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The map label for this gene is htrA [H]

Identifier: 158318956

GI number: 158318956

Start: 8839011

End: 8840720

Strand: Direct

Name: htrA [H]

Synonym: Franean1_7239

Alternate gene names: 158318956

Gene position: 8839011-8840720 (Clockwise)

Preceding gene: 158318955

Following gene: 158318957

Centisome position: 98.41

GC content: 73.63

Gene sequence:

>1710_bases
ATGACTACCACGCACGACGCCCGGTCCCCTTGGGCTCCGCCCGACAACGCGCCGGAGCGGACCAGGGCCGAGGCGAACAG
TTCGGAGGGGTCGGTGGACCCGCGGTCGAATCCCGTCGAACACCAGCAGTACCCCGGTACGCCGCCGGCCGGCGGCCCGC
CGCCCGGGCCCGGCCCGAGCCGTCCTGACCAGACCGGCGGTTTTCCGGCGGGCCCCCCGCCGGCGCCGCACCCGGCCGGG
CCGGCGCCCGGCACGGGCGCGCCCGGCGGGCCCTACGAGCCGGGCCCGCAGCAGGGCCCCCGGCCGACCGCGCCCTACGC
CCAGACCTCCGGCTGGGCCGACCCCCGCTCCACCGCCGGCGCTGGCGACAGCACGCAACGGGTCGACCAGGGCGGCCCGG
CCACCGGCCAGGGCCAGCAGCAGTCCGGCGCGTGGTGGAACCCCGGGCATCCCGGCTGGGGCGCCCCGGTGCCGCCCGGA
GCGGCTCCCGGCGGTCAGGCACCCGGTGGCCAGGCGCCCGGGTCACCGGGCGGCTCCGATCCCTACGGGCGGTTCACCCC
GGCGAAGCCGAACCCGGCGCCCATGCGCCGGCGTCGGATGATCGCGGCCGCGCTGGCGATCGCGCTCGTGTCGGGCGGCA
TCGGCGGCGGCGTCGGCGCACTCGTCGCCAGCGACGACTCCCCGGCGGTGGTGACCTCCTCCGCCGGCCTGCGGCAGTCG
ACCGGCACGGCCGGCGTCTCCCCGGCCGCGGACAACACGGTCGCCGCGGCCGCGCAGGCGATCCTGCCCAGTGTCGTGAC
GATCGCCGAACAGTCCAGCCAGGAGTCGGGCACCGGCTCCGGGACGATCATCCGCGCGGACGGCTACATCCTCACGAACA
ACCACGTGGTGTCCGGCGCCTCGCAGGGCGGCACCCTCACGGTCACGATGCAGGACGGCCGGACCTTCGACGCGCAGGTC
AAGGCGACCGACCCGAGCTCCGACCTCGCCGTGGTCAAGATCGACGCTACCGGCCTGCCCGCTGCCACGTTCGGGGACTC
CGACGCACTGCAGGTCGGCGAGCTCGTCGTCGCTGTCGGCAGCCCGCTGGGCCTCAACGGGACGGTCACCTCCGGCATCG
TCAGCTCGCTGCACCGGCCCGTCCGCACCGGCGACGCGACCGTGCGGGACCAGCAGAACACCGTCCTGGACGCGATCCAG
ACCGACGCGCCCATCAATCCCGGCAACTCGGGTGGGCCGCTGGTGAACAGCAAGGGCGAGATCATCGGCGTGAACACCGC
AATCGCGACGGTCGGCGGCAGTTCACCCTTTGGTGGTAGTCAGCAGTCCGGAAACATCGGGGTTGGTTTCGCGATTCCGG
GCAACTACGCGGAGAAGGTCGCCGGCCAGCTCGTCGACAACGGCGCAGCGCAGCACCCCTATCTGGGTGTGAGCGCCTCC
ACCGCCGACGAGAACACCCGGTCGACGGCCGCGAGTGGGACGGGCGCGCAGATCCGCTCCCTGGTCAGTGGAGGCCCGGC
AGACAAAGCGGGCCTGCACGTAGGTGACGTCATCACCAAAGTGGGGGATCGCGCCGTCACCGACGTGGATTCGCTGATCG
CCGCCGTCCGGTCCTACGAGATCGGCAACCAGGTGCAGGTCACCTACCAGCGCGACGGCTCCAGCCAGACCGCGACGGTC
ACGCTGCTCGAACAACCGCCCAATTCCTGA

Upstream 100 bases:

>100_bases
GGCAGGATGTCCGGGAGCGGACACCCTTCGCGGCGCCGACTAAGCGGAACGTAGGTTGGAATTCAGGAATCGCTCAGGGT
CCCGGGGGAAAGTGCTTACC

Downstream 100 bases:

>100_bases
TCACCACACTGACGATGGTTCTCGGGAATACCAGGCGGTTTCTTCACCAGTCGCCTGGACCGGTCCGGCCCCGGCGATGC
TGGAGCGGATACGTCGAAGC

Product: peptidase S1 and S6 chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 568

Protein sequence:

>569_residues
MTTTHDARSPWAPPDNAPERTRAEANSSEGSVDPRSNPVEHQQYPGTPPAGGPPPGPGPSRPDQTGGFPAGPPPAPHPAG
PAPGTGAPGGPYEPGPQQGPRPTAPYAQTSGWADPRSTAGAGDSTQRVDQGGPATGQGQQQSGAWWNPGHPGWGAPVPPG
AAPGGQAPGGQAPGSPGGSDPYGRFTPAKPNPAPMRRRRMIAAALAIALVSGGIGGGVGALVASDDSPAVVTSSAGLRQS
TGTAGVSPAADNTVAAAAQAILPSVVTIAEQSSQESGTGSGTIIRADGYILTNNHVVSGASQGGTLTVTMQDGRTFDAQV
KATDPSSDLAVVKIDATGLPAATFGDSDALQVGELVVAVGSPLGLNGTVTSGIVSSLHRPVRTGDATVRDQQNTVLDAIQ
TDAPINPGNSGGPLVNSKGEIIGVNTAIATVGGSSPFGGSQQSGNIGVGFAIPGNYAEKVAGQLVDNGAAQHPYLGVSAS
TADENTRSTAASGTGAQIRSLVSGGPADKAGLHVGDVITKVGDRAVTDVDSLIAAVRSYEIGNQVQVTYQRDGSSQTATV
TLLEQPPNS

Sequences:

>Translated_569_residues
MTTTHDARSPWAPPDNAPERTRAEANSSEGSVDPRSNPVEHQQYPGTPPAGGPPPGPGPSRPDQTGGFPAGPPPAPHPAG
PAPGTGAPGGPYEPGPQQGPRPTAPYAQTSGWADPRSTAGAGDSTQRVDQGGPATGQGQQQSGAWWNPGHPGWGAPVPPG
AAPGGQAPGGQAPGSPGGSDPYGRFTPAKPNPAPMRRRRMIAAALAIALVSGGIGGGVGALVASDDSPAVVTSSAGLRQS
TGTAGVSPAADNTVAAAAQAILPSVVTIAEQSSQESGTGSGTIIRADGYILTNNHVVSGASQGGTLTVTMQDGRTFDAQV
KATDPSSDLAVVKIDATGLPAATFGDSDALQVGELVVAVGSPLGLNGTVTSGIVSSLHRPVRTGDATVRDQQNTVLDAIQ
TDAPINPGNSGGPLVNSKGEIIGVNTAIATVGGSSPFGGSQQSGNIGVGFAIPGNYAEKVAGQLVDNGAAQHPYLGVSAS
TADENTRSTAASGTGAQIRSLVSGGPADKAGLHVGDVITKVGDRAVTDVDSLIAAVRSYEIGNQVQVTYQRDGSSQTATV
TLLEQPPNS
>Mature_568_residues
TTTHDARSPWAPPDNAPERTRAEANSSEGSVDPRSNPVEHQQYPGTPPAGGPPPGPGPSRPDQTGGFPAGPPPAPHPAGP
APGTGAPGGPYEPGPQQGPRPTAPYAQTSGWADPRSTAGAGDSTQRVDQGGPATGQGQQQSGAWWNPGHPGWGAPVPPGA
APGGQAPGGQAPGSPGGSDPYGRFTPAKPNPAPMRRRRMIAAALAIALVSGGIGGGVGALVASDDSPAVVTSSAGLRQST
GTAGVSPAADNTVAAAAQAILPSVVTIAEQSSQESGTGSGTIIRADGYILTNNHVVSGASQGGTLTVTMQDGRTFDAQVK
ATDPSSDLAVVKIDATGLPAATFGDSDALQVGELVVAVGSPLGLNGTVTSGIVSSLHRPVRTGDATVRDQQNTVLDAIQT
DAPINPGNSGGPLVNSKGEIIGVNTAIATVGGSSPFGGSQQSGNIGVGFAIPGNYAEKVAGQLVDNGAAQHPYLGVSAST
ADENTRSTAASGTGAQIRSLVSGGPADKAGLHVGDVITKVGDRAVTDVDSLIAAVRSYEIGNQVQVTYQRDGSSQTATVT
LLEQPPNS

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=315, Percent_Identity=33.6507936507937, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI22129776, Length=306, Percent_Identity=34.3137254901961, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI7019477, Length=298, Percent_Identity=36.241610738255, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI24308541, Length=308, Percent_Identity=32.4675324675325, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1786356, Length=296, Percent_Identity=40.2027027027027, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1789629, Length=291, Percent_Identity=38.4879725085911, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1789630, Length=300, Percent_Identity=35.6666666666667, Blast_Score=135, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24646839, Length=268, Percent_Identity=33.955223880597, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 56214; Mature: 56083

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCEEEEEEECCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
TTTHDARSPWAPPDNAPERTRAEANSSEGSVDPRSNPVEHQQYPGTPPAGGPPPGPGPS
CCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RPDQTGGFPAGPPPAPHPAGPAPGTGAPGGPYEPGPQQGPRPTAPYAQTSGWADPRSTAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AGDSTQRVDQGGPATGQGQQQSGAWWNPGHPGWGAPVPPGAAPGGQAPGGQAPGSPGGSD
CCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PYGRFTPAKPNPAPMRRRRMIAAALAIALVSGGIGGGVGALVASDDSPAVVTSSAGLRQS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCCCCC
TGTAGVSPAADNTVAAAAQAILPSVVTIAEQSSQESGTGSGTIIRADGYILTNNHVVSGA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCEEEECC
SQGGTLTVTMQDGRTFDAQVKATDPSSDLAVVKIDATGLPAATFGDSDALQVGELVVAVG
CCCCEEEEEECCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCHHHHCEEEEEEC
SPLGLNGTVTSGIVSSLHRPVRTGDATVRDQQNTVLDAIQTDAPINPGNSGGPLVNSKGE
CCCCCCCCHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCEECCCCC
IIGVNTAIATVGGSSPFGGSQQSGNIGVGFAIPGNYAEKVAGQLVDNGAAQHPYLGVSAS
EEEECEEEEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
TADENTRSTAASGTGAQIRSLVSGGPADKAGLHVGDVITKVGDRAVTDVDSLIAAVRSYE
CCCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHC
IGNQVQVTYQRDGSSQTATVTLLEQPPNS
CCCEEEEEEECCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]