Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 158318910

GI number: 158318910

Start: 8782704

End: 8783825

Strand: Reverse

Name: fadA [H]

Synonym: Franean1_7193

Alternate gene names: 158318910

Gene position: 8783825-8782704 (Counterclockwise)

Preceding gene: 158318917

Following gene: 158318909

Centisome position: 97.79

GC content: 72.73

Gene sequence:

>1122_bases
GTGCGCACGCCGATCGGGAAGCGCAACGGCTCCCTGGCGGGCGTGCACCCGGTGGAGCTGGGCGCCCTGGTGCTCAACGA
GCTCGTCAACCGGACCGGGATCGATCCCGCGCTCGTCGACGACGTCCAGTGGGGGTGCGTGACCCAGCTCGGTGACCAGT
CGAGCAACGTCGGCCGGTACACCGTCCTCGCCGCCGGCTGGCCCGAGAGCGTTCCCGGGGTCACCGTGAACCGGGCGTGC
GGATCGAGCCAGCAGGCGCTCGACCACGCCGCGTTCGCCGTCATGTCCGGCCAGCAGGACCTCGTCGTGGCCGGCGGTGT
CGAGTCGATGAGCCGCATCCCGATGGGTGCCACCCGGCAGATGGGCGAGCCCTACGGGCCGAGCGCCAAGGCACGCTACG
ACGGCACCGACTTCAACCAGATCGTCGGCGCCGAGCGGATCGCGCGGCGGTGGGGCTTCTCCCGCCAGCAGCTGGACGAG
TTCTCCTCGCTGAGCCACGAGCGCGCGGCCGCGGCGATCGACGCCGGCGCCTTCGAGCAGCAGATCGTCGCCGTCCCGAC
CGAGTCCGGCCCGTTCACCGTCGACGAGGGCCTGCGGCGCGGCACGACGCCGGAGAAGCTCGCCGGGCTCAAGCCCGTCA
CCGGCGAGGACGGCCTGCTGCATGCCGGAAGCTCCTCCCAGATCTCCGACGGCGCCGCCGCGCTGCTCGTGACCACCCCC
GAGAAGGCGCGCGAGCTGGGCCTGCGACCGATCGTGCGCTACCGCAGCGGCGCGGTCGTCGGCTCCGACCCGTTGCTCGT
CCTGAGCGGGCCGATCCCGGCGACGGAGAAGGTGCTCGCCCGGGCCGGGCTCTCCATCGGCGACATCGGCGCGTTCGAGG
TCAACGAGGCCTTCGCCTCCGTCCCGCTGGCCTGGCTGGCGGACACCGGCGCCGACCCGAAGGTCCTCAACCCGCTGGGC
GGCGCCATCGCGGTCGGGCATCCCCTGGGTGCCTCGGGCGCGATCCTGATGACCCGCCTCGCCCACCACATGCGCGACAA
CGGCATCCGGTACGGGCTGCAGACCATGTGCGAAGGCGGTGGCACCGCCAACGCCGCGATCGTGGAACTCGTCGCTGACT
GA

Upstream 100 bases:

>100_bases
AGTCGGGCGGCAGGGACGTCAAGGCACGAACTGTGGCACGGTTGGGCGCAGGGACGAGAGAAGAGGGACTGCCGTGCGAG
AAGCAGTGATCGTGGAGGCG

Downstream 100 bases:

>100_bases
CCAGCCGCTCCCGGAGGATCCCCGACCCCGATCCGCCGGAGTGAATCCCGTCGCCGAGGCGCTTTACCGGACCATCCGGC
AGCGTCGGGACGTCCGCGGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MRTPIGKRNGSLAGVHPVELGALVLNELVNRTGIDPALVDDVQWGCVTQLGDQSSNVGRYTVLAAGWPESVPGVTVNRAC
GSSQQALDHAAFAVMSGQQDLVVAGGVESMSRIPMGATRQMGEPYGPSAKARYDGTDFNQIVGAERIARRWGFSRQQLDE
FSSLSHERAAAAIDAGAFEQQIVAVPTESGPFTVDEGLRRGTTPEKLAGLKPVTGEDGLLHAGSSSQISDGAAALLVTTP
EKARELGLRPIVRYRSGAVVGSDPLLVLSGPIPATEKVLARAGLSIGDIGAFEVNEAFASVPLAWLADTGADPKVLNPLG
GAIAVGHPLGASGAILMTRLAHHMRDNGIRYGLQTMCEGGGTANAAIVELVAD

Sequences:

>Translated_373_residues
MRTPIGKRNGSLAGVHPVELGALVLNELVNRTGIDPALVDDVQWGCVTQLGDQSSNVGRYTVLAAGWPESVPGVTVNRAC
GSSQQALDHAAFAVMSGQQDLVVAGGVESMSRIPMGATRQMGEPYGPSAKARYDGTDFNQIVGAERIARRWGFSRQQLDE
FSSLSHERAAAAIDAGAFEQQIVAVPTESGPFTVDEGLRRGTTPEKLAGLKPVTGEDGLLHAGSSSQISDGAAALLVTTP
EKARELGLRPIVRYRSGAVVGSDPLLVLSGPIPATEKVLARAGLSIGDIGAFEVNEAFASVPLAWLADTGADPKVLNPLG
GAIAVGHPLGASGAILMTRLAHHMRDNGIRYGLQTMCEGGGTANAAIVELVAD
>Mature_373_residues
MRTPIGKRNGSLAGVHPVELGALVLNELVNRTGIDPALVDDVQWGCVTQLGDQSSNVGRYTVLAAGWPESVPGVTVNRAC
GSSQQALDHAAFAVMSGQQDLVVAGGVESMSRIPMGATRQMGEPYGPSAKARYDGTDFNQIVGAERIARRWGFSRQQLDE
FSSLSHERAAAAIDAGAFEQQIVAVPTESGPFTVDEGLRRGTTPEKLAGLKPVTGEDGLLHAGSSSQISDGAAALLVTTP
EKARELGLRPIVRYRSGAVVGSDPLLVLSGPIPATEKVLARAGLSIGDIGAFEVNEAFASVPLAWLADTGADPKVLNPLG
GAIAVGHPLGASGAILMTRLAHHMRDNGIRYGLQTMCEGGGTANAAIVELVAD

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=382, Percent_Identity=36.9109947643979, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI4501853, Length=370, Percent_Identity=37.8378378378378, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI167614485, Length=384, Percent_Identity=33.3333333333333, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4557237, Length=382, Percent_Identity=35.3403141361257, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI4504327, Length=414, Percent_Identity=34.0579710144928, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI194353979, Length=372, Percent_Identity=27.9569892473118, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI48994986, Length=382, Percent_Identity=41.3612565445026, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1787663, Length=392, Percent_Identity=41.3265306122449, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI87082165, Length=382, Percent_Identity=40.3141361256544, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=38.9312977099237, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1788683, Length=401, Percent_Identity=29.1770573566085, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI133906874, Length=386, Percent_Identity=36.5284974093264, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=32.8165374677003, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17535921, Length=383, Percent_Identity=32.6370757180157, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=416, Percent_Identity=29.0865384615385, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17535917, Length=383, Percent_Identity=28.4595300261097, Blast_Score=137, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322031, Length=378, Percent_Identity=34.1269841269841, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=32.4050632911392, Blast_Score=166, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24655093, Length=380, Percent_Identity=33.9473684210526, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=33.1619537275064, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24640423, Length=382, Percent_Identity=33.7696335078534, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI17137578, Length=423, Percent_Identity=30.9692671394799, Blast_Score=164, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 38670; Mature: 38670

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTPIGKRNGSLAGVHPVELGALVLNELVNRTGIDPALVDDVQWGCVTQLGDQSSNVGRY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHCCCCCCCCCEE
TVLAAGWPESVPGVTVNRACGSSQQALDHAAFAVMSGQQDLVVAGGVESMSRIPMGATRQ
EEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHCCCCCHHH
MGEPYGPSAKARYDGTDFNQIVGAERIARRWGFSRQQLDEFSSLSHERAAAAIDAGAFEQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
QIVAVPTESGPFTVDEGLRRGTTPEKLAGLKPVTGEDGLLHAGSSSQISDGAAALLVTTP
EEEEEECCCCCEEHHHHHHCCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCEEEEEECC
EKARELGLRPIVRYRSGAVVGSDPLLVLSGPIPATEKVLARAGLSIGDIGAFEVNEAFAS
HHHHHCCCHHHHHHCCCCEECCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHH
VPLAWLADTGADPKVLNPLGGAIAVGHPLGASGAILMTRLAHHMRDNGIRYGLQTMCEGG
CCHHEECCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCC
GTANAAIVELVAD
CCCCCEEEEEECC
>Mature Secondary Structure
MRTPIGKRNGSLAGVHPVELGALVLNELVNRTGIDPALVDDVQWGCVTQLGDQSSNVGRY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHCCCCCCCCCEE
TVLAAGWPESVPGVTVNRACGSSQQALDHAAFAVMSGQQDLVVAGGVESMSRIPMGATRQ
EEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHCCCCCHHH
MGEPYGPSAKARYDGTDFNQIVGAERIARRWGFSRQQLDEFSSLSHERAAAAIDAGAFEQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
QIVAVPTESGPFTVDEGLRRGTTPEKLAGLKPVTGEDGLLHAGSSSQISDGAAALLVTTP
EEEEEECCCCCEEHHHHHHCCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCEEEEEECC
EKARELGLRPIVRYRSGAVVGSDPLLVLSGPIPATEKVLARAGLSIGDIGAFEVNEAFAS
HHHHHCCCHHHHHHCCCCEECCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHH
VPLAWLADTGADPKVLNPLGGAIAVGHPLGASGAILMTRLAHHMRDNGIRYGLQTMCEGG
CCHHEECCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCC
GTANAAIVELVAD
CCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA