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The map label for this gene is kbl [C]

Identifier: 158333914

GI number: 158333914

Start: 710867

End: 712192

Strand: Direct

Name: kbl [C]

Synonym: AM1_0726

Alternate gene names: 158333914

Gene position: 710867-712192 (Clockwise)

Preceding gene: 158333913

Following gene: 158333915

Centisome position: 10.93

GC content: 49.47

Gene sequence:

>1326_bases
ATGAGTAATTCCTCTAATTCCCTGGATCATCTCTCCGCAGAAGAAAAGCGCGAATTGCTGGCGGAATTATTGCAGAAAAA
AGCCGACGCTGAACCTGAGATTCCTCCCGAGCACTATCGCTTCGATCTCTACCCTGAATATCTCCAGCTCAAAGAGCAAC
AAGCCCAACTGCAGGCGAATGATATCCGCAACCCTTATTTCTCCGTCCATGAAGGGATTGCCCGAGATACCACCCGCATT
GATGGAAAAGAGCTGATCAACTTCTCCAGCTACAACTATTTAGGGCTAGCCGGACATCCGACGGTTTCTGAAACAGCTAA
ACAAGCCATTGACCGCTACGGCACTTCGGTGTCAGCCAGCCGCCCCGTTTCTGGTGAGAAACCCTTACATTTAGAGCTTG
AGCAAGGAATTGCAGACTTTATTGGTGTAGATGACGCCGTTCTTTACGTCGCGGGTCACGGTACCAACGTCACAACCATT
GGGCATTTATTTGGCCGTAATGACCTGATTCTTTACGATGCCTATAGTCACAACAGTATTTTTCTTGGCTGTGTACTGTC
GGGCGCTCGGGCCATGTCGTTTGCCCATAATGATGTAGCCGATCTAGAAAGACTTTTAAAGCAGCATCGTCATCGCTATC
AGCGAGTTCTGGTAGTGATTGAAGGGGTCTACAGTGCCGATGGCGACATTCCTGAATTACCTAAATTTATTGAACTCAAA
GAACGCCACAAAGCTTTTCTGATGGTGGATGAAGCCCACTCGATTGGTGTTTTGGGCGAACATGGTCAGGGTATTAGCGA
GCATTTTGGCATTGACCCCAAAACGGTCGATATTTGGATGGGCACCCTTAGTAAGTCCTTTGCCAGCTGTGGCGGATATA
TTGCCGGTTCTCAGCCCCTGATTGAATATCTCAAATGTACGGCACCGGGATTTATCTATAGTATTGGCATTACCCCTGCC
AATACGGCGGCCTCTTTGGCGGCGCTACAAGTTTTGAAACAAGAACCTGAACGCGTAGCTAGGCTCCATGCTCGGGCTCA
GTTGTTCCTCGACTTGGCTAAAGAAAAAGGATTGAATACTGGTACCAGTCACGGTTCAGCGGTGATTCCGGTGATGGTGG
GGGAGACCCTTAAAGCCCTGCACTTGTCGCAGCAGCTATTTCACCAAGGGATTAATGTTCAGCCCATGACCTTCCCGGTG
GTGCCCCAAAACGAGGCTCGACTTCGCTTTTTCCTCAGCAGCACCCATACGGAAGCGCAAATTCGCCAAACCGTAGAGAC
CCTCGCTGCTGCCCTAGCTCATATTGAGACTGAAATCCCTGCCTAA

Upstream 100 bases:

>100_bases
CCCACAGAAGCCGATGAACTCCTATCCAAATTGGATGTACTGAGTGACGATGAAGTGGATGGTCTGCTGAACGCGATGTT
GTCAGAGCATAATGTTGCCC

Downstream 100 bases:

>100_bases
TTGGGGGTGCCCATATGGCTGAAGTAGTGTGGATTGCGCGGCATGGCCATCGGCAAGATTATGCTGACTTAGGCTGGCGA
AAACGGGCAGAACGTCCCCA

Product: aminotransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MSNSSNSLDHLSAEEKRELLAELLQKKADAEPEIPPEHYRFDLYPEYLQLKEQQAQLQANDIRNPYFSVHEGIARDTTRI
DGKELINFSSYNYLGLAGHPTVSETAKQAIDRYGTSVSASRPVSGEKPLHLELEQGIADFIGVDDAVLYVAGHGTNVTTI
GHLFGRNDLILYDAYSHNSIFLGCVLSGARAMSFAHNDVADLERLLKQHRHRYQRVLVVIEGVYSADGDIPELPKFIELK
ERHKAFLMVDEAHSIGVLGEHGQGISEHFGIDPKTVDIWMGTLSKSFASCGGYIAGSQPLIEYLKCTAPGFIYSIGITPA
NTAASLAALQVLKQEPERVARLHARAQLFLDLAKEKGLNTGTSHGSAVIPVMVGETLKALHLSQQLFHQGINVQPMTFPV
VPQNEARLRFFLSSTHTEAQIRQTVETLAAALAHIETEIPA

Sequences:

>Translated_441_residues
MSNSSNSLDHLSAEEKRELLAELLQKKADAEPEIPPEHYRFDLYPEYLQLKEQQAQLQANDIRNPYFSVHEGIARDTTRI
DGKELINFSSYNYLGLAGHPTVSETAKQAIDRYGTSVSASRPVSGEKPLHLELEQGIADFIGVDDAVLYVAGHGTNVTTI
GHLFGRNDLILYDAYSHNSIFLGCVLSGARAMSFAHNDVADLERLLKQHRHRYQRVLVVIEGVYSADGDIPELPKFIELK
ERHKAFLMVDEAHSIGVLGEHGQGISEHFGIDPKTVDIWMGTLSKSFASCGGYIAGSQPLIEYLKCTAPGFIYSIGITPA
NTAASLAALQVLKQEPERVARLHARAQLFLDLAKEKGLNTGTSHGSAVIPVMVGETLKALHLSQQLFHQGINVQPMTFPV
VPQNEARLRFFLSSTHTEAQIRQTVETLAAALAHIETEIPA
>Mature_440_residues
SNSSNSLDHLSAEEKRELLAELLQKKADAEPEIPPEHYRFDLYPEYLQLKEQQAQLQANDIRNPYFSVHEGIARDTTRID
GKELINFSSYNYLGLAGHPTVSETAKQAIDRYGTSVSASRPVSGEKPLHLELEQGIADFIGVDDAVLYVAGHGTNVTTIG
HLFGRNDLILYDAYSHNSIFLGCVLSGARAMSFAHNDVADLERLLKQHRHRYQRVLVVIEGVYSADGDIPELPKFIELKE
RHKAFLMVDEAHSIGVLGEHGQGISEHFGIDPKTVDIWMGTLSKSFASCGGYIAGSQPLIEYLKCTAPGFIYSIGITPAN
TAASLAALQVLKQEPERVARLHARAQLFLDLAKEKGLNTGTSHGSAVIPVMVGETLKALHLSQQLFHQGINVQPMTFPVV
PQNEARLRFFLSSTHTEAQIRQTVETLAAALAHIETEIPA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=441, Percent_Identity=32.8798185941043, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=36.3143631436314, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI7657118, Length=355, Percent_Identity=33.5211267605634, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=33.4293948126801, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI5454084, Length=353, Percent_Identity=30.3116147308782, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI83977442, Length=363, Percent_Identity=32.2314049586777, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI83977444, Length=363, Percent_Identity=32.2314049586777, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI83977440, Length=363, Percent_Identity=32.2314049586777, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4502025, Length=367, Percent_Identity=30.7901907356948, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI40316939, Length=367, Percent_Identity=30.7901907356948, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1790046, Length=356, Percent_Identity=36.5168539325843, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786993, Length=350, Percent_Identity=33.1428571428571, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=35.0974930362117, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=35.0974930362117, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI32566772, Length=360, Percent_Identity=34.4444444444444, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71994529, Length=349, Percent_Identity=33.2378223495702, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71982625, Length=294, Percent_Identity=31.9727891156463, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71982617, Length=294, Percent_Identity=31.9727891156463, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320267, Length=352, Percent_Identity=33.8068181818182, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6320438, Length=356, Percent_Identity=28.6516853932584, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6323954, Length=273, Percent_Identity=30.03663003663, Blast_Score=126, Evalue=9e-30,
Organism=Drosophila melanogaster, GI17136286, Length=360, Percent_Identity=33.6111111111111, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24662918, Length=348, Percent_Identity=32.183908045977, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24653280, Length=319, Percent_Identity=33.2288401253918, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24653276, Length=319, Percent_Identity=33.2288401253918, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24653278, Length=319, Percent_Identity=33.2288401253918, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17137420, Length=368, Percent_Identity=31.5217391304348, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 48580; Mature: 48448

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSSNSLDHLSAEEKRELLAELLQKKADAEPEIPPEHYRFDLYPEYLQLKEQQAQLQAN
CCCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHH
DIRNPYFSVHEGIARDTTRIDGKELINFSSYNYLGLAGHPTVSETAKQAIDRYGTSVSAS
HCCCCHHHHHHHHHHCCCCCCHHHHEEECCCCEEEECCCCCHHHHHHHHHHHHCCCCCCC
RPVSGEKPLHLELEQGIADFIGVDDAVLYVAGHGTNVTTIGHLFGRNDLILYDAYSHNSI
CCCCCCCCEEEEHHHHHHHHHCCCCEEEEEEECCCCEEEHHHHHCCCCEEEEEECCCCCE
FLGCVLSGARAMSFAHNDVADLERLLKQHRHRYQRVLVVIEGVYSADGDIPELPKFIELK
EEEEHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCCCHHHHHHH
ERHKAFLMVDEAHSIGVLGEHGQGISEHFGIDPKTVDIWMGTLSKSFASCGGYIAGSQPL
HHCCEEEEEECCCCCCEECCCCCCHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCCCCHHH
IEYLKCTAPGFIYSIGITPANTAASLAALQVLKQEPERVARLHARAQLFLDLAKEKGLNT
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCC
GTSHGSAVIPVMVGETLKALHLSQQLFHQGINVQPMTFPVVPQNEARLRFFLSSTHTEAQ
CCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEECCCCHHHH
IRQTVETLAAALAHIETEIPA
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNSSNSLDHLSAEEKRELLAELLQKKADAEPEIPPEHYRFDLYPEYLQLKEQQAQLQAN
CCCCCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHH
DIRNPYFSVHEGIARDTTRIDGKELINFSSYNYLGLAGHPTVSETAKQAIDRYGTSVSAS
HCCCCHHHHHHHHHHCCCCCCHHHHEEECCCCEEEECCCCCHHHHHHHHHHHHCCCCCCC
RPVSGEKPLHLELEQGIADFIGVDDAVLYVAGHGTNVTTIGHLFGRNDLILYDAYSHNSI
CCCCCCCCEEEEHHHHHHHHHCCCCEEEEEEECCCCEEEHHHHHCCCCEEEEEECCCCCE
FLGCVLSGARAMSFAHNDVADLERLLKQHRHRYQRVLVVIEGVYSADGDIPELPKFIELK
EEEEHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCCCHHHHHHH
ERHKAFLMVDEAHSIGVLGEHGQGISEHFGIDPKTVDIWMGTLSKSFASCGGYIAGSQPL
HHCCEEEEEECCCCCCEECCCCCCHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCCCCHHH
IEYLKCTAPGFIYSIGITPANTAASLAALQVLKQEPERVARLHARAQLFLDLAKEKGLNT
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCC
GTSHGSAVIPVMVGETLKALHLSQQLFHQGINVQPMTFPVVPQNEARLRFFLSSTHTEAQ
CCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEECCCCHHHH
IRQTVETLAAALAHIETEIPA
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA