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The map label for this gene is proC [H]

Identifier: 158317882

GI number: 158317882

Start: 7469494

End: 7470387

Strand: Reverse

Name: proC [H]

Synonym: Franean1_6140

Alternate gene names: 158317882

Gene position: 7470387-7469494 (Counterclockwise)

Preceding gene: 158317883

Following gene: 158317881

Centisome position: 83.17

GC content: 76.06

Gene sequence:

>894_bases
GTGGTCGCCGTCGGATGCGGTGGGCACCGGAGCGAAGGGAAGTGTTCGGTGGTGGGTTCGAGCGTTGTCGCGATCGTCGG
GGCCGGCCGGCTCGGCGGCGCCCTGATGTCCGGGCTGCTGCGGGCGGGGCGGACGCCGTCCGAGGTCGTCGCGGCCGAGC
GCGACCCGGGCCGGGCCGCCGAGATCACCCGGCGGTACGGCGTCGAGGTGGTGGATCCCGCCACCGCGGCGGCGAAGGCC
GGTGTCGTCGTCCTGGCGACCAAGCCGCAGGACATGGGCACGGTCCTCGCCCAGCTCGCTCCGCACGTCGCGCCCGGGGC
GCTGGTCGTCTCAGTGGCGGCCGGGATCACCTCGGCGTTCGTCGCCGAGCGGCTGGCACCAGGCACCCCTGTCGTGCGGG
TGATGACGAACACGCCGCTGCTCGTCGGCGAGGCGATGTCCGCGGTGTGCGCCGGGCCCGGCGCCGGCGACGAGCACGTC
GCCGCGGTCGAGGAGATGCTCCGCCCGGTCGGTCGCGTCGTCCGGGTGACGGAGACCCAGCTTGACGCGGTCACGGCCCT
GTCGGGCAGCGGCCCGGCCTATTTCTTCTACCTGATCGAGGCGATGATCGAGGGCGGTGTGCTGCTGGGCCTGCCGCGCG
CGCTGGCGGCCGAGCTCGTCGTGCAGACCGCCGCCGGATCCGCGCGCATGCTGCGCGACCCCGGTGCCGGCGACTCGGAT
GGCGCGGGTGGGGCCGCGGGCGAGCACCCGTCGCTGCTGCGGGAGGCGGTCACCTCGCCCGGCGGGACGACCGTGGCCGC
GCTGCGGCAGCTCGACCGCGGCGGGGTACGGGCGGCCGTCCTCGACGCGGTCGTGGCGGCGTGGACGCGTTCCCGGGAAC
TCGGCGCGTCCTAG

Upstream 100 bases:

>100_bases
GCCGAGCCCGACCCGCTGTTCGGGCCGGTCCCGGGCGCGGGGCGCGACTGGTGAGAGCGGTGGGACGTCCCGAGCAGCCC
GGGTCATAACCTTCATCGGC

Downstream 100 bases:

>100_bases
CGCCGTCCCGGCACCGGCCGGGATCCGCACCGGTCGTCTTGCCGGGGGGTTCCGGCGGGTAGGCTCGCTCGGAAAAACCT
CGTCAACAGATCGGTCGGGT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MVAVGCGGHRSEGKCSVVGSSVVAIVGAGRLGGALMSGLLRAGRTPSEVVAAERDPGRAAEITRRYGVEVVDPATAAAKA
GVVVLATKPQDMGTVLAQLAPHVAPGALVVSVAAGITSAFVAERLAPGTPVVRVMTNTPLLVGEAMSAVCAGPGAGDEHV
AAVEEMLRPVGRVVRVTETQLDAVTALSGSGPAYFFYLIEAMIEGGVLLGLPRALAAELVVQTAAGSARMLRDPGAGDSD
GAGGAAGEHPSLLREAVTSPGGTTVAALRQLDRGGVRAAVLDAVVAAWTRSRELGAS

Sequences:

>Translated_297_residues
MVAVGCGGHRSEGKCSVVGSSVVAIVGAGRLGGALMSGLLRAGRTPSEVVAAERDPGRAAEITRRYGVEVVDPATAAAKA
GVVVLATKPQDMGTVLAQLAPHVAPGALVVSVAAGITSAFVAERLAPGTPVVRVMTNTPLLVGEAMSAVCAGPGAGDEHV
AAVEEMLRPVGRVVRVTETQLDAVTALSGSGPAYFFYLIEAMIEGGVLLGLPRALAAELVVQTAAGSARMLRDPGAGDSD
GAGGAAGEHPSLLREAVTSPGGTTVAALRQLDRGGVRAAVLDAVVAAWTRSRELGAS
>Mature_297_residues
MVAVGCGGHRSEGKCSVVGSSVVAIVGAGRLGGALMSGLLRAGRTPSEVVAAERDPGRAAEITRRYGVEVVDPATAAAKA
GVVVLATKPQDMGTVLAQLAPHVAPGALVVSVAAGITSAFVAERLAPGTPVVRVMTNTPLLVGEAMSAVCAGPGAGDEHV
AAVEEMLRPVGRVVRVTETQLDAVTALSGSGPAYFFYLIEAMIEGGVLLGLPRALAAELVVQTAAGSARMLRDPGAGDSD
GAGGAAGEHPSLLREAVTSPGGTTVAALRQLDRGGVRAAVLDAVVAAWTRSRELGAS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=273, Percent_Identity=36.2637362637363, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI21361454, Length=278, Percent_Identity=36.3309352517986, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI24797097, Length=278, Percent_Identity=35.6115107913669, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI24797095, Length=278, Percent_Identity=35.6115107913669, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1786585, Length=277, Percent_Identity=33.5740072202166, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17569021, Length=277, Percent_Identity=37.1841155234657, Blast_Score=157, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17540664, Length=284, Percent_Identity=29.2253521126761, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6320861, Length=297, Percent_Identity=31.3131313131313, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21358587, Length=275, Percent_Identity=38.9090909090909, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24647700, Length=180, Percent_Identity=43.8888888888889, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24648116, Length=286, Percent_Identity=30.0699300699301, Blast_Score=124, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29551; Mature: 29551

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVGCGGHRSEGKCSVVGSSVVAIVGAGRLGGALMSGLLRAGRTPSEVVAAERDPGRAA
CEEECCCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHH
EITRRYGVEVVDPATAAAKAGVVVLATKPQDMGTVLAQLAPHVAPGALVVSVAAGITSAF
HHHHHCCCEEECCHHHHHHCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VAERLAPGTPVVRVMTNTPLLVGEAMSAVCAGPGAGDEHVAAVEEMLRPVGRVVRVTETQ
HHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDAVTALSGSGPAYFFYLIEAMIEGGVLLGLPRALAAELVVQTAAGSARMLRDPGAGDSD
HHHHHHCCCCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCHHHHCCCCCCCCC
GAGGAAGEHPSLLREAVTSPGGTTVAALRQLDRGGVRAAVLDAVVAAWTRSRELGAS
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVAVGCGGHRSEGKCSVVGSSVVAIVGAGRLGGALMSGLLRAGRTPSEVVAAERDPGRAA
CEEECCCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHH
EITRRYGVEVVDPATAAAKAGVVVLATKPQDMGTVLAQLAPHVAPGALVVSVAAGITSAF
HHHHHCCCEEECCHHHHHHCCEEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
VAERLAPGTPVVRVMTNTPLLVGEAMSAVCAGPGAGDEHVAAVEEMLRPVGRVVRVTETQ
HHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDAVTALSGSGPAYFFYLIEAMIEGGVLLGLPRALAAELVVQTAAGSARMLRDPGAGDSD
HHHHHHCCCCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCHHHHCCCCCCCCC
GAGGAAGEHPSLLREAVTSPGGTTVAALRQLDRGGVRAAVLDAVVAAWTRSRELGAS
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]