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The map label for this gene is drrB [H]

Identifier: 158317868

GI number: 158317868

Start: 7454852

End: 7455679

Strand: Direct

Name: drrB [H]

Synonym: Franean1_6126

Alternate gene names: 158317868

Gene position: 7454852-7455679 (Clockwise)

Preceding gene: 158317867

Following gene: 158317869

Centisome position: 83.0

GC content: 71.62

Gene sequence:

>828_bases
ATGAGCAGCTCCGTGCTGACGGGACCGGCGGCGGGGAGCGCCAGGCCGGCCCGCGTTTCCGGGGGCGGGCAGCTCGCCGC
TTTCTTCGTGCGCAACGTGCGCGCGCTGCTGCGCCAGCCGGCTTACCTGTCGATCAGCCTGGTCCAGGCCGTGGTGTGGC
TGCCGCTCTTCGGGTCGCTGTTCCGCGGAGTCGCGGACATACCCGGATTCGGCGACGACTCCTACTTCGACTACCTGACA
CCGGGCGTTGTGATGATGTCGGCGTTCTTCAGCGCCGGCTGGGCCGGGATGGGCTTCATCACGGACATGGAGCGCGGGGT
CATGGACCGGATCCTCGCCGCCCCGGCGAGCCGCTGGGCGATCATCGGTGGCTGTCTGGCCTACCAGGCGCTGATGACAA
CCGCCCAGACCGTGATCATCCTGCTGCTCGGCTGGGCGCTGGGAACCGACTACGGGGGCGGTGCCGTCGGACTGCTCGTG
CTGGTCCTGGTCGCGATCGCGCTCGGCACCGTGGTCGCCGCGCTGTCCATGGCGCTGGCGCTGCTCGTCCGCCGTGAGGA
GTCACTGGTCGCGGCGACCAACTTCCTCGCGCTGCCGCTGACCTTCCTCTCGACGGCGATGATGTCCCGCGACCTGCTGC
CCGGCTGGATCCGGCCGATCGCGCTCGCGAACCCGCTGGACTGGGCCGTCTCGGCGGCGCGCGAGACCATCGCCGCCGAC
CCGAACTGGGCACTGGCCGGCTGGCGGGTGGCCGCCCTGGCCGCCGCCGCCCTCACCGCCACCGCCCTGGCCACCCAGGC
CTTCCGCGCCTACCAACGCTCCCTCTGA

Upstream 100 bases:

>100_bases
ACACCCCACCTACGCCGGACACCCCACGCACGCCGGGCACGGCAGGCCAGTCGGGCACGGCAGGCGAGCACGGCTCGGGC
ACCGGACAGGGGGACGTCCG

Downstream 100 bases:

>100_bases
CCAAATCGGCCTCCGGTCAGGCCGGGCGGCCCGATGTGTGGCGGGGTGGCGCTTGCCGTTTTTCCTTGTGGCCCGTGTGA
CGCGACGGAGAACCCTACGG

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSSSVLTGPAAGSARPARVSGGGQLAAFFVRNVRALLRQPAYLSISLVQAVVWLPLFGSLFRGVADIPGFGDDSYFDYLT
PGVVMMSAFFSAGWAGMGFITDMERGVMDRILAAPASRWAIIGGCLAYQALMTTAQTVIILLLGWALGTDYGGGAVGLLV
LVLVAIALGTVVAALSMALALLVRREESLVAATNFLALPLTFLSTAMMSRDLLPGWIRPIALANPLDWAVSAARETIAAD
PNWALAGWRVAALAAAALTATALATQAFRAYQRSL

Sequences:

>Translated_275_residues
MSSSVLTGPAAGSARPARVSGGGQLAAFFVRNVRALLRQPAYLSISLVQAVVWLPLFGSLFRGVADIPGFGDDSYFDYLT
PGVVMMSAFFSAGWAGMGFITDMERGVMDRILAAPASRWAIIGGCLAYQALMTTAQTVIILLLGWALGTDYGGGAVGLLV
LVLVAIALGTVVAALSMALALLVRREESLVAATNFLALPLTFLSTAMMSRDLLPGWIRPIALANPLDWAVSAARETIAAD
PNWALAGWRVAALAAAALTATALATQAFRAYQRSL
>Mature_274_residues
SSSVLTGPAAGSARPARVSGGGQLAAFFVRNVRALLRQPAYLSISLVQAVVWLPLFGSLFRGVADIPGFGDDSYFDYLTP
GVVMMSAFFSAGWAGMGFITDMERGVMDRILAAPASRWAIIGGCLAYQALMTTAQTVIILLLGWALGTDYGGGAVGLLVL
VLVAIALGTVVAALSMALALLVRREESLVAATNFLALPLTFLSTAMMSRDLLPGWIRPIALANPLDWAVSAARETIAADP
NWALAGWRVAALAAAALTATALATQAFRAYQRSL

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 28781; Mature: 28650

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSVLTGPAAGSARPARVSGGGQLAAFFVRNVRALLRQPAYLSISLVQAVVWLPLFGSL
CCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FRGVADIPGFGDDSYFDYLTPGVVMMSAFFSAGWAGMGFITDMERGVMDRILAAPASRWA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
IIGGCLAYQALMTTAQTVIILLLGWALGTDYGGGAVGLLVLVLVAIALGTVVAALSMALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLVRREESLVAATNFLALPLTFLSTAMMSRDLLPGWIRPIALANPLDWAVSAARETIAAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
PNWALAGWRVAALAAAALTATALATQAFRAYQRSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSSVLTGPAAGSARPARVSGGGQLAAFFVRNVRALLRQPAYLSISLVQAVVWLPLFGSL
CCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FRGVADIPGFGDDSYFDYLTPGVVMMSAFFSAGWAGMGFITDMERGVMDRILAAPASRWA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
IIGGCLAYQALMTTAQTVIILLLGWALGTDYGGGAVGLLVLVLVAIALGTVVAALSMALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLVRREESLVAATNFLALPLTFLSTAMMSRDLLPGWIRPIALANPLDWAVSAARETIAAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
PNWALAGWRVAALAAAALTATALATQAFRAYQRSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]