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The map label for this gene is fgd1 [H]

Identifier: 158317523

GI number: 158317523

Start: 7015549

End: 7016529

Strand: Reverse

Name: fgd1 [H]

Synonym: Franean1_5777

Alternate gene names: 158317523

Gene position: 7016529-7015549 (Counterclockwise)

Preceding gene: 158317524

Following gene: 158317522

Centisome position: 78.12

GC content: 74.21

Gene sequence:

>981_bases
GTGGACGCCACCGCTGAACCCGTCCGCGTTGGCGTACTGTTGCCGACCCGGGAGCAGGCGGTCACCGGCAGGTTCGCGGC
GGAGCCGTTGCTGGCGTTCGCCGGGAAGGCGGAGGCGCTCGGTTTCGACTCAGTGTGGGTCGGCGACTCGCTGACCGCCA
GGCCGCGGTTCGACCCGTTCGTGGTGCTCGCCGCGGTCGCGGCGGTGACCAGCCGAGTAACGCTGGGCACCGCGGCACTG
ACACCGGTGCTGCGCCACCCGCTGATCGTGGCGAACCTGATCGCCAGCCTCGACCACGTGTCCGCGTCCCGCCTGGTGCT
GGGACTCGGCGCCGGCTTCCCGGTCCCCGAGACGGAGGCCGAGTTCGCCGCCGTCGGCGCGTCCTTCGGGCAGCGGGTGG
GCAGGCTGGACGAGTCGGTTGCACTGTGGCGGCAGGCCTGGCGGACCGACGGCGCCGTCGCGGCGGAGTTCACCGGACGG
TACTGGCAGGTGGCCGGTCTCGACCGGCTGCCGCCGCCGCACCGGCCCGGGGGACCGCCACTGTGGCTGGCCGGCAGCGA
CACCCCGGCGGTGACGGCACGGGTGGCGCGGTACTACGACGGCTGGCTTCCCTTCCTGCCCACCGCGCAGGCCTACGACC
AGGCATGGCGCGCTGTCGTCGCCGCTTGCCAGGAGGCGGGCCGGGCGCCGGGGGCCGTCACGGCGGGCCTATACGCCACG
GTCACCGTCGACGAGGACCGGGACCGGGCCAAGGCGGAGCTCGCTGACTACGTCGGTCGCTACTACGGCCGACCGCTCGA
GCAGATGGCCGCGTTGCAGGCGTACGGCTGGGGGAGCGCTGAGGAGTGCGCGCGGTGGCTCGTGGGCTACGTCCGGGCCG
GTGCCCGGCACGTGGTCGTCCGGATCGGTTCGCTCGACCCGGCCAGCCAGCTCGAACTGATCGCGCGCGACGTCCTGCCG
GCGGTACGCGCCGCGGGATGA

Upstream 100 bases:

>100_bases
AAGCTCCTGCGCCGGGTCGTGCGCGAGCAACTGAGCGCCACCTCGACGGCGGCGCCCACCACCGGTGCGCGGGTCGAGGT
TTGCGAGGAAGGAGCCGACG

Downstream 100 bases:

>100_bases
CGGGCGACGACGTGCCCGGCGGGCACGTCCGTCCGACCGGACCACCATCTTCAGGAGGTACCGTGAGTAGCTCGATCGTG
GCGCGGACGTCCGCGCACGG

Product: luciferase family protein

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MDATAEPVRVGVLLPTREQAVTGRFAAEPLLAFAGKAEALGFDSVWVGDSLTARPRFDPFVVLAAVAAVTSRVTLGTAAL
TPVLRHPLIVANLIASLDHVSASRLVLGLGAGFPVPETEAEFAAVGASFGQRVGRLDESVALWRQAWRTDGAVAAEFTGR
YWQVAGLDRLPPPHRPGGPPLWLAGSDTPAVTARVARYYDGWLPFLPTAQAYDQAWRAVVAACQEAGRAPGAVTAGLYAT
VTVDEDRDRAKAELADYVGRYYGRPLEQMAALQAYGWGSAEECARWLVGYVRAGARHVVVRIGSLDPASQLELIARDVLP
AVRAAG

Sequences:

>Translated_326_residues
MDATAEPVRVGVLLPTREQAVTGRFAAEPLLAFAGKAEALGFDSVWVGDSLTARPRFDPFVVLAAVAAVTSRVTLGTAAL
TPVLRHPLIVANLIASLDHVSASRLVLGLGAGFPVPETEAEFAAVGASFGQRVGRLDESVALWRQAWRTDGAVAAEFTGR
YWQVAGLDRLPPPHRPGGPPLWLAGSDTPAVTARVARYYDGWLPFLPTAQAYDQAWRAVVAACQEAGRAPGAVTAGLYAT
VTVDEDRDRAKAELADYVGRYYGRPLEQMAALQAYGWGSAEECARWLVGYVRAGARHVVVRIGSLDPASQLELIARDVLP
AVRAAG
>Mature_326_residues
MDATAEPVRVGVLLPTREQAVTGRFAAEPLLAFAGKAEALGFDSVWVGDSLTARPRFDPFVVLAAVAAVTSRVTLGTAAL
TPVLRHPLIVANLIASLDHVSASRLVLGLGAGFPVPETEAEFAAVGASFGQRVGRLDESVALWRQAWRTDGAVAAEFTGR
YWQVAGLDRLPPPHRPGGPPLWLAGSDTPAVTARVARYYDGWLPFLPTAQAYDQAWRAVVAACQEAGRAPGAVTAGLYAT
VTVDEDRDRAKAELADYVGRYYGRPLEQMAALQAYGWGSAEECARWLVGYVRAGARHVVVRIGSLDPASQLELIARDVLP
AVRAAG

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 34651; Mature: 34651

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATAEPVRVGVLLPTREQAVTGRFAAEPLLAFAGKAEALGFDSVWVGDSLTARPRFDPF
CCCCCCCEEEEEEECCHHHHHHCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCHH
VVLAAVAAVTSRVTLGTAALTPVLRHPLIVANLIASLDHVSASRLVLGLGAGFPVPETEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCH
EFAAVGASFGQRVGRLDESVALWRQAWRTDGAVAAEFTGRYWQVAGLDRLPPPHRPGGPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCE
LWLAGSDTPAVTARVARYYDGWLPFLPTAQAYDQAWRAVVAACQEAGRAPGAVTAGLYAT
EEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECEEEE
VTVDEDRDRAKAELADYVGRYYGRPLEQMAALQAYGWGSAEECARWLVGYVRAGARHVVV
EEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEE
RIGSLDPASQLELIARDVLPAVRAAG
EECCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDATAEPVRVGVLLPTREQAVTGRFAAEPLLAFAGKAEALGFDSVWVGDSLTARPRFDPF
CCCCCCCEEEEEEECCHHHHHHCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCHH
VVLAAVAAVTSRVTLGTAALTPVLRHPLIVANLIASLDHVSASRLVLGLGAGFPVPETEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCH
EFAAVGASFGQRVGRLDESVALWRQAWRTDGAVAAEFTGRYWQVAGLDRLPPPHRPGGPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCE
LWLAGSDTPAVTARVARYYDGWLPFLPTAQAYDQAWRAVVAACQEAGRAPGAVTAGLYAT
EEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECEEEE
VTVDEDRDRAKAELADYVGRYYGRPLEQMAALQAYGWGSAEECARWLVGYVRAGARHVVV
EEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEE
RIGSLDPASQLELIARDVLPAVRAAG
EECCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]