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The map label for this gene is hemF [H]

Identifier: 158333806

GI number: 158333806

Start: 603924

End: 604949

Strand: Direct

Name: hemF [H]

Synonym: AM1_0615

Alternate gene names: 158333806

Gene position: 603924-604949 (Clockwise)

Preceding gene: 158333805

Following gene: 158333808

Centisome position: 9.29

GC content: 49.81

Gene sequence:

>1026_bases
ATGACCGCATCTCCTTCTACTCCTGCAGCGGTAACAAATGCTCCTCCACCTCCTTCAGACTCTAAAGAGCAGGTGGGAAA
ATTTCTGCGAGGTTTGCAGGACAGTATTTGCGACAAGCTGCAAACGTTAGATGGTAAAAGCACTTTTCAGGAAGACTCCT
GGGATCGACCGGAAGGGGGCGGTGGTCGCTCGCGGGTCCTTCGAGAAGGTGGACTCTTAGAACAGGGTGGTGTCAATTAC
TCCGAGGTCTGGGGGGATCATTTGCCTCCCTCTATTCTTAAACAACGGCCAGAAGCTGCAGGGCACCGATTTTATGCGAC
GGGGACTTCGATGGTACTGCATCCCCGCAGTCCCTACGTGCCAACGGTACATCTGAATTATCGATATTTTGAAGCCGGAC
CAGTTTGGTGGTTTGGGGGTGGGATTGATCTGACGCCGTATTATCCCTTCAAAGAAGATGTGGTCCATTTTCATCAAACG
ATGAAAGCGGCCTGCGATCGTCATCACCCTGAATATTACTCCACCTTTAAGCCTTGGTGTGATGAGTATTTTTATCTGAA
GCACCGACAAGAAATGCGGGGAGTTGGCGGTATTTTCTTTGATTATCAGGATGGCATTGGTGCTTTGTATCGTGGCCCCC
ATGCTGAGGGGATTGCTGCTCACCATAGTGATCAGTTGGGTTCTTTACCCCAACGGTCATGGGATGAGATATTTGCCTTT
GCTCAAGACTGCGGTAACGCCTTTTTGCCTGCCTATGTCCCGATTGTCGAGCGACGTCGGGATACTGAGTATGGTGACCG
TGAACGGAACTTCCAACTGTATCGTCGAGGCCGATATGTGGAATTCAACTTGGTCTATGACCGAGGGACTATTTTTGGCT
TGCAGACCAATGGTCGTACTGAATCTATCCTGATGTCGCTGCCACCGCTAGTGCGTTGGGAGTATGCTTATTCTCCTGAG
CCTGATACTCCTGAAGCAGAGTTATATGAGACATTCTTAAAGCCTCAAGATTGGGCTTCAGCTTAG

Upstream 100 bases:

>100_bases
TTCTAGAGTAGATAAAGCAACCTGGCTGGCTCTCTGCTTCCTACAAAATTAGCGAAGCATATTTATAATGGCCCAGCCCC
TATTTCTCTAGAGGCCCCTC

Downstream 100 bases:

>100_bases
ACTCAAACCAATATCTAAAGCAAACACCAGGGGATGAAAGCGCGGCCAACCCCCTGGATTTTTGCATGTTAACCCTCTAC
TCTTTGGGACTCTGGACCAC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTASPSTPAAVTNAPPPPSDSKEQVGKFLRGLQDSICDKLQTLDGKSTFQEDSWDRPEGGGGRSRVLREGGLLEQGGVNY
SEVWGDHLPPSILKQRPEAAGHRFYATGTSMVLHPRSPYVPTVHLNYRYFEAGPVWWFGGGIDLTPYYPFKEDVVHFHQT
MKAACDRHHPEYYSTFKPWCDEYFYLKHRQEMRGVGGIFFDYQDGIGALYRGPHAEGIAAHHSDQLGSLPQRSWDEIFAF
AQDCGNAFLPAYVPIVERRRDTEYGDRERNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYAYSPE
PDTPEAELYETFLKPQDWASA

Sequences:

>Translated_341_residues
MTASPSTPAAVTNAPPPPSDSKEQVGKFLRGLQDSICDKLQTLDGKSTFQEDSWDRPEGGGGRSRVLREGGLLEQGGVNY
SEVWGDHLPPSILKQRPEAAGHRFYATGTSMVLHPRSPYVPTVHLNYRYFEAGPVWWFGGGIDLTPYYPFKEDVVHFHQT
MKAACDRHHPEYYSTFKPWCDEYFYLKHRQEMRGVGGIFFDYQDGIGALYRGPHAEGIAAHHSDQLGSLPQRSWDEIFAF
AQDCGNAFLPAYVPIVERRRDTEYGDRERNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYAYSPE
PDTPEAELYETFLKPQDWASA
>Mature_340_residues
TASPSTPAAVTNAPPPPSDSKEQVGKFLRGLQDSICDKLQTLDGKSTFQEDSWDRPEGGGGRSRVLREGGLLEQGGVNYS
EVWGDHLPPSILKQRPEAAGHRFYATGTSMVLHPRSPYVPTVHLNYRYFEAGPVWWFGGGIDLTPYYPFKEDVVHFHQTM
KAACDRHHPEYYSTFKPWCDEYFYLKHRQEMRGVGGIFFDYQDGIGALYRGPHAEGIAAHHSDQLGSLPQRSWDEIFAFA
QDCGNAFLPAYVPIVERRRDTEYGDRERNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYAYSPEP
DTPEAELYETFLKPQDWASA

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:
GO:0004109: Coproporphyrinogen-III oxidase, aerobic
GO:0005737: Coproporphyrinogen-III oxidase, aerobic
GO:0006779: Coproporphyrinogen-III oxidase, aerobic
GO:0016491: Coproporphyrinogen-III oxidase, aerobic
GO:0042803: Coproporphyrinogen-III oxidase, aerobic
GO:0055114: Coproporphyrinogen-III oxidase, aerobic

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=335, Percent_Identity=43.2835820895522, Blast_Score=282, Evalue=3e-76,
Organism=Escherichia coli, GI1788777, Length=321, Percent_Identity=54.8286604361371, Blast_Score=346, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6320249, Length=343, Percent_Identity=42.8571428571429, Blast_Score=266, Evalue=5e-72,
Organism=Drosophila melanogaster, GI17864388, Length=347, Percent_Identity=44.956772334294, Blast_Score=293, Evalue=8e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 38936; Mature: 38804

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASPSTPAAVTNAPPPPSDSKEQVGKFLRGLQDSICDKLQTLDGKSTFQEDSWDRPEGG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGRSRVLREGGLLEQGGVNYSEVWGDHLPPSILKQRPEAAGHRFYATGTSMVLHPRSPYV
CCHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHCCCHHHCCEEEEECCEEEEECCCCCC
PTVHLNYRYFEAGPVWWFGGGIDLTPYYPFKEDVVHFHQTMKAACDRHHPEYYSTFKPWC
CEEEEEEEEEECCCEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DEYFYLKHRQEMRGVGGIFFDYQDGIGALYRGPHAEGIAAHHSDQLGSLPQRSWDEIFAF
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHCCCCCCCCHHHCCHHHCCCCCHHHHHHHHH
AQDCGNAFLPAYVPIVERRRDTEYGDRERNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRT
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEEEEEEEEECCEEEEEECCCCC
ESILMSLPPLVRWEYAYSPEPDTPEAELYETFLKPQDWASA
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TASPSTPAAVTNAPPPPSDSKEQVGKFLRGLQDSICDKLQTLDGKSTFQEDSWDRPEGG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GGRSRVLREGGLLEQGGVNYSEVWGDHLPPSILKQRPEAAGHRFYATGTSMVLHPRSPYV
CCHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHCCCHHHCCEEEEECCEEEEECCCCCC
PTVHLNYRYFEAGPVWWFGGGIDLTPYYPFKEDVVHFHQTMKAACDRHHPEYYSTFKPWC
CEEEEEEEEEECCCEEEECCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DEYFYLKHRQEMRGVGGIFFDYQDGIGALYRGPHAEGIAAHHSDQLGSLPQRSWDEIFAF
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHCCCCCCCCHHHCCHHHCCCCCHHHHHHHHH
AQDCGNAFLPAYVPIVERRRDTEYGDRERNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRT
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEEEEEEEEECCEEEEEECCCCC
ESILMSLPPLVRWEYAYSPEPDTPEAELYETFLKPQDWASA
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]