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The map label for this gene is dxr

Identifier: 158333754

GI number: 158333754

Start: 549493

End: 550698

Strand: Direct

Name: dxr

Synonym: AM1_0563

Alternate gene names: 158333754

Gene position: 549493-550698 (Clockwise)

Preceding gene: 158333753

Following gene: 158333758

Centisome position: 8.45

GC content: 50.83

Gene sequence:

>1206_bases
GTGAAAGCAATTACTCTTCTCGGCTCAACAGGATCCATCGGCACCCAAACCCTGGATATTGTCGCTCAGTATCCCGATCA
GTTTCGAATTGTGGGGATGGCTGCTGGTCGCAATATTGAGCTGCTGTCACAACAAATACGGCAGTTCCGGCCTGAGATTG
TGGCGATCGCAGATCCGAATCAACTCTCTGATCTCAAAGATGCGATCGCAGATGTTGATCCTCAACCCCAACTTTTAGCC
GGAGAAGCGGGTGTGGTGGAAGTGGCCGCTTACGGTGATGCCGAATCCGTGGTTACCGGGATTGTTGGCTGTGCAGGTCT
ATTACCCACTATTGCCGCCATCAAGGCTGGAAAAGATATTGCCCTCGCCAATAAAGAGACCCTAATTGCGGGCGGTCCGG
TGGTACTACCCCTAGTGGAGAAACATGGGGTCAAGCTATTACCTGCAGACTCAGAGCATTCCGCCATTTTTCAGTGTTTA
CAAGGTGTGCCAGAAGGGGGACTACGCCGGATTATCCTGACGGCATCTGGGGGAGCATTCCGAGATTGGCCCGTAGAAAA
GTTACCGGAAGTCACCGTTGCTGATGCCCTCAAGCATCCCAATTGGTCCATGGGCAAAAAAATTACTGTTGACTCCGCCA
CCTTGATGAACAAAGGGCTGGAAGTGATTGAAGCCCATTACCTATTTGGCGTGGATTACGACCATATTGATATTGTTATC
CATCCCCAAAGCATTATTCACTCTTTGATTGAACTGCAAGATACGTCAGTGCTGGCTCAGCTAGGCTGGCCCGATATGCG
GCTTCCTCTGCTCTATTCCTTGTCCTGGCCCGAGCGCATTGCCACCGATTGGGAACAGTTAGATCTCGTTAAGTCTGGGG
ATCTAACCTTCCGTGAACCCAACCACCAGAAATATCCCTGTATGCAGTTGGCCTATGATGTGGGCCGCATGGGGGGAGCC
ATGCCAGCGGTAATGAATGCCGCCAATGAGCAGGCCGTTGCCTTGTTCTTAGAAGAAAAAATTAGCTTCTTAGATATTCC
CAAGGTGATTGAAACGGCTTGCGATCGCTATCAATCCCAAAACACCTTGCAACCTAGCCTAGAAGACATCCTGGCTGCTG
ATCAGTGGGCAAGACAAGAGATACTCACCATTAGCCAAAGCCAAACCCCAGTGGTTACGGCGAGTCCACAACTGTCGGCG
ATTTAG

Upstream 100 bases:

>100_bases
TCCCCACAGTTTACTTAAGCCATGCGTTGGTGATTGCCTCTCTCCCCTAGAGGTCCATTGACCTAGTAAGATAGGAGAGA
CCCGCAATTATTAAGAAACT

Downstream 100 bases:

>100_bases
TTGCGAGTTCTGTAGCCTGACGCCCCAGACTACAGGAGCTAGCAATGGCAAAGGGGACGGTTTGGGTGAACTGAAAAGGT
TCTTCGGCACGATGGACCTC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKAITLLGSTGSIGTQTLDIVAQYPDQFRIVGMAAGRNIELLSQQIRQFRPEIVAIADPNQLSDLKDAIADVDPQPQLLA
GEAGVVEVAAYGDAESVVTGIVGCAGLLPTIAAIKAGKDIALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQCL
QGVPEGGLRRIILTASGGAFRDWPVEKLPEVTVADALKHPNWSMGKKITVDSATLMNKGLEVIEAHYLFGVDYDHIDIVI
HPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYSLSWPERIATDWEQLDLVKSGDLTFREPNHQKYPCMQLAYDVGRMGGA
MPAVMNAANEQAVALFLEEKISFLDIPKVIETACDRYQSQNTLQPSLEDILAADQWARQEILTISQSQTPVVTASPQLSA
I

Sequences:

>Translated_401_residues
MKAITLLGSTGSIGTQTLDIVAQYPDQFRIVGMAAGRNIELLSQQIRQFRPEIVAIADPNQLSDLKDAIADVDPQPQLLA
GEAGVVEVAAYGDAESVVTGIVGCAGLLPTIAAIKAGKDIALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQCL
QGVPEGGLRRIILTASGGAFRDWPVEKLPEVTVADALKHPNWSMGKKITVDSATLMNKGLEVIEAHYLFGVDYDHIDIVI
HPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYSLSWPERIATDWEQLDLVKSGDLTFREPNHQKYPCMQLAYDVGRMGGA
MPAVMNAANEQAVALFLEEKISFLDIPKVIETACDRYQSQNTLQPSLEDILAADQWARQEILTISQSQTPVVTASPQLSA
I
>Mature_401_residues
MKAITLLGSTGSIGTQTLDIVAQYPDQFRIVGMAAGRNIELLSQQIRQFRPEIVAIADPNQLSDLKDAIADVDPQPQLLA
GEAGVVEVAAYGDAESVVTGIVGCAGLLPTIAAIKAGKDIALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQCL
QGVPEGGLRRIILTASGGAFRDWPVEKLPEVTVADALKHPNWSMGKKITVDSATLMNKGLEVIEAHYLFGVDYDHIDIVI
HPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYSLSWPERIATDWEQLDLVKSGDLTFREPNHQKYPCMQLAYDVGRMGGA
MPAVMNAANEQAVALFLEEKISFLDIPKVIETACDRYQSQNTLQPSLEDILAADQWARQEILTISQSQTPVVTASPQLSA
I

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:
GO:0005488: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
GO:0008299: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
GO:0016491: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
GO:0030604: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
GO:0046872: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
GO:0055114: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=389, Percent_Identity=42.4164524421594, Blast_Score=317, Evalue=6e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_ACAM1 (B0CD21)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001514926.1
- ProteinModelPortal:   B0CD21
- SMR:   B0CD21
- GeneID:   5679390
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_0563
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   AMAR329726:AM1_0563-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 43419; Mature: 43419

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 176-176 BINDING 199-199 BINDING 221-221

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAITLLGSTGSIGTQTLDIVAQYPDQFRIVGMAAGRNIELLSQQIRQFRPEIVAIADPN
CCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCH
QLSDLKDAIADVDPQPQLLAGEAGVVEVAAYGDAESVVTGIVGCAGLLPTIAAIKAGKDI
HHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
ALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQCLQGVPEGGLRRIILTASGGAF
EECCCCEEEECCCEEEEEHHHCCCEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCC
RDWPVEKLPEVTVADALKHPNWSMGKKITVDSATLMNKGLEVIEAHYLFGVDYDHIDIVI
CCCCHHHCCCCHHHHHHCCCCCCCCCEEEECHHHHHHCCHHHHEEHEEEECCCCCEEEEE
HPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYSLSWPERIATDWEQLDLVKSGDLTFREP
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHCCHHHHHEEECCCEEEECC
NHQKYPCMQLAYDVGRMGGAMPAVMNAANEQAVALFLEEKISFLDIPKVIETACDRYQSQ
CCCCCCHHHHHHHHHHCCCCHHHHHHCCCCHHEEHHHHHHHHHCCHHHHHHHHHHHHCCC
NTLQPSLEDILAADQWARQEILTISQSQTPVVTASPQLSAI
CCCCCCHHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCC
>Mature Secondary Structure
MKAITLLGSTGSIGTQTLDIVAQYPDQFRIVGMAAGRNIELLSQQIRQFRPEIVAIADPN
CCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCH
QLSDLKDAIADVDPQPQLLAGEAGVVEVAAYGDAESVVTGIVGCAGLLPTIAAIKAGKDI
HHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
ALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQCLQGVPEGGLRRIILTASGGAF
EECCCCEEEECCCEEEEEHHHCCCEEECCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCC
RDWPVEKLPEVTVADALKHPNWSMGKKITVDSATLMNKGLEVIEAHYLFGVDYDHIDIVI
CCCCHHHCCCCHHHHHHCCCCCCCCCEEEECHHHHHHCCHHHHEEHEEEECCCCCEEEEE
HPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYSLSWPERIATDWEQLDLVKSGDLTFREP
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHCCHHHHHEEECCCEEEECC
NHQKYPCMQLAYDVGRMGGAMPAVMNAANEQAVALFLEEKISFLDIPKVIETACDRYQSQ
CCCCCCHHHHHHHHHHCCCCHHHHHHCCCCHHEEHHHHHHHHHCCHHHHHHHHHHHHCCC
NTLQPSLEDILAADQWARQEILTISQSQTPVVTASPQLSAI
CCCCCCHHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA