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The map label for this gene is tmk [H]

Identifier: 158318239

GI number: 158318239

Start: 7911930

End: 7912655

Strand: Direct

Name: tmk [H]

Synonym: Franean1_6504

Alternate gene names: 158318239

Gene position: 7911930-7912655 (Clockwise)

Preceding gene: 158318238

Following gene: 158318240

Centisome position: 88.09

GC content: 75.07

Gene sequence:

>726_bases
ATGACCAGCACCGGGACTGACCAGCATGACCAGCACCTCGGCCACCCCTGCGACCTCGGCGTGGCCGGCACCGGGCGGGC
GGGCGGCCCGATGATCGTGGCGATCGAGGGGGTCGACGGCGCGGGCAAGAACACACTGACGTCCCGGCTGGTCGAGGCGG
TGACCGCGACCGGGCGCACCGCCGGCACCTTCGCCTTCCCGCGCTATGCCGCGGGCCCGCTGGGCACGGCGGTGCGGGCG
ATGCTCGACGGCGACGAACGGCTTGCCGGCCTGGCCGGTTCGGCCCGCGCGACCGCGCTGCTGTTCGCGCTCGACCGGGC
GAACGCCCTGCCCGAGCTGGCGAGGTGCGTGGCCGCGTACGACGTGCTGATCGTGGACCGCTACCTCGGCTCGAACGCGG
CCTACGGAGCAGCCCGGCTGCCCGCCCCCGAGCGCGCCGAGTTCCTCGACTGGATCGCCGAACTCGAGCTGACGCGGCTG
GGCCTGCCCCGGCCCGACCTGCAGGTGCTGCTGGACGTCCCGGTGGAGACGGCGCGGGCCGGGGCGCGGGCCCGCGCGGC
GGAGGATACCGCCCGGGCGTTGGACACCTTCGAGAGCGACGCGGGCCTGCAGGCGCGCTGCGCCGAGATCTACCTGTCGC
TGGCCGCCGACAGCTGGGTCGCGCCCTGGCTGGTCGTCGACCGCGAGTCGGGCGCTCCGAAGATCCTCAGCGCACTGTTC
GGCTGA

Upstream 100 bases:

>100_bases
AGCCGGGGCGCGAGACGACCGCCGTCACGTCGTCGCGTTCCTCCGGCCGGTCGAGCGGTCCCCGGGTCACCGCGCCGGCT
CCCGCTACGCTTGAGGATTG

Downstream 100 bases:

>100_bases
CGCCGGACTCGGCTGACGCCGGGCGTACCGTTCCGCGTTCCGCGGGACCCCATTTCGTCCCCGAGTTGTCCCGGGATGGC
GAGATGGTCCCTGACCGGTC

Product: thymidylate kinase

Products: NA

Alternate protein names: Thymidine monophosphate kinase; dTMP kinase; TMPK [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MTSTGTDQHDQHLGHPCDLGVAGTGRAGGPMIVAIEGVDGAGKNTLTSRLVEAVTATGRTAGTFAFPRYAAGPLGTAVRA
MLDGDERLAGLAGSARATALLFALDRANALPELARCVAAYDVLIVDRYLGSNAAYGAARLPAPERAEFLDWIAELELTRL
GLPRPDLQVLLDVPVETARAGARARAAEDTARALDTFESDAGLQARCAEIYLSLAADSWVAPWLVVDRESGAPKILSALF
G

Sequences:

>Translated_241_residues
MTSTGTDQHDQHLGHPCDLGVAGTGRAGGPMIVAIEGVDGAGKNTLTSRLVEAVTATGRTAGTFAFPRYAAGPLGTAVRA
MLDGDERLAGLAGSARATALLFALDRANALPELARCVAAYDVLIVDRYLGSNAAYGAARLPAPERAEFLDWIAELELTRL
GLPRPDLQVLLDVPVETARAGARARAAEDTARALDTFESDAGLQARCAEIYLSLAADSWVAPWLVVDRESGAPKILSALF
G
>Mature_240_residues
TSTGTDQHDQHLGHPCDLGVAGTGRAGGPMIVAIEGVDGAGKNTLTSRLVEAVTATGRTAGTFAFPRYAAGPLGTAVRAM
LDGDERLAGLAGSARATALLFALDRANALPELARCVAAYDVLIVDRYLGSNAAYGAARLPAPERAEFLDWIAELELTRLG
LPRPDLQVLLDVPVETARAGARARAAEDTARALDTFESDAGLQARCAEIYLSLAADSWVAPWLVVDRESGAPKILSALFG

Specific function: Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 25140; Mature: 25008

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTGTDQHDQHLGHPCDLGVAGTGRAGGPMIVAIEGVDGAGKNTLTSRLVEAVTATGRT
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
AGTFAFPRYAAGPLGTAVRAMLDGDERLAGLAGSARATALLFALDRANALPELARCVAAY
CCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
DVLIVDRYLGSNAAYGAARLPAPERAEFLDWIAELELTRLGLPRPDLQVLLDVPVETARA
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHC
GARARAAEDTARALDTFESDAGLQARCAEIYLSLAADSWVAPWLVVDRESGAPKILSALF
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHC
G
C
>Mature Secondary Structure 
TSTGTDQHDQHLGHPCDLGVAGTGRAGGPMIVAIEGVDGAGKNTLTSRLVEAVTATGRT
CCCCCCCHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
AGTFAFPRYAAGPLGTAVRAMLDGDERLAGLAGSARATALLFALDRANALPELARCVAAY
CCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
DVLIVDRYLGSNAAYGAARLPAPERAEFLDWIAELELTRLGLPRPDLQVLLDVPVETARA
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHC
GARARAAEDTARALDTFESDAGLQARCAEIYLSLAADSWVAPWLVVDRESGAPKILSALF
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 11369858; 10666613; 11469859; 11914484; 12454011; 12662932 [H]