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The map label for this gene is manB [H]

Identifier: 158317602

GI number: 158317602

Start: 7107036

End: 7108397

Strand: Reverse

Name: manB [H]

Synonym: Franean1_5858

Alternate gene names: 158317602

Gene position: 7108397-7107036 (Counterclockwise)

Preceding gene: 158317603

Following gene: 158317601

Centisome position: 79.14

GC content: 71.59

Gene sequence:

>1362_bases
GTGCACGACCTCTCACGGATCTTCAAGGCATACGACGTGCGAGGTGTGGTGCCGTCCGAGTTCGACGTGGAGGTGGCTCG
GGCCACCGGCGCGGCGTTCGTCTGCCTGCTCGGAGCCGACCGGATCGTCACCGCCCACGACATGCGCGAGTCCTCCGTCC
CGCTGGCGGCCGCCTTCGCGGACGGCGCCACCAGCCAGGGCGCGGACGTCATCGCCGCCGGTCTCGGGTCGACCGACCTG
CTCTACTTCGCGGCCGGCTCGCTGGACCTGCCCGGCGCCATGTTCACCGCCTCGCACAACCCGGCGAAGTACAACGGCAT
GAAGCTGTGCCGGGCCGGCGCGGCGCCGATCGGGCAGCAGACCGGCCTGGCGGAGATCCGGGCGCTGATCGAGGCCGGCG
TGCCGGAGCACACCGGCCGGCCGGGCACCGTCACCACCCGCGACCTGCGTGACGACTACGCGCGTCACCTGCGCTCCCTC
GTCGACCTGAGCCGGATCCGCCCGCTGAAGGTCGTCGTGGACGCCGGCAACGGCATGGCGGGTCTGACCGTCCCGGCGGT
GTTCGACGGGCTGCCGCTGACCGTCACCCCGATGTACTTCGAGCTCGACGGCTCCTTCCCGAACCACGAGGCCAACCCGA
TCGAGCCGGAGAACCTGCGCGACCTGCAGGCCGCCGTGCGCTCCTCGGGCGCGGACATCGGGCTCGCCTTCGACGGCGAC
GCCGACCGCTGCTTCGTCGTCGACGAGCGCGGCGAGATCGTCTCCCCGTCGGTCATCACCGCACTGGTCGCCGAGCGCGA
GCTGCGCCGCGAGCCGGGCGCGACCATCATCCACAACGTGATCGTCAGCCGGGCCGTCCCCGAGCTGGTGACCGAGCGCG
GCGGCGCGCCGGTGCGCACCCGCGTCGGCCACTCGTTCATCAAGGCCGAGATGGCCCGTACCGGCGCGGTGTTCGGCGGC
GAGCACTCCGGTCACTTCTACTTCCGGGACTTCTGGCGCGCGGACTCCGGCATGCTCGCGGCCCTGCACGTGCTGGCCGC
GCTGGGCGGGCAGGGTGGCCCGCTGTCCGGCCTGCTCGGCGGCTACGCCCGCTACGCGGCCTCCGGGGAGATCAACTCCG
AGGTCGCGGACGCCGACGTGGCGATGAACGAGGTCGAGAAGGCCTACGCCGCCCGGGCGGTCGACATCGACCACATGGAC
GGGCTGACCGTGTCGCTGGCCGACGGGTCATGGTTCAACCTCCGGCCGTCCAATACCGAGCCACTGCTGCGCCTGAACGT
CGAAGGGCGCGATGATGCCATGATGTGCCGGCTGCGCGACGACATCCTCGTCTGCATCCGCGGTGGAAGGGAGAACTCCT
GA

Upstream 100 bases:

>100_bases
CCGAACCCGCCCCGCGCGGCAAGGCGCTGACGGGGATGTCGCCCCGGCCGGATAAGGTCAACCCGGTCGATCGACGCCGG
TCAGGGAAGGTGGTTACGGG

Downstream 100 bases:

>100_bases
TGAGCCTCGACCCCCTGTTGCTGGAGATCCTCGCCTGCCCGTGCCCGGAGCATGCTCCGCTGCGGCAGGAGACGCTGGAC
GGCGCTCCCGTGCTGGTCTG

Product: phosphomannomutase/phosphoglucomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MHDLSRIFKAYDVRGVVPSEFDVEVARATGAAFVCLLGADRIVTAHDMRESSVPLAAAFADGATSQGADVIAAGLGSTDL
LYFAAGSLDLPGAMFTASHNPAKYNGMKLCRAGAAPIGQQTGLAEIRALIEAGVPEHTGRPGTVTTRDLRDDYARHLRSL
VDLSRIRPLKVVVDAGNGMAGLTVPAVFDGLPLTVTPMYFELDGSFPNHEANPIEPENLRDLQAAVRSSGADIGLAFDGD
ADRCFVVDERGEIVSPSVITALVAERELRREPGATIIHNVIVSRAVPELVTERGGAPVRTRVGHSFIKAEMARTGAVFGG
EHSGHFYFRDFWRADSGMLAALHVLAALGGQGGPLSGLLGGYARYAASGEINSEVADADVAMNEVEKAYAARAVDIDHMD
GLTVSLADGSWFNLRPSNTEPLLRLNVEGRDDAMMCRLRDDILVCIRGGRENS

Sequences:

>Translated_453_residues
MHDLSRIFKAYDVRGVVPSEFDVEVARATGAAFVCLLGADRIVTAHDMRESSVPLAAAFADGATSQGADVIAAGLGSTDL
LYFAAGSLDLPGAMFTASHNPAKYNGMKLCRAGAAPIGQQTGLAEIRALIEAGVPEHTGRPGTVTTRDLRDDYARHLRSL
VDLSRIRPLKVVVDAGNGMAGLTVPAVFDGLPLTVTPMYFELDGSFPNHEANPIEPENLRDLQAAVRSSGADIGLAFDGD
ADRCFVVDERGEIVSPSVITALVAERELRREPGATIIHNVIVSRAVPELVTERGGAPVRTRVGHSFIKAEMARTGAVFGG
EHSGHFYFRDFWRADSGMLAALHVLAALGGQGGPLSGLLGGYARYAASGEINSEVADADVAMNEVEKAYAARAVDIDHMD
GLTVSLADGSWFNLRPSNTEPLLRLNVEGRDDAMMCRLRDDILVCIRGGRENS
>Mature_453_residues
MHDLSRIFKAYDVRGVVPSEFDVEVARATGAAFVCLLGADRIVTAHDMRESSVPLAAAFADGATSQGADVIAAGLGSTDL
LYFAAGSLDLPGAMFTASHNPAKYNGMKLCRAGAAPIGQQTGLAEIRALIEAGVPEHTGRPGTVTTRDLRDDYARHLRSL
VDLSRIRPLKVVVDAGNGMAGLTVPAVFDGLPLTVTPMYFELDGSFPNHEANPIEPENLRDLQAAVRSSGADIGLAFDGD
ADRCFVVDERGEIVSPSVITALVAERELRREPGATIIHNVIVSRAVPELVTERGGAPVRTRVGHSFIKAEMARTGAVFGG
EHSGHFYFRDFWRADSGMLAALHVLAALGGQGGPLSGLLGGYARYAASGEINSEVADADVAMNEVEKAYAARAVDIDHMD
GLTVSLADGSWFNLRPSNTEPLLRLNVEGRDDAMMCRLRDDILVCIRGGRENS

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=449, Percent_Identity=41.2026726057906, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI1789566, Length=354, Percent_Identity=28.2485875706215, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 48151; Mature: 48151

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDLSRIFKAYDVRGVVPSEFDVEVARATGAAFVCLLGADRIVTAHDMRESSVPLAAAFA
CCHHHHHHHHHCCCCCCCCCCCEEEEHHCCCEEEEEECCCCEEEHHCCCCCCCCEEEEEC
DGATSQGADVIAAGLGSTDLLYFAAGSLDLPGAMFTASHNPAKYNGMKLCRAGAAPIGQQ
CCCCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCHHHHHCCCCCCCCC
TGLAEIRALIEAGVPEHTGRPGTVTTRDLRDDYARHLRSLVDLSRIRPLKVVVDAGNGMA
CCHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
GLTVPAVFDGLPLTVTPMYFELDGSFPNHEANPIEPENLRDLQAAVRSSGADIGLAFDGD
CCCHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCC
ADRCFVVDERGEIVSPSVITALVAERELRREPGATIIHNVIVSRAVPELVTERGGAPVRT
CCEEEEEECCCCEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
RVGHSFIKAEMARTGAVFGGEHSGHFYFRDFWRADSGMLAALHVLAALGGQGGPLSGLLG
HHHHHHHHHHHHHCCCEECCCCCCCEEEEHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHH
GYARYAASGEINSEVADADVAMNEVEKAYAARAVDIDHMDGLTVSLADGSWFNLRPSNTE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEECCCCEEECCCCCCC
PLLRLNVEGRDDAMMCRLRDDILVCIRGGRENS
CEEEEEECCCCCCEEEEECCCEEEEEECCCCCC
>Mature Secondary Structure
MHDLSRIFKAYDVRGVVPSEFDVEVARATGAAFVCLLGADRIVTAHDMRESSVPLAAAFA
CCHHHHHHHHHCCCCCCCCCCCEEEEHHCCCEEEEEECCCCEEEHHCCCCCCCCEEEEEC
DGATSQGADVIAAGLGSTDLLYFAAGSLDLPGAMFTASHNPAKYNGMKLCRAGAAPIGQQ
CCCCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCHHHHHCCCCCCCCC
TGLAEIRALIEAGVPEHTGRPGTVTTRDLRDDYARHLRSLVDLSRIRPLKVVVDAGNGMA
CCHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
GLTVPAVFDGLPLTVTPMYFELDGSFPNHEANPIEPENLRDLQAAVRSSGADIGLAFDGD
CCCHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCC
ADRCFVVDERGEIVSPSVITALVAERELRREPGATIIHNVIVSRAVPELVTERGGAPVRT
CCEEEEEECCCCEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
RVGHSFIKAEMARTGAVFGGEHSGHFYFRDFWRADSGMLAALHVLAALGGQGGPLSGLLG
HHHHHHHHHHHHHCCCEECCCCCCCEEEEHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHH
GYARYAASGEINSEVADADVAMNEVEKAYAARAVDIDHMDGLTVSLADGSWFNLRPSNTE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEECCCCEEECCCCCCC
PLLRLNVEGRDDAMMCRLRDDILVCIRGGRENS
CEEEEEECCCCCCEEEEECCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9673232; 10222209; 11206551; 11258796 [H]