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The map label for this gene is phr [H]

Identifier: 158318950

GI number: 158318950

Start: 8831178

End: 8832407

Strand: Reverse

Name: phr [H]

Synonym: Franean1_7233

Alternate gene names: 158318950

Gene position: 8832407-8831178 (Counterclockwise)

Preceding gene: 158318954

Following gene: 158318946

Centisome position: 98.33

GC content: 74.63

Gene sequence:

>1230_bases
GTGTGGTGGCTTCGCCGTGACCTCCGCCTCGACGACAACCCGGCGCTGCTCGCCGCCGCCGAGTCCGGCCGGGTGCTGGC
TCTCTTCGTCCTCGACGACGCGCTGCGGCGCCCGTCCGGTCCCGTCCGCCTGGCGTTCCTCCACCGGTGCCTGCGCGACC
TGGACGCCCAGCTCGGCGGCCGGCTGTGCGTGCGCACCGGCTCGCCCTACGCGGTAGCGCCCGGCCGCCTGCGCAAGGCC
GACGGGACGTCCTACCGGGTGTTCACGCCCTTCTACCGGGCCTGGAAGGAACACGGCTGGCGCGGGCCGGCCATCCCGGC
GGATCCGGTCTGGCTCCAGCCCGCCGACCTCGACGGCGGCAGCGAACCGATCCCGGCGGATCCGGAGCTCGGGGGCACCG
AGCTACCCCCGGCCGGCGAACACGCCGCGCACGAGCGCCTGCGCGCCTTCCTGACCGAATCGCTGGCCGGCTACGCGGCG
CACCGCGACGAGCCGGCCGCGGCCAGCGAATCGGGAGACGCCGTACCCGGCTGGTCCGGGGCCAGCCGGGCTGGCGGGGC
CGGTGGCGCTGGCGGGGCTGGCGGGGCCGATGCGGCTGGCGGGGGCGGCGGGCTGGCCGGTTCGGCCGAGAAGTTCCGCT
CCGAGCTCGCCTGGCGGGAGTTCTACGCGGACGTCCTCGCCGGCACCCCCTCGTCGGCCCGGACCGACCTCACCGACACC
CTGGCCGCGTTGGCCTACGAGCCTCCCGGTGACACCTTCGAGGCGTGGAAGTGGGGCCGCACCGGTTACCCGATCGTCGA
CGCCGGCATGCGCCAGCTCCTCGCCGAGGGCTGGGTGCACAACCGGGTCCGGATGATCGAGGCCTCGTTCGTCTGCAAGG
ACCTGAACGTCCACCGGACGCACGGCGCCCGCTGGTACCTCGAGCGCCTCGTCGACGGCGACCTCGCGTCCAACAACCAC
GGCTGGCAGTGGACGGCCGGCACCGGAACCGACGCCGCCCCGTACTTCCGGGTCTTCAACCCCGTCTCGCAGGGGCGCAA
GTTCGATCCCGCCGGGGAGTACATCCGCCGATGGGTCCCCGAACTGCGCGGCCTCCCGCCCGACGCGGTGCACGAGCCGT
GGAAACTCCCGGCCGGCCCGCCGAACGGCTACCCACGCCCAGTCGTCGATCACGCTGTCGAACGCCGGGAGGCCCTCGAC
CGCCACGCCCGAGCCCGACACCACGACTAA

Upstream 100 bases:

>100_bases
CTCGCGTGACATCGGAGTGGTCTCCGTTGGTTACCCGTGGTGACGGGCTACCGTCCGTCGGATGAGCTCGCCCCCCTCGA
CGCAGGCGGTGACGCAGGCG

Downstream 100 bases:

>100_bases
CCGGCTTAACCGGCTTAACCGGCATGACCGGCATGACCGGCTCGGGCACCACCGGGCCGGGCCGGGCGGGTCCGCGGCGG
ATCGTCAGGTTCGTCCAAAT

Product: deoxyribodipyrimidine photo-lyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MWWLRRDLRLDDNPALLAAAESGRVLALFVLDDALRRPSGPVRLAFLHRCLRDLDAQLGGRLCVRTGSPYAVAPGRLRKA
DGTSYRVFTPFYRAWKEHGWRGPAIPADPVWLQPADLDGGSEPIPADPELGGTELPPAGEHAAHERLRAFLTESLAGYAA
HRDEPAAASESGDAVPGWSGASRAGGAGGAGGAGGADAAGGGGGLAGSAEKFRSELAWREFYADVLAGTPSSARTDLTDT
LAALAYEPPGDTFEAWKWGRTGYPIVDAGMRQLLAEGWVHNRVRMIEASFVCKDLNVHRTHGARWYLERLVDGDLASNNH
GWQWTAGTGTDAAPYFRVFNPVSQGRKFDPAGEYIRRWVPELRGLPPDAVHEPWKLPAGPPNGYPRPVVDHAVERREALD
RHARARHHD

Sequences:

>Translated_409_residues
MWWLRRDLRLDDNPALLAAAESGRVLALFVLDDALRRPSGPVRLAFLHRCLRDLDAQLGGRLCVRTGSPYAVAPGRLRKA
DGTSYRVFTPFYRAWKEHGWRGPAIPADPVWLQPADLDGGSEPIPADPELGGTELPPAGEHAAHERLRAFLTESLAGYAA
HRDEPAAASESGDAVPGWSGASRAGGAGGAGGAGGADAAGGGGGLAGSAEKFRSELAWREFYADVLAGTPSSARTDLTDT
LAALAYEPPGDTFEAWKWGRTGYPIVDAGMRQLLAEGWVHNRVRMIEASFVCKDLNVHRTHGARWYLERLVDGDLASNNH
GWQWTAGTGTDAAPYFRVFNPVSQGRKFDPAGEYIRRWVPELRGLPPDAVHEPWKLPAGPPNGYPRPVVDHAVERREALD
RHARARHHD
>Mature_409_residues
MWWLRRDLRLDDNPALLAAAESGRVLALFVLDDALRRPSGPVRLAFLHRCLRDLDAQLGGRLCVRTGSPYAVAPGRLRKA
DGTSYRVFTPFYRAWKEHGWRGPAIPADPVWLQPADLDGGSEPIPADPELGGTELPPAGEHAAHERLRAFLTESLAGYAA
HRDEPAAASESGDAVPGWSGASRAGGAGGAGGAGGADAAGGGGGLAGSAEKFRSELAWREFYADVLAGTPSSARTDLTDT
LAALAYEPPGDTFEAWKWGRTGYPIVDAGMRQLLAEGWVHNRVRMIEASFVCKDLNVHRTHGARWYLERLVDGDLASNNH
GWQWTAGTGTDAAPYFRVFNPVSQGRKFDPAGEYIRRWVPELRGLPPDAVHEPWKLPAGPPNGYPRPVVDHAVERREALD
RHARARHHD

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=203, Percent_Identity=31.5270935960591, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI188536103, Length=203, Percent_Identity=31.5270935960591, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI4758072, Length=203, Percent_Identity=31.0344827586207, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI1786926, Length=377, Percent_Identity=38.9920424403183, Blast_Score=225, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6324962, Length=353, Percent_Identity=32.5779036827195, Blast_Score=173, Evalue=5e-44,
Organism=Drosophila melanogaster, GI17137248, Length=196, Percent_Identity=37.7551020408163, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24585455, Length=196, Percent_Identity=37.7551020408163, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24648152, Length=201, Percent_Identity=31.3432835820896, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 44408; Mature: 44408

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWWLRRDLRLDDNPALLAAAESGRVLALFVLDDALRRPSGPVRLAFLHRCLRDLDAQLGG
CCCCCCCCCCCCCCCEEEEECCCCEEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
RLCVRTGSPYAVAPGRLRKADGTSYRVFTPFYRAWKEHGWRGPAIPADPVWLQPADLDGG
EEEEECCCCCEECCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCC
SEPIPADPELGGTELPPAGEHAAHERLRAFLTESLAGYAAHRDEPAAASESGDAVPGWSG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
ASRAGGAGGAGGAGGADAAGGGGGLAGSAEKFRSELAWREFYADVLAGTPSSARTDLTDT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LAALAYEPPGDTFEAWKWGRTGYPIVDAGMRQLLAEGWVHNRVRMIEASFVCKDLNVHRT
HHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
HGARWYLERLVDGDLASNNHGWQWTAGTGTDAAPYFRVFNPVSQGRKFDPAGEYIRRWVP
CCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHCHHHCCCCCCHHHHHHHHHHH
ELRGLPPDAVHEPWKLPAGPPNGYPRPVVDHAVERREALDRHARARHHD
HHCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MWWLRRDLRLDDNPALLAAAESGRVLALFVLDDALRRPSGPVRLAFLHRCLRDLDAQLGG
CCCCCCCCCCCCCCCEEEEECCCCEEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
RLCVRTGSPYAVAPGRLRKADGTSYRVFTPFYRAWKEHGWRGPAIPADPVWLQPADLDGG
EEEEECCCCCEECCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCC
SEPIPADPELGGTELPPAGEHAAHERLRAFLTESLAGYAAHRDEPAAASESGDAVPGWSG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
ASRAGGAGGAGGAGGADAAGGGGGLAGSAEKFRSELAWREFYADVLAGTPSSARTDLTDT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LAALAYEPPGDTFEAWKWGRTGYPIVDAGMRQLLAEGWVHNRVRMIEASFVCKDLNVHRT
HHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
HGARWYLERLVDGDLASNNHGWQWTAGTGTDAAPYFRVFNPVSQGRKFDPAGEYIRRWVP
CCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHCHHHCCCCCCHHHHHHHHHHH
ELRGLPPDAVHEPWKLPAGPPNGYPRPVVDHAVERREALDRHARARHHD
HHCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]