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The map label for this gene is purR [H]

Identifier: 158318745

GI number: 158318745

Start: 8555558

End: 8555884

Strand: Reverse

Name: purR [H]

Synonym: Franean1_7016

Alternate gene names: 158318745

Gene position: 8555884-8555558 (Counterclockwise)

Preceding gene: 158318748

Following gene: 158318744

Centisome position: 95.26

GC content: 66.06

Gene sequence:

>327_bases
ATGGTCAAGATGGCGGACGTGGCGAAGATCGCGGGCGTCTCCGTGTCCACGGTCTCGCACGTCCTCAACGACACGCGGGC
GGTGCGGGCCGAGACCCGCGCGGCCGTGCTCGCAGCCATCGAACAGACCGGTTACACACAGAACACGATCGCGCGGGCGC
TCGTCACGGCCAGCAGTGGCCTGATCGGCCTATCGATCCCGGTGATCACCAACCCCTACTTCACCGACGTGATCCACGCG
ATCGAGACGAACGTGTCGGCCACCAGCTACACCCTGATACTCGCCGACTCGCGCGAGGACCCCGAGCAACGTGTACCGGG
CCGTTGA

Upstream 100 bases:

>100_bases
CGGGGTTGCGCCGGAATGTAGCTCGGGTCACAGTAGGAGCGCAAGCGCTTGCGCGAACGTTTGCCCAACTTCTCGTCGGG
ACGTCCGGTAGGGAGATCGC

Downstream 100 bases:

>100_bases
CCAGTCAGTCAGGTCATCGATGTCCTCGTCAGCGACCATCGTGACCAGGCCGCGGCCCGGTGGTTCTTCACCGCCGCGCT
GGCCCAGGGTCGTCGGCCGG

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 108; Mature: 108

Protein sequence:

>108_residues
MVKMADVAKIAGVSVSTVSHVLNDTRAVRAETRAAVLAAIEQTGYTQNTIARALVTASSGLIGLSIPVITNPYFTDVIHA
IETNVSATSYTLILADSREDPEQRVPGR

Sequences:

>Translated_108_residues
MVKMADVAKIAGVSVSTVSHVLNDTRAVRAETRAAVLAAIEQTGYTQNTIARALVTASSGLIGLSIPVITNPYFTDVIHA
IETNVSATSYTLILADSREDPEQRVPGR
>Mature_108_residues
MVKMADVAKIAGVSVSTVSHVLNDTRAVRAETRAAVLAAIEQTGYTQNTIARALVTASSGLIGLSIPVITNPYFTDVIHA
IETNVSATSYTLILADSREDPEQRVPGR

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=104, Percent_Identity=42.3076923076923, Blast_Score=78, Evalue=1e-16,
Organism=Escherichia coli, GI1790194, Length=105, Percent_Identity=39.0476190476191, Blast_Score=78, Evalue=1e-16,
Organism=Escherichia coli, GI1787580, Length=106, Percent_Identity=40.5660377358491, Blast_Score=65, Evalue=9e-13,
Organism=Escherichia coli, GI1788474, Length=103, Percent_Identity=33.9805825242718, Blast_Score=62, Evalue=7e-12,
Organism=Escherichia coli, GI1789202, Length=103, Percent_Identity=32.0388349514563, Blast_Score=62, Evalue=8e-12,
Organism=Escherichia coli, GI1789068, Length=108, Percent_Identity=36.1111111111111, Blast_Score=60, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 11439; Mature: 11439

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKMADVAKIAGVSVSTVSHVLNDTRAVRAETRAAVLAAIEQTGYTQNTIARALVTASSG
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
LIGLSIPVITNPYFTDVIHAIETNVSATSYTLILADSREDPEQRVPGR
EEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHCCCCC
>Mature Secondary Structure
MVKMADVAKIAGVSVSTVSHVLNDTRAVRAETRAAVLAAIEQTGYTQNTIARALVTASSG
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
LIGLSIPVITNPYFTDVIHAIETNVSATSYTLILADSREDPEQRVPGR
EEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA