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The map label for this gene is gds [H]

Identifier: 158334022

GI number: 158334022

Start: 819672

End: 820568

Strand: Direct

Name: gds [H]

Synonym: AM1_0836

Alternate gene names: 158334022

Gene position: 819672-820568 (Clockwise)

Preceding gene: 158334021

Following gene: 158334023

Centisome position: 12.6

GC content: 49.28

Gene sequence:

>897_bases
ATGGGGAAGGGCTTGCGTCCCGCCTTATGTATGGCGACCTGTCAGGCCTTTGGGGGGACTGAAGAACAGTCCCTCAAATC
AGCCGTTGCCTTAGAAATGATTCACAATGCTTTCCTAGTCCATGATGACGTGGAAGATAACAGTGAATGCCGCCATCGCA
TGCCCACCCTGCAGGCAGAGCAGGGGGTGCCCATCGCGGTTAATATTGGCGATGCCATGAATGCCTTAAGCCTGAGATTG
GTCCGGGAAAATATTCCCATGCTGGGTCATCAACTGACCCAACGGATCTATGAAGAGTTTGAGCATTTAATGTTGAAATC
CTTAGAGGGGCAAGCCTCAGAACTAGGGTGGGTAAGGGACAACCGCTGTGATATCACCGAAGCGGATTACCTACAGATGA
TTTTGAATAAGACCTGTTGGTATAGCTTTATGCATCCCTGCCGGATTGGGGGTCTGATTGCCTCTAAAGACACCCTGGAC
CTGGACCGCTTTAATAAGTTTGGATACTTTATGGGGGCGGCCTTTCAGATTCAAGATGATGTGCTGAATTTGGTGGGGGA
TTCCCACCAGTATGGCAAAGAAATTGGCGGTGATATTTGGGAAGGTAAGCGAACGTTGATGTTAGTGCACCTATTTAAAC
AAGGCACCCCATCAGAGCGGGATGTGCTCCAAGCCTTTATGGCAAAACCTCGGGGAGAACGGTCTGAAGAGGAGGTGAGC
TGGGTGATTCAACGCATGCAAGATTACGGCAGTATTGACTATGCGATCGCAGTCGCCCATCAGTTTGCCGAAGCAGCCTT
AGAAGAATTCTCGGTGGCCTATCAGGATACGCCCAACTCTGGGGAAAAAGCGTTTATCCCCAAATTGATTCACTATATGA
TTAGCCGTAATCTATAG

Upstream 100 bases:

>100_bases
TCATTACCGAGAGGTGACGTTGGCCGCGTTGTTGGCTGTGATTCCCACGGGCGAACCCCAACAGTATCTGTATGAGCCGA
TCAAAAGACACCTCTCCCAT

Downstream 100 bases:

>100_bases
GACCACTGGTTTTGAGTCGCAAGTAGAGGACAGTCAAGATGAAACACTATCGACGTAAACCCCTCCAGCTCATCGATCAA
GGGCTACCCGAATCGGTCAC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MGKGLRPALCMATCQAFGGTEEQSLKSAVALEMIHNAFLVHDDVEDNSECRHRMPTLQAEQGVPIAVNIGDAMNALSLRL
VRENIPMLGHQLTQRIYEEFEHLMLKSLEGQASELGWVRDNRCDITEADYLQMILNKTCWYSFMHPCRIGGLIASKDTLD
LDRFNKFGYFMGAAFQIQDDVLNLVGDSHQYGKEIGGDIWEGKRTLMLVHLFKQGTPSERDVLQAFMAKPRGERSEEEVS
WVIQRMQDYGSIDYAIAVAHQFAEAALEEFSVAYQDTPNSGEKAFIPKLIHYMISRNL

Sequences:

>Translated_298_residues
MGKGLRPALCMATCQAFGGTEEQSLKSAVALEMIHNAFLVHDDVEDNSECRHRMPTLQAEQGVPIAVNIGDAMNALSLRL
VRENIPMLGHQLTQRIYEEFEHLMLKSLEGQASELGWVRDNRCDITEADYLQMILNKTCWYSFMHPCRIGGLIASKDTLD
LDRFNKFGYFMGAAFQIQDDVLNLVGDSHQYGKEIGGDIWEGKRTLMLVHLFKQGTPSERDVLQAFMAKPRGERSEEEVS
WVIQRMQDYGSIDYAIAVAHQFAEAALEEFSVAYQDTPNSGEKAFIPKLIHYMISRNL
>Mature_297_residues
GKGLRPALCMATCQAFGGTEEQSLKSAVALEMIHNAFLVHDDVEDNSECRHRMPTLQAEQGVPIAVNIGDAMNALSLRLV
RENIPMLGHQLTQRIYEEFEHLMLKSLEGQASELGWVRDNRCDITEADYLQMILNKTCWYSFMHPCRIGGLIASKDTLDL
DRFNKFGYFMGAAFQIQDDVLNLVGDSHQYGKEIGGDIWEGKRTLMLVHLFKQGTPSERDVLQAFMAKPRGERSEEEVSW
VIQRMQDYGSIDYAIAVAHQFAEAALEEFSVAYQDTPNSGEKAFIPKLIHYMISRNL

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI4758430, Length=264, Percent_Identity=27.6515151515151, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI83700220, Length=264, Percent_Identity=27.6515151515151, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789578, Length=296, Percent_Identity=28.0405405405405, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1786623, Length=226, Percent_Identity=28.7610619469027, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508563, Length=222, Percent_Identity=32.4324324324324, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6325188, Length=213, Percent_Identity=29.1079812206573, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281365769, Length=301, Percent_Identity=24.9169435215947, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24660002, Length=301, Percent_Identity=24.9169435215947, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10 [H]

Molecular weight: Translated: 33729; Mature: 33598

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKGLRPALCMATCQAFGGTEEQSLKSAVALEMIHNAFLVHDDVEDNSECRHRMPTLQAE
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCCC
QGVPIAVNIGDAMNALSLRLVRENIPMLGHQLTQRIYEEFEHLMLKSLEGQASELGWVRD
CCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
NRCDITEADYLQMILNKTCWYSFMHPCRIGGLIASKDTLDLDRFNKFGYFMGAAFQIQDD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHHHEEEHHH
VLNLVGDSHQYGKEIGGDIWEGKRTLMLVHLFKQGTPSERDVLQAFMAKPRGERSEEEVS
HHHHHCCCHHHHHHHCCCHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHH
WVIQRMQDYGSIDYAIAVAHQFAEAALEEFSVAYQDTPNSGEKAFIPKLIHYMISRNL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GKGLRPALCMATCQAFGGTEEQSLKSAVALEMIHNAFLVHDDVEDNSECRHRMPTLQAE
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCCC
QGVPIAVNIGDAMNALSLRLVRENIPMLGHQLTQRIYEEFEHLMLKSLEGQASELGWVRD
CCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
NRCDITEADYLQMILNKTCWYSFMHPCRIGGLIASKDTLDLDRFNKFGYFMGAAFQIQDD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHHHEEEHHH
VLNLVGDSHQYGKEIGGDIWEGKRTLMLVHLFKQGTPSERDVLQAFMAKPRGERSEEEVS
HHHHHCCCHHHHHHHCCCHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHH
WVIQRMQDYGSIDYAIAVAHQFAEAALEEFSVAYQDTPNSGEKAFIPKLIHYMISRNL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]