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The map label for this gene is pkn1 [H]

Identifier: 158333542

GI number: 158333542

Start: 313423

End: 315324

Strand: Direct

Name: pkn1 [H]

Synonym: AM1_0341

Alternate gene names: 158333542

Gene position: 313423-315324 (Clockwise)

Preceding gene: 158333539

Following gene: 158333543

Centisome position: 4.82

GC content: 51.42

Gene sequence:

>1902_bases
ATGGGTAAAAACTGGGCAATTGCCATTGGGATTAACGATTATCAAAATATGCGTCCGCTGAAATTTGCCCGAAAAGACGC
GGAGGCGGTGTGCCAGTTTTTTCAGGAGTCCTTGCATTTCGATAAGGTAGATTTGTTTGCCAAAGGGGCAGAGCCTGTCC
GCTATGAAGATGGTCCTCCCATTCAAGCTGACCCTACTGTCGGCAATTTAGATACGTTTTTTGATGTCCGGTTTGAACAC
CCATTTCTAGAGCCAGGAGATAACCTGTGGTTTTTCTTTGCTGGGCATGGCAAACGCCACAAGGGGCGAGATTATTTGAT
GCCGATTGATGGCAGCCCCCGTCGTGTTGAAAGGATGGGTATTGCCATTGATTATATTGCTGAGCGACTGCGACGTAGTG
GGGCGGATAATGTGATTTTGATGATTGACGCCTGCCGAGGCGAGGATGATCGGGATGGGGGTGAAGGGGTGGGTCGGCAA
CAGCAGAAAGGGATTATTACTCTGTTTGCCTGTAGCCCCAATGAGCTGTCCTATGAAATTGAGGAGATAGAGCAAGGGGC
GTTTACCCATACGCTGCTTGCCGGACTCCAGATCCAGGGGGCGGGTAATTGCGCGACGGTGGAACGTTTGAGCCAATACC
TGAGGGCGCAGGTGCCCGAGGTTAACCGTCGGTATAATAAACCTGCTCAGACGCCATATACTCGGATAGAACCTGAATCG
AAGCTGCATTTTATTTTGCTGCCGGGGCAAGCCACGCTGCAAGATGTAGCCACAATGAAAATTGATGCCCTGGTAGCTGA
GACGGAAAATGATTTGGATGGGGCTGAGCATCTGTGGACTCGGGTGTTAGCAGCTTCTCAGGCAGACTTTCAAGCGATTA
AGGGATTACAGCGAATTGCGGTCAAACGGGCAACGGGCCAGTCCCTTAGATCGACACCGACTCCAAGTCCAGAGACGCTA
ACCACTGGGGCTGATAACTCTTCCCGAGAACCTGCGAGTAATCTTCCGCCAGAATCGAAGGACAACCTGGCTGACAACAA
ACCGTCTAAACCTCAACCCTCAAGGGTGACGTTTTCGGTGGTCAAGGTGAATGCCCAAGGCGAGGTGATTGAGCAGCAAG
AGCAACAGACAGAACAAAGCTTGGTAATGTTGCCGGGAGAAGTCCCCCTATCTCTGGTTCACATTCCCCAGGGGAAGTTT
TGGATGGGTGCCCAGAAGAATGAAATAGATGCTCAAGATACTGAATACCCTAGGCATCAGGTATCGGTGCCCTCTTTTTG
GATGGGGCAATATCCGGTAACACAACGACAGTGGCAAGCGATTGCGGGGCTGAGCAAAGTCAAGGTGGATCTGGATCCAG
ACTGTTCCAATTTCAAAGGAGAGGCTTTACCTGTGGAGAAGGTGTCTTGGTATCAGGCCGTTGAATTTTGTGAGCGCCTA
TCACGACATTCCGGCCAAGACTATCGGTTACCGACTGAGGCAGAGTGGGAATATGCCTGTCGAGCGGGTACCGAAACCCC
TTTTTATTGTGGGGAAACTATTACAACAGATCAAGCCAATTACTGTGGTGATGCCACCTATGGGAACGGTCCAAAAGGGC
AGTATAGATCGAAAACCATAGCCGTCGGTTCATCTGCTGCCAATGCCTTTGGCTTATTTGCCATGCATGGCAATGTCTGG
GAATGGTGTCTGGATCATTGGCATGAGGATTATACAAACGCTCCTACCGATGGGACTGCTTGGTTAAGTGAAAATGATAA
TCATTATCGTCTGCTGCGGGGCGGTTCCTGGGGCAACTCTCCGAGGAGCTGCCGCTCGGCCTCGCGCCTCAGGCTCAGGC
CCGACTCCCAGAACGACTGCGTCGGTTTCCGTGTCGTGTGTGTTTCGGCGAGGGCCTTCTAG

Upstream 100 bases:

>100_bases
GGTGCTTTTTTGCAGATGTGGGCTGCTTGATATTGCTTGGGGGAGAAACCCGTTAAAAATATATGCGACATTAGAGAACA
GTTGGAAGTTCTGCTAGGTA

Downstream 100 bases:

>100_bases
CCCTTTACCCTCTTTCCCTTTTGCCCTTTGATCGAATTATTTTTTAAATTATCCTAATAAATAAAATCTTTATGGAAGAT
CTACCCGTTATTCAAAAGAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MGKNWAIAIGINDYQNMRPLKFARKDAEAVCQFFQESLHFDKVDLFAKGAEPVRYEDGPPIQADPTVGNLDTFFDVRFEH
PFLEPGDNLWFFFAGHGKRHKGRDYLMPIDGSPRRVERMGIAIDYIAERLRRSGADNVILMIDACRGEDDRDGGEGVGRQ
QQKGIITLFACSPNELSYEIEEIEQGAFTHTLLAGLQIQGAGNCATVERLSQYLRAQVPEVNRRYNKPAQTPYTRIEPES
KLHFILLPGQATLQDVATMKIDALVAETENDLDGAEHLWTRVLAASQADFQAIKGLQRIAVKRATGQSLRSTPTPSPETL
TTGADNSSREPASNLPPESKDNLADNKPSKPQPSRVTFSVVKVNAQGEVIEQQEQQTEQSLVMLPGEVPLSLVHIPQGKF
WMGAQKNEIDAQDTEYPRHQVSVPSFWMGQYPVTQRQWQAIAGLSKVKVDLDPDCSNFKGEALPVEKVSWYQAVEFCERL
SRHSGQDYRLPTEAEWEYACRAGTETPFYCGETITTDQANYCGDATYGNGPKGQYRSKTIAVGSSAANAFGLFAMHGNVW
EWCLDHWHEDYTNAPTDGTAWLSENDNHYRLLRGGSWGNSPRSCRSASRLRLRPDSQNDCVGFRVVCVSARAF

Sequences:

>Translated_633_residues
MGKNWAIAIGINDYQNMRPLKFARKDAEAVCQFFQESLHFDKVDLFAKGAEPVRYEDGPPIQADPTVGNLDTFFDVRFEH
PFLEPGDNLWFFFAGHGKRHKGRDYLMPIDGSPRRVERMGIAIDYIAERLRRSGADNVILMIDACRGEDDRDGGEGVGRQ
QQKGIITLFACSPNELSYEIEEIEQGAFTHTLLAGLQIQGAGNCATVERLSQYLRAQVPEVNRRYNKPAQTPYTRIEPES
KLHFILLPGQATLQDVATMKIDALVAETENDLDGAEHLWTRVLAASQADFQAIKGLQRIAVKRATGQSLRSTPTPSPETL
TTGADNSSREPASNLPPESKDNLADNKPSKPQPSRVTFSVVKVNAQGEVIEQQEQQTEQSLVMLPGEVPLSLVHIPQGKF
WMGAQKNEIDAQDTEYPRHQVSVPSFWMGQYPVTQRQWQAIAGLSKVKVDLDPDCSNFKGEALPVEKVSWYQAVEFCERL
SRHSGQDYRLPTEAEWEYACRAGTETPFYCGETITTDQANYCGDATYGNGPKGQYRSKTIAVGSSAANAFGLFAMHGNVW
EWCLDHWHEDYTNAPTDGTAWLSENDNHYRLLRGGSWGNSPRSCRSASRLRLRPDSQNDCVGFRVVCVSARAF
>Mature_632_residues
GKNWAIAIGINDYQNMRPLKFARKDAEAVCQFFQESLHFDKVDLFAKGAEPVRYEDGPPIQADPTVGNLDTFFDVRFEHP
FLEPGDNLWFFFAGHGKRHKGRDYLMPIDGSPRRVERMGIAIDYIAERLRRSGADNVILMIDACRGEDDRDGGEGVGRQQ
QKGIITLFACSPNELSYEIEEIEQGAFTHTLLAGLQIQGAGNCATVERLSQYLRAQVPEVNRRYNKPAQTPYTRIEPESK
LHFILLPGQATLQDVATMKIDALVAETENDLDGAEHLWTRVLAASQADFQAIKGLQRIAVKRATGQSLRSTPTPSPETLT
TGADNSSREPASNLPPESKDNLADNKPSKPQPSRVTFSVVKVNAQGEVIEQQEQQTEQSLVMLPGEVPLSLVHIPQGKFW
MGAQKNEIDAQDTEYPRHQVSVPSFWMGQYPVTQRQWQAIAGLSKVKVDLDPDCSNFKGEALPVEKVSWYQAVEFCERLS
RHSGQDYRLPTEAEWEYACRAGTETPFYCGETITTDQANYCGDATYGNGPKGQYRSKTIAVGSSAANAFGLFAMHGNVWE
WCLDHWHEDYTNAPTDGTAWLSENDNHYRLLRGGSWGNSPRSCRSASRLRLRPDSQNDCVGFRVVCVSARAF

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI257470975, Length=272, Percent_Identity=27.5735294117647, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI194248087, Length=276, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI38202250, Length=297, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI194248088, Length=285, Percent_Identity=27.3684210526316, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI226437577, Length=175, Percent_Identity=30.8571428571429, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI20130397, Length=314, Percent_Identity=25.1592356687898, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 70765; Mature: 70634

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKNWAIAIGINDYQNMRPLKFARKDAEAVCQFFQESLHFDKVDLFAKGAEPVRYEDGPP
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCCCC
IQADPTVGNLDTFFDVRFEHPFLEPGDNLWFFFAGHGKRHKGRDYLMPIDGSPRRVERMG
CCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHH
IAIDYIAERLRRSGADNVILMIDACRGEDDRDGGEGVGRQQQKGIITLFACSPNELSYEI
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEH
EEIEQGAFTHTLLAGLQIQGAGNCATVERLSQYLRAQVPEVNRRYNKPAQTPYTRIEPES
HHHHCCHHHHHHHHCEEEECCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCC
KLHFILLPGQATLQDVATMKIDALVAETENDLDGAEHLWTRVLAASQADFQAIKGLQRIA
CEEEEEECCCHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
VKRATGQSLRSTPTPSPETLTTGADNSSREPASNLPPESKDNLADNKPSKPQPSRVTFSV
HHHHCCCHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
VKVNAQGEVIEQQEQQTEQSLVMLPGEVPLSLVHIPQGKFWMGAQKNEIDAQDTEYPRHQ
EEECCCCCHHHHHHHHHHCCEEEECCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCC
VSVPSFWMGQYPVTQRQWQAIAGLSKVKVDLDPDCSNFKGEALPVEKVSWYQAVEFCERL
CCCCCEECCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
SRHSGQDYRLPTEAEWEYACRAGTETPFYCGETITTDQANYCGDATYGNGPKGQYRSKTI
HHCCCCCCCCCCCCCCHHHHHCCCCCCEECCCEEECCCCCCCCCCCCCCCCCCCCCCEEE
AVGSSAANAFGLFAMHGNVWEWCLDHWHEDYTNAPTDGTAWLSENDNHYRLLRGGSWGNS
EECCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCCCC
PRSCRSASRLRLRPDSQNDCVGFRVVCVSARAF
CHHHHCCCCEEECCCCCCCCEEEEEEEEECCCC
>Mature Secondary Structure 
GKNWAIAIGINDYQNMRPLKFARKDAEAVCQFFQESLHFDKVDLFAKGAEPVRYEDGPP
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCCCCCCCCC
IQADPTVGNLDTFFDVRFEHPFLEPGDNLWFFFAGHGKRHKGRDYLMPIDGSPRRVERMG
CCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCHHHHHHH
IAIDYIAERLRRSGADNVILMIDACRGEDDRDGGEGVGRQQQKGIITLFACSPNELSYEI
HHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEH
EEIEQGAFTHTLLAGLQIQGAGNCATVERLSQYLRAQVPEVNRRYNKPAQTPYTRIEPES
HHHHCCHHHHHHHHCEEEECCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCC
KLHFILLPGQATLQDVATMKIDALVAETENDLDGAEHLWTRVLAASQADFQAIKGLQRIA
CEEEEEECCCHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHH
VKRATGQSLRSTPTPSPETLTTGADNSSREPASNLPPESKDNLADNKPSKPQPSRVTFSV
HHHHCCCHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
VKVNAQGEVIEQQEQQTEQSLVMLPGEVPLSLVHIPQGKFWMGAQKNEIDAQDTEYPRHQ
EEECCCCCHHHHHHHHHHCCEEEECCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCC
VSVPSFWMGQYPVTQRQWQAIAGLSKVKVDLDPDCSNFKGEALPVEKVSWYQAVEFCERL
CCCCCEECCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
SRHSGQDYRLPTEAEWEYACRAGTETPFYCGETITTDQANYCGDATYGNGPKGQYRSKTI
HHCCCCCCCCCCCCCCHHHHHCCCCCCEECCCEEECCCCCCCCCCCCCCCCCCCCCCEEE
AVGSSAANAFGLFAMHGNVWEWCLDHWHEDYTNAPTDGTAWLSENDNHYRLLRGGSWGNS
EECCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCCCC
PRSCRSASRLRLRPDSQNDCVGFRVVCVSARAF
CHHHHCCCCEEECCCCCCCCEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]