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The map label for this gene is degU [H]

Identifier: 158318162

GI number: 158318162

Start: 7808199

End: 7808915

Strand: Reverse

Name: degU [H]

Synonym: Franean1_6427

Alternate gene names: 158318162

Gene position: 7808915-7808199 (Counterclockwise)

Preceding gene: 158318163

Following gene: 158318156

Centisome position: 86.94

GC content: 74.34

Gene sequence:

>717_bases
GTGAGCGCCGCCGGGCCCGCGCTGCGGGTGCTGCTCGTCGACGACCAGCAGCTCGTCCGCGCGGGCATCGCGCTCGTCCT
GAGCGGGGAGCCGGGTATCGAGATCGTCGCCGAGCGCTCGGACGGCGACGAGGTCGTCGCGGCGGTGCGCGCGGTCCGCC
CGGACGTCATCCTGCTCGACATCCGCATGGCCCGGATGGACGGGGTGGACGCCCTGCGCGCCCTGGCCCGGCTGGGGGAG
CACCCGCCGGCCCTGGTGCTCACCACGTTCAGCGACGACGACGTCGTCTGGGGCGCCATGGCAGCCGGGGCGGCGGGCTT
CATCCTCAAGGACCGGCCGGCCGAGGACATCGTGCGCGCGATCAGGCTGGTCGCCGAGGGAGGCTCGTGGATCGACCCGT
CGGCGAGCGGACGTCTGCTCGGCGCGCTGCGCACCGGGGCCGTGGCCGATCTCGCGGTCCGGCGCCGGTTCGAGCGCCTC
TCCGAGCGGGAGCTGCAGGTGCTGCGGGCGATGGCGCGCGGGGCCAGTAACCGGGAGATAGCGATCGAGCTGCGGGTCAG
CGAACGGACGGTCAAGGCGCACGTCGGCAGCATCTTCGGCAAGCTCGAGGTGCGGGACCGGGCCGGGGCGATCGTGTTGG
CGCACGATGTGGGGCTACGAGCGCCGGGCTCGGGCGGATCCGGCCCCGCGGGGGGTGTGCGAAACCTGAGCAGATGA

Upstream 100 bases:

>100_bases
CGCTCGGTGGGTCGGTCGTCGCGGGACCCCGGGACGGCGGCTGGGAGGTCACGGCGACGATCCCCACGGTGGCCGTCGGC
CCGGTCGGGGGTGGCCCCCG

Downstream 100 bases:

>100_bases
GCGAATGGTGTGCGTCCGGTGCTGACAGTGGCGGTTTATACTCGATACTGTCAGCCCACAGACTAGCCCTTTAGTGCGAC
CATGGTGTTACGGGTTGTAC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSAAGPALRVLLVDDQQLVRAGIALVLSGEPGIEIVAERSDGDEVVAAVRAVRPDVILLDIRMARMDGVDALRALARLGE
HPPALVLTTFSDDDVVWGAMAAGAAGFILKDRPAEDIVRAIRLVAEGGSWIDPSASGRLLGALRTGAVADLAVRRRFERL
SERELQVLRAMARGASNREIAIELRVSERTVKAHVGSIFGKLEVRDRAGAIVLAHDVGLRAPGSGGSGPAGGVRNLSR

Sequences:

>Translated_238_residues
MSAAGPALRVLLVDDQQLVRAGIALVLSGEPGIEIVAERSDGDEVVAAVRAVRPDVILLDIRMARMDGVDALRALARLGE
HPPALVLTTFSDDDVVWGAMAAGAAGFILKDRPAEDIVRAIRLVAEGGSWIDPSASGRLLGALRTGAVADLAVRRRFERL
SERELQVLRAMARGASNREIAIELRVSERTVKAHVGSIFGKLEVRDRAGAIVLAHDVGLRAPGSGGSGPAGGVRNLSR
>Mature_237_residues
SAAGPALRVLLVDDQQLVRAGIALVLSGEPGIEIVAERSDGDEVVAAVRAVRPDVILLDIRMARMDGVDALRALARLGEH
PPALVLTTFSDDDVVWGAMAAGAAGFILKDRPAEDIVRAIRLVAEGGSWIDPSASGRLLGALRTGAVADLAVRRRFERLS
ERELQVLRAMARGASNREIAIELRVSERTVKAHVGSIFGKLEVRDRAGAIVLAHDVGLRAPGSGGSGPAGGVRNLSR

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=213, Percent_Identity=38.4976525821596, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1788222, Length=208, Percent_Identity=32.6923076923077, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1786747, Length=194, Percent_Identity=28.8659793814433, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790102, Length=199, Percent_Identity=30.6532663316583, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788712, Length=200, Percent_Identity=25.5, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787473, Length=215, Percent_Identity=31.1627906976744, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI87082052, Length=103, Percent_Identity=36.8932038834951, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25052; Mature: 24921

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAGPALRVLLVDDQQLVRAGIALVLSGEPGIEIVAERSDGDEVVAAVRAVRPDVILLD
CCCCCCEEEEEEECCHHHHHCCEEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEE
IRMARMDGVDALRALARLGEHPPALVLTTFSDDDVVWGAMAAGAAGFILKDRPAEDIVRA
EEHHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEHHHHCCCCCEEECCCCHHHHHHH
IRLVAEGGSWIDPSASGRLLGALRTGAVADLAVRRRFERLSERELQVLRAMARGASNREI
HHHHHCCCCCCCCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
AIELRVSERTVKAHVGSIFGKLEVRDRAGAIVLAHDVGLRAPGSGGSGPAGGVRNLSR
EEEEEECCHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAAGPALRVLLVDDQQLVRAGIALVLSGEPGIEIVAERSDGDEVVAAVRAVRPDVILLD
CCCCCEEEEEEECCHHHHHCCEEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEE
IRMARMDGVDALRALARLGEHPPALVLTTFSDDDVVWGAMAAGAAGFILKDRPAEDIVRA
EEHHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEHHHHCCCCCEEECCCCHHHHHHH
IRLVAEGGSWIDPSASGRLLGALRTGAVADLAVRRRFERLSERELQVLRAMARGASNREI
HHHHHCCCCCCCCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
AIELRVSERTVKAHVGSIFGKLEVRDRAGAIVLAHDVGLRAPGSGGSGPAGGVRNLSR
EEEEEECCHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]