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The map label for this gene is mprA [H]

Identifier: 158318323

GI number: 158318323

Start: 8017878

End: 8018567

Strand: Reverse

Name: mprA [H]

Synonym: Franean1_6588

Alternate gene names: 158318323

Gene position: 8018567-8017878 (Counterclockwise)

Preceding gene: 158318324

Following gene: 158318322

Centisome position: 89.27

GC content: 71.59

Gene sequence:

>690_bases
ATGGAGCGTCCCGTCCGGGTCCTCGTCGTTGACGACGAGGAGGCGATCACCGATCTCGTCGCCATGGCGCTGCGCTACGA
GGGCTTCGACGTGAGCGCCGCGCACTCGGGGCAGGCGGCGCTCACGCAGGTCTCGCGGGAGCCGCCCGACCTGCTCGTGC
TGGACGTCATGCTGCCCGACATCGACGGCTTCGCCGTCTGCCAGCGGCTGCGCAACGCCGGGCGGGACGTGCCGACGCTG
TTCCTGACCGCTCGCGACACCACCGAGGACAAGGTGCACGGGCTGACGCTCGGCGGCGACGACTACGTCACGAAGCCGTT
CGTGGTCAGTGAACTGGTCGCCCGGGTCCGGGCGATCCTGCGCCGGGCCGGAATGGCCGACGGCGCGCCGGAGCCGCTGC
GCTTCGCCGATCTCGAGCTGGACCCGGAGACCCGCGAGGTGCGCCGGGCCGGGCGCCTCGTCGAGCTGACCGTCACCGAG
TACCGGCTGCTGCACTACCTGCTGGTCAACGCCCGCAAGGTGCTGACCCGGGCCCAACTCCTCGACCACGTCTGGGGGCA
CGACTTCGGCGGTGACGCCCGGGTCCTGGAGACCTACGTCAGCTATCTGCGCCGCAAGATCGACGACGCCCCGCCGGCGC
TGATCCACACGGTGCGCGGGGTTGGCTACGTGCTGCGCCTGCCGCGGTGA

Upstream 100 bases:

>100_bases
GAGCGACAGCCCCGAGGCCAGCCGTGCGAGCGACCGCCCCGAGGCCGGCCGCCGGACGTCCCGACGGGAGATGACACTGA
CGGGAGGTGACACTGAGCGG

Downstream 100 bases:

>100_bases
GACGTCCGGCCCTGCCCCGGCGCGTCCTGCACCGCGTCCTGCACCGGCGCGTCCTGCGTCGGCATCTCGTGTCCTCGCGG
GTGGTCTCTTTGCGGGCACG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MERPVRVLVVDDEEAITDLVAMALRYEGFDVSAAHSGQAALTQVSREPPDLLVLDVMLPDIDGFAVCQRLRNAGRDVPTL
FLTARDTTEDKVHGLTLGGDDYVTKPFVVSELVARVRAILRRAGMADGAPEPLRFADLELDPETREVRRAGRLVELTVTE
YRLLHYLLVNARKVLTRAQLLDHVWGHDFGGDARVLETYVSYLRRKIDDAPPALIHTVRGVGYVLRLPR

Sequences:

>Translated_229_residues
MERPVRVLVVDDEEAITDLVAMALRYEGFDVSAAHSGQAALTQVSREPPDLLVLDVMLPDIDGFAVCQRLRNAGRDVPTL
FLTARDTTEDKVHGLTLGGDDYVTKPFVVSELVARVRAILRRAGMADGAPEPLRFADLELDPETREVRRAGRLVELTVTE
YRLLHYLLVNARKVLTRAQLLDHVWGHDFGGDARVLETYVSYLRRKIDDAPPALIHTVRGVGYVLRLPR
>Mature_229_residues
MERPVRVLVVDDEEAITDLVAMALRYEGFDVSAAHSGQAALTQVSREPPDLLVLDVMLPDIDGFAVCQRLRNAGRDVPTL
FLTARDTTEDKVHGLTLGGDDYVTKPFVVSELVARVRAILRRAGMADGAPEPLRFADLELDPETREVRRAGRLVELTVTE
YRLLHYLLVNARKVLTRAQLLDHVWGHDFGGDARVLETYVSYLRRKIDDAPPALIHTVRGVGYVLRLPR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=40.4444444444444, Blast_Score=160, Evalue=7e-41,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=37.8378378378378, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=41.3636363636364, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=37.8378378378378, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=35.3448275862069, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=34.5454545454545, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=34.375, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=34.841628959276, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=34.841628959276, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=37.117903930131, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=32, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=30.9012875536481, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.3030303030303, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=30.7017543859649, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=31.6666666666667, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=116, Percent_Identity=32.7586206896552, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790299, Length=120, Percent_Identity=31.6666666666667, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25618; Mature: 25618

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERPVRVLVVDDEEAITDLVAMALRYEGFDVSAAHSGQAALTQVSREPPDLLVLDVMLPD
CCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEECCC
IDGFAVCQRLRNAGRDVPTLFLTARDTTEDKVHGLTLGGDDYVTKPFVVSELVARVRAIL
CCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHH
RRAGMADGAPEPLRFADLELDPETREVRRAGRLVELTVTEYRLLHYLLVNARKVLTRAQL
HHCCCCCCCCCCCEEECCCCCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
LDHVWGHDFGGDARVLETYVSYLRRKIDDAPPALIHTVRGVGYVLRLPR
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHEEECCC
>Mature Secondary Structure
MERPVRVLVVDDEEAITDLVAMALRYEGFDVSAAHSGQAALTQVSREPPDLLVLDVMLPD
CCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEEEEECCC
IDGFAVCQRLRNAGRDVPTLFLTARDTTEDKVHGLTLGGDDYVTKPFVVSELVARVRAIL
CCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHH
RRAGMADGAPEPLRFADLELDPETREVRRAGRLVELTVTEYRLLHYLLVNARKVLTRAQL
HHCCCCCCCCCCCEEECCCCCCCHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
LDHVWGHDFGGDARVLETYVSYLRRKIDDAPPALIHTVRGVGYVLRLPR
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA