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The map label for this gene is cutR [H]

Identifier: 158318678

GI number: 158318678

Start: 8463761

End: 8464420

Strand: Direct

Name: cutR [H]

Synonym: Franean1_6946

Alternate gene names: 158318678

Gene position: 8463761-8464420 (Clockwise)

Preceding gene: 158318676

Following gene: 158318679

Centisome position: 94.23

GC content: 71.67

Gene sequence:

>660_bases
GTGCGGATCCTGGTGGTCGAGGACGAGGCGATGCTGGCCGAGGCCATCGCCGAGGGCCTCCGCCAGCGGGCCATGGCGGT
GGACACCTGCGGGGACGGGGCCAGCGCTCTGGAACTGGCCACGCTCCATCCCTACGACGTGATCGTGCTCGACCGGGATC
TGCCCGCGGTGCACGGCGACGACGTGTGCCGGGCCGTGGTGGCCGCCGGCGGCGACACCCGGGTCATCATGCTGACCGCC
GCCGGGGACATCGCCGACCGGGTCCACGGGTTCGGGGTGGGGGCCGACGACTATCTGACCAAGCCGTTCGCGTTCGCCGA
GCTCGTCGCCCGGGTTCAGGCACTGGGTCGACGGGCCCGTGCCGCGGTGCCGCCGGTCCTGACCCGCGCCGGCGTCGAGT
TGGACGTGCCGAGGCACCAGGTGTCGCGGGACGGCCGTTTTGTCCCGCTGTCCCGCAAGGAGTTCGCCGTCCTGGAGGTC
CTCATGCGGGCCGACGGGTCCGTGGTCAGCGCCGAGGAGCTCTTGGAGAAGGCTTGGGATTCCAACGTCGACCCCTTCAC
CAACGCCGTACGGATGGCGGTGATGACGTTGCGCCGCAAGCTGGGGCCGCCCCCGCTGATCGAGACGGTCGCCGGGGTCG
GGTACCGCATGAAGGGCTGA

Upstream 100 bases:

>100_bases
CAGATCTAGTGAACGGGCGATCCGGGTTCCGTAAGCGTCGCCCCTTACGCTTTCTTTATGGCCCGCTGCCGATGATCGAC
GTGAGCGGAGAGGCGGTCGC

Downstream 100 bases:

>100_bases
GGAGACCCCGGCCGGTCGCGATGTCGGTCAGGATCCGGCTCGCGCTGATGTGCGGTGGCCTGTTTCTCCTCAGTGGCGTG
GTGCTGCTGGCCGTCAACTA

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Defective melC1 suppressor protein [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MRILVVEDEAMLAEAIAEGLRQRAMAVDTCGDGASALELATLHPYDVIVLDRDLPAVHGDDVCRAVVAAGGDTRVIMLTA
AGDIADRVHGFGVGADDYLTKPFAFAELVARVQALGRRARAAVPPVLTRAGVELDVPRHQVSRDGRFVPLSRKEFAVLEV
LMRADGSVVSAEELLEKAWDSNVDPFTNAVRMAVMTLRRKLGPPPLIETVAGVGYRMKG

Sequences:

>Translated_219_residues
MRILVVEDEAMLAEAIAEGLRQRAMAVDTCGDGASALELATLHPYDVIVLDRDLPAVHGDDVCRAVVAAGGDTRVIMLTA
AGDIADRVHGFGVGADDYLTKPFAFAELVARVQALGRRARAAVPPVLTRAGVELDVPRHQVSRDGRFVPLSRKEFAVLEV
LMRADGSVVSAEELLEKAWDSNVDPFTNAVRMAVMTLRRKLGPPPLIETVAGVGYRMKG
>Mature_219_residues
MRILVVEDEAMLAEAIAEGLRQRAMAVDTCGDGASALELATLHPYDVIVLDRDLPAVHGDDVCRAVVAAGGDTRVIMLTA
AGDIADRVHGFGVGADDYLTKPFAFAELVARVQALGRRARAAVPPVLTRAGVELDVPRHQVSRDGRFVPLSRKEFAVLEV
LMRADGSVVSAEELLEKAWDSNVDPFTNAVRMAVMTLRRKLGPPPLIETVAGVGYRMKG

Specific function: Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=40.5405405405405, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1789402, Length=217, Percent_Identity=39.1705069124424, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=37.6146788990826, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=34.5291479820628, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=36.4864864864865, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1790552, Length=217, Percent_Identity=33.6405529953917, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=33.1858407079646, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=30.2752293577982, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.6491228070175, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=29.3333333333333, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787229, Length=221, Percent_Identity=33.4841628959276, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=32.5892857142857, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 23510; Mature: 23510

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDEAMLAEAIAEGLRQRAMAVDTCGDGASALELATLHPYDVIVLDRDLPAVHGD
CEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEECCCCCCCCCH
DVCRAVVAAGGDTRVIMLTAAGDIADRVHGFGVGADDYLTKPFAFAELVARVQALGRRAR
HHHHHHHHCCCCCEEEEEEECCHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
AAVPPVLTRAGVELDVPRHQVSRDGRFVPLSRKEFAVLEVLMRADGSVVSAEELLEKAWD
HCCCHHHHHCCCEECCCHHHHCCCCCEECCCCHHHHHHHHHHHCCCCEECHHHHHHHHHC
SNVDPFTNAVRMAVMTLRRKLGPPPLIETVAGVGYRMKG
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEECCC
>Mature Secondary Structure
MRILVVEDEAMLAEAIAEGLRQRAMAVDTCGDGASALELATLHPYDVIVLDRDLPAVHGD
CEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEECCCCCCCCCH
DVCRAVVAAGGDTRVIMLTAAGDIADRVHGFGVGADDYLTKPFAFAELVARVQALGRRAR
HHHHHHHHCCCCCEEEEEEECCHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
AAVPPVLTRAGVELDVPRHQVSRDGRFVPLSRKEFAVLEVLMRADGSVVSAEELLEKAWD
HCCCHHHHHCCCEECCCHHHHCCCCCEECCCCHHHHHHHHHHHCCCCEECHHHHHHHHHC
SNVDPFTNAVRMAVMTLRRKLGPPPLIETVAGVGYRMKG
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]