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The map label for this gene is vraR [H]

Identifier: 158318878

GI number: 158318878

Start: 8742804

End: 8743481

Strand: Direct

Name: vraR [H]

Synonym: Franean1_7161

Alternate gene names: 158318878

Gene position: 8742804-8743481 (Clockwise)

Preceding gene: 158318877

Following gene: 158318880

Centisome position: 97.34

GC content: 68.29

Gene sequence:

>678_bases
ATGAGCATCCGCGTCCTCATCGTCGACGACCAGGCGCTGGTCCGCGGAGGCCTGGCCATGGTCCTGCGGGTACACGGCGA
CATCGAGGTTGTGGCCGAGGCCGGGACCGGGCTCGAGGCGATCGAGGCGGCGCGACAGCATCGTCCCGATGTGATCCTCA
TGGACATCCGGATGCCGGCGATGGACGGACTCGAAGCGACCTCAAGAATCCTCGCCGAGGCCGACTGGGACGTGCGGGTG
CTCATCCTGACCACGTTCGATCCGGACGAGTACGTCTACCAGGCACTACGCGCCGGCGCCAGCGCCTTCGTGCTCAAGGA
CATCCCCGCCGACCAGCTCGCCGGCGCCGTCCGCACGGTGGCAGACGGCGGCGCGCTGCTGGCACCGTCGATCACCCGGC
GTCTCATCGGGCGGTTCACCGAGCGCCGGGCTGTCGGCTCCGCCCCCTCCCGCCGTGTGGAGCGCCTCACCGACCGGGAG
CGTGATGTGGTGGTCGCCGTCGCCCGGGGGTCCAGCAACTCGGAGATCGCCCAGGAACTCTTCATCGGACCCGCGACCGT
CAAGTCGCACGTGTCGAGCATCCTCACCAAGCTCGGATTGCGCGACCGTACCCAGGTTGTGGTCTTCGCGTACGAAAGTG
GACTGGTCGAAGCCGGCGACCATGACATCGGCCGATGA

Upstream 100 bases:

>100_bases
GGGAGCGAGCGCTGCTGCTGGGCGGGAGCCTCGACGCGGGACCGTGCGCGGGCGGCGGGTTCCGGGTGGTCGCCCGCCTG
CCGATCGGAGGGAGTCCCGC

Downstream 100 bases:

>100_bases
GTCCGGACCGACGGTAGCTCGCGCAGCTCGAGCTGCCGGTCGTCGGCGGAGCGCCGCGGTCAAAGATGCTGAACATAGCG
AAAGCCACTTTTGTCTTTTC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSIRVLIVDDQALVRGGLAMVLRVHGDIEVVAEAGTGLEAIEAARQHRPDVILMDIRMPAMDGLEATSRILAEADWDVRV
LILTTFDPDEYVYQALRAGASAFVLKDIPADQLAGAVRTVADGGALLAPSITRRLIGRFTERRAVGSAPSRRVERLTDRE
RDVVVAVARGSSNSEIAQELFIGPATVKSHVSSILTKLGLRDRTQVVVFAYESGLVEAGDHDIGR

Sequences:

>Translated_225_residues
MSIRVLIVDDQALVRGGLAMVLRVHGDIEVVAEAGTGLEAIEAARQHRPDVILMDIRMPAMDGLEATSRILAEADWDVRV
LILTTFDPDEYVYQALRAGASAFVLKDIPADQLAGAVRTVADGGALLAPSITRRLIGRFTERRAVGSAPSRRVERLTDRE
RDVVVAVARGSSNSEIAQELFIGPATVKSHVSSILTKLGLRDRTQVVVFAYESGLVEAGDHDIGR
>Mature_224_residues
SIRVLIVDDQALVRGGLAMVLRVHGDIEVVAEAGTGLEAIEAARQHRPDVILMDIRMPAMDGLEATSRILAEADWDVRVL
ILTTFDPDEYVYQALRAGASAFVLKDIPADQLAGAVRTVADGGALLAPSITRRLIGRFTERRAVGSAPSRRVERLTDRER
DVVVAVARGSSNSEIAQELFIGPATVKSHVSSILTKLGLRDRTQVVVFAYESGLVEAGDHDIGR

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=204, Percent_Identity=35.7843137254902, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788222, Length=216, Percent_Identity=30.5555555555556, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1788521, Length=213, Percent_Identity=36.150234741784, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1787473, Length=208, Percent_Identity=34.6153846153846, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1786747, Length=210, Percent_Identity=29.5238095238095, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=23.5576923076923, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI87082052, Length=106, Percent_Identity=38.6792452830189, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788192, Length=104, Percent_Identity=36.5384615384615, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24306; Mature: 24175

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRVLIVDDQALVRGGLAMVLRVHGDIEVVAEAGTGLEAIEAARQHRPDVILMDIRMPA
CEEEEEEECCHHHHHCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCC
MDGLEATSRILAEADWDVRVLILTTFDPDEYVYQALRAGASAFVLKDIPADQLAGAVRTV
CCCHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
ADGGALLAPSITRRLIGRFTERRAVGSAPSRRVERLTDRERDVVVAVARGSSNSEIAQEL
CCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
FIGPATVKSHVSSILTKLGLRDRTQVVVFAYESGLVEAGDHDIGR
HCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEECCCCCCCC
>Mature Secondary Structure 
SIRVLIVDDQALVRGGLAMVLRVHGDIEVVAEAGTGLEAIEAARQHRPDVILMDIRMPA
EEEEEEECCHHHHHCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCC
MDGLEATSRILAEADWDVRVLILTTFDPDEYVYQALRAGASAFVLKDIPADQLAGAVRTV
CCCHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
ADGGALLAPSITRRLIGRFTERRAVGSAPSRRVERLTDRERDVVVAVARGSSNSEIAQEL
CCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
FIGPATVKSHVSSILTKLGLRDRTQVVVFAYESGLVEAGDHDIGR
HCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]