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The map label for this gene is purM [H]

Identifier: 158318926

GI number: 158318926

Start: 8801947

End: 8803107

Strand: Reverse

Name: purM [H]

Synonym: Franean1_7209

Alternate gene names: 158318926

Gene position: 8803107-8801947 (Counterclockwise)

Preceding gene: 158318927

Following gene: 158318923

Centisome position: 98.01

GC content: 73.39

Gene sequence:

>1161_bases
GTGAGGCACGCCAACGGATCCGGCCAGGGCTCAGAGGCCGGCGGCCAGGGGAGCACCACCGAGGGGCGCTCGGTCTCCTA
CCGGGACGCCGGGGTCGACGTCGAGGCCGGCGACCGGGCCGTGCAGCTCATGCGCCAGCACGTCGCCCGCGCCACCCGGC
CCGAGGTCGTCGGGTCACTCGGCGGCTTCGCGGGCCTGTTCGCGCTGGACGTGGCCCGTTACCGGCACCCGCTGCTCGCC
TCGTCCACCGACGGCGTGGGCACGAAGATCGCCCTGGCCAGGGCGATGGACGTCCATGACACGGTGGGCATCGACCTGGT
CGCCATGGTGGTCGACGATCTCGTTGTCTGCGGCGCGGAGCCGCTGTTCCTGCTCGACTACATCGCCTGTGGCTCCCTCG
AGCCGGCGCGGATCGCCTCGATCGTCGCCGGGATCGCCGCCGGCTGCGAGCAGGCCGGGTGCGCCCTGGTGGGTGGCGAG
ACCGCGGAGCACCCCGGCCTCATGGGAATCGACGACTACGACCTGGCCGCGACGGGGGTCGGGGTCGTCGAGGCCGACGC
CGTGCTCGGGCCGGAGCTGGTCCGGCCGGGGGACGTGGTGGTCGCGATGGGGTCATCCGGTCTCCACTCCAACGGTTTCT
CGCTGGTAAGACACATCCTGTTCGGTCCGGTCGAGCCTGACCAGCCCGGAGGCGTCTCCGTGGCGGGTCGGGAGGCACTG
TCGAGGCACGAAGAGGCCCTGGGGACGACGCTCGGGCAGGCGTTGCTCACGCCCACCCGCATCTACGCCCGGGACTGCCT
GGCCGTCATCGAGACGGCCGAGGTGCACGCCTTCGCCCACATCACCGGCGGCGGTCTCGCGGCGAACCTGGCCCGCGTGA
TCCCGCCGGGGACGGCTGCCGTCGTGGAGAGATCGACCTGGGCTCCGCAGGCCGTGTTCGGCCTGCTCGCCGAGCGCGGC
GGGGTGAGCGAGGCCGACATGGAGGCCACGTTCAACCAGGGGGTCGGAATGGTCGCGGTCGTCGCTCCCGCCGAGGCCGA
GGCTGTGGTGCGGACGCTGGCTGACCGCGGCGTCGCTGCCTGGATCGCGGGGCGGGTCGAGCCGCTGCCCGGCGGAGCTG
GAGAGGACGGCGTGGCGCGCCTCGTGGGTGCCCACCCCTGA

Upstream 100 bases:

>100_bases
GCGCACCGGCCGACGGGGTGGCCACGAACGGAGCCATCGTGAACGGGATGACAGCGGACGGGGTGGCAGTGGACGGCGCA
CCGCTGGGCAGCGCGCGGTG

Downstream 100 bases:

>100_bases
TGTGGCTGGCGGCCCGGCCACGGGCGGCCCTGGTGCGGCTCGCCCCGCCACGGCCGCCCGGGCAAAGGGGCGGCTGGTCA
CGAGCCGGCTCGTCGGGGGC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MRHANGSGQGSEAGGQGSTTEGRSVSYRDAGVDVEAGDRAVQLMRQHVARATRPEVVGSLGGFAGLFALDVARYRHPLLA
SSTDGVGTKIALARAMDVHDTVGIDLVAMVVDDLVVCGAEPLFLLDYIACGSLEPARIASIVAGIAAGCEQAGCALVGGE
TAEHPGLMGIDDYDLAATGVGVVEADAVLGPELVRPGDVVVAMGSSGLHSNGFSLVRHILFGPVEPDQPGGVSVAGREAL
SRHEEALGTTLGQALLTPTRIYARDCLAVIETAEVHAFAHITGGGLAANLARVIPPGTAAVVERSTWAPQAVFGLLAERG
GVSEADMEATFNQGVGMVAVVAPAEAEAVVRTLADRGVAAWIAGRVEPLPGGAGEDGVARLVGAHP

Sequences:

>Translated_386_residues
MRHANGSGQGSEAGGQGSTTEGRSVSYRDAGVDVEAGDRAVQLMRQHVARATRPEVVGSLGGFAGLFALDVARYRHPLLA
SSTDGVGTKIALARAMDVHDTVGIDLVAMVVDDLVVCGAEPLFLLDYIACGSLEPARIASIVAGIAAGCEQAGCALVGGE
TAEHPGLMGIDDYDLAATGVGVVEADAVLGPELVRPGDVVVAMGSSGLHSNGFSLVRHILFGPVEPDQPGGVSVAGREAL
SRHEEALGTTLGQALLTPTRIYARDCLAVIETAEVHAFAHITGGGLAANLARVIPPGTAAVVERSTWAPQAVFGLLAERG
GVSEADMEATFNQGVGMVAVVAPAEAEAVVRTLADRGVAAWIAGRVEPLPGGAGEDGVARLVGAHP
>Mature_386_residues
MRHANGSGQGSEAGGQGSTTEGRSVSYRDAGVDVEAGDRAVQLMRQHVARATRPEVVGSLGGFAGLFALDVARYRHPLLA
SSTDGVGTKIALARAMDVHDTVGIDLVAMVVDDLVVCGAEPLFLLDYIACGSLEPARIASIVAGIAAGCEQAGCALVGGE
TAEHPGLMGIDDYDLAATGVGVVEADAVLGPELVRPGDVVVAMGSSGLHSNGFSLVRHILFGPVEPDQPGGVSVAGREAL
SRHEEALGTTLGQALLTPTRIYARDCLAVIETAEVHAFAHITGGGLAANLARVIPPGTAAVVERSTWAPQAVFGLLAERG
GVSEADMEATFNQGVGMVAVVAPAEAEAVVRTLADRGVAAWIAGRVEPLPGGAGEDGVARLVGAHP

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=348, Percent_Identity=47.1264367816092, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI209869995, Length=348, Percent_Identity=47.1264367816092, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI209869993, Length=348, Percent_Identity=47.1264367816092, Blast_Score=285, Evalue=7e-77,
Organism=Escherichia coli, GI1788845, Length=348, Percent_Identity=47.1264367816092, Blast_Score=298, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17567511, Length=383, Percent_Identity=33.420365535248, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321203, Length=363, Percent_Identity=42.1487603305785, Blast_Score=256, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24582400, Length=286, Percent_Identity=37.4125874125874, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 39119; Mature: 39119

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHANGSGQGSEAGGQGSTTEGRSVSYRDAGVDVEAGDRAVQLMRQHVARATRPEVVGSL
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
GGFAGLFALDVARYRHPLLASSTDGVGTKIALARAMDVHDTVGIDLVAMVVDDLVVCGAE
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
PLFLLDYIACGSLEPARIASIVAGIAAGCEQAGCALVGGETAEHPGLMGIDDYDLAATGV
HHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHCCEEEECCCCCCCCCCCCCCCCCHHHCCC
GVVEADAVLGPELVRPGDVVVAMGSSGLHSNGFSLVRHILFGPVEPDQPGGVSVAGREAL
CEEECCHHCCHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
SRHEEALGTTLGQALLTPTRIYARDCLAVIETAEVHAFAHITGGGLAANLARVIPPGTAA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCCCHHH
VVERSTWAPQAVFGLLAERGGVSEADMEATFNQGVGMVAVVAPAEAEAVVRTLADRGVAA
HHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCHHH
WIAGRVEPLPGGAGEDGVARLVGAHP
HHHCCCCCCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MRHANGSGQGSEAGGQGSTTEGRSVSYRDAGVDVEAGDRAVQLMRQHVARATRPEVVGSL
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
GGFAGLFALDVARYRHPLLASSTDGVGTKIALARAMDVHDTVGIDLVAMVVDDLVVCGAE
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
PLFLLDYIACGSLEPARIASIVAGIAAGCEQAGCALVGGETAEHPGLMGIDDYDLAATGV
HHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHCCEEEECCCCCCCCCCCCCCCCCHHHCCC
GVVEADAVLGPELVRPGDVVVAMGSSGLHSNGFSLVRHILFGPVEPDQPGGVSVAGREAL
CEEECCHHCCHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
SRHEEALGTTLGQALLTPTRIYARDCLAVIETAEVHAFAHITGGGLAANLARVIPPGTAA
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCCCHHH
VVERSTWAPQAVFGLLAERGGVSEADMEATFNQGVGMVAVVAPAEAEAVVRTLADRGVAA
HHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCHHH
WIAGRVEPLPGGAGEDGVARLVGAHP
HHHCCCCCCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA