEPGMTTADLDAHAEKRIREMGATPSFK
GYHGFPASICASINHEVVHGIPNPKKVIQSGDVLKVDTGAYFEGFHGDSCITIAVEEVTPDAAKLIKIAEESLFKGIEQV
KEGNYLMDIAGAIQDHVEGNGFVVVEDFTGHGVGRNLHEEPSVFNYRTRQMRNVKLRSGMTLAIEPILNAGSKVTKILKD
RWTAVTVDNALSAQFEHTILVTKTGYEILTDRNLV

Sequences:

>Translated_275_residues
MNILSNLLAQPAQPSVPKQRGRGIEIKSKREIEIMRQASRIVATVLKEISELVEPGMTTADLDAHAEKRIREMGATPSFK
GYHGFPASICASINHEVVHGIPNPKKVIQSGDVLKVDTGAYFEGFHGDSCITIAVEEVTPDAAKLIKIAEESLFKGIEQV
KEGNYLMDIAGAIQDHVEGNGFVVVEDFTGHGVGRNLHEEPSVFNYRTRQMRNVKLRSGMTLAIEPILNAGSKVTKILKD
RWTAVTVDNALSAQFEHTILVTKTGYEILTDRNLV
>Mature_275_residues
MNILSNLLAQPAQPSVPKQRGRGIEIKSKREIEIMRQASRIVATVLKEISELVEPGMTTADLDAHAEKRIREMGATPSFK
GYHGFPASICASINHEVVHGIPNPKKVIQSGDVLKVDTGAYFEGFHGDSCITIAVEEVTPDAAKLIKIAEESLFKGIEQV
KEGNYLMDIAGAIQDHVEGNGFVVVEDFTGHGVGRNLHEEPSVFNYRTRQMRNVKLRSGMTLAIEPILNAGSKVTKILKD
RWTAVTVDNALSAQFEHTILVTKTGYEILTDRNLV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=249, Percent_Identity=38.5542168674699, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=36, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=45.6, Blast_Score=219, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71996291, Length=253, Percent_Identity=38.7351778656126, Blast_Score=174, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6323273, Length=255, Percent_Identity=36.078431372549, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21355531, Length=265, Percent_Identity=39.2452830188679, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=38.6178861788618, Blast_Score=176, Evalue=1e-44,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 30228; Mature: 30228

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILSNLLAQPAQPSVPKQRGRGIEIKSKREIEIMRQASRIVATVLKEISELVEPGMTTA
CCHHHHHHCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DLDAHAEKRIREMGATPSFKGYHGFPASICASINHEVVHGIPNPKKVIQSGDVLKVDTGA
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCHHHHHCCCCEEEECCCC
YFEGFHGDSCITIAVEEVTPDAAKLIKIAEESLFKGIEQVKEGNYLMDIAGAIQDHVEGN
EECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCC
GFVVVEDFTGHGVGRNLHEEPSVFNYRTRQMRNVKLRSGMTLAIEPILNAGSKVTKILKD
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHH
RWTAVTVDNALSAQFEHTILVTKTGYEILTDRNLV
CCCEEEECCHHHCCCCEEEEEEECCCEEECCCCCC
>Mature Secondary Structure
MNILSNLLAQPAQPSVPKQRGRGIEIKSKREIEIMRQASRIVATVLKEISELVEPGMTTA
CCHHHHHHCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DLDAHAEKRIREMGATPSFKGYHGFPASICASINHEVVHGIPNPKKVIQSGDVLKVDTGA
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHCCCCCHHHHHCCCCEEEECCCC
YFEGFHGDSCITIAVEEVTPDAAKLIKIAEESLFKGIEQVKEGNYLMDIAGAIQDHVEGN
EECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCC
GFVVVEDFTGHGVGRNLHEEPSVFNYRTRQMRNVKLRSGMTLAIEPILNAGSKVTKILKD
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHH
RWTAVTVDNALSAQFEHTILVTKTGYEILTDRNLV
CCCEEEECCHHHCCCCEEEEEEECCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]