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The map label for this gene is lpdA [H]

Identifier: 158317672

GI number: 158317672

Start: 7202353

End: 7203804

Strand: Direct

Name: lpdA [H]

Synonym: Franean1_5930

Alternate gene names: 158317672

Gene position: 7202353-7203804 (Clockwise)

Preceding gene: 158317670

Following gene: 158317673

Centisome position: 80.19

GC content: 71.01

Gene sequence:

>1452_bases
GTGACGCGCATCGTCATCCTTGGCGGCGGACCCGGCGGCTACGAGGCGGCCCTGGTCGCCGCGTCCCTCGGCGCGACCGT
GACCGTGATCGACTCAGACGGCATCGGCGGGGCGTGTGTCCTGACCGACTGCGTGCCGTCGAAGACCCTCATCGCGACAT
CGGAGACGATGACGAACTTCGCGATGGCGCCGGCGCTGGGGGTGCGCCCACATGGCGACCCCTCGGCCGAGGTCGGCAGC
TGGGAGCTGACCGGCCTGCCCCACCTCACGCCACCGGACGTGGTCACGGTCGACCCCGAGCAGGTCAACGAACGGGTGCG
GGCGCTGGCCCAGGCCCAGTCCGCCGACATCGAGCGCCGCCTGGAGCGGGAGCGGGTCGAGGTGGTGCACGGCACCGGAC
GCCTGGTCGGCCCGCACGCGGTCGAGACGTCCGACGGCGAGACGTTCGTCGGCGACATCGTCCTGGTCGCCACCGGGGCG
TCGCCGCGGGAGATCTCCGGCTGCGAGCCGGACGGCGAGCGCATCCTCACCTGGCGCCACCTGTACGACCTCAAGGAGAT
CCCCGAGCACCTGGTCGTGGTCGGTTCCGGCGTCACCGGCGCCGAGTTCGCCAGCGCCTACCGGGCGCTCGGCGCCGAGG
TGACACTTGTCTCCTCACGCGAGCGGGTGCTGCCCGGCGAGGACCCGGACGCGGCCCGGGTGATCGAGGATGTCTTCGTC
CGCCGCGGCATCGAGGTACTCAACCGCTCCCGGGCCGCCGCGGCGCGCCGGATCGGTGACGGCGTCCTCGTCGAGCTCAC
CGACGGCCGGACGGTGACAGGCAGCCACGCGCTGATGGCGGTGGGTTCGGTGCCGCGGACGAAGGGCCTCGGTCTCACCG
AGGTCGGCGTCCGGCTCGGCTCCGGCGGCCACGTCGTCGTCGACCGCATGTCCCGGACGTCGGTTCCCGGCGTGTACGCG
GCCGGCGACTGCACCGGCGTGCTCCCGCTGGCGTCCGTCGCCGCGATGCAGGGCCGGATCGCGATGTGGCACGCCCTCGG
CGAGGCGGTGACCCCGCTGCGCCTGGGCACCGTGTCGTCGAACATCTTCACCGAGCCCGAGATCGCCACCGTCGGGGTGA
CCCAGCGGATGAAGGACTCCGGCGCGATCGCCGCCGAGGTCACCACAGTGCCACTGATGCGCAATCCTCGAGCGAAGATG
ATGGGGATAGCGGATGGCTTCGTGAAGTTGTTCTGCCGGCCCGGAAGTGGCAGCGTCCTGGGTGGCGTCATCGTTGCTCC
GCGTGCAAGTGAACTGATCCTCTCAATTTCACTCGCGGTGGAGAACGGTCTGACCGTCGACCAGATCGCGCACACCTTCT
CGATCTATCCCTCCTTGTCCGGTTCCATCACTGAGGCGGCCCGTGTCCTGCGGCCGCGCGACCTGTTCGCCGGCTTCGAC
ACCCCCGCCTGA

Upstream 100 bases:

>100_bases
ACGTCGGTGGAAGATACTACGGAGGCCGCCGCACCGGGACGAGAGGGACGTCGGAAGAGGGGCAAACTAGGGAGGTACGA
CGAGCTCTGGAGGATCCCAC

Downstream 100 bases:

>100_bases
ACAGGCCTGTCACTCCGGCCCAGGCCGGATAATGGGCCCATGAAAGGCGTCTTCGTCGGCCTGACGACGCTTGATTCGGT
CTACCTCGTGGATCGGCTTC

Product: flavoprotein disulfide reductase

Products: NA

Alternate protein names: NAD(P)H quinone reductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTRIVILGGGPGGYEAALVAASLGATVTVIDSDGIGGACVLTDCVPSKTLIATSETMTNFAMAPALGVRPHGDPSAEVGS
WELTGLPHLTPPDVVTVDPEQVNERVRALAQAQSADIERRLERERVEVVHGTGRLVGPHAVETSDGETFVGDIVLVATGA
SPREISGCEPDGERILTWRHLYDLKEIPEHLVVVGSGVTGAEFASAYRALGAEVTLVSSRERVLPGEDPDAARVIEDVFV
RRGIEVLNRSRAAAARRIGDGVLVELTDGRTVTGSHALMAVGSVPRTKGLGLTEVGVRLGSGGHVVVDRMSRTSVPGVYA
AGDCTGVLPLASVAAMQGRIAMWHALGEAVTPLRLGTVSSNIFTEPEIATVGVTQRMKDSGAIAAEVTTVPLMRNPRAKM
MGIADGFVKLFCRPGSGSVLGGVIVAPRASELILSISLAVENGLTVDQIAHTFSIYPSLSGSITEAARVLRPRDLFAGFD
TPA

Sequences:

>Translated_483_residues
MTRIVILGGGPGGYEAALVAASLGATVTVIDSDGIGGACVLTDCVPSKTLIATSETMTNFAMAPALGVRPHGDPSAEVGS
WELTGLPHLTPPDVVTVDPEQVNERVRALAQAQSADIERRLERERVEVVHGTGRLVGPHAVETSDGETFVGDIVLVATGA
SPREISGCEPDGERILTWRHLYDLKEIPEHLVVVGSGVTGAEFASAYRALGAEVTLVSSRERVLPGEDPDAARVIEDVFV
RRGIEVLNRSRAAAARRIGDGVLVELTDGRTVTGSHALMAVGSVPRTKGLGLTEVGVRLGSGGHVVVDRMSRTSVPGVYA
AGDCTGVLPLASVAAMQGRIAMWHALGEAVTPLRLGTVSSNIFTEPEIATVGVTQRMKDSGAIAAEVTTVPLMRNPRAKM
MGIADGFVKLFCRPGSGSVLGGVIVAPRASELILSISLAVENGLTVDQIAHTFSIYPSLSGSITEAARVLRPRDLFAGFD
TPA
>Mature_482_residues
TRIVILGGGPGGYEAALVAASLGATVTVIDSDGIGGACVLTDCVPSKTLIATSETMTNFAMAPALGVRPHGDPSAEVGSW
ELTGLPHLTPPDVVTVDPEQVNERVRALAQAQSADIERRLERERVEVVHGTGRLVGPHAVETSDGETFVGDIVLVATGAS
PREISGCEPDGERILTWRHLYDLKEIPEHLVVVGSGVTGAEFASAYRALGAEVTLVSSRERVLPGEDPDAARVIEDVFVR
RGIEVLNRSRAAAARRIGDGVLVELTDGRTVTGSHALMAVGSVPRTKGLGLTEVGVRLGSGGHVVVDRMSRTSVPGVYAA
GDCTGVLPLASVAAMQGRIAMWHALGEAVTPLRLGTVSSNIFTEPEIATVGVTQRMKDSGAIAAEVTTVPLMRNPRAKMM
GIADGFVKLFCRPGSGSVLGGVIVAPRASELILSISLAVENGLTVDQIAHTFSIYPSLSGSITEAARVLRPRDLFAGFDT
PA

Specific function: May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NAD(P)H is the physiological reductant rather than NADH [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=475, Percent_Identity=30.5263157894737, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI50301238, Length=467, Percent_Identity=26.5524625267666, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=25.2118644067797, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI291045266, Length=473, Percent_Identity=23.2558139534884, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI148277065, Length=475, Percent_Identity=23.5789473684211, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI33519430, Length=475, Percent_Identity=23.5789473684211, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI33519428, Length=475, Percent_Identity=23.5789473684211, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI33519426, Length=475, Percent_Identity=23.5789473684211, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI148277071, Length=475, Percent_Identity=23.5789473684211, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI291045268, Length=467, Percent_Identity=22.9122055674518, Blast_Score=83, Evalue=7e-16,
Organism=Escherichia coli, GI1786307, Length=484, Percent_Identity=29.5454545454545, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87082354, Length=475, Percent_Identity=27.7894736842105, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789915, Length=459, Percent_Identity=25.9259259259259, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI87081717, Length=480, Percent_Identity=23.75, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32565766, Length=474, Percent_Identity=29.746835443038, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71983419, Length=460, Percent_Identity=26.9565217391304, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71983429, Length=460, Percent_Identity=26.9565217391304, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17557007, Length=482, Percent_Identity=24.4813278008299, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17559934, Length=205, Percent_Identity=28.780487804878, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=27.5933609958506, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6325166, Length=457, Percent_Identity=25.382932166302, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=493, Percent_Identity=23.9350912778905, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21358499, Length=490, Percent_Identity=31.2244897959184, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24640553, Length=516, Percent_Identity=26.7441860465116, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24640549, Length=516, Percent_Identity=26.7441860465116, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24640551, Length=516, Percent_Identity=26.7441860465116, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17737741, Length=495, Percent_Identity=25.4545454545455, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.5.2 [H]

Molecular weight: Translated: 50333; Mature: 50202

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIVILGGGPGGYEAALVAASLGATVTVIDSDGIGGACVLTDCVPSKTLIATSETMTNF
CEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCEEEEECHHHHHH
AMAPALGVRPHGDPSAEVGSWELTGLPHLTPPDVVTVDPEQVNERVRALAQAQSADIERR
HHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHH
LERERVEVVHGTGRLVGPHAVETSDGETFVGDIVLVATGASPREISGCEPDGERILTWRH
HHHHHEEEEECCCCEECCCEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEEEHHH
LYDLKEIPEHLVVVGSGVTGAEFASAYRALGAEVTLVSSRERVLPGEDPDAARVIEDVFV
HHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
RRGIEVLNRSRAAAARRIGDGVLVELTDGRTVTGSHALMAVGSVPRTKGLGLTEVGVRLG
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCEEEEECCCCCCCCCCHHHHCEEEC
SGGHVVVDRMSRTSVPGVYAAGDCTGVLPLASVAAMQGRIAMWHALGEAVTPLRLGTVSS
CCCEEEEECCCCCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCC
NIFTEPEIATVGVTQRMKDSGAIAAEVTTVPLMRNPRAKMMGIADGFVKLFCRPGSGSVL
CCCCCCCEEEECHHHHHCCCCCEEEEEEEECCCCCCCHHEEEHHCCEEEEEEECCCCCEE
GGVIVAPRASELILSISLAVENGLTVDQIAHTFSIYPSLSGSITEAARVLRPRDLFAGFD
EEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHEECCCCCCCHHHHHHHCCCHHHHCCCC
TPA
CCC
>Mature Secondary Structure 
TRIVILGGGPGGYEAALVAASLGATVTVIDSDGIGGACVLTDCVPSKTLIATSETMTNF
EEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCEEEEECHHHHHH
AMAPALGVRPHGDPSAEVGSWELTGLPHLTPPDVVTVDPEQVNERVRALAQAQSADIERR
HHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHH
LERERVEVVHGTGRLVGPHAVETSDGETFVGDIVLVATGASPREISGCEPDGERILTWRH
HHHHHEEEEECCCCEECCCEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEEEHHH
LYDLKEIPEHLVVVGSGVTGAEFASAYRALGAEVTLVSSRERVLPGEDPDAARVIEDVFV
HHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
RRGIEVLNRSRAAAARRIGDGVLVELTDGRTVTGSHALMAVGSVPRTKGLGLTEVGVRLG
HHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCEEEEECCCCCCCCCCHHHHCEEEC
SGGHVVVDRMSRTSVPGVYAAGDCTGVLPLASVAAMQGRIAMWHALGEAVTPLRLGTVSS
CCCEEEEECCCCCCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCC
NIFTEPEIATVGVTQRMKDSGAIAAEVTTVPLMRNPRAKMMGIADGFVKLFCRPGSGSVL
CCCCCCCEEEECHHHHHCCCCCEEEEEEEECCCCCCCHHEEEHHCCEEEEEEECCCCCEE
GGVIVAPRASELILSISLAVENGLTVDQIAHTFSIYPSLSGSITEAARVLRPRDLFAGFD
EEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHEECCCCCCCHHHHHHHCCCHHHHCCCC
TPA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]