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The map label for this gene is rpfC [H]

Identifier: 158333667

GI number: 158333667

Start: 447139

End: 449445

Strand: Direct

Name: rpfC [H]

Synonym: AM1_0469

Alternate gene names: 158333667

Gene position: 447139-449445 (Clockwise)

Preceding gene: 158333666

Following gene: 158333669

Centisome position: 6.88

GC content: 45.9

Gene sequence:

>2307_bases
ATGACTGAAGACTTTGTAACCTCATCGCCTCAGCATTCACAGTCCTGGCAGCAAGCCATTCTAGATAGTGCCGATTTCGT
TATTGTTTCAACAGATATTAATGGGTTAATTCAAACCCTAAATGCAGGAGCATTAAAACAATTTGGCTATTCACCTGAGG
AAATCATTGATAGAGTCACCCCAATCATCTTTCATGACCCAGAAGAAGTCGAGCAGCGGGCGCAAGTCCTCTCCCATGAG
TTGGGCCATGCCATTGAACCAGGTATGGAGACCCTTATCGTCAAAGCACGTATGGGGATGGTCGATGAAAATATCTGGAC
CTTGATTCGCAAAGATCACAGTCGGTTCCCCGTTCGCTTATCTGTTACAGCACTTAGGAATGATTTAGGCCATTTAACAG
GGTTTCTCGGGATTGGCAAAGATATTACTGCGCAACAAGCTGCTGAAGCCTCTCTAGTCGAAAGCGAAGCGCGATTCTCA
GCCGCGTTTCAAAATGCTCCTATAGGCATGGCTTTAGTGTCTCCCAGTGGTCAGTGCCTAAGAGTGAATCATGCCCTAGC
TCATTTACTGGGATATCCCCAAACCAAACTGATGGATCTCATCCTCACTGAGATGATCCATCCCAAAGATCGATCCATAG
AAGAAACGAACCGACTACGACTTGTTGCAAGAGAGATTGGCAACTACTGCTTAGAGCTACGCTGTCTTCATCAGCAGGGG
CATGAGGTATGGGTTTTGATGAATGTATCTCTGGTCAATGGCCAAGAGGTTTACCCTCCCTACTGCATTGTCCAAGTACA
AGATATTACCAGGCGCAAACAAGCAGAAGCACAACTCCAGCGCCTCAACGCCAATCTGGAGCAACTGGTTGAGGAACGGA
CTCGCCAACTCAAAGAAGCGATTGAAACCACTGAAATCGCCAATCAAGCCAAAAGCCGATTTATCGCCAATATGAGCCAT
GAGTTTCGCACGCCTCTCAACGGCATCATGGGTTTTAGTCAACTCTTGCTTCAAGATCGTCGCATTACGTCAGATCAGCA
ATCTAACCTCAATGTCATCCTTCGCAGTGGTGAGCACTTACTCTCGCTGGTCAACGAAGTCATTACCCTCTCCAAGATTG
AAGCAGGAATGCTTGCCTATGAGTCCAAAGATGTCAATCTGCACCATCTTTGTGAGGGGGTGGAAGACTTATTATCCCTA
CAGGCGAATTCCAAAGACATTCAGTTTCAAATTCATATCGCTCCTGACGTTCCCCAATACGTGAGAACAGATGCTAAAAA
ACTACGGCAAATCTTGATTAACTTACTGGGTAATGCCTTGAAGTTTACGAAACGAGGCAGTGTCGTGTGTCAGGTGCAGT
GGCGGCCTTCGGCACCGGAGCGCTCTGCCCATGAATTACATTTCATCATTCAAGATACAGGTCCAGGGATTCCTGGGCAT
TTACTACCTCAACTTTTTGAACCCTTTGCTCAAGACCCGTTGAATCGTGAGACATTTGGTGGCATTGGCTTGGGGCTAAC
CATTTGCCAAAGATTTATCCATCTGATGAAGGGGGACATTTCCATTGAGAGTGTTGAGGGGCAAGGAACAACCGTTAGTT
TTTACATTCAAGTTGAATCAGGTGAGCCTGTTCTAGAACCAGCAATATCTGAGACAACCGTTGAGGGTCTTGCAGAGAAT
ACTCCCTCCTATCGCGTTTTAGTCGTAGAAGATTATCCTGATAACCGCGAGATTTTGCTCATGATGCTTGAAGTAGTGGG
GTTTGAGGTCAAAGAGGCTGTGAATGGCCAAGAGGCAGTGGACCTTAACCGAACATGGCAACCCCATTTAATTTGGATGG
ATTTACAGCTGCCTGTATTAAATGGCCTGGAGGCTACTCAATTAATCAAATCCCAGAATCCAAATCCACCTGTCATCATT
GCCATCACCGCCCAGGCGCTGGAATCTGACGAAGTGAAAGCGCTCAAAGCTGGGTGCGATGACTATCTTCGTAAACCCTA
TCAAGCCGCTCAAGTTTTTGAGAAAATGGCTCAACATTTAGATATCACCTATCGTTATAAAACGTCCAATTCATCTCATA
CTTCAGCAGATCCGATTTCTCTCTCGGCAGATGAGTTAGCCAACATGCCCCCTTCCTGGATACAGCTTCTGTATGATGCT
GCCATTATGTTGGATGAAGATATGCTTGATCTCTTGCTTAGAGACATTCCTGATGACCAGCACTCCCTTAAATCTTCTTT
GGAGTATCTAATGGCCACTTATCAATATGACGTCATTATGGAGAAGGCTCAAGCGGTTTTGAGATAG

Upstream 100 bases:

>100_bases
TCAGCTGCCTCAACCTCACAAAAGATTGGAAAATCATAAGGTATAGGAATAGCTCAATGACTGTCCATTCGCATCTCTAG
AGAAGGGCAAGGTTGAAGAT

Downstream 100 bases:

>100_bases
TTAACGACGTGCCAACCTTTGGTCAGGGACTACGCGGGTCAACAAAATCTAACAATGGGAAAATCTGTGAGCATTGCTGA
GCTGTTCTGGGTGTCAGAAT

Product: two-component hybrid histidine kinase sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 768; Mature: 767

Protein sequence:

>768_residues
MTEDFVTSSPQHSQSWQQAILDSADFVIVSTDINGLIQTLNAGALKQFGYSPEEIIDRVTPIIFHDPEEVEQRAQVLSHE
LGHAIEPGMETLIVKARMGMVDENIWTLIRKDHSRFPVRLSVTALRNDLGHLTGFLGIGKDITAQQAAEASLVESEARFS
AAFQNAPIGMALVSPSGQCLRVNHALAHLLGYPQTKLMDLILTEMIHPKDRSIEETNRLRLVAREIGNYCLELRCLHQQG
HEVWVLMNVSLVNGQEVYPPYCIVQVQDITRRKQAEAQLQRLNANLEQLVEERTRQLKEAIETTEIANQAKSRFIANMSH
EFRTPLNGIMGFSQLLLQDRRITSDQQSNLNVILRSGEHLLSLVNEVITLSKIEAGMLAYESKDVNLHHLCEGVEDLLSL
QANSKDIQFQIHIAPDVPQYVRTDAKKLRQILINLLGNALKFTKRGSVVCQVQWRPSAPERSAHELHFIIQDTGPGIPGH
LLPQLFEPFAQDPLNRETFGGIGLGLTICQRFIHLMKGDISIESVEGQGTTVSFYIQVESGEPVLEPAISETTVEGLAEN
TPSYRVLVVEDYPDNREILLMMLEVVGFEVKEAVNGQEAVDLNRTWQPHLIWMDLQLPVLNGLEATQLIKSQNPNPPVII
AITAQALESDEVKALKAGCDDYLRKPYQAAQVFEKMAQHLDITYRYKTSNSSHTSADPISLSADELANMPPSWIQLLYDA
AIMLDEDMLDLLLRDIPDDQHSLKSSLEYLMATYQYDVIMEKAQAVLR

Sequences:

>Translated_768_residues
MTEDFVTSSPQHSQSWQQAILDSADFVIVSTDINGLIQTLNAGALKQFGYSPEEIIDRVTPIIFHDPEEVEQRAQVLSHE
LGHAIEPGMETLIVKARMGMVDENIWTLIRKDHSRFPVRLSVTALRNDLGHLTGFLGIGKDITAQQAAEASLVESEARFS
AAFQNAPIGMALVSPSGQCLRVNHALAHLLGYPQTKLMDLILTEMIHPKDRSIEETNRLRLVAREIGNYCLELRCLHQQG
HEVWVLMNVSLVNGQEVYPPYCIVQVQDITRRKQAEAQLQRLNANLEQLVEERTRQLKEAIETTEIANQAKSRFIANMSH
EFRTPLNGIMGFSQLLLQDRRITSDQQSNLNVILRSGEHLLSLVNEVITLSKIEAGMLAYESKDVNLHHLCEGVEDLLSL
QANSKDIQFQIHIAPDVPQYVRTDAKKLRQILINLLGNALKFTKRGSVVCQVQWRPSAPERSAHELHFIIQDTGPGIPGH
LLPQLFEPFAQDPLNRETFGGIGLGLTICQRFIHLMKGDISIESVEGQGTTVSFYIQVESGEPVLEPAISETTVEGLAEN
TPSYRVLVVEDYPDNREILLMMLEVVGFEVKEAVNGQEAVDLNRTWQPHLIWMDLQLPVLNGLEATQLIKSQNPNPPVII
AITAQALESDEVKALKAGCDDYLRKPYQAAQVFEKMAQHLDITYRYKTSNSSHTSADPISLSADELANMPPSWIQLLYDA
AIMLDEDMLDLLLRDIPDDQHSLKSSLEYLMATYQYDVIMEKAQAVLR
>Mature_767_residues
TEDFVTSSPQHSQSWQQAILDSADFVIVSTDINGLIQTLNAGALKQFGYSPEEIIDRVTPIIFHDPEEVEQRAQVLSHEL
GHAIEPGMETLIVKARMGMVDENIWTLIRKDHSRFPVRLSVTALRNDLGHLTGFLGIGKDITAQQAAEASLVESEARFSA
AFQNAPIGMALVSPSGQCLRVNHALAHLLGYPQTKLMDLILTEMIHPKDRSIEETNRLRLVAREIGNYCLELRCLHQQGH
EVWVLMNVSLVNGQEVYPPYCIVQVQDITRRKQAEAQLQRLNANLEQLVEERTRQLKEAIETTEIANQAKSRFIANMSHE
FRTPLNGIMGFSQLLLQDRRITSDQQSNLNVILRSGEHLLSLVNEVITLSKIEAGMLAYESKDVNLHHLCEGVEDLLSLQ
ANSKDIQFQIHIAPDVPQYVRTDAKKLRQILINLLGNALKFTKRGSVVCQVQWRPSAPERSAHELHFIIQDTGPGIPGHL
LPQLFEPFAQDPLNRETFGGIGLGLTICQRFIHLMKGDISIESVEGQGTTVSFYIQVESGEPVLEPAISETTVEGLAENT
PSYRVLVVEDYPDNREILLMMLEVVGFEVKEAVNGQEAVDLNRTWQPHLIWMDLQLPVLNGLEATQLIKSQNPNPPVIIA
ITAQALESDEVKALKAGCDDYLRKPYQAAQVFEKMAQHLDITYRYKTSNSSHTSADPISLSADELANMPPSWIQLLYDAA
IMLDEDMLDLLLRDIPDDQHSLKSSLEYLMATYQYDVIMEKAQAVLR

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=384, Percent_Identity=32.8125, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI1789149, Length=265, Percent_Identity=38.1132075471698, Blast_Score=167, Evalue=3e-42,
Organism=Escherichia coli, GI1788713, Length=383, Percent_Identity=32.1148825065274, Blast_Score=163, Evalue=4e-41,
Organism=Escherichia coli, GI87081816, Length=387, Percent_Identity=31.5245478036176, Blast_Score=162, Evalue=1e-40,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=33.8775510204082, Blast_Score=131, Evalue=2e-31,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=30.1310043668122, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788381, Length=139, Percent_Identity=36.6906474820144, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=272, Percent_Identity=27.9411764705882, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788549, Length=231, Percent_Identity=27.7056277056277, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790436, Length=248, Percent_Identity=25.4032258064516, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=27.4368231046931, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786599, Length=163, Percent_Identity=31.2883435582822, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1789809, Length=114, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1790300, Length=246, Percent_Identity=28.0487804878049, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786784, Length=112, Percent_Identity=33.9285714285714, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=25.2293577981651, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1787894, Length=236, Percent_Identity=28.8135593220339, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=163, Percent_Identity=36.1963190184049, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323034, Length=154, Percent_Identity=37.6623376623377, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 86223; Mature: 86092

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDFVTSSPQHSQSWQQAILDSADFVIVSTDINGLIQTLNAGALKQFGYSPEEIIDRVT
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCHHHHHCCCCHHHHHHHCC
PIIFHDPEEVEQRAQVLSHELGHAIEPGMETLIVKARMGMVDENIWTLIRKDHSRFPVRL
CEEEECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEE
SVTALRNDLGHLTGFLGIGKDITAQQAAEASLVESEARFSAAFQNAPIGMALVSPSGQCL
EHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEE
RVNHALAHLLGYPQTKLMDLILTEMIHPKDRSIEETNRLRLVAREIGNYCLELRCLHQQG
EHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
HEVWVLMNVSLVNGQEVYPPYCIVQVQDITRRKQAEAQLQRLNANLEQLVEERTRQLKEA
CEEEEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IETTEIANQAKSRFIANMSHEFRTPLNGIMGFSQLLLQDRRITSDQQSNLNVILRSGEHL
HHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHH
LSLVNEVITLSKIEAGMLAYESKDVNLHHLCEGVEDLLSLQANSKDIQFQIHIAPDVPQY
HHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHH
VRTDAKKLRQILINLLGNALKFTKRGSVVCQVQWRPSAPERSAHELHFIIQDTGPGIPGH
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCCHH
LLPQLFEPFAQDPLNRETFGGIGLGLTICQRFIHLMKGDISIESVEGQGTTVSFYIQVES
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECC
GEPVLEPAISETTVEGLAENTPSYRVLVVEDYPDNREILLMMLEVVGFEVKEAVNGQEAV
CCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEE
DLNRTWQPHLIWMDLQLPVLNGLEATQLIKSQNPNPPVIIAITAQALESDEVKALKAGCD
CCCCCCCCEEEEEEEECHHHCCCHHHHHHHCCCCCCCEEEEEEHHHCCCHHHHHHHHCHH
DYLRKPYQAAQVFEKMAQHLDITYRYKTSNSSHTSADPISLSADELANMPPSWIQLLYDA
HHHHCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHH
AIMLDEDMLDLLLRDIPDDQHSLKSSLEYLMATYQYDVIMEKAQAVLR
HHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEDFVTSSPQHSQSWQQAILDSADFVIVSTDINGLIQTLNAGALKQFGYSPEEIIDRVT
CCCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCHHHHHCCCCHHHHHHHCC
PIIFHDPEEVEQRAQVLSHELGHAIEPGMETLIVKARMGMVDENIWTLIRKDHSRFPVRL
CEEEECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEE
SVTALRNDLGHLTGFLGIGKDITAQQAAEASLVESEARFSAAFQNAPIGMALVSPSGQCL
EHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEE
RVNHALAHLLGYPQTKLMDLILTEMIHPKDRSIEETNRLRLVAREIGNYCLELRCLHQQG
EHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
HEVWVLMNVSLVNGQEVYPPYCIVQVQDITRRKQAEAQLQRLNANLEQLVEERTRQLKEA
CEEEEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IETTEIANQAKSRFIANMSHEFRTPLNGIMGFSQLLLQDRRITSDQQSNLNVILRSGEHL
HHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHH
LSLVNEVITLSKIEAGMLAYESKDVNLHHLCEGVEDLLSLQANSKDIQFQIHIAPDVPQY
HHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHH
VRTDAKKLRQILINLLGNALKFTKRGSVVCQVQWRPSAPERSAHELHFIIQDTGPGIPGH
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCCHH
LLPQLFEPFAQDPLNRETFGGIGLGLTICQRFIHLMKGDISIESVEGQGTTVSFYIQVES
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECC
GEPVLEPAISETTVEGLAENTPSYRVLVVEDYPDNREILLMMLEVVGFEVKEAVNGQEAV
CCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEE
DLNRTWQPHLIWMDLQLPVLNGLEATQLIKSQNPNPPVIIAITAQALESDEVKALKAGCD
CCCCCCCCEEEEEEEECHHHCCCHHHHHHHCCCCCCCEEEEEEHHHCCCHHHHHHHHCHH
DYLRKPYQAAQVFEKMAQHLDITYRYKTSNSSHTSADPISLSADELANMPPSWIQLLYDA
HHHHCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHH
AIMLDEDMLDLLLRDIPDDQHSLKSSLEYLMATYQYDVIMEKAQAVLR
HHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]