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The map label for this gene is bccA [H]

Identifier: 158317658

GI number: 158317658

Start: 7186404

End: 7188167

Strand: Direct

Name: bccA [H]

Synonym: Franean1_5916

Alternate gene names: 158317658

Gene position: 7186404-7188167 (Clockwise)

Preceding gene: 158317657

Following gene: 158317659

Centisome position: 80.01

GC content: 72.34

Gene sequence:

>1764_bases
GTGCGTAAGATCCTCATCGCCAACCGGGGGGAAATTGCCGTCCGGGTGGCGCGGGCCTGCCGCGACGCGGGATATTCAAG
CGTCGCCGTGTATGCGGAGCCCGACATCGACGCCATGCATGTCCGGGTCGCGGACGAGGCGTACGCGCTGGGCGGGACAA
CGCCCGGCGACTCGTACCTGAGAATCGACAAGATTCTTCAGGCGTGCGAGCTCTCCGGCGCGGACGCGGTGCACCCCGGC
TACGGTTTCCTCTCCGAGAACGCGGATTTCGCCGAAGCCGTGATCTCCGCCGGGCTGACCTGGATCGGCCCGCCGCCCGA
GGCCATTCGCCGGCTCGGTGACAAGACCGCCGCGCGCCACATCGCGCTGGCCGTCGGCGCCCCGCTCGCCCCGGGCACCG
CCGACCCGGTCGCCGGGGTCGACGAGGTGGTCGCGTTCGCGAACGAGCACGGCCTGCCGGTCGCCATCAAGGCCGCCTTC
GGCGGCGGCGGCCGTGGGCTCAAGGTCGCGTGGAGCGCCGAGGAGCTGCCCGAGCTGTTCGAGAGCGCGGTACGCGAGGC
CGTCGCGGCCTTCGGCCGGGGCGAGTGCTTCGTCGAGCGCTACCTCGACCAGCCCCGCCACGTCGAGACCCAGATCCTGG
CCGACACGCACGGCAACGTCGTCGTCGTCGGCACCCGGGACTGCTCCCTGCAGCGGCGCTACCAGAAGCTCGTCGAGGAG
GCGCCCGCGCCGTTCCTCACCGAGGCGCAGAACACCGCCCTGTACGAGGCGTCCAAGTCGATCATCCACGAGGCCGGCTA
CGTCGGCGCCGGCACGGTGGAGTTCCTCGTCGCCAAGGACGGGATGATCAGCTTCCTCGAGGTCAACACCCGGTTGCAGG
TCGAGCACCCGGTGACCGAGGAGACCTCCGGCGTCGACCTGGTGCGGGCCCAGTTCCGCATCGCCGAGGGCGAGGCCCTC
GACCCGGTCGACCCGACCCCGCGCGGCCACTCGATCGAGTTCCGCATCAACGGCGAGGACCCGGGTCGCAACTTCCTCCC
GGCGCCGGGCACCGTGACCACGTTCACGGCTCCGGCCGGCCCCGGGGTCCGCCTGGACACCGGCGTCGAGAGCGGCAGCG
TCATCGGTGGGGCGTTCGACTCGCTGCTCGCCAAGCTCATCGTCACCGGGGCGACCCGCCAGGAAGCCCTCGAGCGGGCC
CGGCGCGCCCTCGACGAGATGGTCGTCGAGGGCATGGCCACCGCGCTGCCGTTCCACCGCGCGGTCGTACGCGACCCGGC
GTTCGCGCCGGAGGCGGCGGACGAGCCGTTCCGGGTGCACAACCGCTGGATCGAGACCGAGTTCGACAACACGATCCCGC
CGTTCGCCGGCGGCACCGACGCCGACACCGAGACCGACCCGCGGGAGACCGTGGTCGTCGAGGTCGGTGGCAAGCGGCTG
GAGGTCGTCCTGCCCGCCGGGTTCGGCGCGGGCGGCGGCGCGGCCGTCTCCGCCGGTGCCGCGGCACCCAGGCGGCGCTC
GGCGAGCAAGGCCGCGGCCAAGGTCACCGGCGACGCGCTGACCAGCCCGATGCAGGGCACCATCGTCAAGGTCGCGGTCA
GCGACGGCGACACCGTCGAGGCCGGCGACCTGATCGTCGTCCTCGAGGCGATGAAGATGGAGCAGCCCATCAACGCGCAC
CGGGCCGGGACCGTCGGCGGGCTCGCGGCAGCGGTCGGGGCTGTCGTGACCAGCGGTGCCATTCTCTGCGAGATCAAGGA
CTGA

Upstream 100 bases:

>100_bases
CAGGTCTTTCCCACCCTCGCCGGCAGAGCCGGAATGGCAAAGAAGAAATATGGTGCGGCCCGACTCGCCTAGACTCAGGC
CGGACGAGGACGGGAGGAAC

Downstream 100 bases:

>100_bases
CCGAACGACGCCCACCGGCGGCGTTCCCCGGACGGGGAGCGCCGCCGCCGCCGTTTCCGACACGGCCGCGATGGCGGTGG
CGGCCATCCGCGATCAGCGC

Product: carbamoyl-phosphate synthase L chain ATP-binding

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MRKILIANRGEIAVRVARACRDAGYSSVAVYAEPDIDAMHVRVADEAYALGGTTPGDSYLRIDKILQACELSGADAVHPG
YGFLSENADFAEAVISAGLTWIGPPPEAIRRLGDKTAARHIALAVGAPLAPGTADPVAGVDEVVAFANEHGLPVAIKAAF
GGGGRGLKVAWSAEELPELFESAVREAVAAFGRGECFVERYLDQPRHVETQILADTHGNVVVVGTRDCSLQRRYQKLVEE
APAPFLTEAQNTALYEASKSIIHEAGYVGAGTVEFLVAKDGMISFLEVNTRLQVEHPVTEETSGVDLVRAQFRIAEGEAL
DPVDPTPRGHSIEFRINGEDPGRNFLPAPGTVTTFTAPAGPGVRLDTGVESGSVIGGAFDSLLAKLIVTGATRQEALERA
RRALDEMVVEGMATALPFHRAVVRDPAFAPEAADEPFRVHNRWIETEFDNTIPPFAGGTDADTETDPRETVVVEVGGKRL
EVVLPAGFGAGGGAAVSAGAAAPRRRSASKAAAKVTGDALTSPMQGTIVKVAVSDGDTVEAGDLIVVLEAMKMEQPINAH
RAGTVGGLAAAVGAVVTSGAILCEIKD

Sequences:

>Translated_587_residues
MRKILIANRGEIAVRVARACRDAGYSSVAVYAEPDIDAMHVRVADEAYALGGTTPGDSYLRIDKILQACELSGADAVHPG
YGFLSENADFAEAVISAGLTWIGPPPEAIRRLGDKTAARHIALAVGAPLAPGTADPVAGVDEVVAFANEHGLPVAIKAAF
GGGGRGLKVAWSAEELPELFESAVREAVAAFGRGECFVERYLDQPRHVETQILADTHGNVVVVGTRDCSLQRRYQKLVEE
APAPFLTEAQNTALYEASKSIIHEAGYVGAGTVEFLVAKDGMISFLEVNTRLQVEHPVTEETSGVDLVRAQFRIAEGEAL
DPVDPTPRGHSIEFRINGEDPGRNFLPAPGTVTTFTAPAGPGVRLDTGVESGSVIGGAFDSLLAKLIVTGATRQEALERA
RRALDEMVVEGMATALPFHRAVVRDPAFAPEAADEPFRVHNRWIETEFDNTIPPFAGGTDADTETDPRETVVVEVGGKRL
EVVLPAGFGAGGGAAVSAGAAAPRRRSASKAAAKVTGDALTSPMQGTIVKVAVSDGDTVEAGDLIVVLEAMKMEQPINAH
RAGTVGGLAAAVGAVVTSGAILCEIKD
>Mature_587_residues
MRKILIANRGEIAVRVARACRDAGYSSVAVYAEPDIDAMHVRVADEAYALGGTTPGDSYLRIDKILQACELSGADAVHPG
YGFLSENADFAEAVISAGLTWIGPPPEAIRRLGDKTAARHIALAVGAPLAPGTADPVAGVDEVVAFANEHGLPVAIKAAF
GGGGRGLKVAWSAEELPELFESAVREAVAAFGRGECFVERYLDQPRHVETQILADTHGNVVVVGTRDCSLQRRYQKLVEE
APAPFLTEAQNTALYEASKSIIHEAGYVGAGTVEFLVAKDGMISFLEVNTRLQVEHPVTEETSGVDLVRAQFRIAEGEAL
DPVDPTPRGHSIEFRINGEDPGRNFLPAPGTVTTFTAPAGPGVRLDTGVESGSVIGGAFDSLLAKLIVTGATRQEALERA
RRALDEMVVEGMATALPFHRAVVRDPAFAPEAADEPFRVHNRWIETEFDNTIPPFAGGTDADTETDPRETVVVEVGGKRL
EVVLPAGFGAGGGAAVSAGAAAPRRRSASKAAAKVTGDALTSPMQGTIVKVAVSDGDTVEAGDLIVVLEAMKMEQPINAH
RAGTVGGLAAAVGAVVTSGAILCEIKD

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=46.1711711711712, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=46.1711711711712, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=46.1711711711712, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI116805327, Length=433, Percent_Identity=44.8036951501155, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI295821183, Length=632, Percent_Identity=35.6012658227848, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI65506442, Length=430, Percent_Identity=42.3255813953488, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI189095269, Length=430, Percent_Identity=42.3255813953488, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI38679971, Length=472, Percent_Identity=32.8389830508475, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679974, Length=472, Percent_Identity=32.8389830508475, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679960, Length=472, Percent_Identity=32.8389830508475, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679977, Length=472, Percent_Identity=32.8389830508475, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI38679967, Length=472, Percent_Identity=32.8389830508475, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI134142062, Length=476, Percent_Identity=32.3529411764706, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1789654, Length=431, Percent_Identity=45.2436194895592, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI1786216, Length=326, Percent_Identity=24.2331288343558, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562816, Length=444, Percent_Identity=45.7207207207207, Blast_Score=374, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17567343, Length=431, Percent_Identity=42.92343387471, Blast_Score=343, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI71987519, Length=433, Percent_Identity=42.0323325635104, Blast_Score=331, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI133931226, Length=457, Percent_Identity=28.0087527352298, Blast_Score=185, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI71997163, Length=474, Percent_Identity=29.1139240506329, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI71997168, Length=474, Percent_Identity=29.3248945147679, Blast_Score=178, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6319695, Length=435, Percent_Identity=44.8275862068966, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321376, Length=435, Percent_Identity=44.8275862068966, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6319685, Length=453, Percent_Identity=41.5011037527594, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6323863, Length=435, Percent_Identity=31.7241379310345, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324343, Length=483, Percent_Identity=31.4699792960663, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=46.6216216216216, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=46.6216216216216, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=46.6216216216216, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=46.6216216216216, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=46.6216216216216, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=46.6216216216216, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=46.6216216216216, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=46.6216216216216, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=46.6216216216216, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=46.6216216216216, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651757, Length=459, Percent_Identity=41.6122004357298, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24651759, Length=421, Percent_Identity=40.6175771971496, Blast_Score=310, Evalue=3e-84,
Organism=Drosophila melanogaster, GI161076409, Length=470, Percent_Identity=31.9148936170213, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24586458, Length=474, Percent_Identity=32.2784810126582, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI161076407, Length=470, Percent_Identity=31.9148936170213, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24586460, Length=470, Percent_Identity=31.9148936170213, Blast_Score=202, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 61442; Mature: 61442

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKILIANRGEIAVRVARACRDAGYSSVAVYAEPDIDAMHVRVADEAYALGGTTPGDSYL
CCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCEEECCCCCCCCCHH
RIDKILQACELSGADAVHPGYGFLSENADFAEAVISAGLTWIGPPPEAIRRLGDKTAARH
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHE
IALAVGAPLAPGTADPVAGVDEVVAFANEHGLPVAIKAAFGGGGRGLKVAWSAEELPELF
EEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEECHHHHHHHH
ESAVREAVAAFGRGECFVERYLDQPRHVETQILADTHGNVVVVGTRDCSLQRRYQKLVEE
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHH
APAPFLTEAQNTALYEASKSIIHEAGYVGAGTVEFLVAKDGMISFLEVNTRLQVEHPVTE
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCEEEECCCCCC
ETSGVDLVRAQFRIAEGEALDPVDPTPRGHSIEFRINGEDPGRNFLPAPGTVTTFTAPAG
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCC
PGVRLDTGVESGSVIGGAFDSLLAKLIVTGATRQEALERARRALDEMVVEGMATALPFHR
CCCEEECCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVRDPAFAPEAADEPFRVHNRWIETEFDNTIPPFAGGTDADTETDPRETVVVEVGGKRL
HHHCCCCCCCCCCCCCHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEE
EVVLPAGFGAGGGAAVSAGAAAPRRRSASKAAAKVTGDALTSPMQGTIVKVAVSDGDTVE
EEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHCCCCCCEEEEEEECCCCEEC
AGDLIVVLEAMKMEQPINAHRAGTVGGLAAAVGAVVTSGAILCEIKD
CCCEEEEEEHHHCCCCCCHHCCCCHHHHHHHHHHHHHCCEEEEEECC
>Mature Secondary Structure
MRKILIANRGEIAVRVARACRDAGYSSVAVYAEPDIDAMHVRVADEAYALGGTTPGDSYL
CCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCEEECCCCCCCCCHH
RIDKILQACELSGADAVHPGYGFLSENADFAEAVISAGLTWIGPPPEAIRRLGDKTAARH
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHE
IALAVGAPLAPGTADPVAGVDEVVAFANEHGLPVAIKAAFGGGGRGLKVAWSAEELPELF
EEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEECHHHHHHHH
ESAVREAVAAFGRGECFVERYLDQPRHVETQILADTHGNVVVVGTRDCSLQRRYQKLVEE
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHH
APAPFLTEAQNTALYEASKSIIHEAGYVGAGTVEFLVAKDGMISFLEVNTRLQVEHPVTE
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCEEEECCCCCC
ETSGVDLVRAQFRIAEGEALDPVDPTPRGHSIEFRINGEDPGRNFLPAPGTVTTFTAPAG
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCC
PGVRLDTGVESGSVIGGAFDSLLAKLIVTGATRQEALERARRALDEMVVEGMATALPFHR
CCCEEECCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVRDPAFAPEAADEPFRVHNRWIETEFDNTIPPFAGGTDADTETDPRETVVVEVGGKRL
HHHCCCCCCCCCCCCCHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEE
EVVLPAGFGAGGGAAVSAGAAAPRRRSASKAAAKVTGDALTSPMQGTIVKVAVSDGDTVE
EEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHCCCCCCEEEEEEECCCCEEC
AGDLIVVLEAMKMEQPINAHRAGTVGGLAAAVGAVVTSGAILCEIKD
CCCEEEEEEHHHCCCCCCHHCCCCHHHHHHHHHHHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]