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The map label for this gene is pdhA [H]

Identifier: 158318984

GI number: 158318984

Start: 8871021

End: 8872100

Strand: Direct

Name: pdhA [H]

Synonym: Franean1_7267

Alternate gene names: 158318984

Gene position: 8871021-8872100 (Clockwise)

Preceding gene: 158318980

Following gene: 158318985

Centisome position: 98.76

GC content: 71.67

Gene sequence:

>1080_bases
GTGACGGAGCTCGTGCAGCTGCTCACCCCCGACGGCCGCCGCATCGCCTCGGACTCCGGGCAGGAGACCGACTACCAGGC
ATTCGTGGCCGACGTAACCGACGACGACCTGCTCGGCCTGCTGCGGGACATGATCATCGTCCGGCGTCTCGACGACGAGG
GAACAGCGCTGCAGCGCCAGGGTGAGCTGTGCCTGTGGGCCAGCCTGCGCGGCCAGGAGGCGGCGCAGGTCGGCTCCGGT
CGCGCGCTCGGCCCATCCGACATGGCCTTCCCCTCCTACCGGGAACACGGTGTGGCCTGGTGTCGGGAGGTCGATCCGCT
GCACGTCTTCGGCCTGTTCCGGGGGACGTCGCTCGGTGGTTGGGACCCGGCCGAACACGGGTTCGCTCTCTACGCGATCG
TCGTCGGGTCGCAGACCCTGCACGCCGCCGGTTACGCCATGGGCATCACCCGGGACGGCGGCGACGGCGCCGCGATCTCC
TACTTCGGGGACGGCGCGTCCAGCGAGGGCGACGTGAGCGAGGCCTTCGGATGGGCCAGCGTCTTCTCCGCGCCGCTGGT
GTTCTTCTGCCAGAACAACCAGTGGGCGATCTCCGAGCCGTACCGGCGGCAGAGCCGGGTGCCGGTCTACCAGCGGGCGC
GCGGCTTCGGCTTCCCCAGCGTGCGAGTGGATGGCAACGACGTCCTCGCGACCCTCGCCGTGACCCGGTGGGCGCTGCGG
CAGGCCCGATCGGGGGGCGGCCCCGTCCTGGTCGAGGCGCTGACGTACCGGATCAATCCGCACACCACCGCCGACGACCC
GTCGCGTTACCGCCCGGCGGACGAGGTGTCCAGCTGGCGGATGCGCGACCCAATCGAGCGGCTGACGATCCATCTGCGGG
CCCGCGGCGCGCTGACCGACGAGCGGGAGGCCGGCCTGGCCGCTGAGGCGAACGCCGTGGCGGCGGACCTGCGCGCCCGC
TGCCTCGCGCTCCCCGACCCGCCCGAGGCCGCACTGTTCGACCACGTCCAGGTGACGGAGAACAATCTGGTTGCCGCCGA
GCGCGCCGCGTTCACGGAACTACGGGGAGCATTGCTTTGA

Upstream 100 bases:

>100_bases
ACCCGGCCCGGCGAACATCGTCCACCGGGATCTCACCAGGCGCGACGAACATCGCGTTGTCGGGTTGCCGCGGCCGGGAC
GAGGACTATCGTTTGCCCGT

Downstream 100 bases:

>100_bases
CGACCAGCGATACGGCCACGGGGGCGGCAACCGGCCCGATCGGCTCTATCGACGCCATCGACCCGGGTCCGGTCGATCCG
GTCTCCATCGGTCCGGACTC

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTELVQLLTPDGRRIASDSGQETDYQAFVADVTDDDLLGLLRDMIIVRRLDDEGTALQRQGELCLWASLRGQEAAQVGSG
RALGPSDMAFPSYREHGVAWCREVDPLHVFGLFRGTSLGGWDPAEHGFALYAIVVGSQTLHAAGYAMGITRDGGDGAAIS
YFGDGASSEGDVSEAFGWASVFSAPLVFFCQNNQWAISEPYRRQSRVPVYQRARGFGFPSVRVDGNDVLATLAVTRWALR
QARSGGGPVLVEALTYRINPHTTADDPSRYRPADEVSSWRMRDPIERLTIHLRARGALTDEREAGLAAEANAVAADLRAR
CLALPDPPEAALFDHVQVTENNLVAAERAAFTELRGALL

Sequences:

>Translated_359_residues
MTELVQLLTPDGRRIASDSGQETDYQAFVADVTDDDLLGLLRDMIIVRRLDDEGTALQRQGELCLWASLRGQEAAQVGSG
RALGPSDMAFPSYREHGVAWCREVDPLHVFGLFRGTSLGGWDPAEHGFALYAIVVGSQTLHAAGYAMGITRDGGDGAAIS
YFGDGASSEGDVSEAFGWASVFSAPLVFFCQNNQWAISEPYRRQSRVPVYQRARGFGFPSVRVDGNDVLATLAVTRWALR
QARSGGGPVLVEALTYRINPHTTADDPSRYRPADEVSSWRMRDPIERLTIHLRARGALTDEREAGLAAEANAVAADLRAR
CLALPDPPEAALFDHVQVTENNLVAAERAAFTELRGALL
>Mature_358_residues
TELVQLLTPDGRRIASDSGQETDYQAFVADVTDDDLLGLLRDMIIVRRLDDEGTALQRQGELCLWASLRGQEAAQVGSGR
ALGPSDMAFPSYREHGVAWCREVDPLHVFGLFRGTSLGGWDPAEHGFALYAIVVGSQTLHAAGYAMGITRDGGDGAAISY
FGDGASSEGDVSEAFGWASVFSAPLVFFCQNNQWAISEPYRRQSRVPVYQRARGFGFPSVRVDGNDVLATLAVTRWALRQ
ARSGGGPVLVEALTYRINPHTTADDPSRYRPADEVSSWRMRDPIERLTIHLRARGALTDEREAGLAAEANAVAADLRARC
LALPDPPEAALFDHVQVTENNLVAAERAAFTELRGALL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI258645172, Length=316, Percent_Identity=34.4936708860759, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI11386135, Length=317, Percent_Identity=34.384858044164, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=30.0911854103343, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI4505685, Length=314, Percent_Identity=29.2993630573248, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI291084742, Length=314, Percent_Identity=29.2993630573248, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI291084744, Length=321, Percent_Identity=28.9719626168224, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI291084757, Length=307, Percent_Identity=27.0358306188925, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI86563355, Length=279, Percent_Identity=34.7670250896057, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI86563357, Length=279, Percent_Identity=34.7670250896057, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17536047, Length=312, Percent_Identity=28.525641025641, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32564172, Length=312, Percent_Identity=28.525641025641, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321026, Length=322, Percent_Identity=32.2981366459627, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21355903, Length=324, Percent_Identity=31.7901234567901, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24639744, Length=301, Percent_Identity=29.5681063122924, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571106, Length=301, Percent_Identity=29.5681063122924, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24639740, Length=301, Percent_Identity=29.5681063122924, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24639746, Length=289, Percent_Identity=29.757785467128, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24639748, Length=282, Percent_Identity=29.0780141843972, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39005; Mature: 38874

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELVQLLTPDGRRIASDSGQETDYQAFVADVTDDDLLGLLRDMIIVRRLDDEGTALQRQ
CCCHHHHHCCCCCEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHC
GELCLWASLRGQEAAQVGSGRALGPSDMAFPSYREHGVAWCREVDPLHVFGLFRGTSLGG
CCEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCC
WDPAEHGFALYAIVVGSQTLHAAGYAMGITRDGGDGAAISYFGDGASSEGDVSEAFGWAS
CCCCCCCEEEEEEEECCCHHHHCCEEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHH
VFSAPLVFFCQNNQWAISEPYRRQSRVPVYQRARGFGFPSVRVDGNDVLATLAVTRWALR
HHCCCEEEEECCCCEECCCCHHHHCCCCHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHH
QARSGGGPVLVEALTYRINPHTTADDPSRYRPADEVSSWRMRDPIERLTIHLRARGALTD
HHHCCCCCEEEEEEEEEECCCCCCCCCHHCCCHHHHHCCHHCCCHHHEEEEEEECCCCCC
EREAGLAAEANAVAADLRARCLALPDPPEAALFDHVQVTENNLVAAERAAFTELRGALL
HHHCCCCHHHHHHHHHHHHHEECCCCCCCHHHHCCEEECCCCEEHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TELVQLLTPDGRRIASDSGQETDYQAFVADVTDDDLLGLLRDMIIVRRLDDEGTALQRQ
CCHHHHHCCCCCEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHC
GELCLWASLRGQEAAQVGSGRALGPSDMAFPSYREHGVAWCREVDPLHVFGLFRGTSLGG
CCEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCC
WDPAEHGFALYAIVVGSQTLHAAGYAMGITRDGGDGAAISYFGDGASSEGDVSEAFGWAS
CCCCCCCEEEEEEEECCCHHHHCCEEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHH
VFSAPLVFFCQNNQWAISEPYRRQSRVPVYQRARGFGFPSVRVDGNDVLATLAVTRWALR
HHCCCEEEEECCCCEECCCCHHHHCCCCHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHH
QARSGGGPVLVEALTYRINPHTTADDPSRYRPADEVSSWRMRDPIERLTIHLRARGALTD
HHHCCCCCEEEEEEEEEECCCCCCCCCHHCCCHHHHHCCHHCCCHHHEEEEEEECCCCCC
EREAGLAAEANAVAADLRARCLALPDPPEAALFDHVQVTENNLVAAERAAFTELRGALL
HHHCCCCHHHHHHHHHHHHHEECCCCCCCHHHHCCEEECCCCEEHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA