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The map label for this gene is tuaD [H]

Identifier: 158318997

GI number: 158318997

Start: 8890013

End: 8891410

Strand: Reverse

Name: tuaD [H]

Synonym: Franean1_7280

Alternate gene names: 158318997

Gene position: 8891410-8890013 (Counterclockwise)

Preceding gene: 158319001

Following gene: 158318996

Centisome position: 98.99

GC content: 72.96

Gene sequence:

>1398_bases
ATGAGCACACCAGAAGCGGGGAGCCCGCTCCGGATCAGCGTTATAGGCACCGGATATCTCGGGGCCACACACGCGATCTG
CATGAGCGAGCTCGGTTTCGACGTTGTCGGCGTCGACGTCGACCAGGACAAGGTGCGCCGGCTCGCCGACGGCGAGGTGC
CCTTCTTCGAGCCGGGCCTCGAGGAGCTCCTGCGCAAGAACCTCGAGACCGGCCGGCTGGCCTTCACGACCTCCTTCGCC
GACGCGGCGAACGCGGACGTGCATTTCCTGTGCGTGGGCACCCCGCAGCGCGCGGACTCGGGCGCGGCCGACATGAGCTA
CGTCGACGGCGCCGTCGAGCGGCTCCTCGCCGCCCAACCGAAGGCCGGATCCCTGCTGGTGGGCAAGTCGACCGTCCCGG
CGGGGACGGCCGTGCGCCTCGCCGACTGGCTCGCCCGGGAGGCACCCGAGGTCGACCTCGCGTGGAACCCGGAGTTCCTG
CGGGAGGGCTTCGCGGTCGAGGACACCCTGCGCCCGGACCGGCTGGTCTTCGGCCTGCCCGCCGACGACGAGTGGTACGG
CGTGGCCGACCGCACCGACCAGGGCGACCACACCGGGCGCCGGGTCCGGGTCGAGGCCAGGCTGCGGGAGGTGTACGCGA
CCGCGCTGGCCGCCGGCACGCCGGCGGTCGTCGCCGACTTCGCCACCGCCGAGCTGGTCAAGGTGGCGGCGAACGCGTTC
CTCGCCACGAAGATCTCCTTCATCAACGCGATGTCCGAGGTCTGCGAGGTGGCGGGCGCCGACGTCAAGACCCTGGCCTC
GGCCCTCGCCTACGACACCCGGATCGGCGGGCGGTTCCTCGGCGCGGGCCTCGGCTTCGGTGGCGGCTGCCTGCCCAAGG
ACATCCGCGCCTTCCAGGCACGCGCCGAGGAGATGGGCGCCGGCCCGGCGCTCGGCTTCCTGAGCGAGGTCGACCGCGTC
AACCTGCGCCGCCGCAGCCGGACGGTGGAGCTGGCCATCCACCTGCTCGGCGGCGGCGCGGCCGGGCGGCGGGTCGCCGT
GCTCGGGGCCGCGTTCAAGCCGAACAGCGACGACATCCGCGACTCACCGGCGCTCGACGTCGCCGACGCGCTGCGCAAGG
CGGGTGCCCGCGTGACGGTCTACGACCCCGCGGCCATGGCGAACGCCGCCCGCAAGTTCCCCGACCTGCGCTACGCCTCG
GGCGTCTCCGAGGCGGTCACCGACGCCGACGTCGTGCTGCATCTCACCGAGTGGGCCGACTTCCGCGAGATCGAGCCGTC
GCTGCTGACGTCGCTGGTGCGTCGCCCGGTCATCATCGACGGCCGCAACACCCTCGACCCGCAGCGGTGGCGTGCCGCCG
GCTGGATCTACCACGCGCTCGGCCGCCCCAACGTATGA

Upstream 100 bases:

>100_bases
CGCCTCGCCCCGGCACCCCGCCTCATCTCCCGGAAACACGAGCGGTCCACAATGCGCTCCGCGGCCTTGCAGCCCGACGT
TGAGTGGGGGGATACACACA

Downstream 100 bases:

>100_bases
GCGGTCCGGGCAGGCCGGGGGAGGCCGGTCCGGACCGGCGCGGCTGGACGAGGCGGGCCCTGCTCGCCTCGTCCCTCGGC
GCGTTCGCGCTGGCGGGGAC

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSTPEAGSPLRISVIGTGYLGATHAICMSELGFDVVGVDVDQDKVRRLADGEVPFFEPGLEELLRKNLETGRLAFTTSFA
DAANADVHFLCVGTPQRADSGAADMSYVDGAVERLLAAQPKAGSLLVGKSTVPAGTAVRLADWLAREAPEVDLAWNPEFL
REGFAVEDTLRPDRLVFGLPADDEWYGVADRTDQGDHTGRRVRVEARLREVYATALAAGTPAVVADFATAELVKVAANAF
LATKISFINAMSEVCEVAGADVKTLASALAYDTRIGGRFLGAGLGFGGGCLPKDIRAFQARAEEMGAGPALGFLSEVDRV
NLRRRSRTVELAIHLLGGGAAGRRVAVLGAAFKPNSDDIRDSPALDVADALRKAGARVTVYDPAAMANAARKFPDLRYAS
GVSEAVTDADVVLHLTEWADFREIEPSLLTSLVRRPVIIDGRNTLDPQRWRAAGWIYHALGRPNV

Sequences:

>Translated_465_residues
MSTPEAGSPLRISVIGTGYLGATHAICMSELGFDVVGVDVDQDKVRRLADGEVPFFEPGLEELLRKNLETGRLAFTTSFA
DAANADVHFLCVGTPQRADSGAADMSYVDGAVERLLAAQPKAGSLLVGKSTVPAGTAVRLADWLAREAPEVDLAWNPEFL
REGFAVEDTLRPDRLVFGLPADDEWYGVADRTDQGDHTGRRVRVEARLREVYATALAAGTPAVVADFATAELVKVAANAF
LATKISFINAMSEVCEVAGADVKTLASALAYDTRIGGRFLGAGLGFGGGCLPKDIRAFQARAEEMGAGPALGFLSEVDRV
NLRRRSRTVELAIHLLGGGAAGRRVAVLGAAFKPNSDDIRDSPALDVADALRKAGARVTVYDPAAMANAARKFPDLRYAS
GVSEAVTDADVVLHLTEWADFREIEPSLLTSLVRRPVIIDGRNTLDPQRWRAAGWIYHALGRPNV
>Mature_464_residues
STPEAGSPLRISVIGTGYLGATHAICMSELGFDVVGVDVDQDKVRRLADGEVPFFEPGLEELLRKNLETGRLAFTTSFAD
AANADVHFLCVGTPQRADSGAADMSYVDGAVERLLAAQPKAGSLLVGKSTVPAGTAVRLADWLAREAPEVDLAWNPEFLR
EGFAVEDTLRPDRLVFGLPADDEWYGVADRTDQGDHTGRRVRVEARLREVYATALAAGTPAVVADFATAELVKVAANAFL
ATKISFINAMSEVCEVAGADVKTLASALAYDTRIGGRFLGAGLGFGGGCLPKDIRAFQARAEEMGAGPALGFLSEVDRVN
LRRRSRTVELAIHLLGGGAAGRRVAVLGAAFKPNSDDIRDSPALDVADALRKAGARVTVYDPAAMANAARKFPDLRYASG
VSEAVTDADVVLHLTEWADFREIEPSLLTSLVRRPVIIDGRNTLDPQRWRAAGWIYHALGRPNV

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=463, Percent_Identity=30.2375809935205, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI296040438, Length=365, Percent_Identity=30.958904109589, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI296040443, Length=305, Percent_Identity=32.1311475409836, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI48994968, Length=436, Percent_Identity=27.0642201834862, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788340, Length=410, Percent_Identity=23.6585365853659, Blast_Score=126, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17560350, Length=487, Percent_Identity=30.5954825462012, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17136908, Length=478, Percent_Identity=30.1255230125523, Blast_Score=207, Evalue=9e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 49612; Mature: 49480

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPEAGSPLRISVIGTGYLGATHAICMSELGFDVVGVDVDQDKVRRLADGEVPFFEPGL
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCCH
EELLRKNLETGRLAFTTSFADAANADVHFLCVGTPQRADSGAADMSYVDGAVERLLAAQP
HHHHHCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
KAGSLLVGKSTVPAGTAVRLADWLAREAPEVDLAWNPEFLREGFAVEDTLRPDRLVFGLP
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEECCCHHHHHCCCCCCCCCCCCCEEEECC
ADDEWYGVADRTDQGDHTGRRVRVEARLREVYATALAAGTPAVVADFATAELVKVAANAF
CCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LATKISFINAMSEVCEVAGADVKTLASALAYDTRIGGRFLGAGLGFGGGCLPKDIRAFQA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHEECCCCCCCCCCHHHHHHHHH
RAEEMGAGPALGFLSEVDRVNLRRRSRTVELAIHLLGGGAAGRRVAVLGAAFKPNSDDIR
HHHHHCCCCHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCC
DSPALDVADALRKAGARVTVYDPAAMANAARKFPDLRYASGVSEAVTDADVVLHLTEWAD
CCCCCCHHHHHHHCCCEEEEECCHHHHHHHHHCCCCHHHCCHHHHHCCCHHEEEEHHCCC
FREIEPSLLTSLVRRPVIIDGRNTLDPQRWRAAGWIYHALGRPNV
HHCCCHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STPEAGSPLRISVIGTGYLGATHAICMSELGFDVVGVDVDQDKVRRLADGEVPFFEPGL
CCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCCH
EELLRKNLETGRLAFTTSFADAANADVHFLCVGTPQRADSGAADMSYVDGAVERLLAAQP
HHHHHCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
KAGSLLVGKSTVPAGTAVRLADWLAREAPEVDLAWNPEFLREGFAVEDTLRPDRLVFGLP
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEECCCHHHHHCCCCCCCCCCCCCEEEECC
ADDEWYGVADRTDQGDHTGRRVRVEARLREVYATALAAGTPAVVADFATAELVKVAANAF
CCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LATKISFINAMSEVCEVAGADVKTLASALAYDTRIGGRFLGAGLGFGGGCLPKDIRAFQA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHEECCCCCCCCCCHHHHHHHHH
RAEEMGAGPALGFLSEVDRVNLRRRSRTVELAIHLLGGGAAGRRVAVLGAAFKPNSDDIR
HHHHHCCCCHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCC
DSPALDVADALRKAGARVTVYDPAAMANAARKFPDLRYASGVSEAVTDADVVLHLTEWAD
CCCCCCHHHHHHHCCCEEEEECCHHHHHHHHHCCCCHHHCCHHHHHCCCHHEEEEHHCCC
FREIEPSLLTSLVRRPVIIDGRNTLDPQRWRAAGWIYHALGRPNV
HHCCCHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]