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The map label for this gene is mtaP [H]

Identifier: 158333808

GI number: 158333808

Start: 605733

End: 606605

Strand: Direct

Name: mtaP [H]

Synonym: AM1_0617

Alternate gene names: 158333808

Gene position: 605733-606605 (Clockwise)

Preceding gene: 158333806

Following gene: 158333809

Centisome position: 9.31

GC content: 50.06

Gene sequence:

>873_bases
ATGGCTCAGGTAAAAATTGGCATTATTGGCGGTAGTGGCCTTTATAAAATGGAGGCTCTGACGGATGTAGAAGAAGTTCA
AATCAAGACCCCCTTCGGAGACCCTTCAGACGCACTGATTGTCGGCACCTTGGAAGGGGCACGGGTGGCTTTCCTCGCTC
GCCATGGTCGGAATCATCATCTTATTCCGAGTGAATTGCCCTTTCGCGCTAACATCTATGCCATGAAGTCCTTGGGTGTG
GAGTATTTGATCTCAGCTTCAGCCGTCGGCTCCCTTAAGGAAGAAGCAAAACCTTTGGATATGGTGGTGCCGGACCAGTT
TATCGATCGCACCAAGAATCGGGTGTCTACTTTTTTTGGCAATGGCATTGTGGCCCATATTGGCTTTGGTGATCCAGTCT
GTGGCGCATTGGCTGGGGTATTGGGGGATGCGATCGCATCCCTGAATCTCCCCGATGTCACCCTCCATCGCCAAGGCACC
TACGTGTGTATGGAAGGCCCTGCCTTTTCTACCAAAGCTGAATCTAATTTGTATCGAAGTTGGGGGGGCACTGTAATTGG
CATGACCAATTTGCCGGAAGCTAAACTGGCGCGGGAAGCTGAAATTGCCTATGCCACCCTAGCCCTAGTCACGGACTACG
ATTGCTGGCATCCTGAACATGACAGCGTCACGGTGGAAATGATTATTGGCAATCTTCACAAGAATGCGAGTAATGCCCAA
AGCGTGATTAAAGAAACCGTTAAACGTCTCAGTCAATCCCCCCCTGCTTCTAAGGCTCACAAGGCTCTGAAACACGCAAT
CTTTACCCCCTTGGATCAGGCTCCAGCGGCTACCAAGGAACAGCTTTCCTTGATTTTGCAAAAGTATCTCTAA

Upstream 100 bases:

>100_bases
TCATTGACCGATGATGAAATGGTAGTAGGCAAAAAACTAGTTGCTACACCTAACTTTCCCAGTACACTACGAAAGGATTA
AACACTCACGAACCTTAGAT

Downstream 100 bases:

>100_bases
GCTATGCCCTGGTATATCAAAATTGAACGCGGCATTGTGGATAAAACCACCTTTGATCGCCATGTGCCTGCCCACCTCGC
CTATGTTAAAAACCTAGAGA

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MAQVKIGIIGGSGLYKMEALTDVEEVQIKTPFGDPSDALIVGTLEGARVAFLARHGRNHHLIPSELPFRANIYAMKSLGV
EYLISASAVGSLKEEAKPLDMVVPDQFIDRTKNRVSTFFGNGIVAHIGFGDPVCGALAGVLGDAIASLNLPDVTLHRQGT
YVCMEGPAFSTKAESNLYRSWGGTVIGMTNLPEAKLAREAEIAYATLALVTDYDCWHPEHDSVTVEMIIGNLHKNASNAQ
SVIKETVKRLSQSPPASKAHKALKHAIFTPLDQAPAATKEQLSLILQKYL

Sequences:

>Translated_290_residues
MAQVKIGIIGGSGLYKMEALTDVEEVQIKTPFGDPSDALIVGTLEGARVAFLARHGRNHHLIPSELPFRANIYAMKSLGV
EYLISASAVGSLKEEAKPLDMVVPDQFIDRTKNRVSTFFGNGIVAHIGFGDPVCGALAGVLGDAIASLNLPDVTLHRQGT
YVCMEGPAFSTKAESNLYRSWGGTVIGMTNLPEAKLAREAEIAYATLALVTDYDCWHPEHDSVTVEMIIGNLHKNASNAQ
SVIKETVKRLSQSPPASKAHKALKHAIFTPLDQAPAATKEQLSLILQKYL
>Mature_289_residues
AQVKIGIIGGSGLYKMEALTDVEEVQIKTPFGDPSDALIVGTLEGARVAFLARHGRNHHLIPSELPFRANIYAMKSLGVE
YLISASAVGSLKEEAKPLDMVVPDQFIDRTKNRVSTFFGNGIVAHIGFGDPVCGALAGVLGDAIASLNLPDVTLHRQGTY
VCMEGPAFSTKAESNLYRSWGGTVIGMTNLPEAKLAREAEIAYATLALVTDYDCWHPEHDSVTVEMIIGNLHKNASNAQS
VIKETVKRLSQSPPASKAHKALKHAIFTPLDQAPAATKEQLSLILQKYL

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=273, Percent_Identity=41.7582417582418, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI71980569, Length=254, Percent_Identity=42.5196850393701, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6323045, Length=304, Percent_Identity=40.1315789473684, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI20130079, Length=254, Percent_Identity=40.1574803149606, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI221459247, Length=264, Percent_Identity=36.3636363636364, Blast_Score=181, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 31246; Mature: 31115

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVKIGIIGGSGLYKMEALTDVEEVQIKTPFGDPSDALIVGTLEGARVAFLARHGRNHH
CCEEEEEEEECCCCEEHHHHCCHHHEEEECCCCCCCCEEEEEECCCCEEEEEECCCCCCC
LIPSELPFRANIYAMKSLGVEYLISASAVGSLKEEAKPLDMVVPDQFIDRTKNRVSTFFG
CCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHC
NGIVAHIGFGDPVCGALAGVLGDAIASLNLPDVTLHRQGTYVCMEGPAFSTKAESNLYRS
CCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHH
WGGTVIGMTNLPEAKLAREAEIAYATLALVTDYDCWHPEHDSVTVEMIIGNLHKNASNAQ
CCCEEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEEEEHHCCCCHHHH
SVIKETVKRLSQSPPASKAHKALKHAIFTPLDQAPAATKEQLSLILQKYL
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
AQVKIGIIGGSGLYKMEALTDVEEVQIKTPFGDPSDALIVGTLEGARVAFLARHGRNHH
CEEEEEEEECCCCEEHHHHCCHHHEEEECCCCCCCCEEEEEECCCCEEEEEECCCCCCC
LIPSELPFRANIYAMKSLGVEYLISASAVGSLKEEAKPLDMVVPDQFIDRTKNRVSTFFG
CCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHC
NGIVAHIGFGDPVCGALAGVLGDAIASLNLPDVTLHRQGTYVCMEGPAFSTKAESNLYRS
CCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCHHHHHHHHH
WGGTVIGMTNLPEAKLAREAEIAYATLALVTDYDCWHPEHDSVTVEMIIGNLHKNASNAQ
CCCEEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCEEEEEEEEHHCCCCHHHH
SVIKETVKRLSQSPPASKAHKALKHAIFTPLDQAPAATKEQLSLILQKYL
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA