Click here to switch to the map view.

The map label for this gene is rkpK [H]

Identifier: 158317647

GI number: 158317647

Start: 7174100

End: 7175587

Strand: Direct

Name: rkpK [H]

Synonym: Franean1_5905

Alternate gene names: 158317647

Gene position: 7174100-7175587 (Clockwise)

Preceding gene: 158317646

Following gene: 158317649

Centisome position: 79.87

GC content: 76.48

Gene sequence:

>1488_bases
ATGCCCGGCGGCGGTAGCGACGACGTGACCCGGCGGCCCGCGGTCCCCCGGCCGCTCATGACGGGCGGCCTGCCGGCCGT
CCGCCGCATCGGCGTGGTCGGGACGGGCTACCTCGGCGCCACGCACGCGGTCTGCATGGCCGAGCTGGGCTATGAGGTCG
TGGGGCTCGACACGGACGCCGACAAGGTCCGCCGACTCGGCGCGGGCGAGGTGCCGTTCTTCGAGCCGGGGCTCGAGGAG
CTGCTGCGCAAGAACCTGGAGGCGGGCCGGCTGTCGTTCACCTGCGACCCGGCCGAGGTCGCCGGGTGGGCCGACGTCCA
CTTCATCTGTGTCGGCACGCCGCAGCGGGCCGGTGACGGCGCCGCCGACATGACCTACGTGGACGCGGCCGTCGAGACAC
TGATCCGCGCCGGCCTGCGGCCGGACGCGCTCGTGGTCGGCAAGTCGACGGTGCCGGCGGGCAGCGCCGAGCGGCTCGCG
CGCCGGCTGGCAGCGGGAACCGGCGGCACCGGGCCGGGCGGCGCCCGGACGGGCGAGGCGGCGCCAGGCGGAACGGGGAC
AGGCCGGGCACGGACGGCACAGCCGGCGCCGGGCGGAGTCGAGCTGGCGTGGAACCCGGAGTTCCTGCGCGAGGGGTTCG
CGGTCGACGACACGCTGCGCCCGGACAGGCTGGTCTTCGGCGTCCGGCCGGGCGGGCGCGGGGAGGCGGTGCTGCGGGCC
GTCTACGCGCCGGTGATCGAGGCCGGCACGCCCGTGATCGTCACCGACTACGCCACCGCCGAGCTGGTGAAGGTCGCGGC
GAACGCCTTCCTGGCGACCAAGATCTCCTTCATCAACGCGATGTCGGAGGTCTGCGACGCCGCCGGCGGAGACGTGACGA
GCCTGGCGCGGGCGCTCTCCCACGACGCCAGGATCGGCGGGAGGTTCCTGCGGCCGGGGATCGGCTTCGGCGGCGGCTGC
CTGCCCAAGGACATCCGGGCCTTCCATGCGCGGGCGGCCGAGCTCGGCGCCGGCCCGGCGCTGGGCTTCCTGGCCGAGGT
CGACCGGATCAACCTGCGGGCCCGGGAGCGGACCGTCGCCCTGATCACCAGGGCACTCGGGGGCCGCGCGGAGGGCCGGC
GGATCACGGTGCTCGGCGCGGCGTTCAAGCCGAACTCGGACGACATCCGCGACTCGCCCGCCCTGGAGATCTCCGCCGAG
CTGCACCGGGCCGGCGCCCGGGTGGTCGTGTACGACCCGGCCGCGATGGCCAACGCCCGGCGGCGCTTCCCCGAGCTGGA
GTACGCGCCGTCCGCGCACGAGGCGGCGACCGGCGCGGACGCGCTTGCGGTGCTCACCGAGTGGACCGAGTTCCGCGACC
TGGACCCGGACGCGCTCACCCCGCGGGTGGCCGGGCGGGTCGTCGTCGACGGCCGGCACGCGCTCGACGGCCCGGCCTGG
CGCCGGGCCGGGTGGGCGTACTACGCGCTCGGCCGTCCACCGGCCTGA

Upstream 100 bases:

>100_bases
GCCGACAGCGAACGGATCACCGCGGTGGACTGGTCCGTGCCGGGGCCACTCACCGAAGCCCTGCCGGCCGGGGTTCGTCC
CATCGACCCCGTCGACGCGC

Downstream 100 bases:

>100_bases
CCGTCAGCCGGGGCTCAGCCAGCCGGGGCTCAGCCGCGCAGGTCAGGCGGTCGCCTGGGTGGGCGCGCACGCGGCCGGCT
GTGGGCTCTCGGTGATCTCA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MPGGGSDDVTRRPAVPRPLMTGGLPAVRRIGVVGTGYLGATHAVCMAELGYEVVGLDTDADKVRRLGAGEVPFFEPGLEE
LLRKNLEAGRLSFTCDPAEVAGWADVHFICVGTPQRAGDGAADMTYVDAAVETLIRAGLRPDALVVGKSTVPAGSAERLA
RRLAAGTGGTGPGGARTGEAAPGGTGTGRARTAQPAPGGVELAWNPEFLREGFAVDDTLRPDRLVFGVRPGGRGEAVLRA
VYAPVIEAGTPVIVTDYATAELVKVAANAFLATKISFINAMSEVCDAAGGDVTSLARALSHDARIGGRFLRPGIGFGGGC
LPKDIRAFHARAAELGAGPALGFLAEVDRINLRARERTVALITRALGGRAEGRRITVLGAAFKPNSDDIRDSPALEISAE
LHRAGARVVVYDPAAMANARRRFPELEYAPSAHEAATGADALAVLTEWTEFRDLDPDALTPRVAGRVVVDGRHALDGPAW
RRAGWAYYALGRPPA

Sequences:

>Translated_495_residues
MPGGGSDDVTRRPAVPRPLMTGGLPAVRRIGVVGTGYLGATHAVCMAELGYEVVGLDTDADKVRRLGAGEVPFFEPGLEE
LLRKNLEAGRLSFTCDPAEVAGWADVHFICVGTPQRAGDGAADMTYVDAAVETLIRAGLRPDALVVGKSTVPAGSAERLA
RRLAAGTGGTGPGGARTGEAAPGGTGTGRARTAQPAPGGVELAWNPEFLREGFAVDDTLRPDRLVFGVRPGGRGEAVLRA
VYAPVIEAGTPVIVTDYATAELVKVAANAFLATKISFINAMSEVCDAAGGDVTSLARALSHDARIGGRFLRPGIGFGGGC
LPKDIRAFHARAAELGAGPALGFLAEVDRINLRARERTVALITRALGGRAEGRRITVLGAAFKPNSDDIRDSPALEISAE
LHRAGARVVVYDPAAMANARRRFPELEYAPSAHEAATGADALAVLTEWTEFRDLDPDALTPRVAGRVVVDGRHALDGPAW
RRAGWAYYALGRPPA
>Mature_494_residues
PGGGSDDVTRRPAVPRPLMTGGLPAVRRIGVVGTGYLGATHAVCMAELGYEVVGLDTDADKVRRLGAGEVPFFEPGLEEL
LRKNLEAGRLSFTCDPAEVAGWADVHFICVGTPQRAGDGAADMTYVDAAVETLIRAGLRPDALVVGKSTVPAGSAERLAR
RLAAGTGGTGPGGARTGEAAPGGTGTGRARTAQPAPGGVELAWNPEFLREGFAVDDTLRPDRLVFGVRPGGRGEAVLRAV
YAPVIEAGTPVIVTDYATAELVKVAANAFLATKISFINAMSEVCDAAGGDVTSLARALSHDARIGGRFLRPGIGFGGGCL
PKDIRAFHARAAELGAGPALGFLAEVDRINLRARERTVALITRALGGRAEGRRITVLGAAFKPNSDDIRDSPALEISAEL
HRAGARVVVYDPAAMANARRRFPELEYAPSAHEAATGADALAVLTEWTEFRDLDPDALTPRVAGRVVVDGRHALDGPAWR
RAGWAYYALGRPPA

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=477, Percent_Identity=29.559748427673, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI296040438, Length=377, Percent_Identity=30.5039787798408, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI296040443, Length=292, Percent_Identity=33.5616438356164, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI48994968, Length=454, Percent_Identity=29.295154185022, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788340, Length=389, Percent_Identity=24.9357326478149, Blast_Score=122, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17560350, Length=496, Percent_Identity=31.4516129032258, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17136908, Length=489, Percent_Identity=29.2433537832311, Blast_Score=206, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51610; Mature: 51479

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGGGSDDVTRRPAVPRPLMTGGLPAVRRIGVVGTGYLGATHAVCMAELGYEVVGLDTDA
CCCCCCCCCCCCCCCCCCHHHCCCHHHHHHCCEECCCHHHHHHHHHHHCCCEEEECCCCH
DKVRRLGAGEVPFFEPGLEELLRKNLEAGRLSFTCDPAEVAGWADVHFICVGTPQRAGDG
HHHHHCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECHHHHCCCCCEEEEEEECCCCCCCC
AADMTYVDAAVETLIRAGLRPDALVVGKSTVPAGSAERLARRLAAGTGGTGPGGARTGEA
CCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
APGGTGTGRARTAQPAPGGVELAWNPEFLREGFAVDDTLRPDRLVFGVRPGGRGEAVLRA
CCCCCCCCCCCCCCCCCCCEEEEECHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
VYAPVIEAGTPVIVTDYATAELVKVAANAFLATKISFINAMSEVCDAAGGDVTSLARALS
HHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
HDARIGGRFLRPGIGFGGGCLPKDIRAFHARAAELGAGPALGFLAEVDRINLRARERTVA
HHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHH
LITRALGGRAEGRRITVLGAAFKPNSDDIRDSPALEISAELHRAGARVVVYDPAAMANAR
HHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEHHHHHCCCEEEEECCHHHHHHH
RRFPELEYAPSAHEAATGADALAVLTEWTEFRDLDPDALTPRVAGRVVVDGRHALDGPAW
HCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCHHCCHHHCCEEEECCCCCCCCCHH
RRAGWAYYALGRPPA
HHCCEEEEECCCCCC
>Mature Secondary Structure 
PGGGSDDVTRRPAVPRPLMTGGLPAVRRIGVVGTGYLGATHAVCMAELGYEVVGLDTDA
CCCCCCCCCCCCCCCCCHHHCCCHHHHHHCCEECCCHHHHHHHHHHHCCCEEEECCCCH
DKVRRLGAGEVPFFEPGLEELLRKNLEAGRLSFTCDPAEVAGWADVHFICVGTPQRAGDG
HHHHHCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECHHHHCCCCCEEEEEEECCCCCCCC
AADMTYVDAAVETLIRAGLRPDALVVGKSTVPAGSAERLARRLAAGTGGTGPGGARTGEA
CCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
APGGTGTGRARTAQPAPGGVELAWNPEFLREGFAVDDTLRPDRLVFGVRPGGRGEAVLRA
CCCCCCCCCCCCCCCCCCCEEEEECHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
VYAPVIEAGTPVIVTDYATAELVKVAANAFLATKISFINAMSEVCDAAGGDVTSLARALS
HHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
HDARIGGRFLRPGIGFGGGCLPKDIRAFHARAAELGAGPALGFLAEVDRINLRARERTVA
HHHHCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHH
LITRALGGRAEGRRITVLGAAFKPNSDDIRDSPALEISAELHRAGARVVVYDPAAMANAR
HHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEHHHHHCCCEEEEECCHHHHHHH
RRFPELEYAPSAHEAATGADALAVLTEWTEFRDLDPDALTPRVAGRVVVDGRHALDGPAW
HCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCCHHCCHHHCCEEEECCCCCCCCCHH
RRAGWAYYALGRPPA
HHCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]