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The map label for this gene is cutS [H]

Identifier: 158318679

GI number: 158318679

Start: 8464441

End: 8465643

Strand: Direct

Name: cutS [H]

Synonym: Franean1_6947

Alternate gene names: 158318679

Gene position: 8464441-8465643 (Clockwise)

Preceding gene: 158318678

Following gene: 158318680

Centisome position: 94.24

GC content: 72.24

Gene sequence:

>1203_bases
ATGTCGGTCAGGATCCGGCTCGCGCTGATGTGCGGTGGCCTGTTTCTCCTCAGTGGCGTGGTGCTGCTGGCCGTCAACTA
CATTCTGGTTCGCTCCGCGCTGCCGCCGGCCGCCGCTCCCGTCGCACATGCCTTCGAGGGAACGATCGCGATGCCCGGGC
AGTCGGGTCCCGGACTGCCCGGCACCGTCGGGACCGGTTCGGGCCCGGAGACCGGTGTGCTGACCGTGGTCAGCGCCGTC
CGCAACTATCGCGGGGGTGTGCTGAACACCCTGCTGGTGCAGTCAGGGGTGGCGATCGGGGCCACGCTGATCCTGGCGTT
GCTGCTGGGGTGGGTGGTGGCCGACCGGACGTTGCGTCCGGTGCAGGCGGTGGTCGCGACGGCCCGCCGGCTCGGGGCGG
ACAATCTTGATGCGCGGATCCGGTTGCGCGGGCCACGCGACGAGCTGACCGAGCTCGCCGACACGTTCGACGAGATGCTC
GACCGGCTGGCCGCGTCCTTCGACAGCCAGCGCCGGTTCGTGGCCAACGCGTCGCACGAGCTGCGCACCCCGCTGGCCGC
TCAGCGCACCCTCGTCGAGGTCGCGATGGGCCGGCCCGGGGCCGAACCGGCGTTGCGCGAGCTCGGTACCCGCCTGTTGA
CGATGAACGTGCGCATCGAGGCACTCATCGAAGGGCTGCTGGTGCTGGCGCGCAGCGACCGTGGCCTCGCGGCCCGCCAG
GTGGTGTGCCTTGACGAGGTCGTCGAGACGGTCGTCGACACGCACCGGGCGGTCGCCGCCGAGGCCGGGGTGGACCTGCG
GTGGGAGCGTACGGGCCGCGACCGTCCCGCTCGGCCGCCCGATCTCGTGTGGGGCGACCGGGTGCTGCTGGAGCGGATGG
TCTCCAACCTGGTCGACAACGCGATCAAGTACAACCGACGCGGCGGGACGGTGTGGGTGCGCGACGGCAGGGATCCGGTG
CTGTGGGTCGCCAACACCGGTCCCCCGGTGCCTTCGTCCTCGGCCGCCGACCTTTTCGAACCGTTCAGCCAGGCCGGCCG
GGGATCGCGGGGGGCCGAGCCCGGCGCCCAGCCCGGTGCCGGGCTCGGCCTGTCGATTGTCGCCTCGATCGTCCGCGCCC
ACGGCGGCTCGGTCCGGGCCGTGTCCCGGCCCGAAGGCGGCCTGGAGATGGCCGTCTTCCTCCCGACCCGGGAAAGTGCG
TGA

Upstream 100 bases:

>100_bases
TGATGACGTTGCGCCGCAAGCTGGGGCCGCCCCCGCTGATCGAGACGGTCGCCGGGGTCGGGTACCGCATGAAGGGCTGA
GGAGACCCCGGCCGGTCGCG

Downstream 100 bases:

>100_bases
TCCGGACCGCGGGCCCATGGTCCCGGCGAGACCTGGCCGACAAACCGAAAACCGCCTGCCGGACGGCCGATGTCCGTCTC
CGCCCGCGATGCGAGATTCG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSVRIRLALMCGGLFLLSGVVLLAVNYILVRSALPPAAAPVAHAFEGTIAMPGQSGPGLPGTVGTGSGPETGVLTVVSAV
RNYRGGVLNTLLVQSGVAIGATLILALLLGWVVADRTLRPVQAVVATARRLGADNLDARIRLRGPRDELTELADTFDEML
DRLAASFDSQRRFVANASHELRTPLAAQRTLVEVAMGRPGAEPALRELGTRLLTMNVRIEALIEGLLVLARSDRGLAARQ
VVCLDEVVETVVDTHRAVAAEAGVDLRWERTGRDRPARPPDLVWGDRVLLERMVSNLVDNAIKYNRRGGTVWVRDGRDPV
LWVANTGPPVPSSSAADLFEPFSQAGRGSRGAEPGAQPGAGLGLSIVASIVRAHGGSVRAVSRPEGGLEMAVFLPTRESA

Sequences:

>Translated_400_residues
MSVRIRLALMCGGLFLLSGVVLLAVNYILVRSALPPAAAPVAHAFEGTIAMPGQSGPGLPGTVGTGSGPETGVLTVVSAV
RNYRGGVLNTLLVQSGVAIGATLILALLLGWVVADRTLRPVQAVVATARRLGADNLDARIRLRGPRDELTELADTFDEML
DRLAASFDSQRRFVANASHELRTPLAAQRTLVEVAMGRPGAEPALRELGTRLLTMNVRIEALIEGLLVLARSDRGLAARQ
VVCLDEVVETVVDTHRAVAAEAGVDLRWERTGRDRPARPPDLVWGDRVLLERMVSNLVDNAIKYNRRGGTVWVRDGRDPV
LWVANTGPPVPSSSAADLFEPFSQAGRGSRGAEPGAQPGAGLGLSIVASIVRAHGGSVRAVSRPEGGLEMAVFLPTRESA
>Mature_399_residues
SVRIRLALMCGGLFLLSGVVLLAVNYILVRSALPPAAAPVAHAFEGTIAMPGQSGPGLPGTVGTGSGPETGVLTVVSAVR
NYRGGVLNTLLVQSGVAIGATLILALLLGWVVADRTLRPVQAVVATARRLGADNLDARIRLRGPRDELTELADTFDEMLD
RLAASFDSQRRFVANASHELRTPLAAQRTLVEVAMGRPGAEPALRELGTRLLTMNVRIEALIEGLLVLARSDRGLAARQV
VCLDEVVETVVDTHRAVAAEAGVDLRWERTGRDRPARPPDLVWGDRVLLERMVSNLVDNAIKYNRRGGTVWVRDGRDPVL
WVANTGPPVPSSSAADLFEPFSQAGRGSRGAEPGAQPGAGLGLSIVASIVRAHGGSVRAVSRPEGGLEMAVFLPTRESA

Specific function: Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=322, Percent_Identity=28.8819875776398, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788393, Length=291, Percent_Identity=32.3024054982818, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790346, Length=279, Percent_Identity=27.5985663082437, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082128, Length=317, Percent_Identity=27.7602523659306, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787894, Length=280, Percent_Identity=30.3571428571429, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790551, Length=290, Percent_Identity=26.8965517241379, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788279, Length=298, Percent_Identity=25.1677852348993, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786912, Length=263, Percent_Identity=29.6577946768061, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790861, Length=249, Percent_Identity=30.1204819277108, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789403, Length=296, Percent_Identity=29.0540540540541, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789149, Length=346, Percent_Identity=24.2774566473988, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787374, Length=312, Percent_Identity=25, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42296; Mature: 42165

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRIRLALMCGGLFLLSGVVLLAVNYILVRSALPPAAAPVAHAFEGTIAMPGQSGPGLP
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEECCCCCCCCCC
GTVGTGSGPETGVLTVVSAVRNYRGGVLNTLLVQSGVAIGATLILALLLGWVVADRTLRP
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHH
VQAVVATARRLGADNLDARIRLRGPRDELTELADTFDEMLDRLAASFDSQRRFVANASHE
HHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LRTPLAAQRTLVEVAMGRPGAEPALRELGTRLLTMNVRIEALIEGLLVLARSDRGLAARQ
HHCCHHHHHHHHHHHHCCCCCCHHHHHHCHHEEEEHHHHHHHHHHHHHHHCCCCCCHHHH
VVCLDEVVETVVDTHRAVAAEAGVDLRWERTGRDRPARPPDLVWGDRVLLERMVSNLVDN
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AIKYNRRGGTVWVRDGRDPVLWVANTGPPVPSSSAADLFEPFSQAGRGSRGAEPGAQPGA
HHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
GLGLSIVASIVRAHGGSVRAVSRPEGGLEMAVFLPTRESA
CCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SVRIRLALMCGGLFLLSGVVLLAVNYILVRSALPPAAAPVAHAFEGTIAMPGQSGPGLP
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEECCCCCCCCCC
GTVGTGSGPETGVLTVVSAVRNYRGGVLNTLLVQSGVAIGATLILALLLGWVVADRTLRP
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHH
VQAVVATARRLGADNLDARIRLRGPRDELTELADTFDEMLDRLAASFDSQRRFVANASHE
HHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LRTPLAAQRTLVEVAMGRPGAEPALRELGTRLLTMNVRIEALIEGLLVLARSDRGLAARQ
HHCCHHHHHHHHHHHHCCCCCCHHHHHHCHHEEEEHHHHHHHHHHHHHHHCCCCCCHHHH
VVCLDEVVETVVDTHRAVAAEAGVDLRWERTGRDRPARPPDLVWGDRVLLERMVSNLVDN
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
AIKYNRRGGTVWVRDGRDPVLWVANTGPPVPSSSAADLFEPFSQAGRGSRGAEPGAQPGA
HHHCCCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
GLGLSIVASIVRAHGGSVRAVSRPEGGLEMAVFLPTRESA
CCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]