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The map label for this gene is corA [H]

Identifier: 158333309

GI number: 158333309

Start: 84449

End: 85570

Strand: Direct

Name: corA [H]

Synonym: AM1_0079

Alternate gene names: 158333309

Gene position: 84449-85570 (Clockwise)

Preceding gene: 158333308

Following gene: 158333310

Centisome position: 1.3

GC content: 45.28

Gene sequence:

>1122_bases
ATGACCAATCCTCTATCAGACCCTTTGCAGCAAGGTTACGTTGATTATTTTTATGACCAAGCAGGCAGCTCTCCTGGAAC
CCTGACGATTGACGAAGATGCTTCACCCACTCGGATTGTTGTCATCGATTACAACCCACATCAAGCCCGCCGGATCATCG
TTGAACAACCTGAAGAAAGTGCAGATTATCTGACCACAGAAACCGTTTCTTGGATTGATGTTCAGGGACTAGGGGATGAG
GATATTCTGCGCCGATTAGGACAAACTTTCGATCTGCATCCCTTGGTTTTGGAAGATGTGGTGAATGTACCTCAACGCCA
AAAAGTTGAGGATTTCGATGATCAGCTTTTAATTATTGCCCGTATGGTTCTTCCTCACCCTGAAGGCGTCGGGTTTGTAA
GTGAACAAGTCAGCTTTATCTTGCATCAGCAAGCATTATTGACGATTCAAGAAGAGCCTTTCCATGATTCATTTGGGCCA
GTTCGCAAGCGAATTCGATTGCAGAAGGGATTGATGCGAAAAATGGGGGCTGACTTTCTCACCTATGCCCTCTTAGACGC
CATTATTGATGGTTTCTTCCCGGTGCTAGAACTTTACGGAGAGCGGTTAGAAACCTTAGAAGATGAAATACTCGACAATC
CCACGCGAGAGACCCTCAACCAAGTTCACTCTCTCAAACGTGAGTTGATGAATCTACGACGACTGAGTTGGTCACAACGG
GATGCTTTATCTGCCCTCCTACGGGAAGATAGCCCCCTAATCAGCCAAGAGGTAAAAGTGTATCTAAGGGACTGTTACGA
CCATTCCATCCAGATCTTAGACATGGTTGAAACATATCGAGATTTCGCGGCCAGTCTGATGGATGTTTATCTATCTTCTG
TGAGCAATAAAATGAACGAAGTGATGAAAGTCCTCACGGTCATCTCAACAATCTTTATTCCCTTAACCTTTATTTCAGGG
CTCTATGGCATGAACTTTAACCCTCAAGTTTCCCCTTTTAACATGCCTGAGTTGAGCTGGTACTGGGGATATCCTGCGGT
CATCGCTACCATGTTGCTGATTTCGGGAAGTCTAAGCTATTTATTTTGGCGTCGCGGTTGGTTTAGCAAGGTATCACCTT
GA

Upstream 100 bases:

>100_bases
GGTCTCATTCATGTTTGTAAATCAGGACCAGAGAAAGTTCCTGGGTTTGCAGGTAACAAGCAATGCAAACTATAGATGCA
GAAGCATTCTGGTTTCAGAC

Downstream 100 bases:

>100_bases
GTGCTCCACAATATTTCCTAGAGATTCAAAGGATTGATCAATCGCAACTGTTATTTATGGTGAGGCGACGTCTTAATATA
GAAGCGATATTTCCTAAATT

Product: magnesium and cobalt transport protein CorA

Products: Ni2; [Cytoplasm]; Co; 2 [Cytoplasm]; Mg (II) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTNPLSDPLQQGYVDYFYDQAGSSPGTLTIDEDASPTRIVVIDYNPHQARRIIVEQPEESADYLTTETVSWIDVQGLGDE
DILRRLGQTFDLHPLVLEDVVNVPQRQKVEDFDDQLLIIARMVLPHPEGVGFVSEQVSFILHQQALLTIQEEPFHDSFGP
VRKRIRLQKGLMRKMGADFLTYALLDAIIDGFFPVLELYGERLETLEDEILDNPTRETLNQVHSLKRELMNLRRLSWSQR
DALSALLREDSPLISQEVKVYLRDCYDHSIQILDMVETYRDFAASLMDVYLSSVSNKMNEVMKVLTVISTIFIPLTFISG
LYGMNFNPQVSPFNMPELSWYWGYPAVIATMLLISGSLSYLFWRRGWFSKVSP

Sequences:

>Translated_373_residues
MTNPLSDPLQQGYVDYFYDQAGSSPGTLTIDEDASPTRIVVIDYNPHQARRIIVEQPEESADYLTTETVSWIDVQGLGDE
DILRRLGQTFDLHPLVLEDVVNVPQRQKVEDFDDQLLIIARMVLPHPEGVGFVSEQVSFILHQQALLTIQEEPFHDSFGP
VRKRIRLQKGLMRKMGADFLTYALLDAIIDGFFPVLELYGERLETLEDEILDNPTRETLNQVHSLKRELMNLRRLSWSQR
DALSALLREDSPLISQEVKVYLRDCYDHSIQILDMVETYRDFAASLMDVYLSSVSNKMNEVMKVLTVISTIFIPLTFISG
LYGMNFNPQVSPFNMPELSWYWGYPAVIATMLLISGSLSYLFWRRGWFSKVSP
>Mature_372_residues
TNPLSDPLQQGYVDYFYDQAGSSPGTLTIDEDASPTRIVVIDYNPHQARRIIVEQPEESADYLTTETVSWIDVQGLGDED
ILRRLGQTFDLHPLVLEDVVNVPQRQKVEDFDDQLLIIARMVLPHPEGVGFVSEQVSFILHQQALLTIQEEPFHDSFGPV
RKRIRLQKGLMRKMGADFLTYALLDAIIDGFFPVLELYGERLETLEDEILDNPTRETLNQVHSLKRELMNLRRLSWSQRD
ALSALLREDSPLISQEVKVYLRDCYDHSIQILDMVETYRDFAASLMDVYLSSVSNKMNEVMKVLTVISTIFIPLTFISGL
YGMNFNPQVSPFNMPELSWYWGYPAVIATMLLISGSLSYLFWRRGWFSKVSP

Specific function: Mediates influx of magnesium ions [H]

COG id: COG0598

COG function: function code P; Mg2+ and Co2+ transporters

Gene ontology:
GO:0006824: Magnesium and cobalt transport protein CorA
GO:0015087: Magnesium and cobalt transport protein CorA
GO:0015095: Magnesium and cobalt transport protein CorA
GO:0015693: Magnesium and cobalt transport protein CorA
GO:0016020: Magnesium and cobalt transport protein CorA
GO:0030001: Magnesium and cobalt transport protein CorA
GO:0046873: Magnesium and cobalt transport protein CorA
GO:0055085: Magnesium and cobalt transport protein CorA

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family [H]

Homologues:

Organism=Escherichia coli, GI2367297, Length=307, Percent_Identity=27.0358306188925, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321058, Length=359, Percent_Identity=21.7270194986072, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004488
- InterPro:   IPR002523 [H]

Pfam domain/function: PF01544 CorA [H]

EC number: NA

Molecular weight: Translated: 42839; Mature: 42707

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLSDPLQQGYVDYFYDQAGSSPGTLTIDEDASPTRIVVIDYNPHQARRIIVEQPEES
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCCHHHHHHHHCCCCCH
ADYLTTETVSWIDVQGLGDEDILRRLGQTFDLHPLVLEDVVNVPQRQKVEDFDDQLLIIA
HHHHHHCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
RMVLPHPEGVGFVSEQVSFILHQQALLTIQEEPFHDSFGPVRKRIRLQKGLMRKMGADFL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHH
TYALLDAIIDGFFPVLELYGERLETLEDEILDNPTRETLNQVHSLKRELMNLRRLSWSQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
DALSALLREDSPLISQEVKVYLRDCYDHSIQILDMVETYRDFAASLMDVYLSSVSNKMNE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMKVLTVISTIFIPLTFISGLYGMNFNPQVSPFNMPELSWYWGYPAVIATMLLISGSLSY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHCCHHH
LFWRRGWFSKVSP
HHHHHCCCCCCCC
>Mature Secondary Structure 
TNPLSDPLQQGYVDYFYDQAGSSPGTLTIDEDASPTRIVVIDYNPHQARRIIVEQPEES
CCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCCHHHHHHHHCCCCCH
ADYLTTETVSWIDVQGLGDEDILRRLGQTFDLHPLVLEDVVNVPQRQKVEDFDDQLLIIA
HHHHHHCCCCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
RMVLPHPEGVGFVSEQVSFILHQQALLTIQEEPFHDSFGPVRKRIRLQKGLMRKMGADFL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHH
TYALLDAIIDGFFPVLELYGERLETLEDEILDNPTRETLNQVHSLKRELMNLRRLSWSQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHH
DALSALLREDSPLISQEVKVYLRDCYDHSIQILDMVETYRDFAASLMDVYLSSVSNKMNE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMKVLTVISTIFIPLTFISGLYGMNFNPQVSPFNMPELSWYWGYPAVIATMLLISGSLSY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHCCHHH
LFWRRGWFSKVSP
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; Co; 2 [Periplasm]; Mg (II) [Periplasm] [C]

Specific reaction: Ni2+ [Periplasm] = Ni2+ [Cytoplasm] Co+2 [Periplasm] = Co+2 [Cytoplasm] Mg (II) [Periplasm] = Mg (II) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]