Click here to switch to the map view.

The map label for this gene is purM [H]

Identifier: 158333629

GI number: 158333629

Start: 405212

End: 406273

Strand: Direct

Name: purM [H]

Synonym: AM1_0430

Alternate gene names: 158333629

Gene position: 405212-406273 (Clockwise)

Preceding gene: 158333627

Following gene: 158333633

Centisome position: 6.23

GC content: 50.28

Gene sequence:

>1062_bases
ATGGATTATCGTGACGCTGGTGTGGACGTACAGGCAGGACGGACCTTTGTCAGTGATATCAAGCAGATGGTGGCCGACAC
CATTCGCCCAGAAGTTTTAGGCAATCTAGGGGGGTTCAATGGCCTATTTCAATTACCGACAGGCTATCAAGAACCAGTTC
TAGTCTCAGGGACTGACGGCGTCGGCACTAAGCTGAAGTTGGCCCAGGCTCTCAATCAGCATCACACCGTTGGCATCGAT
CTAGTCGCCATGTGTGTTAATGACGTGCTGACTTGTGGAGCAGAGCCTTTATTCTTCCTGGATTATCTCGCCACTAGCCA
ACTCCAACCTGAACAGCTCAAACAAGTCATCGCTGGGATCGCCCAAGGCTGCAAAACAGCTGGATGTGCCCTGCTAGGGG
GAGAGACCGCCGAAATGCCTGGGTTTTATCAGCCCAGTGAATATGACCTCGCAGGCTTTTGCGTTGGGATTGTCGATAAA
CAGAAACTGTTGAATGGAACCAAGATCAACATTGGAGATTCTGTAATTGGTTTAGCCAGTCAGGGCGTTCACAGTAATGG
ATTTAGCCTAGTGAGAAAGATCGTAGCTGAAGGCATCAATCCCCATCGAGCAGAACCTGGATGGGATTGGCAAGACTGTC
CTGAAAGGCTAGGGGGAATGAGCCTAGGCGAAACTCTTCTGACGCCAACTCAAATTTACGTCAAGCCCGTCTTGTCTGCT
CTTCGCTCCGGCTTAGATATTCACGGCATGGCCCATATCACCGGAGGCGGATTACCTGAGAATGGGCCTCGCTGCTTACA
ACCCGATCAATCCCTACAGCTCAACACCGGACAATGGCCGATTCCACCTATTTTTGCATGGCTTGCAGAGGCTGGACAGG
TGAGTCCAGCCGATATGTTTGAGACCTTCAATATGGGGATCGGATTTATGTTGGTCGTTGCCCCAGAGCAAACCCAAACA
ACCCTAGACTGGTTGGGTAAACATCAAATTTTAGCTTATGAGATTGGTTCAGTGGTTCCGGGAGACCAGTCAGTGCTGGG
ATTACCAATTGCTGAGAGTTAA

Upstream 100 bases:

>100_bases
GACTATAACTAGATTGATTTGGTCTTGATGATGTATTGCTTTGGTGGATCATAATCTGTCAATATGTCATGTTGCTCTTA
GGTATCGGAAAGGTTTGGGC

Downstream 100 bases:

>100_bases
ACCATGGGTTGTCCCAAAAAGACTCAGACATCCCTGAACCCAGAAAGCACCTTAACAAGACTCCCAATCTGGACAGGAAT
TGGTAGAAGCACCATAAGGA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MDYRDAGVDVQAGRTFVSDIKQMVADTIRPEVLGNLGGFNGLFQLPTGYQEPVLVSGTDGVGTKLKLAQALNQHHTVGID
LVAMCVNDVLTCGAEPLFFLDYLATSQLQPEQLKQVIAGIAQGCKTAGCALLGGETAEMPGFYQPSEYDLAGFCVGIVDK
QKLLNGTKINIGDSVIGLASQGVHSNGFSLVRKIVAEGINPHRAEPGWDWQDCPERLGGMSLGETLLTPTQIYVKPVLSA
LRSGLDIHGMAHITGGGLPENGPRCLQPDQSLQLNTGQWPIPPIFAWLAEAGQVSPADMFETFNMGIGFMLVVAPEQTQT
TLDWLGKHQILAYEIGSVVPGDQSVLGLPIAES

Sequences:

>Translated_353_residues
MDYRDAGVDVQAGRTFVSDIKQMVADTIRPEVLGNLGGFNGLFQLPTGYQEPVLVSGTDGVGTKLKLAQALNQHHTVGID
LVAMCVNDVLTCGAEPLFFLDYLATSQLQPEQLKQVIAGIAQGCKTAGCALLGGETAEMPGFYQPSEYDLAGFCVGIVDK
QKLLNGTKINIGDSVIGLASQGVHSNGFSLVRKIVAEGINPHRAEPGWDWQDCPERLGGMSLGETLLTPTQIYVKPVLSA
LRSGLDIHGMAHITGGGLPENGPRCLQPDQSLQLNTGQWPIPPIFAWLAEAGQVSPADMFETFNMGIGFMLVVAPEQTQT
TLDWLGKHQILAYEIGSVVPGDQSVLGLPIAES
>Mature_353_residues
MDYRDAGVDVQAGRTFVSDIKQMVADTIRPEVLGNLGGFNGLFQLPTGYQEPVLVSGTDGVGTKLKLAQALNQHHTVGID
LVAMCVNDVLTCGAEPLFFLDYLATSQLQPEQLKQVIAGIAQGCKTAGCALLGGETAEMPGFYQPSEYDLAGFCVGIVDK
QKLLNGTKINIGDSVIGLASQGVHSNGFSLVRKIVAEGINPHRAEPGWDWQDCPERLGGMSLGETLLTPTQIYVKPVLSA
LRSGLDIHGMAHITGGGLPENGPRCLQPDQSLQLNTGQWPIPPIFAWLAEAGQVSPADMFETFNMGIGFMLVVAPEQTQT
TLDWLGKHQILAYEIGSVVPGDQSVLGLPIAES

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=341, Percent_Identity=50.733137829912, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI209869995, Length=341, Percent_Identity=50.733137829912, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI209869993, Length=341, Percent_Identity=50.733137829912, Blast_Score=320, Evalue=1e-87,
Organism=Escherichia coli, GI1788845, Length=344, Percent_Identity=48.546511627907, Blast_Score=328, Evalue=4e-91,
Organism=Caenorhabditis elegans, GI17567511, Length=345, Percent_Identity=40.8695652173913, Blast_Score=240, Evalue=8e-64,
Organism=Saccharomyces cerevisiae, GI6321203, Length=343, Percent_Identity=46.6472303206997, Blast_Score=284, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24582400, Length=314, Percent_Identity=43.9490445859873, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37596; Mature: 37596

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00359 RIBOSOMAL_L11

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYRDAGVDVQAGRTFVSDIKQMVADTIRPEVLGNLGGFNGLFQLPTGYQEPVLVSGTDG
CCCCCCCCCHHHCHHHHHHHHHHHHHHHCHHHHHCCCCCCCEEECCCCCCCCEEEECCCC
VGTKLKLAQALNQHHTVGIDLVAMCVNDVLTCGAEPLFFLDYLATSQLQPEQLKQVIAGI
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AQGCKTAGCALLGGETAEMPGFYQPSEYDLAGFCVGIVDKQKLLNGTKINIGDSVIGLAS
HHHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHEEHHHHHHHHHCCCEEECCCHHHHHHH
QGVHSNGFSLVRKIVAEGINPHRAEPGWDWQDCPERLGGMSLGETLLTPTQIYVKPVLSA
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHH
LRSGLDIHGMAHITGGGLPENGPRCLQPDQSLQLNTGQWPIPPIFAWLAEAGQVSPADMF
HHCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCHHHHH
ETFNMGIGFMLVVAPEQTQTTLDWLGKHQILAYEIGSVVPGDQSVLGLPIAES
HHHCCCCEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCCCCC
>Mature Secondary Structure
MDYRDAGVDVQAGRTFVSDIKQMVADTIRPEVLGNLGGFNGLFQLPTGYQEPVLVSGTDG
CCCCCCCCCHHHCHHHHHHHHHHHHHHHCHHHHHCCCCCCCEEECCCCCCCCEEEECCCC
VGTKLKLAQALNQHHTVGIDLVAMCVNDVLTCGAEPLFFLDYLATSQLQPEQLKQVIAGI
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AQGCKTAGCALLGGETAEMPGFYQPSEYDLAGFCVGIVDKQKLLNGTKINIGDSVIGLAS
HHHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHEEHHHHHHHHHCCCEEECCCHHHHHHH
QGVHSNGFSLVRKIVAEGINPHRAEPGWDWQDCPERLGGMSLGETLLTPTQIYVKPVLSA
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHH
LRSGLDIHGMAHITGGGLPENGPRCLQPDQSLQLNTGQWPIPPIFAWLAEAGQVSPADMF
HHCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCHHHHH
ETFNMGIGFMLVVAPEQTQTTLDWLGKHQILAYEIGSVVPGDQSVLGLPIAES
HHHCCCCEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA