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The map label for this gene is vanX [H]

Identifier: 158318855

GI number: 158318855

Start: 8717019

End: 8717669

Strand: Reverse

Name: vanX [H]

Synonym: Franean1_7136

Alternate gene names: 158318855

Gene position: 8717669-8717019 (Counterclockwise)

Preceding gene: 158318856

Following gene: 158318854

Centisome position: 97.06

GC content: 58.06

Gene sequence:

>651_bases
ATGAAGGATGACTTCGTCTTTGTGGACGAGTTTGTACCCGGAATACGCTGGGATGCCAAGTACGCCACCTGGGACAACTT
CACCGGCAGACCGGTGAACGGATACCTGGCAAATCGAATCGTCGGTACGAGGGCTCTGTGCGCCGCCCTGGAAGGTGCGC
GAGAAGAAGCCAGATCCCTTGGCCTGGGCCTGCTTCTCTGGGATGGTTATCGCCCGCAACGCGCCGTAGACTGCTTTCTG
CGCTGGTCAACACAGCCGGAGGACGGCCAGACGAAGCCACGGCACTATCCGAACCTTGACAGAGCCGAGCTGTTCGAGAA
GGGATACGTGGCCGCCAGGTCGGGCCACAGCCGGGGAAGCACCATTGACCTGACGCTCTTTCACCTGGCCACCGGTGACC
TTGCTCCCATGGGCGGTGACCATGATCTGATGGACTCAGTCTCACATCATGGAGCAAAGGGAATCACGCAGATCGAAGCG
AGAAACCGTCAACATCTTCGTTCCGTCATGGAGGCCTGTGGTTTCAGCTCCTACGAATGCGAGTGGTGGCACTACACACT
GAAGGACGAACCCCATCCAGACACCTATTTCGATTTTCCCATCACACCGCTGGGCCGGGCCAGGAAAATTGGTGAAACTT
CGAAGCGCTGA

Upstream 100 bases:

>100_bases
ACATCGTACAGCCGTTATCCGAGAATGATGGCGGCCGCGGGGCTGCCGCTCGCCGAGGTGATCGACCGGCTGGTGTCGCT
GACATTGGCGGGAAAAGTCG

Downstream 100 bases:

>100_bases
CGGCGACCGATATTTTGCAGCTCACTCCACACAAGGAACGGGAATGGCACCTCGGAAATCTGTCCTGACAGGCGTGACGG
CACCGCGCGTCGTTGTCGCC

Product: peptidase M15D vanX D-ala-D-ala dipeptidase

Products: NA

Alternate protein names: D-Ala-D-Ala dipeptidase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MKDDFVFVDEFVPGIRWDAKYATWDNFTGRPVNGYLANRIVGTRALCAALEGAREEARSLGLGLLLWDGYRPQRAVDCFL
RWSTQPEDGQTKPRHYPNLDRAELFEKGYVAARSGHSRGSTIDLTLFHLATGDLAPMGGDHDLMDSVSHHGAKGITQIEA
RNRQHLRSVMEACGFSSYECEWWHYTLKDEPHPDTYFDFPITPLGRARKIGETSKR

Sequences:

>Translated_216_residues
MKDDFVFVDEFVPGIRWDAKYATWDNFTGRPVNGYLANRIVGTRALCAALEGAREEARSLGLGLLLWDGYRPQRAVDCFL
RWSTQPEDGQTKPRHYPNLDRAELFEKGYVAARSGHSRGSTIDLTLFHLATGDLAPMGGDHDLMDSVSHHGAKGITQIEA
RNRQHLRSVMEACGFSSYECEWWHYTLKDEPHPDTYFDFPITPLGRARKIGETSKR
>Mature_216_residues
MKDDFVFVDEFVPGIRWDAKYATWDNFTGRPVNGYLANRIVGTRALCAALEGAREEARSLGLGLLLWDGYRPQRAVDCFL
RWSTQPEDGQTKPRHYPNLDRAELFEKGYVAARSGHSRGSTIDLTLFHLATGDLAPMGGDHDLMDSVSHHGAKGITQIEA
RNRQHLRSVMEACGFSSYECEWWHYTLKDEPHPDTYFDFPITPLGRARKIGETSKR

Specific function: Hydrolyzes the cellular pool of D-Ala-D-Ala dipeptides. May play a role in immunity or defense against glycopeptide antibiotics (perhaps at a moderate level) in the soil environment. Might confer vancomycin resistance to S.coelicolor [H]

COG id: COG2173

COG function: function code M; D-alanyl-D-alanine dipeptidase

Gene ontology:

Cell location: Secreted (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M15D family [H]

Homologues:

Organism=Escherichia coli, GI1787763, Length=189, Percent_Identity=31.7460317460317, Blast_Score=77, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009045
- InterPro:   IPR000755 [H]

Pfam domain/function: PF01427 Peptidase_M15 [H]

EC number: =3.4.13.22 [H]

Molecular weight: Translated: 24519; Mature: 24519

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDDFVFVDEFVPGIRWDAKYATWDNFTGRPVNGYLANRIVGTRALCAALEGAREEARSL
CCCCEEEHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLGLLLWDGYRPQRAVDCFLRWSTQPEDGQTKPRHYPNLDRAELFEKGYVAARSGHSRGS
CCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEECCCCCCCC
TIDLTLFHLATGDLAPMGGDHDLMDSVSHHGAKGITQIEARNRQHLRSVMEACGFSSYEC
EEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHCCCCCCE
EWWHYTLKDEPHPDTYFDFPITPLGRARKIGETSKR
EEEEEEECCCCCCCCEECCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MKDDFVFVDEFVPGIRWDAKYATWDNFTGRPVNGYLANRIVGTRALCAALEGAREEARSL
CCCCEEEHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLGLLLWDGYRPQRAVDCFLRWSTQPEDGQTKPRHYPNLDRAELFEKGYVAARSGHSRGS
CCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEECCCCCCCC
TIDLTLFHLATGDLAPMGGDHDLMDSVSHHGAKGITQIEARNRQHLRSVMEACGFSSYEC
EEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCHHHHHHHHHHHCCCCCCE
EWWHYTLKDEPHPDTYFDFPITPLGRARKIGETSKR
EEEEEEECCCCCCCCEECCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11881895; 12000953 [H]