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The map label for this gene is hisN [H]

Identifier: 158333782

GI number: 158333782

Start: 577567

End: 578382

Strand: Reverse

Name: hisN [H]

Synonym: AM1_0590

Alternate gene names: 158333782

Gene position: 578382-577567 (Counterclockwise)

Preceding gene: 158333785

Following gene: 158333781

Centisome position: 8.89

GC content: 51.72

Gene sequence:

>816_bases
ATGCAAACATTCTGGACTTCGGTCGTCACTTTTGCCCACACCGTTACACAACAAGTGGGGGAACGCTTACTCACTGAATT
TGGGAAAGTTCAAGCGACCTCTAAGTCCGATGGTAGCTTAGTCACTCAATCAGACCAATGGGCCGATCACTATCTGCGTC
AGGCCATTGCCACTGCTTTCCCCGACCATGGGGTACTGAGCGAAGAGGTAGAACATATCTTTCCCGATACCGACTGGTGT
TGGGTCATAGATCCGATTGATGGCACCACTAATTTTTCTCGCGGTGTTCCCATTTGGGGAACCTCCTTAGGGTTGCTCTA
TCAAGGGGTGCCAGTGTTTGGGTTTGTTCACTTTCCCCCCTTAGGGCAAACTTTTCATGGGTTTTGGTCTGCACCAGAGC
AACCAGATGGGGCCTTTTGCAATCAAACCCCTATCCACACCCGGCCCGATGCACCCGCTGGAAATCAATGTTTCAGTCTC
TGTGCCCGTAGTCTTTCGGTGTTAAAGAACCCCTTTCCCTGCAAACTTCGAATGCTTGGGTCCGCCAGTTACAACCTACT
CATCGTGGCCCAAGGCGTTACCATTGGTGCGGTAGAGGCGACGCCTAAGATCTGGGATATTGCTGGAGTTTGGCCCATTA
TTCAAGCCGCTGGGGGAGCATGGATCTCCTTAGCCCCTGACCCCATCTTTCCGTTAACCGTGGGTCAAAATTATAGCCAG
GTGGCTTATCCCACCTTAGCCCTTAGTCAGGACCAGTGGGTCGAACAATTTGTCCCCTTGGTGACGTCCATTGGTCAACC
TCCAGCTACGTCATAG

Upstream 100 bases:

>100_bases
GGTATTTAGAACGTTTGACGTCTAACTGAGGGAAATAGTTGCTCGATTATCCTTCATAAAACAAGGTACGGTAGAGGGCA
ACATCCCATATGGAAAATTG

Downstream 100 bases:

>100_bases
TCTCCTTTTTAGGATAAAAATTGCGATGTCCCCTTCCCCCACCGTCCAACAATCTCAAGCGGCCCTTGCCAAATTTGCAG
CCCTGGATCCTCCGCCTATT

Product: inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MQTFWTSVVTFAHTVTQQVGERLLTEFGKVQATSKSDGSLVTQSDQWADHYLRQAIATAFPDHGVLSEEVEHIFPDTDWC
WVIDPIDGTTNFSRGVPIWGTSLGLLYQGVPVFGFVHFPPLGQTFHGFWSAPEQPDGAFCNQTPIHTRPDAPAGNQCFSL
CARSLSVLKNPFPCKLRMLGSASYNLLIVAQGVTIGAVEATPKIWDIAGVWPIIQAAGGAWISLAPDPIFPLTVGQNYSQ
VAYPTLALSQDQWVEQFVPLVTSIGQPPATS

Sequences:

>Translated_271_residues
MQTFWTSVVTFAHTVTQQVGERLLTEFGKVQATSKSDGSLVTQSDQWADHYLRQAIATAFPDHGVLSEEVEHIFPDTDWC
WVIDPIDGTTNFSRGVPIWGTSLGLLYQGVPVFGFVHFPPLGQTFHGFWSAPEQPDGAFCNQTPIHTRPDAPAGNQCFSL
CARSLSVLKNPFPCKLRMLGSASYNLLIVAQGVTIGAVEATPKIWDIAGVWPIIQAAGGAWISLAPDPIFPLTVGQNYSQ
VAYPTLALSQDQWVEQFVPLVTSIGQPPATS
>Mature_271_residues
MQTFWTSVVTFAHTVTQQVGERLLTEFGKVQATSKSDGSLVTQSDQWADHYLRQAIATAFPDHGVLSEEVEHIFPDTDWC
WVIDPIDGTTNFSRGVPIWGTSLGLLYQGVPVFGFVHFPPLGQTFHGFWSAPEQPDGAFCNQTPIHTRPDAPAGNQCFSL
CARSLSVLKNPFPCKLRMLGSASYNLLIVAQGVTIGAVEATPKIWDIAGVWPIIQAAGGAWISLAPDPIFPLTVGQNYSQ
VAYPTLALSQDQWVEQFVPLVTSIGQPPATS

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI221625487, Length=249, Percent_Identity=26.5060240963855, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI5031789, Length=249, Percent_Identity=26.5060240963855, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193202570, Length=235, Percent_Identity=27.6595744680851, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=232, Percent_Identity=27.5862068965517, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320493, Length=244, Percent_Identity=27.8688524590164, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357329, Length=273, Percent_Identity=28.2051282051282, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664918, Length=231, Percent_Identity=26.8398268398268, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 29500; Mature: 29500

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTFWTSVVTFAHTVTQQVGERLLTEFGKVQATSKSDGSLVTQSDQWADHYLRQAIATAF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEECCHHHHHHHHHHHHHHHC
PDHGVLSEEVEHIFPDTDWCWVIDPIDGTTNFSRGVPIWGTSLGLLYQGVPVFGFVHFPP
CCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCC
LGQTFHGFWSAPEQPDGAFCNQTPIHTRPDAPAGNQCFSLCARSLSVLKNPFPCKLRMLG
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
SASYNLLIVAQGVTIGAVEATPKIWDIAGVWPIIQAAGGAWISLAPDPIFPLTVGQNYSQ
CCCCEEEEEECCCEEEEEECCCCEEEHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCH
VAYPTLALSQDQWVEQFVPLVTSIGQPPATS
HHCCEEECCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQTFWTSVVTFAHTVTQQVGERLLTEFGKVQATSKSDGSLVTQSDQWADHYLRQAIATAF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEECCHHHHHHHHHHHHHHHC
PDHGVLSEEVEHIFPDTDWCWVIDPIDGTTNFSRGVPIWGTSLGLLYQGVPVFGFVHFPP
CCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCC
LGQTFHGFWSAPEQPDGAFCNQTPIHTRPDAPAGNQCFSLCARSLSVLKNPFPCKLRMLG
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
SASYNLLIVAQGVTIGAVEATPKIWDIAGVWPIIQAAGGAWISLAPDPIFPLTVGQNYSQ
CCCCEEEEEECCCEEEEEECCCCEEEHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCH
VAYPTLALSQDQWVEQFVPLVTSIGQPPATS
HHCCEEECCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]